GRIA3_HUMAN
Evidence for PS localization
Functions
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 450 | Arg | Gln | Intellectualdevelopmentaldisorder,X-linked,syndromic,Wutype(MRXSW) | - |
| 631 | Arg | Ser | Intellectualdevelopmentaldisorder,X-linked,syndromic,Wutype(MRXSW) | - |
| 706 | Met | Thr | Intellectualdevelopmentaldisorder,X-linked,syndromic,Wutype(MRXSW) | - |
| 833 | Gly | Arg | Intellectualdevelopmentaldisorder,X-linked,syndromic,Wutype(MRXSW) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GRIA3_HUMAN |
|---|---|---|---|---|
| GO:0005216 | monoatomic ion channel activity | 30.7692 | 4 | yes |
| GO:0015267 | channel activity | 30.7692 | 4 | yes |
| GO:0022836 | gated channel activity | 26.9231 | 5 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 26.9231 | 4 | yes |
| GO:0005230 | extracellular ligand-gated monoatomic ion channel activity | 23.0769 | 6 | yes |
| GO:0015276 | ligand-gated monoatomic ion channel activity | 23.0769 | 5 | yes |
| GO:0022824 | transmitter-gated monoatomic ion channel activity | 23.0769 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 23.0769 | 6 | yes |
| GO:0022835 | transmitter-gated channel activity | 23.0769 | 4 | yes |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 23.0769 | 4 | yes |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 23.0769 | 5 | yes |
| GO:1904315 | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | 23.0769 | 6 | yes |
| GO:0043169 | cation binding | 23.0769 | 4 | no |
| GO:0035254 | glutamate receptor binding | 23.0769 | 4 | no |
| GO:0004970 | glutamate-gated receptor activity | 19.2308 | 4 | yes |
| GO:0004971 | AMPA glutamate receptor activity | 19.2308 | 5 | yes |
| GO:0008066 | glutamate receptor activity | 19.2308 | 4 | yes |
| GO:0046943 | carboxylic acid transmembrane transporter activity | 19.2308 | 4 | yes |
| GO:0099507 | ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential | 15.3846 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GRIA3_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 65.3846 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 57.6923 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 50.0000 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 50.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
| GO:0008104 | protein localization | 46.1538 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 42.3077 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 42.3077 | 4 | no |
| GO:0072657 | protein localization to membrane | 42.3077 | 4 | no |
| GO:0007268 | chemical synaptic transmission | 38.4615 | 7 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 38.4615 | 6 | yes |
| GO:0099536 | synaptic signaling | 38.4615 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 38.4615 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 38.4615 | 4 | no |
| GO:0009966 | regulation of signal transduction | 38.4615 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 34.6154 | 5 | no |
| GO:0023056 | positive regulation of signaling | 34.6154 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 34.6154 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 30.7692 | 5 | no |
| GO:0022607 | cellular component assembly | 30.7692 | 4 | no |
| GO:0030030 | cell projection organization | 30.7692 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.7692 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 30.7692 | 5 | no |
| GO:0051049 | regulation of transport | 30.7692 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 26.9231 | 4 | no |
| GO:0006996 | organelle organization | 23.0769 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.0769 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 23.0769 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 23.0769 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.0769 | 6 | no |
| GO:1990778 | protein localization to cell periphery | 23.0769 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 23.0769 | 5 | no |
| GO:0023057 | negative regulation of signaling | 23.0769 | 4 | no |
| GO:0043933 | protein-containing complex organization | 23.0769 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 23.0769 | 5 | no |
| GO:0071702 | organic substance transport | 23.0769 | 4 | no |
| GO:0071705 | nitrogen compound transport | 23.0769 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 23.0769 | 4 | no |
| GO:0010468 | regulation of gene expression | 23.0769 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 23.0769 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 23.0769 | 5 | no |
| GO:0035249 | synaptic transmission, glutamatergic | 19.2308 | 8 | yes |
| GO:0007215 | glutamate receptor signaling pathway | 15.3846 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PICK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NSF_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SQSTM_HUMAN | [view interactions] | Low throughput | no | yes |
| CXCR2_HUMAN | [view interactions] | Low throughput | no | no |
| CXCR1_HUMAN | [view interactions] | Low throughput | no | yes |
| AFAD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHSA6_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SHSA7_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CCG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GRIA4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GLRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MAP2_HUMAN | [view interactions] | High throughput | no | yes |
| DIK1A_HUMAN | [view interactions] | High throughput | no | yes |
| GLBL2_HUMAN | [view interactions] | High throughput | no | no |
| E2AK3_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB9_HUMAN | [view interactions] | High throughput | no | yes |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CBP_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCPG1_HUMAN | [view interactions] | High throughput | no | yes |
| CLH2_HUMAN | [view interactions] | High throughput | no | no |
| SEM4F_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ALG9_HUMAN | [view interactions] | High throughput | no | yes |
| TMPPE_HUMAN | [view interactions] | High throughput | no | yes |
| LMF2_HUMAN | [view interactions] | High throughput | no | yes |
| HLAF_HUMAN | [view interactions] | High throughput | no | no |
| KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLUC_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYCN_HUMAN | [view interactions] | High throughput | no | no |
| CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |