ABHGA_HUMAN
Evidence for PS localization
Functions
Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) . LPS constitutes a class of signaling lipids that regulates immunological and neurological processes . Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase (PubMed). Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z-octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ(2)-G) (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ABHGA_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 25.0000 | 4 | no |
| GO:0046872 | metal ion binding | 25.0000 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ABHGA_HUMAN |
|---|---|---|---|---|
| GO:0071702 | organic substance transport | 62.5000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 62.5000 | 4 | no |
| GO:0006996 | organelle organization | 50.0000 | 4 | no |
| GO:0008104 | protein localization | 50.0000 | 4 | no |
| GO:0015031 | protein transport | 50.0000 | 4 | no |
| GO:0048284 | organelle fusion | 37.5000 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 37.5000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 37.5000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 37.5000 | 4 | no |
| GO:0006644 | phospholipid metabolic process | 25.0000 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 25.0000 | 4 | yes |
| GO:0006811 | ion transport | 25.0000 | 4 | no |
| GO:0051046 | regulation of secretion | 25.0000 | 5 | no |
| GO:0051049 | regulation of transport | 25.0000 | 4 | no |
| GO:1903530 | regulation of secretion by cell | 25.0000 | 4 | no |
| GO:0006886 | intracellular protein transport | 25.0000 | 4 | no |
| GO:0006906 | vesicle fusion | 25.0000 | 6 | no |
| GO:0010468 | regulation of gene expression | 25.0000 | 5 | no |
| GO:0016050 | vesicle organization | 25.0000 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 25.0000 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.0000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 25.0000 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 25.0000 | 5 | no |
| GO:0061024 | membrane organization | 25.0000 | 4 | no |
| GO:0061025 | membrane fusion | 25.0000 | 5 | no |
| GO:0090174 | organelle membrane fusion | 25.0000 | 6 | no |
| GO:0009892 | negative regulation of metabolic process | 25.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 25.0000 | 4 | no |
| GO:0009894 | regulation of catabolic process | 25.0000 | 4 | no |
| GO:0009896 | positive regulation of catabolic process | 25.0000 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 25.0000 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0031329 | regulation of cellular catabolic process | 25.0000 | 5 | no |
| GO:0033043 | regulation of organelle organization | 25.0000 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 25.0000 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 25.0000 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 25.0000 | 4 | no |
| GO:0033993 | response to lipid | 25.0000 | 4 | no |
| GO:0071310 | cellular response to organic substance | 25.0000 | 4 | no |
| GO:0071396 | cellular response to lipid | 25.0000 | 5 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 25.0000 | 4 | no |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in ABHGA_HUMAN |
|---|---|---|---|---|
| DOID:1826 | epilepsy | 25.0000 | 5 | no |
| DOID:331 | central nervous system disease | 25.0000 | 3 | no |
| DOID:936 | brain disease | 25.0000 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DHB13_HUMAN | [view interactions] | High throughput | no | yes |
| LAT2_HUMAN | [view interactions] | High throughput | no | no |
| VMA21_HUMAN | [view interactions] | High throughput | no | no |
| TM139_HUMAN | [view interactions] | High throughput | no | no |
| GOT1A_HUMAN | [view interactions] | High throughput | no | no |
| VAMP5_HUMAN | [view interactions] | High throughput | no | no |
| SC22B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AQP6_HUMAN | [view interactions] | High throughput | no | no |
| PRAF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITAM_HUMAN | [view interactions] | High throughput | no | no |
| GORAB_HUMAN | [view interactions] | High throughput | no | yes |
| TM14B_HUMAN | [view interactions] | High throughput | no | no |
| TMM65_HUMAN | [view interactions] | High throughput | no | no |
| FPPS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLCC_HUMAN | [view interactions] | High throughput | no | no |
| RHBD2_HUMAN | [view interactions] | High throughput | no | yes |
| STMN4_HUMAN | [view interactions] | High throughput | no | no |
| CBARP_HUMAN | [view interactions] | High throughput | no | no |
| UN93A_HUMAN | [view interactions] | High throughput | no | no |
| PMYT1_HUMAN | [view interactions] | High throughput | no | no |
| TM237_HUMAN | [view interactions] | High throughput | no | no |
| AQP7_HUMAN | [view interactions] | High throughput | no | no |
| TMM31_HUMAN | [view interactions] | High throughput | no | no |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| BSCL2_HUMAN | [view interactions] | High throughput | no | yes |
| KCNA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAAL1_HUMAN | [view interactions] | High throughput | no | yes |
| DIK1A_HUMAN | [view interactions] | High throughput | no | yes |
| CKLF5_HUMAN | [view interactions] | High throughput | no | yes |
| COPT2_HUMAN | [view interactions] | High throughput | no | yes |
| RAB43_HUMAN | [view interactions] | High throughput | no | yes |
| SBP1_HUMAN | [view interactions] | High throughput | no | no |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| RNF5_HUMAN | [view interactions] | High throughput | no | yes |
| HM13_HUMAN | [view interactions] | High throughput | no | yes |
| TM147_HUMAN | [view interactions] | High throughput | no | no |
| TM222_HUMAN | [view interactions] | High throughput | no | no |
| DNJC1_HUMAN | [view interactions] | High throughput | no | yes |
| GPC5C_HUMAN | [view interactions] | High throughput | no | no |
| PILRB_HUMAN | [view interactions] | High throughput | no | yes |
| SAFB1_HUMAN | [view interactions] | High throughput | no | yes |
| SPAG7_HUMAN | [view interactions] | High throughput | no | yes |
| AT5G3_HUMAN | [view interactions] | High throughput | no | no |
| NU4LM_HUMAN | [view interactions] | High throughput | no | no |
| RENT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLH1_HUMAN | [view interactions] | High throughput | no | yes |
| CREB3_HUMAN | [view interactions] | High throughput | no | no |
| CSDE1_HUMAN | [view interactions] | High throughput | no | yes |
| 5HT3C_HUMAN | [view interactions] | High throughput | no | no |
| MCLN3_HUMAN | [view interactions] | High throughput | no | no |
| TBCD9_HUMAN | [view interactions] | High throughput | no | yes |
| SCNND_HUMAN | [view interactions] | High throughput | no | yes |
| CRY1_HUMAN | [view interactions] | High throughput | no | yes |
| DTX2_HUMAN | [view interactions] | High throughput | no | yes |
| RETR3_HUMAN | [view interactions] | High throughput | no | yes |
| SPAG4_HUMAN | [view interactions] | High throughput | no | no |
| ERGI3_HUMAN | [view interactions] | High throughput | no | yes |
| BRI3_HUMAN | [view interactions] | High throughput | no | no |
| GDAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZNT2_HUMAN | [view interactions] | High throughput | no | no |
| RHBL1_HUMAN | [view interactions] | High throughput | no | no |
| CIDEB_HUMAN | [view interactions] | High throughput | no | yes |
| STX1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CP1A2_HUMAN | [view interactions] | High throughput | no | no |
| DPOE1_HUMAN | [view interactions] | High throughput | no | no |
| ATP5J_HUMAN | [view interactions] | High throughput | no | yes |
| T4S19_HUMAN | [view interactions] | High throughput | no | no |
| TSN2_HUMAN | [view interactions] | High throughput | no | no |
| TM143_HUMAN | [view interactions] | High throughput | no | yes |
| CXA5_HUMAN | [view interactions] | High throughput | no | yes |
| GP152_HUMAN | [view interactions] | High throughput | no | no |
| EBP_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP7_HUMAN | [view interactions] | High throughput | no | yes |
| WBP1L_HUMAN | [view interactions] | High throughput | no | yes |
| PERP_HUMAN | [view interactions] | High throughput | no | no |
| GLPC_HUMAN | [view interactions] | High throughput | no | yes |
| TNFB_HUMAN | [view interactions] | High throughput | no | no |
| NTCP_HUMAN | [view interactions] | High throughput | no | no |
| SERF1_HUMAN | [view interactions] | High throughput | no | no |
| ABD12_HUMAN | [view interactions] | Computational | no | no |