BCR_HUMAN
Evidence for PS localization
Functions
Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed, PubMed, PubMed). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed, PubMed). The amino terminus contains an intrinsic kinase activity (PubMed). Functions as an important negative regulator of neuronal RAC1 activity . Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI001582 | LIG_PDZ_Class_1 | LIG | 1266 | 1271 | - |
| ELMI000408 | LIG_SH2_GRB2like | LIG | 177 | 180 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in BCR_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 31.4815 | 4 | no |
| GO:0017076 | purine nucleotide binding | 28.7037 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 27.7778 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.7778 | 4 | yes |
| GO:0019900 | kinase binding | 27.7778 | 4 | no |
| GO:0019901 | protein kinase binding | 25.9259 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 24.0741 | 5 | yes |
| GO:0005524 | ATP binding | 23.1481 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 23.1481 | 5 | yes |
| GO:0016301 | kinase activity | 17.5926 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 16.6667 | 4 | yes |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | 13.8889 | 4 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 10.1852 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 8.3333 | 4 | yes |
| GO:0004713 | protein tyrosine kinase activity | 7.4074 | 4 | yes |
| GO:0030695 | GTPase regulator activity | 4.6296 | 4 | yes |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 3.7037 | 5 | yes |
| GO:0005096 | GTPase activator activity | 3.7037 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in BCR_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 60.1852 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 55.5556 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 54.6296 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 53.7037 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 52.7778 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 51.8519 | 4 | yes |
| GO:0010646 | regulation of cell communication | 42.5926 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 39.8148 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 38.8889 | 4 | no |
| GO:0010468 | regulation of gene expression | 38.8889 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 37.9630 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 37.0370 | 5 | no |
| GO:0006996 | organelle organization | 37.0370 | 4 | yes |
| GO:0008104 | protein localization | 37.0370 | 4 | yes |
| GO:0022607 | cellular component assembly | 37.0370 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 35.1852 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0051049 | regulation of transport | 32.4074 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 31.4815 | 4 | no |
| GO:0071702 | organic substance transport | 30.5556 | 4 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 30.5556 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 29.6296 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 29.6296 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 29.6296 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 29.6296 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 29.6296 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 29.6296 | 5 | yes |
| GO:0071705 | nitrogen compound transport | 28.7037 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 28.7037 | 5 | yes |
| GO:0071310 | cellular response to organic substance | 27.7778 | 4 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 26.8519 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.8519 | 5 | no |
| GO:0015031 | protein transport | 26.8519 | 4 | yes |
| GO:0036211 | protein modification process | 26.8519 | 4 | yes |
| GO:0043412 | macromolecule modification | 26.8519 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 25.0000 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 25.0000 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 24.0741 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 24.0741 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 24.0741 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 23.1481 | 4 | no |
| GO:0043933 | protein-containing complex organization | 23.1481 | 4 | no |
| GO:0060341 | regulation of cellular localization | 23.1481 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 23.1481 | 5 | no |
| GO:0023056 | positive regulation of signaling | 23.1481 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 23.1481 | 5 | no |
| GO:0006886 | intracellular protein transport | 23.1481 | 4 | yes |
| GO:0007010 | cytoskeleton organization | 23.1481 | 5 | yes |
| GO:2000145 | regulation of cell motility | 22.2222 | 4 | yes |
| GO:0042325 | regulation of phosphorylation | 22.2222 | 7 | no |
| GO:0006355 | regulation of DNA-templated transcription | 22.2222 | 6 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 22.2222 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 22.2222 | 6 | no |
| GO:0042127 | regulation of cell population proliferation | 22.2222 | 4 | no |
| GO:0032880 | regulation of protein localization | 21.2963 | 5 | no |
| GO:0033043 | regulation of organelle organization | 21.2963 | 5 | no |
| GO:0030030 | cell projection organization | 21.2963 | 4 | no |
| GO:0010941 | regulation of cell death | 21.2963 | 4 | no |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 21.2963 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 21.2963 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 20.3704 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 20.3704 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 20.3704 | 4 | no |
| GO:0016310 | phosphorylation | 20.3704 | 5 | yes |
| GO:0030334 | regulation of cell migration | 20.3704 | 5 | yes |
| GO:0048585 | negative regulation of response to stimulus | 20.3704 | 4 | yes |
| GO:0051726 | regulation of cell cycle | 20.3704 | 4 | yes |
| GO:0043085 | positive regulation of catalytic activity | 19.4444 | 4 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 18.5185 | 4 | yes |
| GO:0006468 | protein phosphorylation | 18.5185 | 5 | yes |
| GO:0050776 | regulation of immune response | 17.5926 | 4 | yes |
| GO:0051336 | regulation of hydrolase activity | 17.5926 | 4 | yes |
| GO:0080134 | regulation of response to stress | 16.6667 | 4 | yes |
| GO:0051050 | positive regulation of transport | 16.6667 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 16.6667 | 4 | yes |
| GO:0033993 | response to lipid | 14.8148 | 4 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 13.8889 | 4 | yes |
| GO:0034330 | cell junction organization | 12.9630 | 4 | yes |
| GO:0071396 | cellular response to lipid | 11.1111 | 5 | yes |
| GO:0032101 | regulation of response to external stimulus | 11.1111 | 4 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 10.1852 | 4 | yes |
| GO:2000146 | negative regulation of cell motility | 10.1852 | 5 | yes |
| GO:0002694 | regulation of leukocyte activation | 10.1852 | 4 | yes |
| GO:0007264 | small GTPase mediated signal transduction | 10.1852 | 4 | yes |
| GO:0040013 | negative regulation of locomotion | 10.1852 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 10.1852 | 5 | yes |
| GO:0050865 | regulation of cell activation | 10.1852 | 4 | yes |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 10.1852 | 6 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 10.1852 | 5 | yes |
| GO:0031347 | regulation of defense response | 9.2593 | 5 | yes |
| GO:0051093 | negative regulation of developmental process | 9.2593 | 4 | yes |
| GO:1903530 | regulation of secretion by cell | 8.3333 | 4 | yes |
| GO:0002683 | negative regulation of immune system process | 8.3333 | 4 | yes |
| GO:0030336 | negative regulation of cell migration | 8.3333 | 6 | yes |
| GO:0032102 | negative regulation of response to external stimulus | 8.3333 | 5 | yes |
| GO:0034329 | cell junction assembly | 8.3333 | 5 | yes |
| GO:0043087 | regulation of GTPase activity | 8.3333 | 5 | yes |
| GO:0051046 | regulation of secretion | 8.3333 | 5 | yes |
| GO:0051051 | negative regulation of transport | 8.3333 | 4 | yes |
| GO:0002237 | response to molecule of bacterial origin | 7.4074 | 4 | yes |
| GO:0031348 | negative regulation of defense response | 7.4074 | 5 | yes |
| GO:0032496 | response to lipopolysaccharide | 7.4074 | 4 | yes |
| GO:0046578 | regulation of Ras protein signal transduction | 7.4074 | 7 | yes |
| GO:0050777 | negative regulation of immune response | 7.4074 | 5 | yes |
| GO:2000377 | regulation of reactive oxygen species metabolic process | 6.4815 | 5 | yes |
| GO:0002685 | regulation of leukocyte migration | 6.4815 | 4 | yes |
| GO:0003018 | vascular process in circulatory system | 6.4815 | 4 | yes |
| GO:0030855 | epithelial cell differentiation | 6.4815 | 4 | yes |
| GO:0048872 | homeostasis of number of cells | 6.4815 | 4 | yes |
| GO:0050727 | regulation of inflammatory response | 6.4815 | 5 | yes |
| GO:0002697 | regulation of immune effector process | 5.5556 | 4 | yes |
| GO:0002703 | regulation of leukocyte mediated immunity | 5.5556 | 5 | yes |
| GO:0017157 | regulation of exocytosis | 5.5556 | 5 | yes |
| GO:0050728 | negative regulation of inflammatory response | 5.5556 | 6 | yes |
| GO:0071219 | cellular response to molecule of bacterial origin | 5.5556 | 4 | yes |
| GO:0071222 | cellular response to lipopolysaccharide | 5.5556 | 5 | yes |
| GO:0090630 | activation of GTPase activity | 4.6296 | 7 | yes |
| GO:1903305 | regulation of regulated secretory pathway | 4.6296 | 6 | yes |
| GO:0035023 | regulation of Rho protein signal transduction | 4.6296 | 8 | yes |
| GO:0043547 | positive regulation of GTPase activity | 4.6296 | 6 | yes |
| GO:0048534 | hematopoietic or lymphoid organ development | 4.6296 | 4 | yes |
| GO:0002886 | regulation of myeloid leukocyte mediated immunity | 3.7037 | 6 | yes |
| GO:0007420 | brain development | 3.7037 | 4 | yes |
| GO:0043300 | regulation of leukocyte degranulation | 3.7037 | 5 | yes |
| GO:0050905 | neuromuscular process | 3.7037 | 4 | yes |
| GO:0150115 | cell-substrate junction organization | 2.7778 | 5 | yes |
| GO:1903531 | negative regulation of secretion by cell | 2.7778 | 5 | yes |
| GO:2000378 | negative regulation of reactive oxygen species metabolic process | 2.7778 | 6 | yes |
| GO:0002695 | negative regulation of leukocyte activation | 2.7778 | 5 | yes |
| GO:0002698 | negative regulation of immune effector process | 2.7778 | 5 | yes |
| GO:0002704 | negative regulation of leukocyte mediated immunity | 2.7778 | 6 | yes |
| GO:0007044 | cell-substrate junction assembly | 2.7778 | 6 | yes |
| GO:0009913 | epidermal cell differentiation | 2.7778 | 5 | yes |
| GO:0030097 | hemopoiesis | 2.7778 | 5 | yes |
| GO:0030216 | keratinocyte differentiation | 2.7778 | 6 | yes |
| GO:0034103 | regulation of tissue remodeling | 2.7778 | 4 | yes |
| GO:0048041 | focal adhesion assembly | 2.7778 | 7 | yes |
| GO:0050764 | regulation of phagocytosis | 2.7778 | 5 | yes |
| GO:0050866 | negative regulation of cell activation | 2.7778 | 5 | yes |
| GO:0050885 | neuromuscular process controlling balance | 2.7778 | 5 | yes |
| GO:0051048 | negative regulation of secretion | 2.7778 | 5 | yes |
| GO:0060263 | regulation of respiratory burst | 2.7778 | 4 | yes |
| GO:0065002 | intracellular protein transmembrane transport | 2.7778 | 4 | yes |
| GO:1902563 | regulation of neutrophil activation | 1.8519 | 5 | yes |
| GO:1902564 | negative regulation of neutrophil activation | 1.8519 | 6 | yes |
| GO:1903306 | negative regulation of regulated secretory pathway | 1.8519 | 7 | yes |
| GO:0002686 | negative regulation of leukocyte migration | 1.8519 | 5 | yes |
| GO:0002691 | regulation of cellular extravasation | 1.8519 | 5 | yes |
| GO:0002692 | negative regulation of cellular extravasation | 1.8519 | 6 | yes |
| GO:0002887 | negative regulation of myeloid leukocyte mediated immunity | 1.8519 | 7 | yes |
| GO:0034104 | negative regulation of tissue remodeling | 1.8519 | 5 | yes |
| GO:0042472 | inner ear morphogenesis | 1.8519 | 4 | yes |
| GO:0043301 | negative regulation of leukocyte degranulation | 1.8519 | 6 | yes |
| GO:0043313 | regulation of neutrophil degranulation | 1.8519 | 5 | yes |
| GO:0043314 | negative regulation of neutrophil degranulation | 1.8519 | 6 | yes |
| GO:0045920 | negative regulation of exocytosis | 1.8519 | 6 | yes |
| GO:0050766 | positive regulation of phagocytosis | 1.8519 | 5 | yes |
| GO:0060216 | definitive hemopoiesis | 1.8519 | 6 | yes |
| GO:0060268 | negative regulation of respiratory burst | 1.8519 | 5 | yes |
| GO:0060312 | regulation of blood vessel remodeling | 1.8519 | 5 | yes |
| GO:0060313 | negative regulation of blood vessel remodeling | 1.8519 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in BCR_HUMAN |
|---|---|---|---|---|
| DOID:0050686 | organ system cancer | 1.8519 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ZO2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GIPC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RGS12_HUMAN | [view interactions] | Low throughput | no | no |
| TCF7_HUMAN | [view interactions] | Low throughput | no | no |
| CFTR_HUMAN | [view interactions] | Low throughput | no | no |
| CLH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| COPB_HUMAN | [view interactions] | Low throughput | no | yes |
| AT2B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KIT_HUMAN | [view interactions] | Low throughput | no | no |
| PK3CG_HUMAN | [view interactions] | Low throughput | no | yes |
| CRKL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TS101_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HCK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PTN6_HUMAN | [view interactions] | Low throughput | no | no |
| FES_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RB_HUMAN | [view interactions] | Low throughput | no | yes |
| ABL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GAB2_HUMAN | [view interactions] | Low throughput | no | yes |
| SOS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PAXI_HUMAN | [view interactions] | Low throughput | no | yes |
| IL3_HUMAN | [view interactions] | Low throughput | no | no |
| VPS28_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHIP1_HUMAN | [view interactions] | Low throughput | no | no |
| HS90A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HIF1A_HUMAN | [view interactions] | Low throughput | no | no |
| GBRR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| UBQL1_HUMAN | [view interactions] | Low throughput | no | yes |
| CRK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CBL_HUMAN | [view interactions] | Low throughput | no | yes |
| RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ERBIN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TEBP_HUMAN | [view interactions] | Low throughput | no | yes |
| HSP74_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CH60_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SCAI_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| P85A_HUMAN | [view interactions] | Low throughput | no | yes |
| UBP1_HUMAN | [view interactions] | Low throughput | no | yes |
| HXA9_HUMAN | [view interactions] | Low throughput | no | yes |
| RAD51_HUMAN | [view interactions] | Low throughput | no | yes |
| CHIP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NHRF3_HUMAN | [view interactions] | Low throughput | no | no |
| PTN1_HUMAN | [view interactions] | Low throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TNKS2_HUMAN | [view interactions] | Low throughput | no | no |
| NUMB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BCR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SH2D5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ERCC3_HUMAN | [view interactions] | Low throughput | no | yes |
| APBA3_HUMAN | [view interactions] | Low throughput | no | yes |
| AFAD_HUMAN | [view interactions] | Low throughput | no | yes |
| DOK1_HUMAN | [view interactions] | Low throughput | no | yes |
| GRAP_HUMAN | [view interactions] | Low throughput | no | no |
| RS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KSYK_HUMAN | [view interactions] | High throughput | no | no |
| PAIRB_HUMAN | [view interactions] | High throughput | no | yes |
| DDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TF3C3_HUMAN | [view interactions] | High throughput | no | no |
| G3BP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PNMA2_HUMAN | [view interactions] | High throughput | no | yes |
| DDX20_HUMAN | [view interactions] | High throughput | no | no |
| KCMF1_HUMAN | [view interactions] | High throughput | no | yes |
| NOP53_HUMAN | [view interactions] | High throughput | no | yes |
| API5_HUMAN | [view interactions] | High throughput | no | no |
| GTPB4_HUMAN | [view interactions] | High throughput | no | yes |
| SIN3A_HUMAN | [view interactions] | High throughput | no | yes |
| LTV1_HUMAN | [view interactions] | High throughput | no | yes |
| GCP3_HUMAN | [view interactions] | High throughput | no | yes |
| P5CR2_HUMAN | [view interactions] | High throughput | no | yes |
| GCN1_HUMAN | [view interactions] | High throughput | no | yes |
| GEMI6_HUMAN | [view interactions] | High throughput | no | yes |
| DDX54_HUMAN | [view interactions] | High throughput | no | yes |
| RM41_HUMAN | [view interactions] | High throughput | no | yes |
| RM10_HUMAN | [view interactions] | High throughput | no | yes |
| TRM1L_HUMAN | [view interactions] | High throughput | no | yes |
| EDC4_HUMAN | [view interactions] | High throughput | no | yes |
| UBR4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NU188_HUMAN | [view interactions] | High throughput | no | yes |
| RRP12_HUMAN | [view interactions] | High throughput | no | no |
| SNUT2_HUMAN | [view interactions] | High throughput | no | yes |
| INF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPSF6_HUMAN | [view interactions] | High throughput | no | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM28_HUMAN | [view interactions] | High throughput | no | yes |
| ECH1_HUMAN | [view interactions] | High throughput | no | yes |
| TFAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTCF_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD8_HUMAN | [view interactions] | High throughput | no | yes |
| UTRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FRK_HUMAN | [view interactions] | High throughput | no | no |
| NU214_HUMAN | [view interactions] | High throughput | no | no |
| RIR2_HUMAN | [view interactions] | High throughput | no | no |
| GYS1_HUMAN | [view interactions] | High throughput | no | yes |
| SC16A_HUMAN | [view interactions] | High throughput | no | yes |
| PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNOT1_HUMAN | [view interactions] | High throughput | no | yes |
| DDR2_HUMAN | [view interactions] | High throughput | no | no |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| U119A_HUMAN | [view interactions] | High throughput | no | no |
| IGS21_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CE128_HUMAN | [view interactions] | High throughput | no | yes |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ST38L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDR1_HUMAN | [view interactions] | High throughput | no | yes |
| JIP4_HUMAN | [view interactions] | High throughput | no | yes |
| WEE1_HUMAN | [view interactions] | High throughput | no | yes |
| MCM4_HUMAN | [view interactions] | High throughput | no | yes |
| KC1A_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| MCM6_HUMAN | [view interactions] | High throughput | no | yes |
| UBP15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LNX1_HUMAN | [view interactions] | High throughput | no | yes |
| TGFR1_HUMAN | [view interactions] | High throughput | no | no |
| BMR1B_HUMAN | [view interactions] | High throughput | no | no |
| GRK5_HUMAN | [view interactions] | High throughput | no | yes |
| UBS3B_HUMAN | [view interactions] | High throughput | no | yes |
| P85B_HUMAN | [view interactions] | High throughput | no | yes |
| SHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CC183_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| REQU_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PTN3_HUMAN | [view interactions] | High throughput | no | yes |
| PLK1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRPF3_HUMAN | [view interactions] | High throughput | no | yes |
| CECR2_HUMAN | [view interactions] | High throughput | no | yes |
| SP110_HUMAN | [view interactions] | High throughput | no | no |
| TRI66_HUMAN | [view interactions] | High throughput | no | yes |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| NUDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M4K1_HUMAN | [view interactions] | High throughput | no | no |
| RADI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSD4_HUMAN | [view interactions] | High throughput | no | yes |
| SLAP2_HUMAN | [view interactions] | High throughput | no | no |
| AGO4_HUMAN | [view interactions] | High throughput | no | no |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAA10_HUMAN | [view interactions] | High throughput | no | yes |
| SURF6_HUMAN | [view interactions] | High throughput | no | yes |
| SYNCI_HUMAN | [view interactions] | High throughput | no | no |
| CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BACE2_HUMAN | [view interactions] | High throughput | no | yes |
| GRAP2_HUMAN | [view interactions] | High throughput | no | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| ATG10_HUMAN | [view interactions] | High throughput | no | yes |
| ATG3_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HOOK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMAG2_HUMAN | [view interactions] | High throughput | no | yes |
| EST1A_HUMAN | [view interactions] | High throughput | no | yes |
| ACTZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| VASP_HUMAN | [view interactions] | High throughput | no | yes |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRASP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR48_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JPH4_HUMAN | [view interactions] | High throughput | no | no |
| PDZ1P_HUMAN | [view interactions] | High throughput | no | no |
| NAGK_HUMAN | [view interactions] | High throughput | no | no |
| COMD1_HUMAN | [view interactions] | High throughput | no | yes |
| TULP3_HUMAN | [view interactions] | High throughput | no | yes |
| SEC13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RSPH9_HUMAN | [view interactions] | High throughput | no | no |
| CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARG39_HUMAN | [view interactions] | High throughput | no | yes |
| CSK21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DOK2_HUMAN | [view interactions] | High throughput | no | no |
| LRRK1_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMAP2_HUMAN | [view interactions] | High throughput | no | yes |
| GPDM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD4_HUMAN | [view interactions] | High throughput | no | yes |
| VPS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS4X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YBOX1_HUMAN | [view interactions] | High throughput | no | yes |
| RL23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL24_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCAR2_HUMAN | [view interactions] | High throughput | no | yes |
| LC7L2_HUMAN | [view interactions] | High throughput | no | yes |
| RS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRP31_HUMAN | [view interactions] | High throughput | no | yes |
| AK17A_HUMAN | [view interactions] | High throughput | no | no |
| RL6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL39_HUMAN | [view interactions] | High throughput | no | no |
| RL39L_HUMAN | [view interactions] | High throughput | no | no |
| RS24_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHRS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PEX1_HUMAN | [view interactions] | High throughput | no | no |
| GRB7_HUMAN | [view interactions] | High throughput | no | no |
| SHC4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| STA5A_HUMAN | [view interactions] | Computational | no | no |
| PHAG1_HUMAN | [view interactions] | Computational | no | yes |
| LYN_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PTEN_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CD79A_HUMAN | [view interactions] | Computational | no | no |
| KS6B1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CD19_HUMAN | [view interactions] | Computational | no | no |
| BLNK_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RASA1_HUMAN | [view interactions] | Computational | no | yes |
| BTK_HUMAN | [view interactions] | Computational | no | no |
| BCL6_HUMAN | [view interactions] | Computational | no | no |
| SHC2_HUMAN | [view interactions] | Computational | no | yes |
| STA5B_HUMAN | [view interactions] | Computational | no | yes |
| PTPRC_HUMAN | [view interactions] | Computational | no | no |
| FCG2B_HUMAN | [view interactions] | Computational | no | no |
| PLCG1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DAPP1_HUMAN | [view interactions] | Computational | no | yes |
| CSK_HUMAN | [view interactions] | Computational | no | yes |
| CD79B_HUMAN | [view interactions] | Computational | no | no |
| 3BP5_HUMAN | [view interactions] | Computational | no | yes |
| JAK2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SHC3_HUMAN | [view interactions] | Computational | no | yes |
| PK3CA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PLCG2_HUMAN | [view interactions] | Computational | no | yes |
| CD22_HUMAN | [view interactions] | Computational | no | no |
| IBTK_HUMAN | [view interactions] | Computational | no | yes |
| MTOR_HUMAN | [view entry] [view interactions] | Computational | yes | yes |