IF2A_HUMAN
Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex (PubMed). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex (PubMed). In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (PubMed). EIF2S1/eIF-2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to an attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (PubMed, PubMed). [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in IF2A_HUMAN |
---|---|---|---|---|
GO:0003723 | RNA binding | 63.3094 | 4 | yes |
GO:0017076 | purine nucleotide binding | 28.0576 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 28.0576 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 28.0576 | 4 | no |
GO:0005524 | ATP binding | 23.7410 | 5 | no |
GO:0030554 | adenyl nucleotide binding | 23.7410 | 5 | no |
GO:0032559 | adenyl ribonucleotide binding | 23.7410 | 5 | no |
GO:0003743 | translation initiation factor activity | 7.1942 | 4 | yes |
GO:0043022 | ribosome binding | 4.3165 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in IF2A_HUMAN |
---|---|---|---|---|
GO:0060255 | regulation of macromolecule metabolic process | 55.3957 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 53.9568 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 53.9568 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 53.9568 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 51.0791 | 4 | yes |
GO:0044271 | cellular nitrogen compound biosynthetic process | 44.6043 | 4 | no |
GO:0009059 | macromolecule biosynthetic process | 43.8849 | 4 | no |
GO:0010468 | regulation of gene expression | 42.4460 | 5 | yes |
GO:1901566 | organonitrogen compound biosynthetic process | 42.4460 | 4 | no |
GO:0034645 | cellular macromolecule biosynthetic process | 41.7266 | 4 | no |
GO:0043603 | cellular amide metabolic process | 41.7266 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 41.0072 | 4 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 41.0072 | 5 | yes |
GO:0048523 | negative regulation of cellular process | 41.0072 | 4 | yes |
GO:0043604 | amide biosynthetic process | 41.0072 | 5 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 40.2878 | 5 | yes |
GO:0006518 | peptide metabolic process | 40.2878 | 4 | no |
GO:0006412 | translation | 39.5683 | 4 | no |
GO:0043043 | peptide biosynthetic process | 39.5683 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 37.4101 | 5 | yes |
GO:0009893 | positive regulation of metabolic process | 37.4101 | 4 | no |
GO:0002181 | cytoplasmic translation | 35.2518 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 33.8129 | 5 | no |
GO:0022607 | cellular component assembly | 33.0935 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 33.0935 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 31.6547 | 5 | no |
GO:0010646 | regulation of cell communication | 31.6547 | 4 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 30.2158 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 29.4964 | 5 | no |
GO:0009966 | regulation of signal transduction | 29.4964 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 28.7770 | 4 | yes |
GO:0031324 | negative regulation of cellular metabolic process | 26.6187 | 5 | yes |
GO:0010605 | negative regulation of macromolecule metabolic process | 25.8993 | 5 | yes |
GO:0036211 | protein modification process | 25.8993 | 4 | yes |
GO:0043412 | macromolecule modification | 25.8993 | 4 | yes |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 25.1799 | 5 | yes |
GO:1902531 | regulation of intracellular signal transduction | 23.7410 | 5 | no |
GO:0010941 | regulation of cell death | 23.0216 | 4 | yes |
GO:0009891 | positive regulation of biosynthetic process | 23.0216 | 5 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 23.0216 | 6 | no |
GO:0048584 | positive regulation of response to stimulus | 23.0216 | 4 | no |
GO:2000112 | regulation of cellular macromolecule biosynthetic process | 22.3022 | 6 | yes |
GO:0043933 | protein-containing complex organization | 22.3022 | 4 | no |
GO:0010647 | positive regulation of cell communication | 22.3022 | 5 | no |
GO:0023056 | positive regulation of signaling | 22.3022 | 4 | no |
GO:0051247 | positive regulation of protein metabolic process | 22.3022 | 6 | no |
GO:0006996 | organelle organization | 21.5827 | 4 | yes |
GO:0010608 | post-transcriptional regulation of gene expression | 21.5827 | 6 | yes |
GO:0042981 | regulation of apoptotic process | 21.5827 | 6 | yes |
GO:0043067 | regulation of programmed cell death | 21.5827 | 5 | yes |
GO:0090304 | nucleic acid metabolic process | 21.5827 | 4 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 21.5827 | 6 | no |
GO:0051252 | regulation of RNA metabolic process | 21.5827 | 5 | no |
GO:0065003 | protein-containing complex assembly | 21.5827 | 5 | no |
GO:0010628 | positive regulation of gene expression | 21.5827 | 6 | no |
GO:0034248 | regulation of cellular amide metabolic process | 20.8633 | 5 | yes |
GO:0006417 | regulation of translation | 20.1439 | 6 | yes |
GO:0006796 | phosphate-containing compound metabolic process | 20.1439 | 4 | yes |
GO:0051338 | regulation of transferase activity | 20.1439 | 4 | no |
GO:0051248 | negative regulation of protein metabolic process | 18.7050 | 6 | yes |
GO:0009890 | negative regulation of biosynthetic process | 14.3885 | 5 | yes |
GO:0010558 | negative regulation of macromolecule biosynthetic process | 14.3885 | 6 | yes |
GO:0031327 | negative regulation of cellular biosynthetic process | 14.3885 | 6 | yes |
GO:0010629 | negative regulation of gene expression | 13.6691 | 6 | yes |
GO:0006468 | protein phosphorylation | 12.9496 | 5 | yes |
GO:0016310 | phosphorylation | 12.9496 | 5 | yes |
GO:0051336 | regulation of hydrolase activity | 10.0719 | 4 | yes |
GO:0006446 | regulation of translational initiation | 9.3525 | 7 | yes |
GO:0010942 | positive regulation of cell death | 9.3525 | 5 | yes |
GO:0017148 | negative regulation of translation | 8.6331 | 7 | yes |
GO:0034249 | negative regulation of cellular amide metabolic process | 8.6331 | 6 | yes |
GO:2000113 | negative regulation of cellular macromolecule biosynthetic process | 8.6331 | 7 | yes |
GO:0043065 | positive regulation of apoptotic process | 7.9137 | 7 | yes |
GO:0043068 | positive regulation of programmed cell death | 7.9137 | 6 | yes |
GO:0046777 | protein autophosphorylation | 6.4748 | 6 | yes |
GO:0051099 | positive regulation of binding | 6.4748 | 4 | yes |
GO:0070925 | organelle assembly | 6.4748 | 5 | yes |
GO:0140694 | non-membrane-bounded organelle assembly | 6.4748 | 6 | yes |
GO:1901214 | regulation of neuron death | 6.4748 | 5 | yes |
GO:0009416 | response to light stimulus | 5.7554 | 4 | yes |
GO:0010038 | response to metal ion | 5.0360 | 4 | yes |
GO:0031667 | response to nutrient levels | 5.0360 | 4 | yes |
GO:0062197 | cellular response to chemical stress | 5.0360 | 4 | yes |
GO:0071241 | cellular response to inorganic substance | 5.0360 | 4 | yes |
GO:0031669 | cellular response to nutrient levels | 4.3165 | 4 | yes |
GO:0034063 | stress granule assembly | 4.3165 | 7 | yes |
GO:0034599 | cellular response to oxidative stress | 4.3165 | 4 | yes |
GO:0071248 | cellular response to metal ion | 4.3165 | 5 | yes |
GO:0009267 | cellular response to starvation | 3.5971 | 4 | yes |
GO:0034976 | response to endoplasmic reticulum stress | 3.5971 | 4 | yes |
GO:0043087 | regulation of GTPase activity | 3.5971 | 5 | yes |
GO:0043555 | regulation of translation in response to stress | 3.5971 | 7 | yes |
GO:0034198 | cellular response to amino acid starvation | 2.8777 | 5 | yes |
GO:0045947 | negative regulation of translational initiation | 2.8777 | 8 | yes |
GO:0071478 | cellular response to radiation | 2.8777 | 4 | yes |
GO:1901216 | positive regulation of neuron death | 2.8777 | 6 | yes |
GO:1990928 | response to amino acid starvation | 2.8777 | 4 | yes |
GO:0009411 | response to UV | 2.1583 | 5 | yes |
GO:0010042 | response to manganese ion | 2.1583 | 5 | yes |
GO:0034605 | cellular response to heat | 2.1583 | 4 | yes |
GO:0034644 | cellular response to UV | 2.1583 | 6 | yes |
GO:0043558 | regulation of translational initiation in response to stress | 2.1583 | 8 | yes |
GO:0071287 | cellular response to manganese ion | 2.1583 | 6 | yes |
GO:0071482 | cellular response to light stimulus | 2.1583 | 5 | yes |
GO:1904035 | regulation of epithelial cell apoptotic process | 2.1583 | 7 | yes |
GO:0032057 | negative regulation of translational initiation in response to stress | 1.4388 | 9 | yes |
GO:0036499 | PERK-mediated unfolded protein response | 1.4388 | 4 | yes |
GO:0140467 | integrated stress response signaling | 1.4388 | 4 | yes |
GO:1904037 | positive regulation of epithelial cell apoptotic process | 1.4388 | 8 | yes |
GO:1904424 | regulation of GTP binding | 1.4388 | 4 | yes |
GO:1905097 | regulation of guanyl-nucleotide exchange factor activity | 1.4388 | 5 | yes |
GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity | 1.4388 | 4 | yes |
GO:1990737 | response to manganese-induced endoplasmic reticulum stress | 1.4388 | 5 | yes |
GO:2000674 | regulation of type B pancreatic cell apoptotic process | 1.4388 | 8 | yes |
GO:2000676 | positive regulation of type B pancreatic cell apoptotic process | 1.4388 | 9 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in IF2A_HUMAN |
---|---|---|---|---|
DOID:1289 | neurodegenerative disease | 1.4388 | 4 | no |
DOID:231 | motor neuron disease | 1.4388 | 5 | no |
DOID:331 | central nervous system disease | 1.4388 | 3 | no |
DOID:574 | peripheral nervous system disease | 1.4388 | 3 | no |
DOID:870 | neuropathy | 1.4388 | 4 | no |
DOID:0050686 | organ system cancer | 1.4388 | 3 | no |
DOID:193 | reproductive organ cancer | 1.4388 | 4 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
E2AK3_HUMAN | [view interactions] | Low throughput | no | yes |
IF4G2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
E2AK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
IF2G_HUMAN | [view interactions] | Low throughput | no | yes |
SET_HUMAN | [view interactions] | Low throughput | no | yes |
KPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
E2AK1_HUMAN | [view interactions] | Low throughput | no | yes |
ANM7_HUMAN | [view interactions] | Low throughput | no | yes |
PP1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EI2BB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EI2BE_HUMAN | [view interactions] | Low throughput | no | yes |
IF2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RENT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
1433S_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SYVN1_HUMAN | [view interactions] | Low throughput | no | yes |
EI2BA_HUMAN | [view interactions] | Low throughput | no | yes |
CDC37_HUMAN | [view interactions] | Low throughput | no | yes |
HS90A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EI2BD_HUMAN | [view interactions] | Low throughput | no | yes |
DDX3X_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PR15A_HUMAN | [view interactions] | Low throughput | no | yes |
EI2BG_HUMAN | [view interactions] | Low throughput | no | yes |
IF2B_HUMAN | [view interactions] | Low throughput | no | yes |
MECOM_HUMAN | [view interactions] | High throughput | no | yes |
PAK4_HUMAN | [view interactions] | High throughput | no | yes |
LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
MP2K2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VCAM1_HUMAN | [view interactions] | High throughput | no | no |
DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SDHA_HUMAN | [view interactions] | High throughput | no | yes |
SODC_HUMAN | [view interactions] | High throughput | no | yes |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SNF5_HUMAN | [view interactions] | High throughput | no | yes |
HG2A_HUMAN | [view interactions] | High throughput | no | yes |
DDX60_HUMAN | [view interactions] | High throughput | no | no |
MB212_HUMAN | [view interactions] | High throughput | no | no |
FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
VGFR2_HUMAN | [view interactions] | High throughput | no | no |
BCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STAM2_HUMAN | [view interactions] | High throughput | no | yes |
DYRK3_HUMAN | [view interactions] | High throughput | no | no |
MAK_HUMAN | [view interactions] | High throughput | no | no |
NEK7_HUMAN | [view interactions] | High throughput | no | yes |
LYAR_HUMAN | [view interactions] | High throughput | no | no |
EIF1B_HUMAN | [view interactions] | High throughput | no | no |
TRAF6_HUMAN | [view interactions] | High throughput | no | yes |
SNW1_HUMAN | [view interactions] | High throughput | no | yes |
JUN_HUMAN | [view interactions] | High throughput | no | yes |
PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
BMI1_HUMAN | [view interactions] | High throughput | no | yes |
CSK21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VAC14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HDGF_HUMAN | [view interactions] | High throughput | no | yes |
CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CSN5_HUMAN | [view interactions] | High throughput | no | yes |
RAB3C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RB33A_HUMAN | [view interactions] | High throughput | no | no |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
DCC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
BET1_HUMAN | [view interactions] | High throughput | no | no |
RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ST38L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ALK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UFO_HUMAN | [view interactions] | High throughput | no | no |
EPHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
VGFR1_HUMAN | [view interactions] | High throughput | no | no |
FLT3_HUMAN | [view interactions] | High throughput | no | no |
VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
LMTK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LMTK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MERTK_HUMAN | [view interactions] | High throughput | no | yes |
RON_HUMAN | [view interactions] | High throughput | no | yes |
ROR1_HUMAN | [view interactions] | High throughput | no | no |
ROS1_HUMAN | [view interactions] | High throughput | no | no |
TIE2_HUMAN | [view interactions] | High throughput | no | no |
TERT_HUMAN | [view interactions] | High throughput | no | no |
4ET_HUMAN | [view interactions] | High throughput | no | yes |
PCBP3_HUMAN | [view interactions] | High throughput | no | yes |
SRSF6_HUMAN | [view interactions] | High throughput | no | yes |
SUMO2_HUMAN | [view interactions] | High throughput | no | yes |
SUMO3_HUMAN | [view interactions] | High throughput | no | yes |
RAD21_HUMAN | [view interactions] | High throughput | no | yes |
ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ERG_HUMAN | [view interactions] | High throughput | no | yes |
SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FINC_HUMAN | [view interactions] | High throughput | no | yes |
ITA4_HUMAN | [view interactions] | High throughput | no | no |
MMS19_HUMAN | [view interactions] | High throughput | no | yes |
NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PLCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RFA1_HUMAN | [view interactions] | High throughput | no | yes |
RFA2_HUMAN | [view interactions] | High throughput | no | yes |
RFA3_HUMAN | [view interactions] | High throughput | no | yes |
HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
RING2_HUMAN | [view interactions] | High throughput | no | yes |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
CEBPA_HUMAN | [view interactions] | High throughput | no | yes |
CDC73_HUMAN | [view interactions] | High throughput | no | yes |
PTN2_HUMAN | [view interactions] | High throughput | no | yes |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRP8_HUMAN | [view interactions] | High throughput | no | yes |
U5S1_HUMAN | [view interactions] | High throughput | no | yes |
AAR2_HUMAN | [view interactions] | High throughput | no | no |
PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
CHD3_HUMAN | [view interactions] | High throughput | no | yes |
CHD4_HUMAN | [view interactions] | High throughput | no | yes |
SPDLY_HUMAN | [view interactions] | High throughput | no | yes |
RIOK1_HUMAN | [view interactions] | High throughput | no | yes |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
REST_HUMAN | [view interactions] | High throughput | no | yes |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
LYRIC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TFE3_HUMAN | [view interactions] | High throughput | no | yes |
RU17_HUMAN | [view interactions] | High throughput | no | yes |
MRP6_HUMAN | [view interactions] | High throughput | no | no |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BIRC3_HUMAN | [view interactions] | High throughput | no | no |
STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LMBRL_HUMAN | [view interactions] | High throughput | no | no |
NFX1_HUMAN | [view interactions] | High throughput | no | yes |
WWP2_HUMAN | [view interactions] | High throughput | no | no |
BRD7_HUMAN | [view interactions] | High throughput | no | yes |
RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
CMTR1_HUMAN | [view interactions] | High throughput | no | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
PINK1_HUMAN | [view interactions] | High throughput | no | yes |
ZCH18_HUMAN | [view interactions] | High throughput | no | yes |
EMC4_HUMAN | [view interactions] | High throughput | no | yes |
CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
NMRL1_HUMAN | [view interactions] | High throughput | no | yes |
MAFB_HUMAN | [view interactions] | High throughput | no | yes |
BRD4_HUMAN | [view interactions] | High throughput | no | yes |
MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NUPR1_HUMAN | [view interactions] | High throughput | no | no |
RBM39_HUMAN | [view interactions] | High throughput | no | yes |
DNJC2_HUMAN | [view interactions] | High throughput | no | yes |
PD1L1_HUMAN | [view interactions] | High throughput | no | no |
ANDR_HUMAN | [view interactions] | High throughput | no | no |
UFL1_HUMAN | [view interactions] | High throughput | no | yes |
DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FZR1_HUMAN | [view interactions] | High throughput | no | no |
WDR5_HUMAN | [view interactions] | High throughput | no | no |
RILP_HUMAN | [view interactions] | High throughput | no | no |
BTF3_HUMAN | [view interactions] | High throughput | no | yes |
FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
FGD5_HUMAN | [view interactions] | High throughput | no | yes |
CCNF_HUMAN | [view interactions] | High throughput | no | no |
HECD1_HUMAN | [view interactions] | High throughput | no | yes |
CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DRG1_HUMAN | [view interactions] | High throughput | no | yes |
EIF3B_HUMAN | [view interactions] | High throughput | no | yes |
EIF3G_HUMAN | [view interactions] | High throughput | no | yes |
IF4A1_HUMAN | [view interactions] | High throughput | no | no |
IF5_HUMAN | [view interactions] | High throughput | no | yes |
G3BP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ERF3A_HUMAN | [view interactions] | High throughput | no | yes |
HMGB2_HUMAN | [view interactions] | High throughput | no | yes |
MAP2_HUMAN | [view interactions] | High throughput | no | yes |
PSPC1_HUMAN | [view interactions] | High throughput | no | yes |
RACK1_HUMAN | [view interactions] | High throughput | no | yes |
RBM42_HUMAN | [view interactions] | High throughput | no | yes |
RBM8A_HUMAN | [view interactions] | High throughput | no | yes |
RL19_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRP68_HUMAN | [view interactions] | High throughput | no | yes |
SRP72_HUMAN | [view interactions] | High throughput | no | yes |
SRP09_HUMAN | [view interactions] | High throughput | no | no |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
RIT1_HUMAN | [view interactions] | High throughput | no | yes |
POP1_HUMAN | [view interactions] | High throughput | no | no |
TMED9_HUMAN | [view interactions] | High throughput | no | yes |
NCOA5_HUMAN | [view interactions] | High throughput | no | yes |
DDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
YBOX1_HUMAN | [view interactions] | High throughput | no | yes |
AIMP1_HUMAN | [view interactions] | High throughput | no | yes |
SYDC_HUMAN | [view interactions] | High throughput | no | yes |
MCA3_HUMAN | [view interactions] | High throughput | no | yes |
MAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SYMC_HUMAN | [view interactions] | High throughput | no | yes |
SYQ_HUMAN | [view interactions] | High throughput | no | yes |
RL13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL15_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RL27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL7A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RLA0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RS27L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PYR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TDIF1_HUMAN | [view interactions] | High throughput | no | no |
ERF1_HUMAN | [view interactions] | High throughput | no | yes |
ANM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RPB7_HUMAN | [view interactions] | High throughput | no | yes |
RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TOE1_HUMAN | [view interactions] | High throughput | no | yes |
TCPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TIA1_HUMAN | [view interactions] | High throughput | no | no |
IF4A3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSMD6_HUMAN | [view interactions] | High throughput | no | yes |
SYRC_HUMAN | [view interactions] | High throughput | no | yes |
CAPR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EIF3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FUBP2_HUMAN | [view interactions] | High throughput | no | yes |
PDIA1_HUMAN | [view interactions] | High throughput | no | yes |
RL27_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EIF2A_HUMAN | [view interactions] | High throughput | no | yes |
CIRBP_HUMAN | [view interactions] | High throughput | no | no |
EWS_HUMAN | [view interactions] | High throughput | no | yes |
TRI14_HUMAN | [view interactions] | High throughput | no | yes |
ACTC_HUMAN | [view interactions] | High throughput | no | no |
LEG9_HUMAN | [view interactions] | High throughput | no | yes |
ANC2_HUMAN | [view interactions] | High throughput | no | no |
NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FURIN_HUMAN | [view interactions] | High throughput | no | yes |
IFM1_HUMAN | [view interactions] | High throughput | no | no |
IFM3_HUMAN | [view interactions] | High throughput | no | yes |
ACE2_HUMAN | [view interactions] | High throughput | no | no |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GLUT4_HUMAN | [view interactions] | High throughput | no | no |
EED_HUMAN | [view interactions] | High throughput | no | yes |
MAST3_HUMAN | [view interactions] | High throughput | no | yes |
RL35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RRBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRD16_HUMAN | [view interactions] | High throughput | no | no |
RS26_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RS19_HUMAN | [view entry] [view interactions] | Computational | yes | no |
IF2P_HUMAN | [view interactions] | Computational | no | yes |
RS25_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
DDIT3_HUMAN | [view interactions] | Computational | no | yes |
NPY4R_HUMAN | [view interactions] | Computational | no | yes |
RS28_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ERN1_HUMAN | [view interactions] | Computational | no | yes |
E2AK4_HUMAN | [view interactions] | Computational | no | yes |
EIF3H_HUMAN | [view interactions] | Computational | no | yes |
TCPE_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RL9_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RS6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
LSM4_HUMAN | [view interactions] | Computational | no | yes |
RL14_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RL13A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RS3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ATF5_HUMAN | [view interactions] | Computational | no | yes |
ABCF1_HUMAN | [view interactions] | Computational | no | yes |
EF1G_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RL23A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
IF1AX_HUMAN | [view interactions] | Computational | no | yes |
TCPH_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RS11_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RS21_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
IF4A2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
BIP_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RS15A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RS14_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RS15_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RS4X_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RS27A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
UBB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
UBC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RL40_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EIF3J_HUMAN | [view interactions] | Computational | no | yes |
RSSA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EF1A1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EIFCL_HUMAN | [view interactions] | Computational | no | yes |
DDX6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
HARS1_HUMAN | [view interactions] | Computational | no | yes |
RS24_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RS20_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EIF3C_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RS29_HUMAN | [view interactions] | Computational | no | yes |
RS3A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ABCE1_HUMAN | [view interactions] | Computational | no | yes |
PA2G4_HUMAN | [view interactions] | Computational | no | yes |
RL21_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EIF3D_HUMAN | [view interactions] | Computational | no | yes |
RS13_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EIF3F_HUMAN | [view interactions] | Computational | no | yes |
PSDE_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RS23_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RL5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RS18_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RL18A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
XBP1_HUMAN | [view interactions] | Computational | no | no |
EF2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CELF1_HUMAN | [view interactions] | Computational | no | yes |
RS10_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
TCPB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ATF3_HUMAN | [view interactions] | Computational | no | yes |
TCPA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RS30_HUMAN | [view interactions] | Computational | no | yes |
RS9_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
IF4E_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
TCPZ_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RL11_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SYHM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RS8_HUMAN | [view entry] [view interactions] | Computational | yes | no |
DENR_HUMAN | [view interactions] | Computational | no | yes |
ASNS_HUMAN | [view interactions] | Computational | no | yes |
EIF3L_HUMAN | [view interactions] | Computational | no | yes |
ATF6A_HUMAN | [view interactions] | Computational | no | yes |
IF2GL_HUMAN | [view interactions] | Computational | no | no |
ATF4_HUMAN | [view interactions] | Computational | no | no |
RL7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EIF1_HUMAN | [view interactions] | Computational | no | no |
EIF3M_HUMAN | [view interactions] | Computational | no | yes |
RL3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EIF3K_HUMAN | [view interactions] | Computational | no | yes |
IF4G1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RL8_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
TCPD_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EIF3E_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MK67I_HUMAN | [view interactions] | Computational | no | yes |
RS2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PP1B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RS12_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RL6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RS5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GCN1_HUMAN | [view interactions] | Computational | no | yes |