Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

IGS21_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Involved in synaptic inhibition in the brain. Selectively regulates inhibitory presynaptic differentiation through interacting with presynaptic NRXN2. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in IGS21_HUMAN
GO:0000166 nucleotide binding 33.3333 4 no
GO:0017076 purine nucleotide binding 33.3333 5 no
GO:0030554 adenyl nucleotide binding 25.0000 6 no
GO:0032555 purine ribonucleotide binding 25.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 25.0000 4 no
GO:0043168 anion binding 25.0000 4 no
GO:0019900 kinase binding 25.0000 4 no
GO:0019901 protein kinase binding 25.0000 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in IGS21_HUMAN
GO:0048522 positive regulation of cellular process 66.6667 4 no
GO:0080090 regulation of primary metabolic process 58.3333 4 no
GO:0022603 regulation of anatomical structure morphogenesis 50.0000 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0009889 regulation of biosynthetic process 41.6667 4 no
GO:0006996 organelle organization 41.6667 4 no
GO:0009966 regulation of signal transduction 41.6667 4 no
GO:0010646 regulation of cell communication 41.6667 4 no
GO:0048523 negative regulation of cellular process 41.6667 4 no
GO:0031399 regulation of protein modification process 41.6667 6 no
GO:0051246 regulation of protein metabolic process 41.6667 5 no
GO:0007010 cytoskeleton organization 33.3333 5 no
GO:0008104 protein localization 33.3333 4 no
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0030334 regulation of cell migration 33.3333 5 no
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 no
GO:0050804 modulation of chemical synaptic transmission 33.3333 5 no
GO:0099177 regulation of trans-synaptic signaling 33.3333 4 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:2000145 regulation of cell motility 33.3333 4 no
GO:0010468 regulation of gene expression 33.3333 6 no
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0019220 regulation of phosphate metabolic process 33.3333 6 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0051094 positive regulation of developmental process 33.3333 4 no
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 no
GO:0031401 positive regulation of protein modification process 33.3333 7 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0034330 cell junction organization 25.0000 4 yes
GO:0006886 intracellular protein transport 25.0000 4 no
GO:0015031 protein transport 25.0000 4 no
GO:0022607 cellular component assembly 25.0000 4 no
GO:0033993 response to lipid 25.0000 4 no
GO:0036211 protein modification process 25.0000 4 no
GO:0043085 positive regulation of catalytic activity 25.0000 4 no
GO:0043412 macromolecule modification 25.0000 4 no
GO:0046903 secretion 25.0000 4 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 no
GO:0051049 regulation of transport 25.0000 4 no
GO:0051093 negative regulation of developmental process 25.0000 4 no
GO:0051128 regulation of cellular component organization 25.0000 4 no
GO:0071702 organic substance transport 25.0000 4 no
GO:0071705 nitrogen compound transport 25.0000 4 no
GO:0080134 regulation of response to stress 25.0000 4 no
GO:0098657 import into cell 25.0000 4 no
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0010563 negative regulation of phosphorus metabolic process 25.0000 6 no
GO:0010605 negative regulation of macromolecule metabolic process 25.0000 5 no
GO:0010628 positive regulation of gene expression 25.0000 7 no
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:0031400 negative regulation of protein modification process 25.0000 7 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:0042981 regulation of apoptotic process 25.0000 5 no
GO:0043066 negative regulation of apoptotic process 25.0000 6 no
GO:0043067 regulation of programmed cell death 25.0000 4 no
GO:0043069 negative regulation of programmed cell death 25.0000 5 no
GO:0043086 negative regulation of catalytic activity 25.0000 4 no
GO:0045936 negative regulation of phosphate metabolic process 25.0000 7 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 no
GO:0051248 negative regulation of protein metabolic process 25.0000 6 no
GO:0051338 regulation of transferase activity 25.0000 4 no
GO:0051348 negative regulation of transferase activity 25.0000 5 no
GO:2000026 regulation of multicellular organismal development 25.0000 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GA45A_HUMAN [view interactions] High throughput no no
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
PPT1_HUMAN [view interactions] High throughput no yes
ITM2B_HUMAN [view interactions] High throughput no yes
GIPC2_HUMAN [view interactions] High throughput no yes
SPB9_HUMAN [view interactions] High throughput no no
UB2V2_HUMAN [view entry] [view interactions] High throughput yes no
ALDH2_HUMAN [view entry] [view interactions] High throughput yes no
ANXA3_HUMAN [view entry] [view interactions] High throughput yes no
ATF3_HUMAN [view interactions] High throughput no yes
BCR_HUMAN [view entry] [view interactions] High throughput yes yes
BTBD2_HUMAN [view interactions] High throughput no no
ERH_HUMAN [view interactions] High throughput no yes
GSTM4_HUMAN [view interactions] High throughput no yes
ANM1_HUMAN [view interactions] High throughput no yes
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
MD2BP_HUMAN [view interactions] High throughput no no
CRCT1_HUMAN [view interactions] High throughput no no
PAEP_HUMAN [view interactions] High throughput no no
PA1B3_HUMAN [view interactions] High throughput no no
PCDA4_HUMAN [view interactions] High throughput no yes
PSD11_HUMAN [view entry] [view interactions] High throughput yes yes
S10A8_HUMAN [view interactions] High throughput no no
SPS1_HUMAN [view interactions] High throughput no yes
ST1E1_HUMAN [view interactions] High throughput no no
TYB4_HUMAN [view interactions] High throughput no yes
NREP_HUMAN [view interactions] High throughput no yes
DGKD_HUMAN [view interactions] High throughput no yes
ETHE1_HUMAN [view interactions] High throughput no yes
RPP14_HUMAN [view interactions] High throughput no no
E41L3_HUMAN [view entry] [view interactions] High throughput yes yes
NACAM_HUMAN [view interactions] High throughput no no
RBPS2_HUMAN [view interactions] High throughput no no
GRAK_HUMAN [view interactions] High throughput no no
TBB1_HUMAN [view interactions] High throughput no yes
HXD13_HUMAN [view interactions] High throughput no no
CCG8_HUMAN [view entry] [view interactions] High throughput yes no
ZNG1C_HUMAN [view interactions] High throughput no yes
MIER3_HUMAN [view interactions] High throughput no yes