STX1B_HUMAN
Evidence for PS localization
Functions
Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 216 | Val | Glu | Generalizedepilepsywithfebrileseizuresplus9(GEFSP9) | - |
| 226 | Gly | Arg | Generalizedepilepsywithfebrileseizuresplus9(GEFSP9) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in STX1B_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 24.1379 | 4 | yes |
| GO:0019905 | syntaxin binding | 24.1379 | 4 | no |
| GO:0019901 | protein kinase binding | 10.3448 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in STX1B_HUMAN |
|---|---|---|---|---|
| GO:0051128 | regulation of cellular component organization | 58.6207 | 4 | yes |
| GO:0006996 | organelle organization | 55.1724 | 4 | yes |
| GO:0010646 | regulation of cell communication | 51.7241 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 51.7241 | 4 | yes |
| GO:0022607 | cellular component assembly | 48.2759 | 4 | no |
| GO:0008104 | protein localization | 44.8276 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 44.8276 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 44.8276 | 4 | yes |
| GO:0061024 | membrane organization | 41.3793 | 4 | yes |
| GO:0016050 | vesicle organization | 37.9310 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 37.9310 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 37.9310 | 4 | yes |
| GO:0051049 | regulation of transport | 37.9310 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 34.4828 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 34.4828 | 4 | yes |
| GO:0071702 | organic substance transport | 34.4828 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 34.4828 | 4 | no |
| GO:0009966 | regulation of signal transduction | 31.0345 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 31.0345 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 31.0345 | 4 | yes |
| GO:0006906 | vesicle fusion | 27.5862 | 6 | yes |
| GO:0015031 | protein transport | 27.5862 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 27.5862 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 27.5862 | 5 | yes |
| GO:0046903 | secretion | 27.5862 | 4 | yes |
| GO:0048284 | organelle fusion | 27.5862 | 5 | yes |
| GO:0050806 | positive regulation of synaptic transmission | 27.5862 | 5 | yes |
| GO:0051050 | positive regulation of transport | 27.5862 | 4 | yes |
| GO:0061025 | membrane fusion | 27.5862 | 5 | yes |
| GO:0090174 | organelle membrane fusion | 27.5862 | 6 | yes |
| GO:0065003 | protein-containing complex assembly | 27.5862 | 5 | no |
| GO:0007612 | learning | 27.5862 | 4 | no |
| GO:0030030 | cell projection organization | 27.5862 | 4 | no |
| GO:0050890 | cognition | 27.5862 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 24.1379 | 4 | yes |
| GO:0051046 | regulation of secretion | 24.1379 | 5 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 24.1379 | 4 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 24.1379 | 6 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 24.1379 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 24.1379 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 24.1379 | 4 | no |
| GO:0006886 | intracellular protein transport | 20.6897 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 20.6897 | 5 | yes |
| GO:0023061 | signal release | 20.6897 | 4 | yes |
| GO:0031629 | synaptic vesicle fusion to presynaptic active zone membrane | 20.6897 | 4 | yes |
| GO:0048499 | synaptic vesicle membrane organization | 20.6897 | 5 | yes |
| GO:0051047 | positive regulation of secretion | 20.6897 | 5 | yes |
| GO:1903530 | regulation of secretion by cell | 20.6897 | 4 | yes |
| GO:0032880 | regulation of protein localization | 20.6897 | 5 | no |
| GO:0060341 | regulation of cellular localization | 20.6897 | 4 | no |
| GO:0098657 | import into cell | 20.6897 | 4 | no |
| GO:0031175 | neuron projection development | 20.6897 | 6 | no |
| GO:0048812 | neuron projection morphogenesis | 20.6897 | 5 | no |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 20.6897 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 20.6897 | 5 | no |
| GO:0006836 | neurotransmitter transport | 17.2414 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 17.2414 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 17.2414 | 5 | yes |
| GO:0010975 | regulation of neuron projection development | 17.2414 | 7 | yes |
| GO:0016079 | synaptic vesicle exocytosis | 17.2414 | 4 | yes |
| GO:0017156 | calcium-ion regulated exocytosis | 17.2414 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 17.2414 | 5 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 17.2414 | 5 | yes |
| GO:0045055 | regulated exocytosis | 17.2414 | 4 | yes |
| GO:0048278 | vesicle docking | 17.2414 | 4 | yes |
| GO:0051129 | negative regulation of cellular component organization | 17.2414 | 5 | yes |
| GO:0099643 | signal release from synapse | 17.2414 | 5 | yes |
| GO:1903532 | positive regulation of secretion by cell | 17.2414 | 5 | yes |
| GO:0010468 | regulation of gene expression | 13.7931 | 6 | yes |
| GO:0010807 | regulation of synaptic vesicle priming | 13.7931 | 6 | yes |
| GO:0031644 | regulation of nervous system process | 13.7931 | 5 | yes |
| GO:0044057 | regulation of system process | 13.7931 | 4 | yes |
| GO:0098815 | modulation of excitatory postsynaptic potential | 13.7931 | 4 | yes |
| GO:0001956 | positive regulation of neurotransmitter secretion | 10.3448 | 6 | yes |
| GO:0046928 | regulation of neurotransmitter secretion | 10.3448 | 5 | yes |
| GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter | 10.3448 | 5 | yes |
| GO:0051051 | negative regulation of transport | 10.3448 | 4 | yes |
| GO:0051588 | regulation of neurotransmitter transport | 10.3448 | 5 | yes |
| GO:0051590 | positive regulation of neurotransmitter transport | 10.3448 | 5 | yes |
| GO:2000463 | positive regulation of excitatory postsynaptic potential | 10.3448 | 5 | yes |
| GO:0007269 | neurotransmitter secretion | 6.8966 | 4 | yes |
| GO:0010977 | negative regulation of neuron projection development | 6.8966 | 7 | yes |
| GO:0016081 | synaptic vesicle docking | 6.8966 | 4 | yes |
| GO:0030100 | regulation of endocytosis | 6.8966 | 5 | yes |
| GO:0031345 | negative regulation of cell projection organization | 6.8966 | 6 | yes |
| GO:0045806 | negative regulation of endocytosis | 6.8966 | 5 | yes |
| GO:0098967 | exocytic insertion of neurotransmitter receptor to postsynaptic membrane | 6.8966 | 4 | yes |
| GO:0150003 | regulation of spontaneous synaptic transmission | 6.8966 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| BRE1B_HUMAN | [view interactions] | Low throughput | no | yes |
| SNP23_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| VAMP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SNP25_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STXB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UN13B_HUMAN | [view interactions] | Low throughput | no | no |
| VAMP1_HUMAN | [view interactions] | Low throughput | no | no |
| CNTP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC4C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| ARMC1_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| DJC11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNP47_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNAB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TXLNA_HUMAN | [view interactions] | High throughput | no | yes |
| VAMP5_HUMAN | [view interactions] | High throughput | no | no |
| BET1_HUMAN | [view interactions] | High throughput | no | no |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNP29_HUMAN | [view interactions] | High throughput | no | yes |
| F161B_HUMAN | [view interactions] | High throughput | no | yes |
| FBX28_HUMAN | [view interactions] | High throughput | no | yes |
| ABHGA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FA81A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AQP6_HUMAN | [view interactions] | High throughput | no | no |
| KCNN4_HUMAN | [view interactions] | High throughput | no | no |
| ERGI3_HUMAN | [view interactions] | High throughput | no | yes |
| CXA8_HUMAN | [view interactions] | High throughput | no | no |
| EMC5_HUMAN | [view interactions] | High throughput | no | yes |
| GP152_HUMAN | [view interactions] | High throughput | no | no |
| EBP_HUMAN | [view interactions] | High throughput | no | no |
| KISHB_HUMAN | [view interactions] | High throughput | no | no |
| F209A_HUMAN | [view interactions] | High throughput | no | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOX4_HUMAN | [view interactions] | High throughput | no | yes |
| UBC9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACBD5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX2_HUMAN | [view interactions] | High throughput | no | no |
| FIBA_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRRT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |