CCG8_HUMAN
Evidence for PS localization
Functions
Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit . Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CCG8_HUMAN |
|---|---|---|---|---|
| GO:0005216 | ion channel activity | 46.1538 | 4 | yes |
| GO:0005261 | cation channel activity | 46.1538 | 5 | yes |
| GO:0008324 | cation transmembrane transporter activity | 46.1538 | 4 | yes |
| GO:0015267 | channel activity | 46.1538 | 4 | yes |
| GO:0022836 | gated channel activity | 46.1538 | 5 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 46.1538 | 4 | yes |
| GO:0005244 | voltage-gated ion channel activity | 35.8974 | 4 | yes |
| GO:0005262 | calcium channel activity | 35.8974 | 6 | yes |
| GO:0015085 | calcium ion transmembrane transporter activity | 35.8974 | 6 | yes |
| GO:0022832 | voltage-gated channel activity | 35.8974 | 6 | yes |
| GO:0022843 | voltage-gated cation channel activity | 35.8974 | 5 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 35.8974 | 5 | yes |
| GO:0005245 | voltage-gated calcium channel activity | 30.7692 | 6 | yes |
| GO:0046872 | metal ion binding | 20.5128 | 4 | no |
| GO:0005246 | calcium channel regulator activity | 12.8205 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CCG8_HUMAN |
|---|---|---|---|---|
| GO:0051049 | regulation of transport | 64.1026 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 56.4103 | 4 | yes |
| GO:0010646 | regulation of cell communication | 53.8462 | 4 | yes |
| GO:0043269 | regulation of ion transport | 51.2821 | 5 | yes |
| GO:0034762 | regulation of transmembrane transport | 48.7179 | 4 | yes |
| GO:0034765 | regulation of ion transmembrane transport | 48.7179 | 5 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 46.1538 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 46.1538 | 4 | yes |
| GO:1904062 | regulation of cation transmembrane transport | 46.1538 | 6 | yes |
| GO:0022898 | regulation of transmembrane transporter activity | 43.5897 | 4 | yes |
| GO:0032412 | regulation of ion transmembrane transporter activity | 43.5897 | 5 | yes |
| GO:2001257 | regulation of cation channel activity | 43.5897 | 6 | yes |
| GO:0008104 | protein localization | 41.0256 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 38.4615 | 4 | yes |
| GO:0044057 | regulation of system process | 33.3333 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 30.7692 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 30.7692 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 30.7692 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 30.7692 | 4 | no |
| GO:0007268 | chemical synaptic transmission | 30.7692 | 6 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 30.7692 | 5 | no |
| GO:0099537 | trans-synaptic signaling | 30.7692 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 28.2051 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 28.2051 | 4 | yes |
| GO:0030001 | metal ion transport | 28.2051 | 6 | yes |
| GO:0050806 | positive regulation of synaptic transmission | 28.2051 | 5 | yes |
| GO:0099601 | regulation of neurotransmitter receptor activity | 28.2051 | 4 | yes |
| GO:0006811 | ion transport | 28.2051 | 4 | yes |
| GO:0006812 | cation transport | 28.2051 | 5 | yes |
| GO:0006816 | calcium ion transport | 28.2051 | 7 | yes |
| GO:0016192 | vesicle-mediated transport | 25.6410 | 4 | yes |
| GO:2000311 | regulation of AMPA receptor activity | 25.6410 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 25.6410 | 4 | no |
| GO:0051050 | positive regulation of transport | 25.6410 | 4 | no |
| GO:0072657 | protein localization to membrane | 25.6410 | 4 | no |
| GO:0015031 | protein transport | 23.0769 | 4 | yes |
| GO:0033365 | protein localization to organelle | 23.0769 | 5 | yes |
| GO:0071702 | organic substance transport | 23.0769 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 23.0769 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 23.0769 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 23.0769 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 23.0769 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 23.0769 | 5 | no |
| GO:0060341 | regulation of cellular localization | 23.0769 | 4 | no |
| GO:0006886 | intracellular protein transport | 23.0769 | 4 | yes |
| GO:0098970 | postsynaptic neurotransmitter receptor diffusion trapping | 20.5128 | 4 | yes |
| GO:0099628 | neurotransmitter receptor diffusion trapping | 20.5128 | 4 | yes |
| GO:0043085 | positive regulation of catalytic activity | 20.5128 | 4 | no |
| GO:0010959 | regulation of metal ion transport | 20.5128 | 6 | no |
| GO:0006897 | endocytosis | 20.5128 | 5 | yes |
| GO:0007034 | vacuolar transport | 17.9487 | 4 | yes |
| GO:0007041 | lysosomal transport | 17.9487 | 5 | yes |
| GO:0008333 | endosome to lysosome transport | 17.9487 | 5 | yes |
| GO:0031623 | receptor internalization | 17.9487 | 7 | yes |
| GO:0072594 | establishment of protein localization to organelle | 17.9487 | 4 | yes |
| GO:0006898 | receptor-mediated endocytosis | 17.9487 | 6 | yes |
| GO:0051966 | regulation of synaptic transmission, glutamatergic | 15.3846 | 6 | yes |
| GO:0051968 | positive regulation of synaptic transmission, glutamatergic | 15.3846 | 6 | yes |
| GO:0061462 | protein localization to lysosome | 15.3846 | 7 | yes |
| GO:0072665 | protein localization to vacuole | 15.3846 | 6 | yes |
| GO:0072666 | establishment of protein localization to vacuole | 15.3846 | 5 | yes |
| GO:0098943 | neurotransmitter receptor transport, postsynaptic endosome to lysosome | 15.3846 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PP2BA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MAGI3_HUMAN | [view interactions] | Low throughput | no | no |
| MAGI2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CNIH2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CCG8_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CANB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MRS2_HUMAN | [view interactions] | High throughput | no | no |
| CLH2_HUMAN | [view interactions] | High throughput | no | no |
| BCCIP_HUMAN | [view interactions] | High throughput | no | no |
| LRRC1_HUMAN | [view interactions] | High throughput | no | yes |
| FP100_HUMAN | [view interactions] | High throughput | no | yes |
| DI3L2_HUMAN | [view interactions] | High throughput | no | yes |
| TBB8_HUMAN | [view interactions] | High throughput | no | no |
| IGS21_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VPS18_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHSA6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHSA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CACB3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CCG7_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CCG4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CACB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CAC1H_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SHSA9_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| NMDE1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| KCC2B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DLG1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CA2D1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CCG1_HUMAN | [view interactions] | Computational | no | no |
| CA2D4_HUMAN | [view interactions] | Computational | no | no |
| GRIA4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| KCC2D_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CCG3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CAC1F_HUMAN | [view interactions] | Computational | no | no |
| CAC1D_HUMAN | [view interactions] | Computational | no | yes |
| AKAP5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CAC1B_HUMAN | [view interactions] | Computational | no | yes |
| MYO6_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GRIA3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| E41L1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CCG2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CAC1S_HUMAN | [view interactions] | Computational | no | no |
| CACB4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CCG6_HUMAN | [view interactions] | Computational | no | no |