Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RENT1_HUMAN

RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation and allowing the recycling of NMD factors. UPF1 can also activate NMD without UPF2 or UPF3, and in the absence of the NMD-enhancing downstream EJC indicative for alternative NMD pathways. Plays a role in replication-dependent histone mRNA degradation at the end of phase S; the function is independent of UPF2. For the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. The ATPase activity of UPF1 is required for disassembly of mRNPs undergoing NMD. Essential for embryonic viability. Together with UPF2 and dependent on TDRD6, mediates the degradation of mRNA hardoring long 3UTR by inducing the NMD machinery . [View more on UniProt]

Interacting region for partners were not defined.

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in RENT1_HUMAN
GO:0003723 RNA binding 56.4103 4 yes
GO:0003729 mRNA binding 29.9145 5 no
GO:0043168 anion binding 26.4957 4 yes
GO:0000166 nucleotide binding 25.6410 4 yes
GO:0017076 purine nucleotide binding 25.6410 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 24.7863 4 yes
GO:0043169 cation binding 24.7863 4 yes
GO:0046872 metal ion binding 24.7863 5 yes
GO:0032555 purine ribonucleotide binding 24.7863 4 yes
GO:0030554 adenyl nucleotide binding 19.6581 6 yes
GO:0032559 adenyl ribonucleotide binding 18.8034 5 yes
GO:0005524 ATP binding 18.8034 5 yes
GO:0003677 DNA binding 16.2393 4 yes
GO:0016462 pyrophosphatase activity 16.2393 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 16.2393 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 16.2393 6 yes
GO:0016887 ATP hydrolysis activity 11.1111 7 yes
GO:0043565 sequence-specific DNA binding 6.8376 5 yes
GO:0046914 transition metal ion binding 5.1282 6 yes
GO:0008270 zinc ion binding 5.1282 7 yes
GO:0042162 telomeric DNA binding 3.4188 6 yes
GO:0036121 double-stranded DNA helicase activity 1.7094 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RENT1_HUMAN
GO:0060255 regulation of macromolecule metabolic process 66.6667 4 yes
GO:0031323 regulation of cellular metabolic process 66.6667 4 yes
GO:0080090 regulation of primary metabolic process 64.1026 4 yes
GO:0009889 regulation of biosynthetic process 64.1026 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 64.1026 5 yes
GO:0031326 regulation of cellular biosynthetic process 64.1026 5 yes
GO:0010468 regulation of gene expression 61.5385 6 yes
GO:0048522 positive regulation of cellular process 60.6838 4 yes
GO:0048523 negative regulation of cellular process 57.2650 4 yes
GO:0009892 negative regulation of metabolic process 49.5726 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 48.7179 5 yes
GO:0009893 positive regulation of metabolic process 45.2991 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 45.2991 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 45.2991 5 yes
GO:0051246 regulation of protein metabolic process 43.5897 5 yes
GO:0051252 regulation of RNA metabolic process 43.5897 5 yes
GO:0031324 negative regulation of cellular metabolic process 42.7350 5 yes
GO:0010646 regulation of cell communication 41.0256 4 no
GO:0031325 positive regulation of cellular metabolic process 41.0256 5 yes
GO:0009891 positive regulation of biosynthetic process 39.3162 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 39.3162 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 39.3162 6 yes
GO:0051128 regulation of cellular component organization 37.6068 4 yes
GO:0009890 negative regulation of biosynthetic process 37.6068 5 yes
GO:0022607 cellular component assembly 36.7521 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 36.7521 6 yes
GO:0031327 negative regulation of cellular biosynthetic process 36.7521 6 yes
GO:0090304 nucleic acid metabolic process 35.8974 4 yes
GO:0009966 regulation of signal transduction 32.4786 4 no
GO:0006355 regulation of DNA-templated transcription 30.7692 7 no
GO:2001141 regulation of RNA biosynthetic process 30.7692 6 no
GO:0016070 RNA metabolic process 30.7692 5 yes
GO:0006996 organelle organization 29.9145 4 yes
GO:0010629 negative regulation of gene expression 29.9145 7 yes
GO:0051247 positive regulation of protein metabolic process 29.0598 6 no
GO:0010628 positive regulation of gene expression 29.0598 7 yes
GO:0051248 negative regulation of protein metabolic process 28.2051 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 28.2051 5 yes
GO:0009894 regulation of catabolic process 27.3504 4 yes
GO:0043933 protein-containing complex organization 26.4957 4 no
GO:0010608 post-transcriptional regulation of gene expression 25.6410 7 yes
GO:0031399 regulation of protein modification process 24.7863 6 no
GO:0006396 RNA processing 23.9316 6 no
GO:0010647 positive regulation of cell communication 23.9316 5 no
GO:0023056 positive regulation of signaling 23.9316 4 no
GO:0048584 positive regulation of response to stimulus 23.9316 4 no
GO:0033043 regulation of organelle organization 23.9316 5 yes
GO:0042981 regulation of apoptotic process 23.0769 5 no
GO:0043067 regulation of programmed cell death 23.0769 4 no
GO:0008104 protein localization 23.0769 4 no
GO:0043412 macromolecule modification 23.0769 4 no
GO:0044087 regulation of cellular component biogenesis 23.0769 4 no
GO:0065003 protein-containing complex assembly 23.0769 5 no
GO:0009967 positive regulation of signal transduction 22.2222 5 no
GO:0006357 regulation of transcription by RNA polymerase II 22.2222 8 no
GO:0051254 positive regulation of RNA metabolic process 21.3675 6 yes
GO:0042127 regulation of cell population proliferation 21.3675 4 no
GO:1902531 regulation of intracellular signal transduction 21.3675 5 no
GO:0006417 regulation of translation 21.3675 6 yes
GO:0071310 cellular response to organic substance 20.5128 4 yes
GO:0071702 organic substance transport 20.5128 4 yes
GO:0051726 regulation of cell cycle 20.5128 4 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 20.5128 5 no
GO:0071705 nitrogen compound transport 18.8034 4 yes
GO:0016071 mRNA metabolic process 18.8034 6 yes
GO:0141188 nucleic acid catabolic process 16.2393 5 yes
GO:1903311 regulation of mRNA metabolic process 16.2393 6 yes
GO:0009057 macromolecule catabolic process 14.5299 4 yes
GO:0009896 positive regulation of catabolic process 13.6752 5 yes
GO:0061013 regulation of mRNA catabolic process 11.9658 5 yes
GO:1901701 cellular response to oxygen-containing compound 11.9658 4 yes
GO:0034097 response to cytokine 11.9658 4 yes
GO:0043484 regulation of RNA splicing 11.1111 6 yes
GO:0051052 regulation of DNA metabolic process 10.2564 5 yes
GO:0071345 cellular response to cytokine stimulus 10.2564 5 yes
GO:0006259 DNA metabolic process 9.4017 5 yes
GO:0006974 DNA damage response 9.4017 4 yes
GO:0043488 regulation of mRNA stability 9.4017 4 yes
GO:0050684 regulation of mRNA processing 8.5470 7 yes
GO:0051169 nuclear transport 8.5470 4 yes
GO:1901361 organic cyclic compound catabolic process 8.5470 4 yes
GO:0006401 RNA catabolic process 8.5470 5 yes
GO:0006913 nucleocytoplasmic transport 8.5470 5 yes
GO:0034655 nucleobase-containing compound catabolic process 8.5470 4 yes
GO:0048024 regulation of mRNA splicing, via spliceosome 8.5470 7 yes
GO:0051028 mRNA transport 7.6923 5 yes
GO:0051168 nuclear export 7.6923 6 yes
GO:0071396 cellular response to lipid 7.6923 5 yes
GO:0006402 mRNA catabolic process 7.6923 6 yes
GO:0015931 nucleobase-containing compound transport 7.6923 5 yes
GO:0033993 response to lipid 7.6923 4 yes
GO:0050657 nucleic acid transport 7.6923 6 yes
GO:0050658 RNA transport 7.6923 4 yes
GO:1903313 positive regulation of mRNA metabolic process 6.8376 7 yes
GO:0006281 DNA repair 6.8376 5 yes
GO:0006405 RNA export from nucleus 6.8376 5 yes
GO:0061014 positive regulation of mRNA catabolic process 5.9829 6 yes
GO:0000956 nuclear-transcribed mRNA catabolic process 5.9829 7 yes
GO:0006406 mRNA export from nucleus 5.9829 6 yes
GO:0033044 regulation of chromosome organization 5.9829 6 yes
GO:0050779 RNA destabilization 5.1282 4 yes
GO:0051276 chromosome organization 5.1282 5 yes
GO:0061157 mRNA destabilization 5.1282 5 yes
GO:0032204 regulation of telomere maintenance 5.1282 6 yes
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 4.2735 8 yes
GO:0000723 telomere maintenance 4.2735 6 yes
GO:0032200 telomere organization 4.2735 6 yes
GO:0033120 positive regulation of RNA splicing 3.4188 7 yes
GO:0050685 positive regulation of mRNA processing 2.5641 8 yes
GO:0070555 response to interleukin-1 2.5641 5 yes
GO:0071103 DNA conformation change 2.5641 6 yes
GO:0071219 cellular response to molecule of bacterial origin 2.5641 4 yes
GO:0071222 cellular response to lipopolysaccharide 2.5641 5 yes
GO:0071347 cellular response to interleukin-1 2.5641 6 yes
GO:0002237 response to molecule of bacterial origin 2.5641 4 yes
GO:0006260 DNA replication 2.5641 6 yes
GO:0032392 DNA geometric change 2.5641 7 yes
GO:0032496 response to lipopolysaccharide 2.5641 4 yes
GO:0043244 regulation of protein-containing complex disassembly 2.5641 5 yes
GO:0048026 positive regulation of mRNA splicing, via spliceosome 2.5641 8 yes
GO:0061158 3-UTR-mediated mRNA destabilization 1.7094 6 yes
GO:0071044 histone mRNA catabolic process 1.7094 8 yes
GO:1905744 regulation of mRNA cis splicing, via spliceosome 1.7094 8 yes
GO:1905746 positive regulation of mRNA cis splicing, via spliceosome 1.7094 9 yes
GO:0006449 regulation of translational termination 1.7094 6 yes
GO:0008334 histone mRNA metabolic process 1.7094 7 yes
GO:0032508 DNA duplex unwinding 1.7094 8 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RSMN_HUMAN [view interactions] Low throughput no yes
RSMB_HUMAN [view interactions] Low throughput no yes
EIF3A_HUMAN [view entry] [view interactions] Low throughput yes yes
EIF3B_HUMAN [view interactions] Low throughput no yes
IF2A_HUMAN [view entry] [view interactions] Low throughput yes yes
FUS_HUMAN [view entry] [view interactions] Low throughput yes yes
IF2B_HUMAN [view interactions] Low throughput no yes
ATR_HUMAN [view entry] [view interactions] Low throughput yes no
PNRC2_HUMAN [view interactions] Low throughput no yes
PNRC1_HUMAN [view interactions] Low throughput no yes
RENT2_HUMAN [view interactions] Low throughput no no
REN3B_HUMAN [view interactions] Low throughput no yes
DCP1A_HUMAN [view interactions] Low throughput no yes
DCP2_HUMAN [view interactions] Low throughput no yes
REN3A_HUMAN [view interactions] Low throughput no yes
ERF1_HUMAN [view interactions] Low throughput no yes
ERF3A_HUMAN [view interactions] Low throughput no yes
RNPS1_HUMAN [view interactions] Low throughput no yes
ERF3B_HUMAN [view interactions] Low throughput no yes
MKRN3_HUMAN [view interactions] Low throughput no yes
SMG1_HUMAN [view interactions] Low throughput no yes
TERT_HUMAN [view interactions] Low throughput no no
ACD_HUMAN [view interactions] Low throughput no no
STAU1_HUMAN [view entry] [view interactions] Low throughput yes yes
LORF1_HUMAN [view interactions] Low throughput no no
SLBP_HUMAN [view interactions] Low throughput no yes
CASC3_HUMAN [view interactions] Low throughput no yes
ERI1_HUMAN [view interactions] Low throughput no yes
PABP1_HUMAN [view entry] [view interactions] Low throughput yes yes
DSRAD_HUMAN [view entry] [view interactions] Low throughput yes yes
INT6_HUMAN [view interactions] Low throughput no yes
DDX6_HUMAN [view entry] [view interactions] Low throughput yes yes
XRN1_HUMAN [view interactions] Low throughput no yes
EXOS2_HUMAN [view interactions] Low throughput no yes
DPOD1_HUMAN [view interactions] Low throughput no yes
SMG8_HUMAN [view interactions] Low throughput no yes
SMG9_HUMAN [view interactions] Low throughput no yes
RS3_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
IF4A3_HUMAN [view entry] [view interactions] High throughput yes yes
TRI33_HUMAN [view interactions] High throughput no yes
MGN_HUMAN [view interactions] High throughput no yes
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
HBB_HUMAN [view interactions] High throughput no no
FBW1A_HUMAN [view interactions] High throughput no yes
EST1A_HUMAN [view interactions] High throughput no yes
UBP48_HUMAN [view interactions] High throughput no yes
GCSP_HUMAN [view interactions] High throughput no yes
RICTR_HUMAN [view interactions] High throughput no yes
FINC_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
TNIP1_HUMAN [view interactions] High throughput no yes
RN138_HUMAN [view entry] [view interactions] High throughput yes no
ATG12_HUMAN [view interactions] High throughput no yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
SPRNG_HUMAN [view interactions] High throughput no yes
ITA4_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
RUVB1_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RUVB2_HUMAN [view interactions] High throughput no yes
OTUD4_HUMAN [view interactions] High throughput no yes
TADBP_HUMAN [view interactions] High throughput no yes
ITB3_HUMAN [view entry] [view interactions] High throughput yes no
POP1_HUMAN [view interactions] High throughput no no
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
STAU2_HUMAN [view entry] [view interactions] High throughput yes yes
SUMO2_HUMAN [view entry] [view interactions] High throughput yes yes
DNA2_HUMAN [view interactions] High throughput no yes
NS1BP_HUMAN [view interactions] High throughput no yes
VPS35_HUMAN [view entry] [view interactions] High throughput yes yes
EZH2_HUMAN [view interactions] High throughput no no
TMX1_HUMAN [view interactions] High throughput no no
SUZ12_HUMAN [view interactions] High throughput no no
ABCF3_HUMAN [view entry] [view interactions] High throughput yes yes
RING2_HUMAN [view interactions] High throughput no yes
DIAP1_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
SMCA4_HUMAN [view interactions] High throughput no yes
H11_HUMAN [view interactions] High throughput no no
TTC4_HUMAN [view interactions] High throughput no yes
TRA2A_HUMAN [view interactions] High throughput no yes
UBL7_HUMAN [view interactions] High throughput no yes
RL6_HUMAN [view entry] [view interactions] High throughput yes yes
DDX5_HUMAN [view entry] [view interactions] High throughput yes yes
MK67I_HUMAN [view interactions] High throughput no yes
RFIP5_HUMAN [view entry] [view interactions] High throughput yes yes
MEMO1_HUMAN [view interactions] High throughput no yes
MGN2_HUMAN [view interactions] High throughput no yes
ZC3H3_HUMAN [view interactions] High throughput no yes
TIAR_HUMAN [view interactions] High throughput no no
ROA1_HUMAN [view entry] [view interactions] High throughput yes yes
DAZP1_HUMAN [view interactions] High throughput no yes
PRR11_HUMAN [view interactions] High throughput no no
SYYM_HUMAN [view interactions] High throughput no no
ILF2_HUMAN [view interactions] High throughput no yes
NGAL_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
SAP18_HUMAN [view interactions] High throughput no yes
IF16_HUMAN [view interactions] High throughput no no
MYPT1_HUMAN [view entry] [view interactions] High throughput yes yes
CNOT2_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
OAZ1_HUMAN [view interactions] High throughput no yes
BRE1B_HUMAN [view interactions] High throughput no yes
SORT_HUMAN [view interactions] High throughput no yes
SC24A_HUMAN [view interactions] High throughput no no
SAMD1_HUMAN [view interactions] High throughput no no
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
SUMO3_HUMAN [view entry] [view interactions] High throughput yes yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
TAOK2_HUMAN [view entry] [view interactions] High throughput yes yes
XRCC5_HUMAN [view interactions] High throughput no yes
MKRN1_HUMAN [view interactions] High throughput no no
TCTP_HUMAN [view entry] [view interactions] High throughput yes yes
PCGF1_HUMAN [view interactions] High throughput no yes
SAHH_HUMAN [view entry] [view interactions] High throughput yes yes
DPPA4_HUMAN [view interactions] High throughput no no
RBMX_HUMAN [view entry] [view interactions] High throughput yes yes
U2AF2_HUMAN [view interactions] High throughput no yes
SC24C_HUMAN [view entry] [view interactions] High throughput yes yes
IFIX_HUMAN [view interactions] High throughput no no
PRKDC_HUMAN [view entry] [view interactions] High throughput yes yes
WDR46_HUMAN [view interactions] High throughput no yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
ELAV2_HUMAN [view interactions] High throughput no yes
NSUN2_HUMAN [view interactions] High throughput no yes
NOP53_HUMAN [view interactions] High throughput no yes
ROCK1_HUMAN [view entry] [view interactions] High throughput yes yes
DGCR8_HUMAN [view entry] [view interactions] High throughput yes yes
BRE1A_HUMAN [view interactions] High throughput no yes
CDX1_HUMAN [view interactions] High throughput no no
TAXB1_HUMAN [view interactions] High throughput no yes
RU17_HUMAN [view interactions] High throughput no yes
GT251_HUMAN [view interactions] High throughput no no
H1T_HUMAN [view interactions] High throughput no no
CNDP2_HUMAN [view entry] [view interactions] High throughput yes yes
PRDM5_HUMAN [view interactions] High throughput no yes
AGAP3_HUMAN [view entry] [view interactions] High throughput yes yes
ZCRB1_HUMAN [view interactions] High throughput no no
PYM1_HUMAN [view interactions] High throughput no yes
STRBP_HUMAN [view interactions] High throughput no yes
THUM3_HUMAN [view interactions] High throughput no yes
H14_HUMAN [view interactions] High throughput no yes
XRN2_HUMAN [view interactions] High throughput no yes
ZCH18_HUMAN [view interactions] High throughput no yes
NT5D2_HUMAN [view interactions] High throughput no yes
E4F1_HUMAN [view interactions] High throughput no yes
LZTL1_HUMAN [view interactions] High throughput no no
H2AX_HUMAN [view interactions] High throughput no yes
DJB11_HUMAN [view interactions] High throughput no yes
NXF2_HUMAN [view interactions] High throughput no no
NUDT5_HUMAN [view interactions] High throughput no no
ZCCHV_HUMAN [view interactions] High throughput no yes
TR150_HUMAN [view interactions] High throughput no yes
SSF1_HUMAN [view interactions] High throughput no yes
HDGR3_HUMAN [view interactions] High throughput no yes
RPF1_HUMAN [view interactions] High throughput no yes
FBW1B_HUMAN [view interactions] High throughput no yes
NSA2_HUMAN [view interactions] High throughput no yes
EWS_HUMAN [view interactions] High throughput no yes
ZC3H1_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
FGF8_HUMAN [view interactions] High throughput no no
KS6A2_HUMAN [view interactions] High throughput no yes
ZN576_HUMAN [view interactions] High throughput no no
ALG13_HUMAN [view interactions] High throughput no yes
RBM3_HUMAN [view interactions] High throughput no no
CELF1_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
CNOT9_HUMAN [view interactions] High throughput no yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
CPEB4_HUMAN [view entry] [view interactions] High throughput yes no
TRI25_HUMAN [view interactions] High throughput no yes
CSDE1_HUMAN [view interactions] High throughput no yes
G3BP1_HUMAN [view interactions] High throughput no yes
DAZL_HUMAN [view interactions] High throughput no no
BRCA1_HUMAN [view interactions] High throughput no yes
DDX3X_HUMAN [view entry] [view interactions] High throughput yes yes
YAP1_HUMAN [view interactions] High throughput no yes
IF4A1_HUMAN [view interactions] High throughput no no
TRIP4_HUMAN [view interactions] High throughput no yes
IF4A2_HUMAN [view entry] [view interactions] High throughput yes yes
BMP4_HUMAN [view interactions] High throughput no no
F120C_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
PCBP1_HUMAN [view entry] [view interactions] High throughput yes yes
FUBP3_HUMAN [view interactions] High throughput no yes
PPIE_HUMAN [view interactions] High throughput no yes
FXR2_HUMAN [view entry] [view interactions] High throughput yes yes
HBP1_HUMAN [view interactions] High throughput no yes
GRSF1_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
IF2B2_HUMAN [view interactions] High throughput no yes
TNIP2_HUMAN [view interactions] High throughput no yes
KIF1B_HUMAN [view entry] [view interactions] High throughput yes yes
ARI1_HUMAN [view interactions] High throughput no yes
LSM12_HUMAN [view interactions] High throughput no yes
SPDLY_HUMAN [view interactions] High throughput no yes
LS14A_HUMAN [view interactions] High throughput no yes
RIOK1_HUMAN [view interactions] High throughput no yes
MEX3B_HUMAN [view interactions] High throughput no no
SNAI1_HUMAN [view interactions] High throughput no yes
MKRN2_HUMAN [view interactions] High throughput no yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
NUFP2_HUMAN [view interactions] High throughput no no
WWOX_HUMAN [view interactions] High throughput no yes
PAIP2_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
PRC2A_HUMAN [view interactions] High throughput no yes
CGAS_HUMAN [view interactions] High throughput no yes
PUM1_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
R3HD2_HUMAN [view interactions] High throughput no yes
GRWD1_HUMAN [view interactions] High throughput no no
RBMS1_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
TDRD3_HUMAN [view interactions] High throughput no yes
TLR9_HUMAN [view interactions] High throughput no no
TRI56_HUMAN [view interactions] High throughput no yes
AMRA1_HUMAN [view interactions] High throughput no yes
UBP2L_HUMAN [view interactions] High throughput no yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
UNK_HUMAN [view interactions] High throughput no yes
NR2C2_HUMAN [view interactions] High throughput no yes
YTHD1_HUMAN [view interactions] High throughput no no
PP1G_HUMAN [view entry] [view interactions] High throughput yes yes
YTHD2_HUMAN [view interactions] High throughput no yes
ZDH18_HUMAN [view interactions] High throughput no yes
YTHD3_HUMAN [view interactions] High throughput no no
ZDH23_HUMAN [view interactions] High throughput no no
Z3H7A_HUMAN [view interactions] High throughput no no
ATX1_HUMAN [view interactions] High throughput no yes
TTP_HUMAN [view interactions] High throughput no yes
ZBT7B_HUMAN [view interactions] High throughput no no
4ET_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
SMAP2_HUMAN [view interactions] High throughput no yes
LMBRL_HUMAN [view interactions] High throughput no no
TIA1_HUMAN [view interactions] High throughput no no
LSM8_HUMAN [view interactions] High throughput no yes
NFX1_HUMAN [view interactions] High throughput no yes
TOP3B_HUMAN [view interactions] High throughput no no
DXO_HUMAN [view interactions] High throughput no yes
WWP2_HUMAN [view interactions] High throughput no no
CTIF_HUMAN [view interactions] High throughput no yes
HIRA_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
MARF1_HUMAN [view interactions] High throughput no yes
TR112_HUMAN [view interactions] High throughput no yes
EP300_HUMAN [view interactions] High throughput no yes
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
PKHB2_HUMAN [view interactions] High throughput no yes
CMTR1_HUMAN [view interactions] High throughput no yes
CH082_HUMAN [view interactions] High throughput no yes
NADE_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
CHCH1_HUMAN [view interactions] High throughput no yes
ACSA_HUMAN [view interactions] High throughput no no
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
DDX28_HUMAN [view interactions] High throughput no yes
ABHGA_HUMAN [view entry] [view interactions] High throughput yes yes
PLK1_HUMAN [view interactions] High throughput no yes
EXD2_HUMAN [view interactions] High throughput no yes
RHXF2_HUMAN [view interactions] High throughput no no
ANR55_HUMAN [view interactions] High throughput no yes
LEG9_HUMAN [view interactions] High throughput no yes
RPRD2_HUMAN [view interactions] High throughput no yes
MLP3B_HUMAN [view interactions] High throughput no yes
DNJA2_HUMAN [view entry] [view interactions] High throughput yes yes
GNPTG_HUMAN [view interactions] High throughput no yes
UBR5_HUMAN [view interactions] High throughput no no
COX8A_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
AURKB_HUMAN [view interactions] High throughput no yes
RS20_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
SERB1_HUMAN [view interactions] High throughput no yes
CSK2B_HUMAN [view entry] [view interactions] High throughput yes yes
ECT2_HUMAN [view interactions] High throughput no no
STIM1_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
NAA40_HUMAN [view interactions] High throughput no no
KIF23_HUMAN [view interactions] High throughput no yes
PML_HUMAN [view interactions] High throughput no yes
LRC59_HUMAN [view entry] [view interactions] High throughput yes yes
CCNF_HUMAN [view interactions] High throughput no no
EDC3_HUMAN [view interactions] High throughput no yes
INS_HUMAN [view interactions] High throughput no no
DCAF4_HUMAN [view interactions] High throughput no yes
EDC4_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
NUPR1_HUMAN [view interactions] High throughput no no
RFA2_HUMAN [view interactions] High throughput no yes
RENT1_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
RFA3_HUMAN [view interactions] High throughput no yes
AGO2_HUMAN [view entry] [view interactions] High throughput yes yes
RBM39_HUMAN [view interactions] High throughput no yes
AGO1_HUMAN [view interactions] High throughput no no
LIN41_HUMAN [view interactions] High throughput no no
ATF3_HUMAN [view interactions] High throughput no yes
CDN1A_HUMAN [view interactions] High throughput no no
RBM8A_HUMAN [view interactions] High throughput no yes
GA45A_HUMAN [view interactions] High throughput no no
HXA5_HUMAN [view interactions] High throughput no no
SRRM1_HUMAN [view interactions] High throughput no yes
MYB_HUMAN [view interactions] High throughput no yes
NXF1_HUMAN [view interactions] High throughput no yes
E2F7_HUMAN [view interactions] High throughput no no
THOC4_HUMAN [view interactions] High throughput no no
UBP10_HUMAN [view interactions] High throughput no yes
DEK_HUMAN [view interactions] High throughput no yes
CUL4A_HUMAN [view interactions] High throughput no no
FZR1_HUMAN [view interactions] High throughput no no
SPOP_HUMAN [view interactions] High throughput no no
UFL1_HUMAN [view interactions] High throughput no yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
RC3H2_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
RC3H1_HUMAN [view interactions] High throughput no yes
NR4A1_HUMAN [view interactions] High throughput no yes
WDR5_HUMAN [view interactions] High throughput no no
CDC37_HUMAN [view interactions] High throughput no yes
THAP3_HUMAN [view interactions] High throughput no yes
AIM2_HUMAN [view interactions] High throughput no no
SRSF6_HUMAN [view interactions] High throughput no yes
MNDA_HUMAN [view interactions] High throughput no no
RS3A_HUMAN [view entry] [view interactions] High throughput yes yes
LAR4B_HUMAN [view interactions] High throughput no yes
RN151_HUMAN [view interactions] High throughput no no
URM1_HUMAN [view interactions] High throughput no yes
NUP42_HUMAN [view interactions] High throughput no no
ZN346_HUMAN [view interactions] High throughput no yes
NCBP1_HUMAN [view interactions] High throughput no yes
HNRL2_HUMAN [view interactions] High throughput no yes
RED1_HUMAN [view interactions] High throughput no no
IF4E_HUMAN [view entry] [view interactions] High throughput yes yes
RBM47_HUMAN [view interactions] High throughput no yes
PABP2_HUMAN [view interactions] High throughput no yes
PAI2B_HUMAN [view interactions] High throughput no no
NAC1_HUMAN [view entry] [view interactions] High throughput yes yes
RL1D1_HUMAN [view interactions] High throughput no yes
DICER_HUMAN [view entry] [view interactions] High throughput yes yes
RBMS2_HUMAN [view interactions] High throughput no yes
MECOM_HUMAN [view interactions] High throughput no yes
SURF6_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
F120A_HUMAN [view interactions] High throughput no yes
KPCD1_HUMAN [view interactions] High throughput no yes
PRR3_HUMAN [view interactions] High throughput no no
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
MAP7_HUMAN [view interactions] High throughput no yes
NCBP3_HUMAN [view interactions] High throughput no yes
RL17_HUMAN [view entry] [view interactions] High throughput yes yes
NCBP2_HUMAN [view interactions] High throughput no yes
ZBT47_HUMAN [view interactions] High throughput no yes
IMP1L_HUMAN [view interactions] High throughput no yes
RL26_HUMAN [view entry] [view interactions] High throughput yes yes
IMP2L_HUMAN [view interactions] High throughput no yes
PER1_HUMAN [view interactions] High throughput no no
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
ABT1_HUMAN [view interactions] High throughput no no
MOT11_HUMAN [view interactions] High throughput no no
RS30_HUMAN [view interactions] High throughput no yes
VCAM1_HUMAN [view interactions] High throughput no no
HNRC1_HUMAN [view interactions] High throughput no no
PABP5_HUMAN [view interactions] High throughput no yes
SMG7_HUMAN [view interactions] High throughput no no
HNRPC_HUMAN [view interactions] High throughput no yes
SMG5_HUMAN [view interactions] High throughput no no
SRSF3_HUMAN [view interactions] High throughput no yes
KDM4A_HUMAN [view interactions] High throughput no yes
H2AB2_HUMAN [view interactions] High throughput no no
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
PURG_HUMAN [view interactions] High throughput no yes
TBB3_HUMAN [view entry] [view interactions] High throughput yes yes
AT7L1_HUMAN [view interactions] High throughput no yes
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
LN28B_HUMAN [view interactions] High throughput no no
FBRL_HUMAN [view interactions] High throughput no yes
LYAR_HUMAN [view interactions] High throughput no no
B2L14_HUMAN [view interactions] High throughput no yes
RBM4B_HUMAN [view interactions] High throughput no yes
OASL_HUMAN [view interactions] High throughput no no
RFOX2_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
PAIP1_HUMAN [view interactions] High throughput no yes
CPEB1_HUMAN [view entry] [view interactions] High throughput yes no
MBB1A_HUMAN [view interactions] High throughput no yes
KLF4_HUMAN [view interactions] High throughput no no
CBX6_HUMAN [view interactions] High throughput no yes
SOX15_HUMAN [view interactions] High throughput no no
SZRD1_HUMAN [view interactions] High throughput no yes
NDRG1_HUMAN [view entry] [view interactions] High throughput yes yes
PUF60_HUMAN [view interactions] High throughput no yes
TRFE_HUMAN [view interactions] High throughput no no
RU1C_HUMAN [view interactions] High throughput no yes
RL31_HUMAN [view entry] [view interactions] High throughput yes yes
SNW1_HUMAN [view interactions] High throughput no yes
NEIL1_HUMAN [view interactions] High throughput no yes
CDC5L_HUMAN [view interactions] High throughput no yes
SRSF1_HUMAN [view interactions] High throughput no yes
EF2_HUMAN [view entry] [view interactions] High throughput yes yes
SRSF7_HUMAN [view interactions] High throughput no yes
RL11_HUMAN [view entry] [view interactions] High throughput yes yes
BTF3_HUMAN [view interactions] High throughput no yes
RS6_HUMAN [view entry] [view interactions] High throughput yes yes
EF1D_HUMAN [view entry] [view interactions] High throughput yes yes
RL7A_HUMAN [view entry] [view interactions] High throughput yes no
FBXW7_HUMAN [view interactions] High throughput no yes
PTBP3_HUMAN [view interactions] High throughput no no
HECD1_HUMAN [view interactions] High throughput no yes
STING_HUMAN [view interactions] High throughput no yes
SIR6_HUMAN [view interactions] High throughput no yes
YBOX1_HUMAN [view interactions] High throughput no yes
RBCC1_HUMAN [view interactions] High throughput no no
JUN_HUMAN [view interactions] High throughput no yes
PEG10_HUMAN [view interactions] High throughput no no
BCAR1_HUMAN [view interactions] High throughput no yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
RHBT2_HUMAN [view interactions] High throughput no no
HERC2_HUMAN [view interactions] High throughput no yes
CAPR1_HUMAN [view entry] [view interactions] High throughput yes yes
MYCB2_HUMAN [view entry] [view interactions] High throughput yes no
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
ASF1A_HUMAN [view interactions] High throughput no no
CLCA_HUMAN [view entry] [view interactions] High throughput yes no
HDAC4_HUMAN [view interactions] High throughput no yes
CSK21_HUMAN [view entry] [view interactions] High throughput yes yes
IPSP_HUMAN [view interactions] High throughput no no
DDX21_HUMAN [view interactions] High throughput no yes
BMI1_HUMAN [view interactions] High throughput no yes
DHX9_HUMAN [view interactions] High throughput no yes
RYBP_HUMAN [view interactions] High throughput no no
G3BP2_HUMAN [view entry] [view interactions] High throughput yes yes
MOV10_HUMAN [view interactions] High throughput no no
ROA2_HUMAN [view entry] [view interactions] High throughput yes yes
LN28A_HUMAN [view interactions] High throughput no no
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
HNRPL_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
IF2B1_HUMAN [view interactions] High throughput no no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
ILF3_HUMAN [view interactions] High throughput no yes
DYR1A_HUMAN [view interactions] High throughput no yes
MAP2_HUMAN [view interactions] High throughput no yes
CEP63_HUMAN [view interactions] High throughput no yes
PSPC1_HUMAN [view interactions] High throughput no yes
CP135_HUMAN [view interactions] High throughput no no
RL5_HUMAN [view entry] [view interactions] High throughput yes yes
ODFP2_HUMAN [view interactions] High throughput no no
RS16_HUMAN [view entry] [view interactions] High throughput yes yes
CP110_HUMAN [view interactions] High throughput no yes
SRP09_HUMAN [view interactions] High throughput no no
CE192_HUMAN [view interactions] High throughput no yes
MNS1_HUMAN [view interactions] High throughput no no
POC5_HUMAN [view interactions] High throughput no yes
HNRPK_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
UFM1_HUMAN [view interactions] High throughput no yes
CAND1_HUMAN [view entry] [view interactions] High throughput yes no
ROA0_HUMAN [view interactions] High throughput no yes
CSN5_HUMAN [view interactions] High throughput no yes
STRAP_HUMAN [view entry] [view interactions] High throughput yes yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
ZFR_HUMAN [view interactions] High throughput no yes
CUL5_HUMAN [view entry] [view interactions] High throughput yes yes
SRS12_HUMAN [view interactions] High throughput no no
NBEL2_HUMAN [view interactions] High throughput no no
NSRP1_HUMAN [view interactions] High throughput no yes
KAD2_HUMAN [view interactions] High throughput no no
CNTRL_HUMAN [view interactions] High throughput no yes
ATX2_HUMAN [view interactions] High throughput no yes
NIN_HUMAN [view interactions] High throughput no no
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
SCLT1_HUMAN [view interactions] High throughput no yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
CE104_HUMAN [view interactions] High throughput no yes
HNRPU_HUMAN [view interactions] High throughput no yes
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
SMAG2_HUMAN [view interactions] High throughput no yes
STIL_HUMAN [view interactions] High throughput no no
MSI2H_HUMAN [view interactions] High throughput no yes
CE170_HUMAN [view interactions] High throughput no yes
ROAA_HUMAN [view entry] [view interactions] High throughput yes yes
CE162_HUMAN [view interactions] High throughput no yes
NRIP1_HUMAN [view interactions] High throughput no yes
FTM_HUMAN [view interactions] High throughput no yes
ROA3_HUMAN [view entry] [view interactions] High throughput yes yes
CEP19_HUMAN [view interactions] High throughput no no
HNRDL_HUMAN [view interactions] High throughput no yes
DYRK2_HUMAN [view interactions] High throughput no yes
HNRPR_HUMAN [view interactions] High throughput no yes
SOX2_HUMAN [view interactions] High throughput no yes
IF2B3_HUMAN [view interactions] High throughput no no
KIF1C_HUMAN [view interactions] High throughput no yes
HNRPQ_HUMAN [view entry] [view interactions] High throughput yes yes
SMAG1_HUMAN [view entry] [view interactions] High throughput yes yes
TRI31_HUMAN [view interactions] High throughput no no
TISB_HUMAN [view interactions] High throughput no no
ANM1_HUMAN [view interactions] High throughput no yes
NDUBA_HUMAN [view entry] [view interactions] High throughput yes yes
MYCN_HUMAN [view interactions] High throughput no no
PKHA5_HUMAN [view entry] [view interactions] High throughput yes yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
E2F4_HUMAN [view interactions] High throughput no no
HDAC6_HUMAN [view interactions] High throughput no yes
EXOS4_HUMAN [view interactions] High throughput no yes
BHE40_HUMAN [view interactions] High throughput no yes
PARN_HUMAN [view entry] [view interactions] High throughput yes yes
GATA4_HUMAN [view interactions] High throughput no no
EXOSX_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
HDAC5_HUMAN [view interactions] High throughput no yes
DOT1L_HUMAN [view interactions] High throughput no yes
SIR7_HUMAN [view interactions] High throughput no yes
MEN1_HUMAN [view interactions] High throughput no yes
TS101_HUMAN [view entry] [view interactions] High throughput yes yes
AATF_HUMAN [view interactions] High throughput no yes
P5F1B_HUMAN [view interactions] High throughput no no
R113A_HUMAN [view interactions] High throughput no yes
PO5F1_HUMAN [view interactions] High throughput no yes
ACE2_HUMAN [view interactions] High throughput no no
CDK2_HUMAN [view interactions] High throughput no yes
PARPT_HUMAN [view interactions] High throughput no no
VIGLN_HUMAN [view entry] [view interactions] High throughput yes yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no