Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GRIA3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
450 Arg Gln Intellectualdevelopmentaldisorder,X-linked,syndromic,Wutype(MRXSW) -
631 Arg Ser Intellectualdevelopmentaldisorder,X-linked,syndromic,Wutype(MRXSW) -
706 Met Thr Intellectualdevelopmentaldisorder,X-linked,syndromic,Wutype(MRXSW) -
833 Gly Arg Intellectualdevelopmentaldisorder,X-linked,syndromic,Wutype(MRXSW) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GRIA3_HUMAN
GO:0005216 ion channel activity 30.0000 4 yes
GO:0008324 cation transmembrane transporter activity 30.0000 4 yes
GO:0015267 channel activity 30.0000 4 yes
GO:0022836 gated channel activity 30.0000 5 yes
GO:0022890 inorganic cation transmembrane transporter activity 30.0000 4 yes
GO:0005261 cation channel activity 28.3333 5 yes
GO:0046873 metal ion transmembrane transporter activity 21.6667 5 no
GO:0005230 extracellular ligand-gated ion channel activity 20.0000 6 yes
GO:0015276 ligand-gated ion channel activity 20.0000 5 yes
GO:0022824 transmitter-gated ion channel activity 20.0000 5 yes
GO:0022834 ligand-gated channel activity 20.0000 6 yes
GO:0022835 transmitter-gated channel activity 20.0000 4 yes
GO:0004970 ionotropic glutamate receptor activity 18.3333 5 yes
GO:0008066 glutamate receptor activity 18.3333 4 yes
GO:0099094 ligand-gated cation channel activity 18.3333 6 yes
GO:0001540 amyloid-beta binding 15.0000 4 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 11.6667 4 yes
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 11.6667 5 yes
GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential 11.6667 6 yes
GO:0004971 AMPA glutamate receptor activity 8.3333 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GRIA3_HUMAN
GO:0048522 positive regulation of cellular process 61.6667 4 no
GO:0010646 regulation of cell communication 58.3333 4 no
GO:0051049 regulation of transport 55.0000 4 no
GO:0008104 protein localization 51.6667 4 no
GO:0050804 modulation of chemical synaptic transmission 45.0000 5 no
GO:0099177 regulation of trans-synaptic signaling 45.0000 4 no
GO:0009966 regulation of signal transduction 40.0000 4 no
GO:0071702 organic substance transport 38.3333 4 no
GO:0071705 nitrogen compound transport 38.3333 4 no
GO:0016192 vesicle-mediated transport 38.3333 4 no
GO:0048523 negative regulation of cellular process 38.3333 4 no
GO:0023056 positive regulation of signaling 36.6667 4 no
GO:0043269 regulation of ion transport 36.6667 5 no
GO:0010647 positive regulation of cell communication 35.0000 5 no
GO:0015031 protein transport 35.0000 4 no
GO:0006886 intracellular protein transport 33.3333 4 no
GO:0060255 regulation of macromolecule metabolic process 33.3333 4 no
GO:0051128 regulation of cellular component organization 33.3333 4 no
GO:0034762 regulation of transmembrane transport 31.6667 4 no
GO:0034765 regulation of ion transmembrane transport 31.6667 5 no
GO:0051171 regulation of nitrogen compound metabolic process 31.6667 4 no
GO:0080090 regulation of primary metabolic process 31.6667 4 no
GO:1904062 regulation of cation transmembrane transport 31.6667 6 no
GO:0007268 chemical synaptic transmission 30.0000 6 no
GO:0098916 anterograde trans-synaptic signaling 30.0000 5 no
GO:0099537 trans-synaptic signaling 30.0000 4 no
GO:0072657 protein localization to membrane 30.0000 4 no
GO:0022898 regulation of transmembrane transporter activity 26.6667 4 no
GO:0032412 regulation of ion transmembrane transporter activity 26.6667 5 no
GO:2001257 regulation of cation channel activity 26.6667 6 no
GO:0030030 cell projection organization 25.0000 4 no
GO:0050806 positive regulation of synaptic transmission 25.0000 5 no
GO:0060341 regulation of cellular localization 25.0000 4 no
GO:0120036 plasma membrane bounded cell projection organization 25.0000 5 no
GO:0009893 positive regulation of metabolic process 25.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 25.0000 5 no
GO:0031323 regulation of cellular metabolic process 25.0000 4 no
GO:0044057 regulation of system process 25.0000 4 no
GO:0051246 regulation of protein metabolic process 25.0000 5 no
GO:0051050 positive regulation of transport 23.3333 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 23.3333 5 no
GO:0006897 endocytosis 23.3333 5 no
GO:0099601 regulation of neurotransmitter receptor activity 23.3333 4 no
GO:0006811 ion transport 21.6667 4 no
GO:0022607 cellular component assembly 21.6667 4 no
GO:0006898 receptor-mediated endocytosis 21.6667 6 no
GO:0007215 glutamate receptor signaling pathway 15.0000 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in GRIA3_HUMAN
DOID:0050888 syndromic intellectual disability 3.3333 5 yes
DOID:0060038 specific developmental disorder 3.3333 3 yes
DOID:0060309 syndromic X-linked intellectual disability 3.3333 6 yes
DOID:0060823 syndromic X-linked intellectual disability 94 3.3333 7 yes
DOID:1059 intellectual disability 3.3333 4 yes
DOID:331 central nervous system disease 3.3333 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PICK1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
NSF_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
AP2M1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIA2_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIA3_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIA1_HUMAN [view entry] [view interactions] Low throughput yes yes
SQSTM_HUMAN [view interactions] Low throughput no yes
CXCR2_HUMAN [view interactions] Low throughput no no
CXCR1_HUMAN [view interactions] Low throughput no yes
AFAD_HUMAN [view interactions] Low throughput no yes
SHSA6_HUMAN [view entry] [view interactions] Low throughput yes no
SHSA7_HUMAN [view entry] [view interactions] Low throughput yes no
CCG2_HUMAN [view entry] [view interactions] Low throughput yes no
DIK1A_HUMAN [view interactions] High throughput no yes
GRIA4_HUMAN [view entry] [view interactions] High throughput yes no
DNJB9_HUMAN [view interactions] High throughput no yes
E2AK3_HUMAN [view interactions] High throughput no yes
GLBL2_HUMAN [view interactions] High throughput no no
MAP2_HUMAN [view interactions] High throughput no yes
GLRB_HUMAN [view entry] [view interactions] High throughput yes no
MECOM_HUMAN [view interactions] High throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
SDCB1_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
CBP_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
CCPG1_HUMAN [view interactions] High throughput no yes
CLH2_HUMAN [view interactions] High throughput no no
SEM4F_HUMAN [view entry] [view interactions] High throughput yes no
ALG9_HUMAN [view interactions] High throughput no yes
TMPPE_HUMAN [view interactions] High throughput no yes
LMF2_HUMAN [view interactions] High throughput no yes
HLAF_HUMAN [view interactions] High throughput no no
KALRN_HUMAN [view entry] [view interactions] High throughput yes yes
GLUC_HUMAN [view interactions] High throughput no no
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
ADRB2_HUMAN [view entry] [view interactions] High throughput yes no
CCG7_HUMAN [view entry] [view interactions] Computational yes no
NFL_HUMAN [view entry] [view interactions] Computational yes yes
ACTN2_HUMAN [view entry] [view interactions] Computational yes yes
SHSA9_HUMAN [view entry] [view interactions] Computational yes no
NMDE1_HUMAN [view entry] [view interactions] Computational yes yes
KIF5C_HUMAN [view entry] [view interactions] Computational yes yes
MDM2_HUMAN [view interactions] Computational no yes
AP2A1_HUMAN [view entry] [view interactions] Computational yes yes
AP2S1_HUMAN [view entry] [view interactions] Computational yes no
LYN_HUMAN [view entry] [view interactions] Computational yes no
NMDZ1_HUMAN [view entry] [view interactions] Computational yes yes
CNIH3_HUMAN [view entry] [view interactions] Computational yes no
NMDE2_HUMAN [view entry] [view interactions] Computational yes no
KCC2D_HUMAN [view entry] [view interactions] Computational yes yes
CCG8_HUMAN [view entry] [view interactions] Computational yes no
CNIH2_HUMAN [view entry] [view interactions] Computational yes no
NMDE3_HUMAN [view entry] [view interactions] Computational yes no
NMDE4_HUMAN [view entry] [view interactions] Computational yes yes
KIF5A_HUMAN [view entry] [view interactions] Computational yes yes
DLG2_HUMAN [view entry] [view interactions] Computational yes yes
CCG3_HUMAN [view entry] [view interactions] Computational yes no
NOE2_HUMAN [view entry] [view interactions] Computational yes yes
CCG4_HUMAN [view entry] [view interactions] Computational yes no
KPCA_HUMAN [view entry] [view interactions] Computational yes yes
KCC2B_HUMAN [view entry] [view interactions] Computational yes yes
TSN7_HUMAN [view entry] [view interactions] Computational yes yes
NMD3A_HUMAN [view entry] [view interactions] Computational yes no
DLG3_HUMAN [view entry] [view interactions] Computational yes yes
KINH_HUMAN [view entry] [view interactions] Computational yes no
KPCG_HUMAN [view entry] [view interactions] Computational yes yes
DLG1_HUMAN [view entry] [view interactions] Computational yes yes
CCG5_HUMAN [view entry] [view interactions] Computational yes no
AP2A2_HUMAN [view entry] [view interactions] Computational yes yes
E41L1_HUMAN [view entry] [view interactions] Computational yes yes
MYO6_HUMAN [view entry] [view interactions] Computational yes no
AKAP5_HUMAN [view entry] [view interactions] Computational yes yes
AP2B1_HUMAN [view entry] [view interactions] Computational yes yes