IF2A_HUMAN
Evidence for PS localization
Functions
Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex (PubMed). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex (PubMed). In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (PubMed). EIF2S1/eIF-2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to an attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed, PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in IF2A_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 43.9560 | 4 | yes |
| GO:0000166 | nucleotide binding | 36.2637 | 4 | no |
| GO:0043168 | anion binding | 36.2637 | 4 | no |
| GO:0017076 | purine nucleotide binding | 34.0659 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 34.0659 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 34.0659 | 4 | no |
| GO:0005524 | ATP binding | 29.6703 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 29.6703 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 29.6703 | 5 | no |
| GO:0043169 | cation binding | 21.9780 | 4 | no |
| GO:0046872 | metal ion binding | 21.9780 | 5 | no |
| GO:0016301 | kinase activity | 20.8791 | 4 | no |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 20.8791 | 4 | no |
| GO:0019900 | kinase binding | 20.8791 | 4 | no |
| GO:0003743 | translation initiation factor activity | 5.4945 | 4 | yes |
| GO:0043022 | ribosome binding | 4.3956 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in IF2A_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 62.6374 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 62.6374 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 62.6374 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 59.3407 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 57.1429 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 56.0440 | 5 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 54.9451 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 54.9451 | 4 | yes |
| GO:0010468 | regulation of gene expression | 52.7473 | 6 | yes |
| GO:0051128 | regulation of cellular component organization | 48.3516 | 4 | no |
| GO:0010646 | regulation of cell communication | 47.2527 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 46.1538 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 43.9560 | 4 | no |
| GO:0022607 | cellular component assembly | 42.8571 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 42.8571 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 41.7582 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 40.6593 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 39.5604 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 39.5604 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 36.2637 | 5 | yes |
| GO:0036211 | protein modification process | 36.2637 | 4 | no |
| GO:0043412 | macromolecule modification | 36.2637 | 4 | no |
| GO:0006996 | organelle organization | 35.1648 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 35.1648 | 5 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 35.1648 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 35.1648 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 34.0659 | 5 | yes |
| GO:0043067 | regulation of programmed cell death | 34.0659 | 4 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 34.0659 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 34.0659 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 32.9670 | 5 | no |
| GO:0023056 | positive regulation of signaling | 32.9670 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 32.9670 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 31.8681 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 31.8681 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.7692 | 6 | no |
| GO:0009890 | negative regulation of biosynthetic process | 29.6703 | 5 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 29.6703 | 6 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 29.6703 | 6 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 29.6703 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 28.5714 | 4 | no |
| GO:0031399 | regulation of protein modification process | 28.5714 | 6 | no |
| GO:0045595 | regulation of cell differentiation | 28.5714 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 27.4725 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 27.4725 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 27.4725 | 7 | no |
| GO:0008104 | protein localization | 27.4725 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 27.4725 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 27.4725 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 27.4725 | 6 | no |
| GO:0009894 | regulation of catabolic process | 27.4725 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 27.4725 | 7 | no |
| GO:0043933 | protein-containing complex organization | 26.3736 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 26.3736 | 4 | no |
| GO:0060341 | regulation of cellular localization | 26.3736 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 25.2747 | 7 | no |
| GO:0042127 | regulation of cell population proliferation | 24.1758 | 4 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 24.1758 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 24.1758 | 7 | no |
| GO:0044087 | regulation of cellular component biogenesis | 24.1758 | 4 | no |
| GO:0051049 | regulation of transport | 24.1758 | 4 | no |
| GO:0009059 | macromolecule biosynthetic process | 24.1758 | 4 | no |
| GO:0033043 | regulation of organelle organization | 24.1758 | 5 | no |
| GO:0010608 | post-transcriptional regulation of gene expression | 23.0769 | 7 | yes |
| GO:0051726 | regulation of cell cycle | 23.0769 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 23.0769 | 5 | no |
| GO:0010629 | negative regulation of gene expression | 21.9780 | 7 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 21.9780 | 6 | yes |
| GO:0010648 | negative regulation of cell communication | 21.9780 | 5 | no |
| GO:0023057 | negative regulation of signaling | 21.9780 | 4 | no |
| GO:0032101 | regulation of response to external stimulus | 21.9780 | 4 | no |
| GO:0043408 | regulation of MAPK cascade | 21.9780 | 6 | no |
| GO:0048585 | negative regulation of response to stimulus | 21.9780 | 4 | no |
| GO:0080134 | regulation of response to stress | 21.9780 | 4 | no |
| GO:0071702 | organic substance transport | 21.9780 | 4 | no |
| GO:0071705 | nitrogen compound transport | 21.9780 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 21.9780 | 4 | no |
| GO:0032880 | regulation of protein localization | 21.9780 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 20.8791 | 5 | no |
| GO:0016310 | phosphorylation | 20.8791 | 5 | no |
| GO:0043066 | negative regulation of apoptotic process | 20.8791 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 20.8791 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 20.8791 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 20.8791 | 7 | no |
| GO:0060284 | regulation of cell development | 20.8791 | 5 | no |
| GO:0045597 | positive regulation of cell differentiation | 20.8791 | 5 | no |
| GO:0006417 | regulation of translation | 19.7802 | 6 | yes |
| GO:0141124 | intracellular signaling cassette | 16.4835 | 4 | yes |
| GO:0010243 | response to organonitrogen compound | 14.2857 | 4 | yes |
| GO:0014070 | response to organic cyclic compound | 14.2857 | 4 | yes |
| GO:0043065 | positive regulation of apoptotic process | 10.9890 | 6 | yes |
| GO:0043068 | positive regulation of programmed cell death | 10.9890 | 5 | yes |
| GO:0006446 | regulation of translational initiation | 9.8901 | 7 | yes |
| GO:0070925 | organelle assembly | 9.8901 | 5 | yes |
| GO:0010038 | response to metal ion | 8.7912 | 4 | yes |
| GO:0062197 | cellular response to chemical stress | 8.7912 | 4 | yes |
| GO:0140694 | non-membrane-bounded organelle assembly | 8.7912 | 6 | yes |
| GO:0009416 | response to light stimulus | 7.6923 | 4 | yes |
| GO:0017148 | negative regulation of translation | 7.6923 | 7 | yes |
| GO:0034599 | cellular response to oxidative stress | 7.6923 | 4 | yes |
| GO:0071241 | cellular response to inorganic substance | 7.6923 | 4 | yes |
| GO:0009267 | cellular response to starvation | 6.5934 | 4 | yes |
| GO:0034976 | response to endoplasmic reticulum stress | 6.5934 | 4 | yes |
| GO:0071248 | cellular response to metal ion | 6.5934 | 5 | yes |
| GO:0034063 | stress granule assembly | 5.4945 | 7 | yes |
| GO:0034605 | cellular response to heat | 5.4945 | 4 | yes |
| GO:0034198 | cellular response to amino acid starvation | 4.3956 | 5 | yes |
| GO:0043200 | response to amino acid | 4.3956 | 4 | yes |
| GO:0043555 | regulation of translation in response to stress | 4.3956 | 7 | yes |
| GO:1990928 | response to amino acid starvation | 4.3956 | 4 | yes |
| GO:0009411 | response to UV | 3.2967 | 5 | yes |
| GO:0010042 | response to manganese ion | 3.2967 | 5 | yes |
| GO:0034644 | cellular response to UV | 3.2967 | 6 | yes |
| GO:0036490 | regulation of translation in response to endoplasmic reticulum stress | 3.2967 | 8 | yes |
| GO:0043558 | regulation of translational initiation in response to stress | 3.2967 | 8 | yes |
| GO:0071287 | cellular response to manganese ion | 3.2967 | 6 | yes |
| GO:0071478 | cellular response to radiation | 3.2967 | 4 | yes |
| GO:0071482 | cellular response to light stimulus | 3.2967 | 5 | yes |
| GO:1904035 | regulation of epithelial cell apoptotic process | 3.2967 | 6 | yes |
| GO:0032057 | negative regulation of translational initiation in response to stress | 2.1978 | 9 | yes |
| GO:0036499 | PERK-mediated unfolded protein response | 2.1978 | 4 | yes |
| GO:0045947 | negative regulation of translational initiation | 2.1978 | 8 | yes |
| GO:0140467 | integrated stress response signaling | 2.1978 | 4 | yes |
| GO:1904037 | positive regulation of epithelial cell apoptotic process | 2.1978 | 7 | yes |
| GO:1904373 | response to kainic acid | 2.1978 | 4 | yes |
| GO:1990737 | response to manganese-induced endoplasmic reticulum stress | 2.1978 | 5 | yes |
| GO:2000674 | regulation of type B pancreatic cell apoptotic process | 2.1978 | 7 | yes |
| GO:2000676 | positive regulation of type B pancreatic cell apoptotic process | 2.1978 | 8 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| EI2BA_HUMAN | [view interactions] | Low throughput | no | yes |
| CDC37_HUMAN | [view interactions] | Low throughput | no | yes |
| HS90A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EI2BD_HUMAN | [view interactions] | Low throughput | no | yes |
| DDX3X_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PR15A_HUMAN | [view interactions] | Low throughput | no | yes |
| IF2B_HUMAN | [view interactions] | Low throughput | no | yes |
| E2AK3_HUMAN | [view interactions] | Low throughput | no | yes |
| IF4G2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| E2AK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EI2BE_HUMAN | [view interactions] | Low throughput | no | yes |
| EI2BG_HUMAN | [view interactions] | Low throughput | no | yes |
| IF2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IF2G_HUMAN | [view interactions] | Low throughput | no | yes |
| SET_HUMAN | [view interactions] | Low throughput | no | yes |
| KPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| E2AK1_HUMAN | [view interactions] | Low throughput | no | yes |
| ANM7_HUMAN | [view interactions] | Low throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EI2BB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RENT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433S_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYVN1_HUMAN | [view interactions] | Low throughput | no | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2O_HUMAN | [view interactions] | High throughput | no | yes |
| DDX24_HUMAN | [view interactions] | High throughput | no | yes |
| ARC1B_HUMAN | [view interactions] | High throughput | no | no |
| MOB3C_HUMAN | [view interactions] | High throughput | no | no |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| RN207_HUMAN | [view interactions] | High throughput | no | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| OTUD1_HUMAN | [view interactions] | High throughput | no | yes |
| UBP36_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| CEMIP_HUMAN | [view interactions] | High throughput | no | no |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| POP1_HUMAN | [view interactions] | High throughput | no | no |
| TMED9_HUMAN | [view interactions] | High throughput | no | yes |
| NCOA5_HUMAN | [view interactions] | High throughput | no | yes |
| DDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YBOX1_HUMAN | [view interactions] | High throughput | no | yes |
| AIMP1_HUMAN | [view interactions] | High throughput | no | yes |
| SYDC_HUMAN | [view interactions] | High throughput | no | yes |
| MCA3_HUMAN | [view interactions] | High throughput | no | yes |
| MAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYMC_HUMAN | [view interactions] | High throughput | no | yes |
| SYQ_HUMAN | [view interactions] | High throughput | no | yes |
| RL13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL15_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL7A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RLA0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS27L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PYR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TDIF1_HUMAN | [view interactions] | High throughput | no | no |
| ERF1_HUMAN | [view interactions] | High throughput | no | yes |
| ANM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPB7_HUMAN | [view interactions] | High throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| TOE1_HUMAN | [view interactions] | High throughput | no | yes |
| TCPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| MAST3_HUMAN | [view interactions] | High throughput | no | yes |
| IF4A3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD6_HUMAN | [view interactions] | High throughput | no | yes |
| RRBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYRC_HUMAN | [view interactions] | High throughput | no | yes |
| CAPR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| FUBP2_HUMAN | [view interactions] | High throughput | no | yes |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA1_HUMAN | [view interactions] | High throughput | no | yes |
| PAK4_HUMAN | [view interactions] | High throughput | no | yes |
| RL27_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| EIF2A_HUMAN | [view interactions] | High throughput | no | yes |
| MP2K2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CIRBP_HUMAN | [view interactions] | High throughput | no | no |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| XRCC6_HUMAN | [view interactions] | High throughput | no | yes |
| XRCC5_HUMAN | [view interactions] | High throughput | no | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| IF2M_HUMAN | [view interactions] | High throughput | no | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKDC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ILF2_HUMAN | [view interactions] | High throughput | no | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ILF3_HUMAN | [view interactions] | High throughput | no | yes |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| NU205_HUMAN | [view interactions] | High throughput | no | no |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| UBA5_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| UGGG1_HUMAN | [view interactions] | High throughput | no | yes |
| EWS_HUMAN | [view interactions] | High throughput | no | yes |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| SNF5_HUMAN | [view interactions] | High throughput | no | yes |
| ANC2_HUMAN | [view interactions] | High throughput | no | no |
| HG2A_HUMAN | [view interactions] | High throughput | no | yes |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX60_HUMAN | [view interactions] | High throughput | no | no |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| MB212_HUMAN | [view interactions] | High throughput | no | no |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PHLP1_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCDH7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VGFR2_HUMAN | [view interactions] | High throughput | no | no |
| FOXO1_HUMAN | [view interactions] | High throughput | no | yes |
| BCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |
| STAM2_HUMAN | [view interactions] | High throughput | no | yes |
| DYRK3_HUMAN | [view interactions] | High throughput | no | no |
| MAK_HUMAN | [view interactions] | High throughput | no | no |
| NEK7_HUMAN | [view interactions] | High throughput | no | yes |
| LYAR_HUMAN | [view interactions] | High throughput | no | no |
| EIF1B_HUMAN | [view interactions] | High throughput | no | no |
| TRAF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| CSK21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAC14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDGF_HUMAN | [view interactions] | High throughput | no | yes |
| CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| RAB3C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB33A_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| DCC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BET1_HUMAN | [view interactions] | High throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ST38L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| EPHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| VGFR1_HUMAN | [view interactions] | High throughput | no | no |
| FLT3_HUMAN | [view interactions] | High throughput | no | no |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
| LMTK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMTK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LTK_HUMAN | [view interactions] | High throughput | no | no |
| MERTK_HUMAN | [view interactions] | High throughput | no | yes |
| RON_HUMAN | [view interactions] | High throughput | no | yes |
| ROR1_HUMAN | [view interactions] | High throughput | no | no |
| ROS1_HUMAN | [view interactions] | High throughput | no | no |
| TIE2_HUMAN | [view interactions] | High throughput | no | no |
| TERT_HUMAN | [view interactions] | High throughput | no | no |
| 4ET_HUMAN | [view interactions] | High throughput | no | yes |
| PCBP3_HUMAN | [view interactions] | High throughput | no | yes |
| SRSF6_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAD21_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERG_HUMAN | [view interactions] | High throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| MMS19_HUMAN | [view interactions] | High throughput | no | yes |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| CEBPA_HUMAN | [view interactions] | High throughput | no | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| PTN2_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRP8_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| CHD3_HUMAN | [view interactions] | High throughput | no | yes |
| CHD4_HUMAN | [view interactions] | High throughput | no | yes |
| SPDLY_HUMAN | [view interactions] | High throughput | no | yes |
| RIOK1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| REST_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| LYRIC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFE3_HUMAN | [view interactions] | High throughput | no | yes |
| RU17_HUMAN | [view interactions] | High throughput | no | yes |
| MRP6_HUMAN | [view interactions] | High throughput | no | no |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| NFX1_HUMAN | [view interactions] | High throughput | no | yes |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| BRD7_HUMAN | [view interactions] | High throughput | no | yes |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| CMTR1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| ZCH18_HUMAN | [view interactions] | High throughput | no | yes |
| EMC4_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
| NMRL1_HUMAN | [view interactions] | High throughput | no | yes |
| MAFB_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC2_HUMAN | [view interactions] | High throughput | no | yes |
| PD1L1_HUMAN | [view interactions] | High throughput | no | no |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| RILP_HUMAN | [view interactions] | High throughput | no | no |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| FGD5_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| HECD1_HUMAN | [view interactions] | High throughput | no | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DRG1_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3B_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3G_HUMAN | [view interactions] | High throughput | no | yes |
| IF4A1_HUMAN | [view interactions] | High throughput | no | no |
| IF5_HUMAN | [view interactions] | High throughput | no | yes |
| G3BP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERF3A_HUMAN | [view interactions] | High throughput | no | yes |
| HMGB2_HUMAN | [view interactions] | High throughput | no | yes |
| MAP2_HUMAN | [view interactions] | High throughput | no | yes |
| PSPC1_HUMAN | [view interactions] | High throughput | no | yes |
| RACK1_HUMAN | [view interactions] | High throughput | no | yes |
| RBM42_HUMAN | [view interactions] | High throughput | no | yes |
| RBM8A_HUMAN | [view interactions] | High throughput | no | yes |
| RL19_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRP68_HUMAN | [view interactions] | High throughput | no | yes |
| SRP72_HUMAN | [view interactions] | High throughput | no | yes |
| SRP09_HUMAN | [view interactions] | High throughput | no | no |
| TRI11_HUMAN | [view interactions] | High throughput | no | yes |
| TRI31_HUMAN | [view interactions] | High throughput | no | no |
| IF2B3_HUMAN | [view interactions] | High throughput | no | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| RNF43_HUMAN | [view interactions] | High throughput | no | yes |
| MAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF8_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| DOT1L_HUMAN | [view interactions] | High throughput | no | yes |
| MEN1_HUMAN | [view interactions] | High throughput | no | yes |