Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ANM5_HUMAN

Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles (PubMed, PubMed, PubMed). Methylates SUPT5H and may regulate its transcriptional elongation properties (PubMed). Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methylates histone H2A and H4 Arg-3 during germ cell development . Methylates histone H3 Arg-8, which may repress transcription . Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage . Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR Tyr-1197 phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation (PubMed, PubMed). Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (PubMed). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9 (PubMed). Methylates and regulates SRGAP2 which is involved in cell migration and differentiation (PubMed). Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter . Methylates GM130/GOLGA2, regulating Golgi ribbon formation (PubMed). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed). Symmetrically methylates POLR2A, a modification that allows the recruitment to POLR2A of proteins including SMN1/SMN2 and SETX. This is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination (PubMed). Along with LYAR, binds the promoter of gamma-globin HBG1/HBG2 and represses its expression (PubMed). Symmetrically methylates NCL (PubMed). Methylates TP53; methylation might possibly affect TP53 target gene specificity (PubMed). Involved in spliceosome maturation and mRNA splicing in prophase I spermatocytes through the catalysis of the symmetrical arginine dimethylation of SNRPB (small nuclear ribonucleoprotein-associated protein) and the interaction with tudor domain-containing protein TDRD6 . [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in ANM5_HUMAN
GO:0003723 RNA binding 31.8841 4 no
GO:0017076 purine nucleotide binding 26.0870 4 no
GO:0032555 purine ribonucleotide binding 26.0870 4 no
GO:0035639 purine ribonucleoside triphosphate binding 26.0870 4 no
GO:0044389 ubiquitin-like protein ligase binding 21.7391 4 no
GO:0031625 ubiquitin protein ligase binding 20.2899 5 no
GO:0003677 DNA binding 11.5942 4 yes
GO:0043565 sequence-specific DNA binding 8.6957 5 yes
GO:0000976 transcription cis-regulatory region binding 7.2464 5 yes
GO:0001067 transcription regulatory region nucleic acid binding 7.2464 4 yes
GO:0003690 double-stranded DNA binding 7.2464 5 yes
GO:1990837 sequence-specific double-stranded DNA binding 7.2464 6 yes
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding 5.7971 6 yes
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding 4.3478 7 yes
GO:0000987 cis-regulatory region sequence-specific DNA binding 4.3478 6 yes
GO:0046982 protein heterodimerization activity 4.3478 4 yes
GO:0008168 methyltransferase activity 2.8986 4 yes
GO:0008170 N-methyltransferase activity 2.8986 5 yes
GO:0008327 methyl-CpG binding 2.8986 4 yes
GO:0008469 histone-arginine N-methyltransferase activity 2.8986 5 yes
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 2.8986 5 yes
GO:0016273 arginine N-methyltransferase activity 2.8986 6 yes
GO:0016274 protein-arginine N-methyltransferase activity 2.8986 4 yes
GO:0035243 protein-arginine omega-N symmetric methyltransferase activity 2.8986 5 yes
GO:0042054 histone methyltransferase activity 2.8986 4 yes
GO:0044020 histone methyltransferase activity (H4-R3 specific) 2.8986 6 yes
GO:0070888 E-box binding 2.8986 8 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ANM5_HUMAN
GO:0031323 regulation of cellular metabolic process 62.3188 4 yes
GO:0048522 positive regulation of cellular process 62.3188 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 62.3188 4 yes
GO:0060255 regulation of macromolecule metabolic process 62.3188 4 yes
GO:0080090 regulation of primary metabolic process 62.3188 4 yes
GO:0048523 negative regulation of cellular process 56.5217 4 yes
GO:0010646 regulation of cell communication 50.7246 4 yes
GO:0009966 regulation of signal transduction 49.2754 4 yes
GO:0009893 positive regulation of metabolic process 49.2754 4 no
GO:0010468 regulation of gene expression 47.8261 5 yes
GO:0009889 regulation of biosynthetic process 46.3768 4 yes
GO:0031326 regulation of cellular biosynthetic process 46.3768 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 44.9275 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 44.9275 5 yes
GO:0051128 regulation of cellular component organization 43.4783 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 43.4783 5 no
GO:0051246 regulation of protein metabolic process 43.4783 5 no
GO:0006996 organelle organization 42.0290 4 yes
GO:0051252 regulation of RNA metabolic process 40.5797 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 40.5797 5 no
GO:0031325 positive regulation of cellular metabolic process 39.1304 5 no
GO:1902531 regulation of intracellular signal transduction 37.6812 5 yes
GO:0009892 negative regulation of metabolic process 37.6812 4 no
GO:0010605 negative regulation of macromolecule metabolic process 37.6812 5 no
GO:1903506 regulation of nucleic acid-templated transcription 36.2319 7 yes
GO:2001141 regulation of RNA biosynthetic process 36.2319 6 yes
GO:0006355 regulation of DNA-templated transcription 34.7826 6 yes
GO:0048584 positive regulation of response to stimulus 34.7826 4 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 34.7826 5 no
GO:0009967 positive regulation of signal transduction 33.3333 5 yes
GO:0010647 positive regulation of cell communication 33.3333 5 yes
GO:0023056 positive regulation of signaling 33.3333 4 yes
GO:0036211 protein modification process 33.3333 4 yes
GO:0043412 macromolecule modification 33.3333 4 yes
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0022607 cellular component assembly 31.8841 4 yes
GO:0031399 regulation of protein modification process 30.4348 6 no
GO:0009894 regulation of catabolic process 28.9855 4 no
GO:0010941 regulation of cell death 28.9855 4 no
GO:0043067 regulation of programmed cell death 28.9855 5 no
GO:0090304 nucleic acid metabolic process 27.5362 4 yes
GO:0008104 protein localization 27.5362 4 no
GO:0042981 regulation of apoptotic process 27.5362 6 no
GO:0010628 positive regulation of gene expression 26.0870 6 no
GO:0009891 positive regulation of biosynthetic process 26.0870 5 no
GO:0031328 positive regulation of cellular biosynthetic process 26.0870 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 26.0870 6 no
GO:0051130 positive regulation of cellular component organization 26.0870 5 no
GO:0009057 macromolecule catabolic process 26.0870 4 no
GO:0007010 cytoskeleton organization 26.0870 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 24.6377 6 no
GO:1902533 positive regulation of intracellular signal transduction 23.1884 6 no
GO:0033043 regulation of organelle organization 21.7391 5 yes
GO:0051726 regulation of cell cycle 21.7391 4 yes
GO:0006357 regulation of transcription by RNA polymerase II 21.7391 7 no
GO:0009890 negative regulation of biosynthetic process 21.7391 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 21.7391 6 no
GO:0031327 negative regulation of cellular biosynthetic process 21.7391 6 no
GO:0031329 regulation of cellular catabolic process 21.7391 5 no
GO:0042127 regulation of cell population proliferation 21.7391 4 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 21.7391 6 no
GO:0051253 negative regulation of RNA metabolic process 21.7391 6 no
GO:0019220 regulation of phosphate metabolic process 21.7391 6 no
GO:0048585 negative regulation of response to stimulus 21.7391 4 no
GO:0051174 regulation of phosphorus metabolic process 21.7391 5 no
GO:0044265 cellular macromolecule catabolic process 21.7391 4 no
GO:0051248 negative regulation of protein metabolic process 20.2899 6 no
GO:0051338 regulation of transferase activity 20.2899 4 no
GO:0071702 organic substance transport 20.2899 4 no
GO:0071705 nitrogen compound transport 20.2899 4 no
GO:0009968 negative regulation of signal transduction 20.2899 5 no
GO:0010648 negative regulation of cell communication 20.2899 5 no
GO:0023057 negative regulation of signaling 20.2899 4 no
GO:0031401 positive regulation of protein modification process 20.2899 7 no
GO:0043085 positive regulation of catalytic activity 20.2899 4 no
GO:0016070 RNA metabolic process 18.8406 5 yes
GO:0043408 regulation of MAPK cascade 18.8406 6 yes
GO:0051240 positive regulation of multicellular organismal process 18.8406 4 yes
GO:0009059 macromolecule biosynthetic process 17.3913 4 yes
GO:0043933 protein-containing complex organization 17.3913 4 yes
GO:0044271 cellular nitrogen compound biosynthetic process 17.3913 4 yes
GO:0010564 regulation of cell cycle process 15.9420 5 yes
GO:0045595 regulation of cell differentiation 14.4928 4 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 13.0435 7 yes
GO:0018130 heterocycle biosynthetic process 11.5942 4 yes
GO:0019438 aromatic compound biosynthetic process 11.5942 4 yes
GO:0034654 nucleobase-containing compound biosynthetic process 11.5942 4 yes
GO:0051052 regulation of DNA metabolic process 11.5942 5 yes
GO:0065003 protein-containing complex assembly 11.5942 5 yes
GO:1901362 organic cyclic compound biosynthetic process 11.5942 4 yes
GO:0007346 regulation of mitotic cell cycle 10.1449 5 yes
GO:0051093 negative regulation of developmental process 10.1449 4 yes
GO:0045596 negative regulation of cell differentiation 8.6957 5 yes
GO:0045597 positive regulation of cell differentiation 8.6957 5 yes
GO:0051094 positive regulation of developmental process 8.6957 4 yes
GO:0001889 liver development 7.2464 5 yes
GO:0006325 chromatin organization 7.2464 4 yes
GO:0007030 Golgi organization 7.2464 5 yes
GO:0008277 regulation of G protein-coupled receptor signaling pathway 7.2464 5 yes
GO:0032774 RNA biosynthetic process 7.2464 5 yes
GO:0048732 gland development 7.2464 4 yes
GO:0060284 regulation of cell development 7.2464 5 yes
GO:0071826 ribonucleoprotein complex subunit organization 7.2464 5 yes
GO:2000026 regulation of multicellular organismal development 7.2464 4 yes
GO:0016570 histone modification 5.7971 5 yes
GO:0018193 peptidyl-amino acid modification 5.7971 5 yes
GO:0022618 ribonucleoprotein complex assembly 5.7971 6 yes
GO:0050767 regulation of neurogenesis 5.7971 6 yes
GO:0051960 regulation of nervous system development 5.7971 5 yes
GO:1901796 regulation of signal transduction by p53 class mediator 5.7971 6 yes
GO:0007088 regulation of mitotic nuclear division 4.3478 6 yes
GO:0010720 positive regulation of cell development 4.3478 6 yes
GO:0045745 positive regulation of G protein-coupled receptor signaling pathway 4.3478 6 yes
GO:0050769 positive regulation of neurogenesis 4.3478 6 yes
GO:0051783 regulation of nuclear division 4.3478 6 yes
GO:0051962 positive regulation of nervous system development 4.3478 5 yes
GO:0000387 spliceosomal snRNP assembly 2.8986 7 yes
GO:0006353 DNA-templated transcription termination 2.8986 6 yes
GO:0006479 protein methylation 2.8986 4 yes
GO:0008213 protein alkylation 2.8986 5 yes
GO:0014013 regulation of gliogenesis 2.8986 7 yes
GO:0014015 positive regulation of gliogenesis 2.8986 7 yes
GO:0016571 histone methylation 2.8986 5 yes
GO:0018195 peptidyl-arginine modification 2.8986 6 yes
GO:0018216 peptidyl-arginine methylation 2.8986 5 yes
GO:0031100 animal organ regeneration 2.8986 4 yes
GO:0034969 histone arginine methylation 2.8986 6 yes
GO:0035246 peptidyl-arginine N-methylation 2.8986 6 yes
GO:0043985 histone H4-R3 methylation 2.8986 7 yes
GO:0044030 regulation of DNA methylation 2.8986 6 yes
GO:0045685 regulation of glial cell differentiation 2.8986 5 yes
GO:0045687 positive regulation of glial cell differentiation 2.8986 6 yes
GO:0048713 regulation of oligodendrocyte differentiation 2.8986 6 yes
GO:0048714 positive regulation of oligodendrocyte differentiation 2.8986 7 yes
GO:0060159 regulation of dopamine receptor signaling pathway 2.8986 5 yes
GO:0060161 positive regulation of dopamine receptor signaling pathway 2.8986 6 yes
GO:0090161 Golgi ribbon formation 2.8986 6 yes
GO:0097421 liver regeneration 2.8986 5 yes
GO:1904990 regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway 2.8986 6 yes
GO:1904992 positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway 2.8986 7 yes

Disease

Term Name % Distance from top the of the tree Annotated in ANM5_HUMAN
DOID:557 kidney disease 2.8986 3 no
DOID:37 skin disease 2.8986 3 no
DOID:0050686 organ system cancer 2.8986 3 no
DOID:2531 hematologic cancer 2.8986 4 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SNAI1_HUMAN [view interactions] Low throughput no yes
INO80_HUMAN [view interactions] Low throughput no no
PIAS4_HUMAN [view interactions] Low throughput no yes
HD_HUMAN [view entry] [view interactions] Low throughput yes yes
CCND1_HUMAN [view interactions] Low throughput no yes
KLF5_HUMAN [view interactions] Low throughput no yes
E2F1_HUMAN [view interactions] Low throughput no yes
SRGP2_HUMAN [view entry] [view interactions] Low throughput yes no
CHTOP_HUMAN [view interactions] Low throughput no yes
RIOK1_HUMAN [view interactions] Low throughput no yes
FBRL_HUMAN [view interactions] Low throughput no yes
HXA9_HUMAN [view interactions] Low throughput no yes
DNM3A_HUMAN [view interactions] Low throughput no yes
NFE4_HUMAN [view interactions] Low throughput no no
AJUBA_HUMAN [view interactions] Low throughput no yes
SETX_HUMAN [view interactions] Low throughput no yes
SMN_HUMAN [view interactions] Low throughput no yes
RPB1_HUMAN [view interactions] Low throughput no no
JAK1_HUMAN [view interactions] Low throughput no yes
JAK3_HUMAN [view interactions] Low throughput no no
TYK2_HUMAN [view interactions] Low throughput no no
CRY1_HUMAN [view interactions] Low throughput no yes
MEF2D_HUMAN [view interactions] Low throughput no yes
MYOG_HUMAN [view interactions] Low throughput no no
CHIP_HUMAN [view entry] [view interactions] Low throughput yes yes
IOD3_HUMAN [view interactions] Low throughput no no
SCN5A_HUMAN [view interactions] Low throughput no no
PDCD4_HUMAN [view interactions] Low throughput no yes
IF4A1_HUMAN [view interactions] Low throughput no no
MBP_HUMAN [view entry] [view interactions] Low throughput yes no
SF3B4_HUMAN [view interactions] Low throughput no yes
RU1C_HUMAN [view interactions] Low throughput no yes
TCRG1_HUMAN [view interactions] Low throughput no yes
PABP1_HUMAN [view entry] [view interactions] Low throughput yes yes
HNRPD_HUMAN [view entry] [view interactions] Low throughput yes yes
PAIRB_HUMAN [view interactions] Low throughput no yes
H2A2C_HUMAN [view interactions] Low throughput no yes
ILF3_HUMAN [view interactions] Low throughput no yes
H2A1B_HUMAN [view interactions] Low throughput no yes
H31T_HUMAN [view interactions] Low throughput no yes
SMCA4_HUMAN [view interactions] Low throughput no yes
ST7_HUMAN [view interactions] Low throughput no yes
CDK4_HUMAN [view interactions] Low throughput no no
NCOR2_HUMAN [view interactions] Low throughput no yes
JAK2_HUMAN [view entry] [view interactions] Low throughput yes yes
FA47E_HUMAN [view interactions] Low throughput no yes
RSMB_HUMAN [view interactions] Low throughput no yes
SMD1_HUMAN [view interactions] Low throughput no yes
H4_HUMAN [view interactions] Low throughput no yes
ING2_HUMAN [view interactions] Low throughput no yes
SKI_HUMAN [view interactions] Low throughput no yes
SPT5H_HUMAN [view interactions] Low throughput no yes
HDAC3_HUMAN [view interactions] Low throughput no yes
SMAD2_HUMAN [view interactions] Low throughput no yes
SMAD3_HUMAN [view interactions] Low throughput no yes
SMAD4_HUMAN [view interactions] Low throughput no yes
SSR1_HUMAN [view interactions] Low throughput no no
MIB1_HUMAN [view entry] [view interactions] Low throughput yes yes
SMD3_HUMAN [view interactions] Low throughput no yes
PRDM1_HUMAN [view interactions] Low throughput no yes
MYOD1_HUMAN [view interactions] Low throughput no no
ZN224_HUMAN [view interactions] Low throughput no yes
MBD2_HUMAN [view interactions] Low throughput no yes
LSM11_HUMAN [view interactions] Low throughput no yes
NUCL_HUMAN [view interactions] Low throughput no yes
HS90A_HUMAN [view entry] [view interactions] Low throughput yes yes
NR0B2_HUMAN [view interactions] Low throughput no no
ARI1B_HUMAN [view interactions] Low throughput no yes
TLE4_HUMAN [view interactions] Low throughput no no
TRAF4_HUMAN [view interactions] Low throughput no yes
UB2Q2_HUMAN [view interactions] Low throughput no no
TF65_HUMAN [view entry] [view interactions] Low throughput yes yes
WDR5_HUMAN [view interactions] Low throughput no no
H31_HUMAN [view interactions] Low throughput no yes
CDK8_HUMAN [view interactions] Low throughput no no
CDK19_HUMAN [view interactions] Low throughput no yes
SRBP1_HUMAN [view interactions] Low throughput no yes
RO52_HUMAN [view interactions] Low throughput no yes
RBP2_HUMAN [view interactions] Low throughput no yes
GLIS3_HUMAN [view interactions] Low throughput no yes
UHRF1_HUMAN [view interactions] Low throughput no yes
SHRPN_HUMAN [view entry] [view interactions] Low throughput yes yes
DUS14_HUMAN [view interactions] Low throughput no yes
RL5_HUMAN [view entry] [view interactions] Low throughput yes yes
PGFRA_HUMAN [view interactions] Low throughput no no
LSM4_HUMAN [view interactions] Low throughput no yes
PHF1_HUMAN [view interactions] Low throughput no yes
GLI1_HUMAN [view interactions] Low throughput no no
COPRS_HUMAN [view interactions] Low throughput no yes
CFLAR_HUMAN [view interactions] Low throughput no yes
ANM5_HUMAN [view entry] [view interactions] Low throughput yes yes
MEP50_HUMAN [view interactions] Low throughput no yes
ICLN_HUMAN [view interactions] Low throughput no yes
BCL6_HUMAN [view interactions] Low throughput no no
CTDP1_HUMAN [view interactions] Low throughput no yes
GBRL1_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
NONO_HUMAN [view interactions] High throughput no yes
DDX3X_HUMAN [view entry] [view interactions] High throughput yes yes
RS11_HUMAN [view entry] [view interactions] High throughput yes yes
E41L3_HUMAN [view entry] [view interactions] High throughput yes yes
RUXF_HUMAN [view interactions] High throughput no no
WDR3_HUMAN [view interactions] High throughput no no
GATA3_HUMAN [view interactions] High throughput no no
CN178_HUMAN [view interactions] High throughput no no
MTA1_HUMAN [view interactions] High throughput no yes
RM11_HUMAN [view interactions] High throughput no yes
FARP1_HUMAN [view entry] [view interactions] High throughput yes no
PPCS_HUMAN [view interactions] High throughput no yes
WIZ_HUMAN [view interactions] High throughput no yes
RL23_HUMAN [view entry] [view interactions] High throughput yes yes
SAE2_HUMAN [view interactions] High throughput no yes
MYEF2_HUMAN [view interactions] High throughput no no
BCD1_HUMAN [view interactions] High throughput no yes
OSGEP_HUMAN [view interactions] High throughput no yes
KDM3A_HUMAN [view interactions] High throughput no no
GAR1_HUMAN [view interactions] High throughput no yes
HDAC1_HUMAN [view interactions] High throughput no no
PHF8_HUMAN [view interactions] High throughput no yes
IFT88_HUMAN [view interactions] High throughput no no
EZH1_HUMAN [view interactions] High throughput no yes
SFPQ_HUMAN [view entry] [view interactions] High throughput yes yes
KDM6B_HUMAN [view interactions] High throughput no yes
RL15_HUMAN [view entry] [view interactions] High throughput yes no
KDM1A_HUMAN [view interactions] High throughput no yes
RUXE_HUMAN [view interactions] High throughput no no
EP300_HUMAN [view interactions] High throughput no yes
LSM6_HUMAN [view interactions] High throughput no yes
PHF2_HUMAN [view interactions] High throughput no yes
RSMN_HUMAN [view interactions] High throughput no yes
DNMT1_HUMAN [view interactions] High throughput no no
RBM3_HUMAN [view interactions] High throughput no no
KDM4A_HUMAN [view interactions] High throughput no yes
CIRBP_HUMAN [view interactions] High throughput no no
ANM6_HUMAN [view interactions] High throughput no yes
RPB3_HUMAN [view interactions] High throughput no yes
KDM2B_HUMAN [view interactions] High throughput no no
KDM4C_HUMAN [view interactions] High throughput no no
KDM3B_HUMAN [view interactions] High throughput no yes
MBD1_HUMAN [view interactions] High throughput no yes
CARM1_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
MTA70_HUMAN [view interactions] High throughput no no
RIT1_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
LRRK2_HUMAN [view interactions] High throughput no yes
SAP_HUMAN [view interactions] High throughput no yes
ELK4_HUMAN [view interactions] High throughput no yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
SMCE1_HUMAN [view interactions] High throughput no yes
SNF5_HUMAN [view interactions] High throughput no yes
RUVB1_HUMAN [view interactions] High throughput no yes
SMRC1_HUMAN [view interactions] High throughput no yes
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
VCAM1_HUMAN [view interactions] High throughput no no
FINC_HUMAN [view interactions] High throughput no yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
HMGA2_HUMAN [view interactions] High throughput no yes
B2L14_HUMAN [view interactions] High throughput no yes
M3K14_HUMAN [view interactions] High throughput no yes
TR10A_HUMAN [view interactions] High throughput no no
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
UBE3A_HUMAN [view interactions] High throughput no yes
MP2K7_HUMAN [view entry] [view interactions] High throughput yes yes
LATS2_HUMAN [view interactions] High throughput no yes
IRAK4_HUMAN [view interactions] High throughput no yes
MAST1_HUMAN [view interactions] High throughput no yes
DDB1_HUMAN [view interactions] High throughput no yes
DYST_HUMAN [view entry] [view interactions] High throughput yes yes
JUN_HUMAN [view interactions] High throughput no yes
CSN4_HUMAN [view interactions] High throughput no yes
HDAC4_HUMAN [view interactions] High throughput no yes
CSN7A_HUMAN [view interactions] High throughput no yes
CUL4A_HUMAN [view interactions] High throughput no no
DCAF8_HUMAN [view interactions] High throughput no yes
FOXK1_HUMAN [view interactions] High throughput no yes
VASP_HUMAN [view interactions] High throughput no yes
ZDH17_HUMAN [view interactions] High throughput no yes
ECHP_HUMAN [view interactions] High throughput no no
PYRG1_HUMAN [view interactions] High throughput no no
NTAQ1_HUMAN [view interactions] High throughput no yes
DYHC1_HUMAN [view entry] [view interactions] High throughput yes yes
ZMY19_HUMAN [view interactions] High throughput no yes
IF2A_HUMAN [view entry] [view interactions] High throughput yes yes
DRC4_HUMAN [view interactions] High throughput no yes
NCBP1_HUMAN [view interactions] High throughput no yes
CDC37_HUMAN [view interactions] High throughput no yes
NSF1C_HUMAN [view entry] [view interactions] High throughput yes yes
CACB2_HUMAN [view interactions] High throughput no yes
PDIA6_HUMAN [view entry] [view interactions] High throughput yes yes
ELOA1_HUMAN [view interactions] High throughput no yes
MCM5_HUMAN [view interactions] High throughput no no
IF4A3_HUMAN [view entry] [view interactions] High throughput yes yes
RRP12_HUMAN [view interactions] High throughput no no
KANK2_HUMAN [view entry] [view interactions] High throughput yes yes
SBNO1_HUMAN [view interactions] High throughput no yes
LNX1_HUMAN [view interactions] High throughput no yes
ERH_HUMAN [view interactions] High throughput no yes
CA109_HUMAN [view interactions] High throughput no yes
MGN2_HUMAN [view interactions] High throughput no yes
ANGT_HUMAN [view interactions] High throughput no no
TBA1B_HUMAN [view entry] [view interactions] High throughput yes yes
FOS_HUMAN [view interactions] High throughput no yes
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
HSF1_HUMAN [view interactions] High throughput no yes
ANM1_HUMAN [view interactions] High throughput no yes
KLKB1_HUMAN [view interactions] High throughput no no
RBBP5_HUMAN [view interactions] High throughput no yes
LIPL_HUMAN [view interactions] High throughput no no
SMD2_HUMAN [view interactions] High throughput no yes
QCR1_HUMAN [view entry] [view interactions] High throughput yes yes
TRI14_HUMAN [view interactions] High throughput no yes
BRK1_HUMAN [view interactions] High throughput no no
AGR2_HUMAN [view interactions] High throughput no no
TCPB_HUMAN [view entry] [view interactions] High throughput yes yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
PHYIP_HUMAN [view entry] [view interactions] High throughput yes yes
RASN_HUMAN [view entry] [view interactions] High throughput yes no
OLA1_HUMAN [view entry] [view interactions] High throughput yes yes
DYLT1_HUMAN [view interactions] High throughput no no
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
PLEC_HUMAN [view entry] [view interactions] High throughput yes yes
KC1E_HUMAN [view entry] [view interactions] High throughput yes yes
LSM2_HUMAN [view interactions] High throughput no yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
LEG9_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
RAD1_HUMAN [view interactions] High throughput no yes
AKP8L_HUMAN [view interactions] High throughput no yes
TRI54_HUMAN [view interactions] High throughput no no
FHI1A_HUMAN [view interactions] High throughput no yes
CAN1_HUMAN [view entry] [view interactions] High throughput yes yes
EPHB6_HUMAN [view interactions] High throughput no no
KHDR2_HUMAN [view interactions] High throughput no yes
MYSM1_HUMAN [view interactions] High throughput no yes
SMCA2_HUMAN [view interactions] High throughput no yes
SIN3A_HUMAN [view interactions] High throughput no yes
MYD88_HUMAN [view entry] [view interactions] High throughput yes yes
CTBL1_HUMAN [view interactions] High throughput no yes
PAXI1_HUMAN [view interactions] High throughput no no
TERF1_HUMAN [view interactions] High throughput no no
TERF2_HUMAN [view interactions] High throughput no yes
HDAC5_HUMAN [view interactions] High throughput no yes
HDGF_HUMAN [view interactions] High throughput no yes
SIR7_HUMAN [view interactions] High throughput no yes
TFE2_HUMAN [view interactions] High throughput no no
NANOG_HUMAN [view interactions] High throughput no no
NANP8_HUMAN [view interactions] High throughput no no
FBX25_HUMAN [view interactions] High throughput no no
SHC1_HUMAN [view entry] [view interactions] High throughput yes yes
FBX6_HUMAN [view interactions] High throughput no yes
MGN_HUMAN [view interactions] High throughput no yes
SMUF1_HUMAN [view interactions] High throughput no yes
UBL4A_HUMAN [view entry] [view interactions] High throughput yes yes
PAN2_HUMAN [view interactions] High throughput no no
PK3C3_HUMAN [view interactions] High throughput no yes
HECW2_HUMAN [view entry] [view interactions] High throughput yes no
WWOX_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
CUL7_HUMAN [view interactions] High throughput no yes
SIR6_HUMAN [view interactions] High throughput no yes
RFOX2_HUMAN [view interactions] High throughput no yes
TINAL_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
AHSA1_HUMAN [view entry] [view interactions] High throughput yes yes
ID2_HUMAN [view interactions] High throughput no no
GAN_HUMAN [view interactions] High throughput no yes
ALKB3_HUMAN [view interactions] High throughput no yes
WWP2_HUMAN [view interactions] High throughput no no
FARP2_HUMAN [view interactions] High throughput no yes
RFOX1_HUMAN [view interactions] High throughput no yes
CCD33_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
G3BP1_HUMAN [view interactions] High throughput no yes
BRCA1_HUMAN [view interactions] High throughput no yes
MTF1_HUMAN [view interactions] High throughput no no
DC4L2_HUMAN [view interactions] High throughput no no
CUL4B_HUMAN [view interactions] High throughput no yes
ZN598_HUMAN [view interactions] High throughput no no
PPIE_HUMAN [view interactions] High throughput no yes
ACON_HUMAN [view entry] [view interactions] High throughput yes yes
TRIP4_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
RMD5A_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
PIHD1_HUMAN [view interactions] High throughput no yes
ZN326_HUMAN [view interactions] High throughput no yes
UBC12_HUMAN [view entry] [view interactions] High throughput yes yes
SPDLY_HUMAN [view interactions] High throughput no yes
HEXI1_HUMAN [view interactions] High throughput no yes
LARP7_HUMAN [view interactions] High throughput no yes
RUNX1_HUMAN [view interactions] High throughput no yes
RN123_HUMAN [view interactions] High throughput no yes
NBN_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
TISD_HUMAN [view interactions] High throughput no no
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
LTN1_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
RC3H1_HUMAN [view interactions] High throughput no yes
RC3H2_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
NR2C2_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
RU17_HUMAN [view interactions] High throughput no yes
SF3A3_HUMAN [view interactions] High throughput no yes
ACTN4_HUMAN [view entry] [view interactions] High throughput yes yes
RBM23_HUMAN [view interactions] High throughput no yes
PSDE_HUMAN [view entry] [view interactions] High throughput yes yes
CCAR2_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
ARGL1_HUMAN [view interactions] High throughput no yes
DYR1A_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
FUS_HUMAN [view entry] [view interactions] High throughput yes yes
EWS_HUMAN [view interactions] High throughput no yes
RSRP1_HUMAN [view interactions] High throughput no no
LRWD1_HUMAN [view interactions] High throughput no no
CALU_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
CDYL2_HUMAN [view interactions] High throughput no yes
CLK1_HUMAN [view interactions] High throughput no yes
CMTR1_HUMAN [view interactions] High throughput no yes
CLK3_HUMAN [view interactions] High throughput no yes
ARI2_HUMAN [view interactions] High throughput no no
EZH2_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
FA76B_HUMAN [view interactions] High throughput no no
PINK1_HUMAN [view interactions] High throughput no yes
GRHL3_HUMAN [view interactions] High throughput no yes
TRIM6_HUMAN [view interactions] High throughput no no
GTPB2_HUMAN [view interactions] High throughput no yes
EMC4_HUMAN [view interactions] High throughput no yes
H3C_HUMAN [view interactions] High throughput no yes
ANR55_HUMAN [view interactions] High throughput no yes
HXC4_HUMAN [view interactions] High throughput no no
WAPL_HUMAN [view interactions] High throughput no yes
ING5_HUMAN [view interactions] High throughput no yes
CDCA5_HUMAN [view interactions] High throughput no yes
LDH6B_HUMAN [view interactions] High throughput no no
NIPBL_HUMAN [view interactions] High throughput no yes
LENG8_HUMAN [view interactions] High throughput no yes
SCC4_HUMAN [view interactions] High throughput no no
LUC7L_HUMAN [view interactions] High throughput no yes
UCK1_HUMAN [view interactions] High throughput no yes
MAGB2_HUMAN [view interactions] High throughput no no
BRD4_HUMAN [view interactions] High throughput no yes
MCRS1_HUMAN [view interactions] High throughput no yes
CIC_HUMAN [view interactions] High throughput no yes
NUDC2_HUMAN [view entry] [view interactions] High throughput yes yes
RBM39_HUMAN [view interactions] High throughput no yes
PR38A_HUMAN [view interactions] High throughput no no
F16P1_HUMAN [view interactions] High throughput no no
SLU7_HUMAN [view interactions] High throughput no yes
IF16_HUMAN [view interactions] High throughput no no
SPAG8_HUMAN [view interactions] High throughput no no
EIF3F_HUMAN [view interactions] High throughput no yes
NELFD_HUMAN [view interactions] High throughput no yes
INSI1_HUMAN [view interactions] High throughput no no
TRIB3_HUMAN [view interactions] High throughput no yes
INSI2_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
RIN3_HUMAN [view interactions] High throughput no yes
ZNF2_HUMAN [view interactions] High throughput no no
PO2F1_HUMAN [view interactions] High throughput no yes
ZN436_HUMAN [view interactions] High throughput no yes
EIF3H_HUMAN [view interactions] High throughput no yes
ZUP1_HUMAN [view interactions] High throughput no yes
UNKL_HUMAN [view interactions] High throughput no no
UFL1_HUMAN [view interactions] High throughput no yes
PRR5_HUMAN [view interactions] High throughput no yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
AGO1_HUMAN [view interactions] High throughput no no
RHBL4_HUMAN [view interactions] High throughput no no
AGO2_HUMAN [view interactions] High throughput no yes
FZR1_HUMAN [view interactions] High throughput no no
ARRB1_HUMAN [view entry] [view interactions] High throughput yes yes
PAGE4_HUMAN [view interactions] High throughput no no
ARRB2_HUMAN [view entry] [view interactions] High throughput yes no
PP14A_HUMAN [view interactions] High throughput no yes
AGO3_HUMAN [view interactions] High throughput no yes
TOP3B_HUMAN [view interactions] High throughput no no
AGO4_HUMAN [view interactions] High throughput no no
CA115_HUMAN [view interactions] High throughput no no
CBX5_HUMAN [view interactions] High throughput no yes
RUXG_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
THOC4_HUMAN [view interactions] High throughput no no
H2A1C_HUMAN [view interactions] Computational no yes
GEMI7_HUMAN [view interactions] Computational no no
H2AV_HUMAN [view interactions] Computational no yes
MYCN_HUMAN [view interactions] Computational no no
H2AZ_HUMAN [view interactions] Computational no yes
H2AX_HUMAN [view interactions] Computational no yes
GEMI2_HUMAN [view interactions] Computational no yes
ILF2_HUMAN [view interactions] Computational no yes
ANM8_HUMAN [view interactions] Computational no yes
RBBP7_HUMAN [view interactions] Computational no yes
H2A1J_HUMAN [view interactions] Computational no yes
P66A_HUMAN [view interactions] Computational no yes
MTA2_HUMAN [view interactions] Computational no yes
ANM9_HUMAN [view interactions] Computational no no
P66B_HUMAN [view interactions] Computational no yes
HDAC2_HUMAN [view interactions] Computational no yes
GEMI5_HUMAN [view interactions] Computational no yes
H2A1A_HUMAN [view interactions] Computational no yes
GEMI8_HUMAN [view interactions] Computational no yes
ANM3_HUMAN [view interactions] Computational no yes
TCF19_HUMAN [view interactions] Computational no no
TTC5_HUMAN [view interactions] Computational no yes
H2AB1_HUMAN [view interactions] Computational no no
GEMI4_HUMAN [view interactions] Computational no yes
PRDM4_HUMAN [view interactions] Computational no no
GEMI6_HUMAN [view interactions] Computational no yes
H2AJ_HUMAN [view interactions] Computational no yes
DDX20_HUMAN [view interactions] Computational no no
PMYT1_HUMAN [view interactions] Computational no no
PRP8_HUMAN [view interactions] Computational no yes
CHD3_HUMAN [view interactions] Computational no yes
H2A1D_HUMAN [view interactions] Computational no yes
RBBP4_HUMAN [view interactions] Computational no yes
ANM7_HUMAN [view interactions] Computational no yes
H2A1H_HUMAN [view interactions] Computational no yes