Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CCG8_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit . Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CCG8_HUMAN
GO:0005216 monoatomic ion channel activity 22.2222 4 yes
GO:0015267 channel activity 22.2222 4 yes
GO:0022836 gated channel activity 22.2222 5 yes
GO:0022890 inorganic cation transmembrane transporter activity 22.2222 4 yes
GO:0019902 phosphatase binding 22.2222 4 no
GO:0043169 cation binding 22.2222 4 no
GO:0046872 metal ion binding 22.2222 5 no
GO:0005244 voltage-gated monoatomic ion channel activity 11.1111 5 yes
GO:0005245 voltage-gated calcium channel activity 11.1111 7 yes
GO:0005246 calcium channel regulator activity 11.1111 5 yes
GO:0005261 monoatomic cation channel activity 11.1111 5 yes
GO:0005262 calcium channel activity 11.1111 6 yes
GO:0008324 monoatomic cation transmembrane transporter activity 11.1111 4 yes
GO:0015085 calcium ion transmembrane transporter activity 11.1111 6 yes
GO:0022832 voltage-gated channel activity 11.1111 6 yes
GO:0022843 voltage-gated monoatomic cation channel activity 11.1111 6 yes
GO:0046873 metal ion transmembrane transporter activity 11.1111 5 yes
GO:0099106 ion channel regulator activity 11.1111 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CCG8_HUMAN
GO:0010646 regulation of cell communication 72.2222 4 yes
GO:0050804 modulation of chemical synaptic transmission 61.1111 5 yes
GO:0099177 regulation of trans-synaptic signaling 61.1111 4 yes
GO:0008104 protein localization 55.5556 4 yes
GO:0009966 regulation of signal transduction 55.5556 4 yes
GO:0048522 positive regulation of cellular process 50.0000 4 yes
GO:0051049 regulation of transport 50.0000 4 yes
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0010647 positive regulation of cell communication 38.8889 5 yes
GO:0023056 positive regulation of signaling 38.8889 4 yes
GO:0031323 regulation of cellular metabolic process 38.8889 4 no
GO:0051128 regulation of cellular component organization 38.8889 4 no
GO:0060255 regulation of macromolecule metabolic process 38.8889 4 no
GO:0015031 protein transport 33.3333 4 yes
GO:0034762 regulation of transmembrane transport 33.3333 4 yes
GO:0071702 organic substance transport 33.3333 4 yes
GO:0071705 nitrogen compound transport 33.3333 4 yes
GO:0009893 positive regulation of metabolic process 33.3333 4 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0060627 regulation of vesicle-mediated transport 33.3333 4 no
GO:0080090 regulation of primary metabolic process 33.3333 4 no
GO:0006886 intracellular protein transport 33.3333 4 yes
GO:0033365 protein localization to organelle 27.7778 5 yes
GO:0050806 positive regulation of synaptic transmission 27.7778 5 yes
GO:0007268 chemical synaptic transmission 27.7778 7 no
GO:0098916 anterograde trans-synaptic signaling 27.7778 6 no
GO:0099536 synaptic signaling 27.7778 4 no
GO:0099537 trans-synaptic signaling 27.7778 5 no
GO:0010648 negative regulation of cell communication 27.7778 5 no
GO:0023057 negative regulation of signaling 27.7778 4 no
GO:0022898 regulation of transmembrane transporter activity 22.2222 4 yes
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 22.2222 5 yes
GO:0072594 establishment of protein localization to organelle 22.2222 4 yes
GO:0098657 import into cell 22.2222 4 yes
GO:0098970 postsynaptic neurotransmitter receptor diffusion trapping 22.2222 4 yes
GO:0099601 regulation of neurotransmitter receptor activity 22.2222 4 yes
GO:0099628 neurotransmitter receptor diffusion trapping 22.2222 4 yes
GO:0009889 regulation of biosynthetic process 22.2222 4 no
GO:0010468 regulation of gene expression 22.2222 6 no
GO:0010556 regulation of macromolecule biosynthetic process 22.2222 5 no
GO:0030100 regulation of endocytosis 22.2222 5 no
GO:0031326 regulation of cellular biosynthetic process 22.2222 5 no
GO:0051051 negative regulation of transport 22.2222 4 no
GO:0006996 organelle organization 22.2222 4 no
GO:0010038 response to metal ion 22.2222 4 no
GO:0043113 receptor clustering 22.2222 5 no
GO:0050890 cognition 22.2222 4 no
GO:0072657 protein localization to membrane 22.2222 4 no
GO:0009968 negative regulation of signal transduction 22.2222 5 no
GO:0048585 negative regulation of response to stimulus 22.2222 4 no
GO:0006898 receptor-mediated endocytosis 22.2222 4 yes
GO:0030001 metal ion transport 16.6667 6 yes
GO:0031623 receptor internalization 16.6667 5 yes
GO:2000311 regulation of AMPA receptor activity 16.6667 5 yes
GO:0006811 monoatomic ion transport 16.6667 4 yes
GO:0006812 monoatomic cation transport 16.6667 5 yes
GO:0006816 calcium ion transport 16.6667 7 yes
GO:0007034 vacuolar transport 16.6667 4 yes
GO:0007041 lysosomal transport 16.6667 5 yes
GO:0019226 transmission of nerve impulse 11.1111 4 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 11.1111 6 yes
GO:0051968 positive regulation of synaptic transmission, glutamatergic 11.1111 6 yes
GO:0061462 protein localization to lysosome 11.1111 7 yes
GO:0072665 protein localization to vacuole 11.1111 6 yes
GO:0072666 establishment of protein localization to vacuole 11.1111 5 yes
GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome 11.1111 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PP2BA_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIA2_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIA1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG3_HUMAN [view entry] [view interactions] Low throughput yes yes
MAGI3_HUMAN [view interactions] Low throughput no no
MAGI2_HUMAN [view entry] [view interactions] Low throughput yes yes
CCG8_HUMAN [view entry] [view interactions] Low throughput yes no
CNIH2_HUMAN [view entry] [view interactions] Low throughput yes no
MECOM_HUMAN [view interactions] High throughput no yes
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
CANB1_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
MRS2_HUMAN [view interactions] High throughput no no
CLH2_HUMAN [view interactions] High throughput no no
BCCIP_HUMAN [view interactions] High throughput no no
LRRC1_HUMAN [view interactions] High throughput no yes
FP100_HUMAN [view interactions] High throughput no yes
DI3L2_HUMAN [view interactions] High throughput no yes
TBB8_HUMAN [view interactions] High throughput no no
IGS21_HUMAN [view entry] [view interactions] High throughput yes no
VPS18_HUMAN [view entry] [view interactions] High throughput yes no
PRRT2_HUMAN [view entry] [view interactions] High throughput yes no
SSR3_HUMAN [view interactions] High throughput no yes
SHSA6_HUMAN [view entry] [view interactions] High throughput yes no
SHSA7_HUMAN [view entry] [view interactions] High throughput yes no