BCR_HUMAN
Evidence for PS localization
Functions
Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed, PubMed, PubMed). The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed, PubMed). The amino terminus contains an intrinsic kinase activity (PubMed). Functions as an important negative regulator of neuronal RAC1 activity . Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (PubMed). Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI001582 | LIG_PDZ_Class_1 | LIG | 1266 | 1271 | - |
| ELMI000408 | LIG_SH2_GRB2like | LIG | 177 | 180 | - |
| ELMI001582 | LIG_PDZ_Class_1 | LIG | 1266 | 1271 | - |
| ELMI000408 | LIG_SH2_GRB2like | LIG | 177 | 180 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in BCR_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 31.2500 | 4 | no |
| GO:0043168 | anion binding | 25.8929 | 4 | yes |
| GO:0000166 | nucleotide binding | 25.0000 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 25.0000 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 25.0000 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.0000 | 4 | yes |
| GO:0019900 | kinase binding | 25.0000 | 4 | no |
| GO:0019901 | protein kinase binding | 23.2143 | 5 | no |
| GO:0005524 | ATP binding | 20.5357 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 20.5357 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 20.5357 | 5 | yes |
| GO:0016301 | kinase activity | 15.1786 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 14.2857 | 4 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 8.9286 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 7.1429 | 4 | yes |
| GO:0004713 | protein tyrosine kinase activity | 6.2500 | 4 | yes |
| GO:0030695 | GTPase regulator activity | 6.2500 | 4 | yes |
| GO:0005096 | GTPase activator activity | 4.4643 | 4 | yes |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 3.5714 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in BCR_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 58.9286 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 53.5714 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 52.6786 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 52.6786 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 44.6429 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 43.7500 | 4 | yes |
| GO:0008104 | protein localization | 42.8571 | 4 | yes |
| GO:0022607 | cellular component assembly | 41.0714 | 4 | yes |
| GO:0006996 | organelle organization | 40.1786 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 39.2857 | 4 | no |
| GO:0009966 | regulation of signal transduction | 38.3929 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 37.5000 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 36.6071 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 34.8214 | 4 | yes |
| GO:0010468 | regulation of gene expression | 34.8214 | 6 | no |
| GO:0009893 | positive regulation of metabolic process | 33.0357 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 31.2500 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 29.4643 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.4643 | 5 | no |
| GO:0051049 | regulation of transport | 28.5714 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 28.5714 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 27.6786 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.7857 | 5 | yes |
| GO:0043933 | protein-containing complex organization | 26.7857 | 4 | no |
| GO:0060341 | regulation of cellular localization | 25.8929 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.0000 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0007010 | cytoskeleton organization | 24.1071 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.1071 | 5 | no |
| GO:0032880 | regulation of protein localization | 24.1071 | 5 | no |
| GO:0036211 | protein modification process | 23.2143 | 4 | yes |
| GO:0043412 | macromolecule modification | 23.2143 | 4 | yes |
| GO:0071702 | organic substance transport | 23.2143 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 23.2143 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 23.2143 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.3214 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 22.3214 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.3214 | 4 | no |
| GO:0015031 | protein transport | 21.4286 | 4 | yes |
| GO:0048585 | negative regulation of response to stimulus | 21.4286 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 21.4286 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 21.4286 | 6 | no |
| GO:0009890 | negative regulation of biosynthetic process | 21.4286 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 20.5357 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 20.5357 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 20.5357 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 19.6429 | 4 | yes |
| GO:0141124 | intracellular signaling cassette | 18.7500 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 17.8571 | 4 | yes |
| GO:0051726 | regulation of cell cycle | 17.8571 | 4 | yes |
| GO:2000145 | regulation of cell motility | 17.8571 | 4 | yes |
| GO:0006886 | intracellular protein transport | 16.9643 | 4 | yes |
| GO:0051050 | positive regulation of transport | 16.9643 | 4 | yes |
| GO:0030334 | regulation of cell migration | 16.0714 | 5 | yes |
| GO:0050776 | regulation of immune response | 16.0714 | 4 | yes |
| GO:0080134 | regulation of response to stress | 16.0714 | 4 | yes |
| GO:0016310 | phosphorylation | 15.1786 | 5 | yes |
| GO:0034330 | cell junction organization | 15.1786 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 15.1786 | 4 | yes |
| GO:0043085 | positive regulation of catalytic activity | 14.2857 | 4 | yes |
| GO:0006468 | protein phosphorylation | 13.3929 | 5 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 13.3929 | 4 | yes |
| GO:0032101 | regulation of response to external stimulus | 12.5000 | 4 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 12.5000 | 4 | yes |
| GO:0030100 | regulation of endocytosis | 11.6071 | 5 | yes |
| GO:0031347 | regulation of defense response | 11.6071 | 5 | yes |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 11.6071 | 6 | yes |
| GO:0051336 | regulation of hydrolase activity | 11.6071 | 4 | yes |
| GO:0007264 | small GTPase-mediated signal transduction | 10.7143 | 5 | yes |
| GO:0033993 | response to lipid | 10.7143 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 10.7143 | 5 | yes |
| GO:0098657 | import into cell | 10.7143 | 4 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 10.7143 | 4 | yes |
| GO:0040013 | negative regulation of locomotion | 9.8214 | 4 | yes |
| GO:2000146 | negative regulation of cell motility | 9.8214 | 5 | yes |
| GO:0002683 | negative regulation of immune system process | 8.9286 | 4 | yes |
| GO:0034329 | cell junction assembly | 8.9286 | 5 | yes |
| GO:0030336 | negative regulation of cell migration | 8.0357 | 6 | yes |
| GO:0051093 | negative regulation of developmental process | 8.0357 | 4 | yes |
| GO:0071396 | cellular response to lipid | 8.0357 | 5 | yes |
| GO:0031348 | negative regulation of defense response | 7.1429 | 5 | yes |
| GO:0032102 | negative regulation of response to external stimulus | 7.1429 | 5 | yes |
| GO:0051051 | negative regulation of transport | 7.1429 | 4 | yes |
| GO:0002685 | regulation of leukocyte migration | 6.2500 | 4 | yes |
| GO:0003018 | vascular process in circulatory system | 6.2500 | 4 | yes |
| GO:0030855 | epithelial cell differentiation | 6.2500 | 4 | yes |
| GO:0043087 | regulation of GTPase activity | 6.2500 | 5 | yes |
| GO:0045807 | positive regulation of endocytosis | 6.2500 | 5 | yes |
| GO:0050777 | negative regulation of immune response | 6.2500 | 5 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 6.2500 | 5 | yes |
| GO:2000377 | regulation of reactive oxygen species metabolic process | 6.2500 | 5 | yes |
| GO:0002237 | response to molecule of bacterial origin | 5.3571 | 4 | yes |
| GO:0032496 | response to lipopolysaccharide | 5.3571 | 4 | yes |
| GO:0035023 | regulation of Rho protein signal transduction | 5.3571 | 7 | yes |
| GO:0046903 | secretion | 5.3571 | 4 | yes |
| GO:0071675 | regulation of mononuclear cell migration | 5.3571 | 5 | yes |
| GO:0002697 | regulation of immune effector process | 4.4643 | 4 | yes |
| GO:0002703 | regulation of leukocyte mediated immunity | 4.4643 | 5 | yes |
| GO:0050727 | regulation of inflammatory response | 4.4643 | 5 | yes |
| GO:0050728 | negative regulation of inflammatory response | 4.4643 | 6 | yes |
| GO:0051046 | regulation of secretion | 4.4643 | 5 | yes |
| GO:0071219 | cellular response to molecule of bacterial origin | 4.4643 | 4 | yes |
| GO:0071222 | cellular response to lipopolysaccharide | 4.4643 | 5 | yes |
| GO:1903530 | regulation of secretion by cell | 4.4643 | 4 | yes |
| GO:0007044 | cell-substrate junction assembly | 3.5714 | 6 | yes |
| GO:0017157 | regulation of exocytosis | 3.5714 | 5 | yes |
| GO:0043547 | positive regulation of GTPase activity | 3.5714 | 6 | yes |
| GO:0048041 | focal adhesion assembly | 3.5714 | 7 | yes |
| GO:0150115 | cell-substrate junction organization | 3.5714 | 5 | yes |
| GO:0002698 | negative regulation of immune effector process | 2.6786 | 5 | yes |
| GO:0002704 | negative regulation of leukocyte mediated immunity | 2.6786 | 6 | yes |
| GO:0002886 | regulation of myeloid leukocyte mediated immunity | 2.6786 | 6 | yes |
| GO:0009913 | epidermal cell differentiation | 2.6786 | 5 | yes |
| GO:0030097 | hemopoiesis | 2.6786 | 4 | yes |
| GO:0030216 | keratinocyte differentiation | 2.6786 | 6 | yes |
| GO:0034103 | regulation of tissue remodeling | 2.6786 | 4 | yes |
| GO:0043300 | regulation of leukocyte degranulation | 2.6786 | 5 | yes |
| GO:0045055 | regulated exocytosis | 2.6786 | 4 | yes |
| GO:0050764 | regulation of phagocytosis | 2.6786 | 6 | yes |
| GO:0050885 | neuromuscular process controlling balance | 2.6786 | 5 | yes |
| GO:0050905 | neuromuscular process | 2.6786 | 4 | yes |
| GO:0060263 | regulation of respiratory burst | 2.6786 | 4 | yes |
| GO:0090630 | activation of GTPase activity | 2.6786 | 7 | yes |
| GO:1903305 | regulation of regulated secretory pathway | 2.6786 | 6 | yes |
| GO:2000378 | negative regulation of reactive oxygen species metabolic process | 2.6786 | 6 | yes |
| GO:0002686 | negative regulation of leukocyte migration | 1.7857 | 5 | yes |
| GO:0002691 | regulation of cellular extravasation | 1.7857 | 5 | yes |
| GO:0002692 | negative regulation of cellular extravasation | 1.7857 | 6 | yes |
| GO:0002887 | negative regulation of myeloid leukocyte mediated immunity | 1.7857 | 7 | yes |
| GO:0006909 | phagocytosis | 1.7857 | 4 | yes |
| GO:0007420 | brain development | 1.7857 | 4 | yes |
| GO:0034104 | negative regulation of tissue remodeling | 1.7857 | 5 | yes |
| GO:0042472 | inner ear morphogenesis | 1.7857 | 4 | yes |
| GO:0043301 | negative regulation of leukocyte degranulation | 1.7857 | 6 | yes |
| GO:0043312 | neutrophil degranulation | 1.7857 | 4 | yes |
| GO:0043313 | regulation of neutrophil degranulation | 1.7857 | 5 | yes |
| GO:0043314 | negative regulation of neutrophil degranulation | 1.7857 | 6 | yes |
| GO:0045920 | negative regulation of exocytosis | 1.7857 | 6 | yes |
| GO:0050766 | positive regulation of phagocytosis | 1.7857 | 6 | yes |
| GO:0051048 | negative regulation of secretion | 1.7857 | 5 | yes |
| GO:0060216 | definitive hemopoiesis | 1.7857 | 5 | yes |
| GO:0060268 | negative regulation of respiratory burst | 1.7857 | 5 | yes |
| GO:0060312 | regulation of blood vessel remodeling | 1.7857 | 5 | yes |
| GO:0060313 | negative regulation of blood vessel remodeling | 1.7857 | 5 | yes |
| GO:0065002 | intracellular protein transmembrane transport | 1.7857 | 4 | yes |
| GO:0071676 | negative regulation of mononuclear cell migration | 1.7857 | 6 | yes |
| GO:1903306 | negative regulation of regulated secretory pathway | 1.7857 | 7 | yes |
| GO:1903531 | negative regulation of secretion by cell | 1.7857 | 5 | yes |
| GO:1905517 | macrophage migration | 1.7857 | 4 | yes |
| GO:1905521 | regulation of macrophage migration | 1.7857 | 6 | yes |
| GO:1905522 | negative regulation of macrophage migration | 1.7857 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GIPC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ZO2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RGS12_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TCF7_HUMAN | [view interactions] | Low throughput | no | no |
| CFTR_HUMAN | [view interactions] | Low throughput | no | no |
| COPB_HUMAN | [view interactions] | Low throughput | no | yes |
| CLH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AT2B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KIT_HUMAN | [view interactions] | Low throughput | no | no |
| PK3CG_HUMAN | [view interactions] | Low throughput | no | yes |
| CRKL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TS101_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HCK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PTN6_HUMAN | [view interactions] | Low throughput | no | no |
| FES_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RB_HUMAN | [view interactions] | Low throughput | no | yes |
| ABL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GAB2_HUMAN | [view interactions] | Low throughput | no | yes |
| SOS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PAXI_HUMAN | [view interactions] | Low throughput | no | yes |
| IL3_HUMAN | [view interactions] | Low throughput | no | no |
| VPS28_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHIP1_HUMAN | [view interactions] | Low throughput | no | no |
| HS90A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HIF1A_HUMAN | [view interactions] | Low throughput | no | no |
| GBRR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| UBQL1_HUMAN | [view interactions] | Low throughput | no | yes |
| CRK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CBL_HUMAN | [view interactions] | Low throughput | no | yes |
| RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ERBIN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TEBP_HUMAN | [view interactions] | Low throughput | no | yes |
| HSP74_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CH60_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SCAI_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| P85A_HUMAN | [view interactions] | Low throughput | no | yes |
| UBP1_HUMAN | [view interactions] | Low throughput | no | yes |
| SMUF2_HUMAN | [view interactions] | Low throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | Low throughput | no | yes |
| HXA9_HUMAN | [view interactions] | Low throughput | no | yes |
| RAD51_HUMAN | [view interactions] | Low throughput | no | yes |
| CHIP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NHRF3_HUMAN | [view interactions] | Low throughput | no | no |
| PTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TNKS2_HUMAN | [view interactions] | Low throughput | no | no |
| NUMB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SH2D5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ERCC3_HUMAN | [view interactions] | Low throughput | no | yes |
| BCR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| APBA3_HUMAN | [view interactions] | Low throughput | no | yes |
| AFAD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DOK1_HUMAN | [view interactions] | Low throughput | no | yes |
| GRAP_HUMAN | [view interactions] | Low throughput | no | no |
| PSMD4_HUMAN | [view interactions] | High throughput | no | yes |
| RS7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DR4L2_HUMAN | [view interactions] | High throughput | no | no |
| DHRS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RS24_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL39_HUMAN | [view interactions] | High throughput | no | no |
| RL6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AK17A_HUMAN | [view interactions] | High throughput | no | no |
| RS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCAR2_HUMAN | [view interactions] | High throughput | no | yes |
| RL24_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YBOX1_HUMAN | [view interactions] | High throughput | no | yes |
| RS9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS4X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRB7_HUMAN | [view interactions] | High throughput | no | no |
| BCKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SERB1_HUMAN | [view interactions] | High throughput | no | yes |
| KSYK_HUMAN | [view interactions] | High throughput | no | no |
| RS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PEX1_HUMAN | [view interactions] | High throughput | no | no |
| VAV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNOT1_HUMAN | [view interactions] | High throughput | no | yes |
| PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC16A_HUMAN | [view interactions] | High throughput | no | yes |
| GYS1_HUMAN | [view interactions] | High throughput | no | yes |
| RIR2_HUMAN | [view interactions] | High throughput | no | no |
| NU214_HUMAN | [view interactions] | High throughput | no | no |
| FRK_HUMAN | [view interactions] | High throughput | no | no |
| RAGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UTRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD8_HUMAN | [view interactions] | High throughput | no | yes |
| CTCF_HUMAN | [view interactions] | High throughput | no | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TFAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECH1_HUMAN | [view interactions] | High throughput | no | yes |
| RM28_HUMAN | [view interactions] | High throughput | no | yes |
| DYHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPSF6_HUMAN | [view interactions] | High throughput | no | yes |
| INF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP39_HUMAN | [view interactions] | High throughput | no | yes |
| RRP12_HUMAN | [view interactions] | High throughput | no | no |
| NU188_HUMAN | [view interactions] | High throughput | no | yes |
| UBR4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EDC4_HUMAN | [view interactions] | High throughput | no | yes |
| TRM1L_HUMAN | [view interactions] | High throughput | no | yes |
| RM10_HUMAN | [view interactions] | High throughput | no | yes |
| RM41_HUMAN | [view interactions] | High throughput | no | yes |
| DDX54_HUMAN | [view interactions] | High throughput | no | yes |
| GEMI6_HUMAN | [view interactions] | High throughput | no | yes |
| GCN1_HUMAN | [view interactions] | High throughput | no | yes |
| P5CR2_HUMAN | [view interactions] | High throughput | no | yes |
| GCP3_HUMAN | [view interactions] | High throughput | no | yes |
| LTV1_HUMAN | [view interactions] | High throughput | no | yes |
| SIN3A_HUMAN | [view interactions] | High throughput | no | yes |
| GTPB4_HUMAN | [view interactions] | High throughput | no | yes |
| API5_HUMAN | [view interactions] | High throughput | no | no |
| NOP53_HUMAN | [view interactions] | High throughput | no | yes |
| KCMF1_HUMAN | [view interactions] | High throughput | no | yes |
| DDX20_HUMAN | [view interactions] | High throughput | no | no |
| PNMA2_HUMAN | [view interactions] | High throughput | no | yes |
| G3BP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TF3C3_HUMAN | [view interactions] | High throughput | no | no |
| DDR2_HUMAN | [view interactions] | High throughput | no | no |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| U119A_HUMAN | [view interactions] | High throughput | no | no |
| IGS21_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| CE128_HUMAN | [view interactions] | High throughput | no | yes |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ST38L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDR1_HUMAN | [view interactions] | High throughput | no | yes |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| JIP4_HUMAN | [view interactions] | High throughput | no | yes |
| WEE1_HUMAN | [view interactions] | High throughput | no | yes |
| MCM4_HUMAN | [view interactions] | High throughput | no | yes |
| KC1A_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| MCM6_HUMAN | [view interactions] | High throughput | no | yes |
| UBP15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGFR1_HUMAN | [view interactions] | High throughput | no | no |
| BMR1B_HUMAN | [view interactions] | High throughput | no | no |
| GRK5_HUMAN | [view interactions] | High throughput | no | yes |
| UBS3B_HUMAN | [view interactions] | High throughput | no | yes |
| P85B_HUMAN | [view interactions] | High throughput | no | yes |
| SHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CC183_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| REQU_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PTN3_HUMAN | [view interactions] | High throughput | no | yes |
| PLK1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRPF3_HUMAN | [view interactions] | High throughput | no | yes |
| CECR2_HUMAN | [view interactions] | High throughput | no | yes |
| SP110_HUMAN | [view interactions] | High throughput | no | no |
| TRI66_HUMAN | [view interactions] | High throughput | no | no |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| NUDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M4K1_HUMAN | [view interactions] | High throughput | no | no |
| RADI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSD4_HUMAN | [view interactions] | High throughput | no | yes |
| SLAP2_HUMAN | [view interactions] | High throughput | no | no |
| AGO4_HUMAN | [view interactions] | High throughput | no | no |
| NAA10_HUMAN | [view interactions] | High throughput | no | yes |
| SURF6_HUMAN | [view interactions] | High throughput | no | yes |
| SYNCI_HUMAN | [view interactions] | High throughput | no | no |
| CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BACE2_HUMAN | [view interactions] | High throughput | no | yes |
| GRAP2_HUMAN | [view interactions] | High throughput | no | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| ACVL1_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN_HUMAN | [view interactions] | High throughput | no | no |
| TGFR2_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| SHIP2_HUMAN | [view interactions] | High throughput | no | yes |
| DDX41_HUMAN | [view interactions] | High throughput | no | yes |
| KAT7_HUMAN | [view interactions] | High throughput | no | yes |
| NKAP_HUMAN | [view interactions] | High throughput | no | yes |
| GPTC2_HUMAN | [view interactions] | High throughput | no | yes |
| NOLC1_HUMAN | [view interactions] | High throughput | no | yes |
| HIRP3_HUMAN | [view interactions] | High throughput | no | no |
| RBBP4_HUMAN | [view interactions] | High throughput | no | yes |
| RN111_HUMAN | [view interactions] | High throughput | no | yes |
| ATRX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCGF5_HUMAN | [view interactions] | High throughput | no | yes |
| EPS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNL2_HUMAN | [view interactions] | High throughput | no | yes |
| WDR82_HUMAN | [view interactions] | High throughput | no | no |
| GBRAP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| CHD1_HUMAN | [view interactions] | High throughput | no | yes |
| CHD2_HUMAN | [view interactions] | High throughput | no | yes |
| PININ_HUMAN | [view interactions] | High throughput | no | yes |
| TF3C1_HUMAN | [view interactions] | High throughput | no | yes |
| NRDE2_HUMAN | [view interactions] | High throughput | no | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| CL16A_HUMAN | [view interactions] | High throughput | no | yes |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| ATG10_HUMAN | [view interactions] | High throughput | no | yes |
| ATG3_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HOOK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMAG2_HUMAN | [view interactions] | High throughput | no | yes |
| EST1A_HUMAN | [view interactions] | High throughput | no | yes |
| ACTZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRASP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR48_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VASP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BRSK2_HUMAN | [view interactions] | High throughput | no | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| JPH4_HUMAN | [view interactions] | High throughput | no | no |
| TAOK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDZ1P_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| NAGK_HUMAN | [view interactions] | High throughput | no | no |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| COMD1_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| TULP3_HUMAN | [view interactions] | High throughput | no | yes |
| PF21A_HUMAN | [view interactions] | High throughput | no | yes |
| SEC13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCOR1_HUMAN | [view interactions] | High throughput | no | yes |
| RSPH9_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSK3A_HUMAN | [view interactions] | High throughput | no | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| ARG39_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSK21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DOK2_HUMAN | [view interactions] | High throughput | no | no |
| LRRK1_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPDM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |