Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SHSA7_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Transmembrane protein that regulates gamma-aminobutyric acid type A receptor (GABA(A)R) trafficking, channel deactivation kinetics and pharmacology, necessary for fast inhibitory transmission in the brain. Enhances the action of benzodiazepine, a primary GABA(A)Rs target drug, in the brain. May affect channel kinetics of AMPA-type glutamate receptors (AMPAR), the brains main excitatory neurotransmitter, necessary for synaptic hippocampal plasticity, and memory recall. May regulate the induction and maintenance of long-term potentiation at Schaffer collaterals/CA3-CA1 excitatory synapses. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SHSA7_HUMAN
GO:0019900 kinase binding 33.3333 4 no
GO:0005216 monoatomic ion channel activity 26.6667 4 no
GO:0015267 channel activity 26.6667 4 no
GO:0022836 gated channel activity 26.6667 5 no
GO:0022890 inorganic cation transmembrane transporter activity 26.6667 4 no
GO:0019902 phosphatase binding 26.6667 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in SHSA7_HUMAN
GO:0010646 regulation of cell communication 86.6667 4 yes
GO:0048522 positive regulation of cellular process 66.6667 4 yes
GO:0048523 negative regulation of cellular process 60.0000 4 no
GO:0009966 regulation of signal transduction 60.0000 4 yes
GO:0050804 modulation of chemical synaptic transmission 60.0000 5 yes
GO:0099177 regulation of trans-synaptic signaling 60.0000 4 yes
GO:0008104 protein localization 53.3333 4 yes
GO:0031323 regulation of cellular metabolic process 46.6667 4 no
GO:0060255 regulation of macromolecule metabolic process 46.6667 4 no
GO:0007268 chemical synaptic transmission 46.6667 7 no
GO:0098916 anterograde trans-synaptic signaling 46.6667 6 no
GO:0099536 synaptic signaling 46.6667 4 no
GO:0099537 trans-synaptic signaling 46.6667 5 no
GO:0051049 regulation of transport 40.0000 4 no
GO:0010647 positive regulation of cell communication 40.0000 5 yes
GO:0023056 positive regulation of signaling 40.0000 4 yes
GO:0072657 protein localization to membrane 40.0000 4 yes
GO:0009893 positive regulation of metabolic process 40.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 40.0000 5 no
GO:0031325 positive regulation of cellular metabolic process 40.0000 5 no
GO:0051128 regulation of cellular component organization 40.0000 4 no
GO:0080090 regulation of primary metabolic process 40.0000 4 no
GO:0010648 negative regulation of cell communication 33.3333 5 no
GO:0023057 negative regulation of signaling 33.3333 4 no
GO:0043113 receptor clustering 33.3333 5 yes
GO:0050806 positive regulation of synaptic transmission 33.3333 5 yes
GO:0006996 organelle organization 33.3333 4 no
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 no
GO:0019220 regulation of phosphate metabolic process 33.3333 6 no
GO:0031399 regulation of protein modification process 33.3333 6 no
GO:0031401 positive regulation of protein modification process 33.3333 7 no
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 no
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 no
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0022898 regulation of transmembrane transporter activity 26.6667 4 no
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 26.6667 5 no
GO:0034762 regulation of transmembrane transport 26.6667 4 no
GO:0043085 positive regulation of catalytic activity 26.6667 4 no
GO:0050890 cognition 26.6667 4 yes
GO:0001932 regulation of protein phosphorylation 26.6667 7 no
GO:0001934 positive regulation of protein phosphorylation 26.6667 8 no
GO:0022603 regulation of anatomical structure morphogenesis 26.6667 4 no
GO:0022607 cellular component assembly 26.6667 4 no
GO:0031344 regulation of cell projection organization 26.6667 5 no
GO:0042325 regulation of phosphorylation 26.6667 7 no
GO:0042327 positive regulation of phosphorylation 26.6667 8 no
GO:1902531 regulation of intracellular signal transduction 26.6667 5 no
GO:0048168 regulation of neuronal synaptic plasticity 20.0000 4 yes
GO:0007613 memory 13.3333 4 yes
GO:0048172 regulation of short-term neuronal synaptic plasticity 13.3333 5 yes
GO:0072578 neurotransmitter-gated ion channel clustering 13.3333 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GRIA1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIA2_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIA3_HUMAN [view entry] [view interactions] Low throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC4_HUMAN [view interactions] High throughput no yes
KALRN_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
SPPL3_HUMAN [view interactions] High throughput no no
CCG8_HUMAN [view entry] [view interactions] High throughput yes no
PRRT1_HUMAN [view entry] [view interactions] High throughput yes yes
PRRT2_HUMAN [view entry] [view interactions] High throughput yes no
SHSA6_HUMAN [view entry] [view interactions] High throughput yes no
DLG1_HUMAN [view entry] [view interactions] High throughput yes yes
DLG3_HUMAN [view entry] [view interactions] High throughput yes yes
MAGI2_HUMAN [view entry] [view interactions] High throughput yes yes
RAP2B_HUMAN [view interactions] High throughput no no