Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

STX1B_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
216 Val Glu Generalizedepilepsywithfebrileseizuresplus9(GEFSP9) -
226 Gly Arg Generalizedepilepsywithfebrileseizuresplus9(GEFSP9) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in STX1B_HUMAN
GO:0019905 syntaxin binding 46.8750 4 no
GO:0017075 syntaxin-1 binding 28.1250 5 no
GO:0019900 kinase binding 25.0000 4 yes
GO:0019901 protein kinase binding 15.6250 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in STX1B_HUMAN
GO:0016192 vesicle-mediated transport 65.6250 4 yes
GO:0051128 regulation of cellular component organization 62.5000 4 yes
GO:0048522 positive regulation of cellular process 56.2500 4 yes
GO:0006996 organelle organization 53.1250 4 yes
GO:0008104 protein localization 53.1250 4 yes
GO:0022607 cellular component assembly 53.1250 4 no
GO:0006887 exocytosis 50.0000 4 yes
GO:0046903 secretion 50.0000 4 yes
GO:0043933 protein-containing complex organization 50.0000 4 no
GO:0010646 regulation of cell communication 46.8750 4 yes
GO:0051049 regulation of transport 46.8750 4 yes
GO:0015031 protein transport 43.7500 4 yes
GO:0050804 modulation of chemical synaptic transmission 43.7500 5 yes
GO:0071702 organic substance transport 43.7500 4 yes
GO:0071705 nitrogen compound transport 43.7500 4 yes
GO:0099177 regulation of trans-synaptic signaling 43.7500 4 yes
GO:0016050 vesicle organization 40.6250 5 yes
GO:0051046 regulation of secretion 40.6250 5 yes
GO:0061024 membrane organization 40.6250 4 yes
GO:1903530 regulation of secretion by cell 40.6250 4 yes
GO:0065003 protein-containing complex assembly 40.6250 5 no
GO:0023056 positive regulation of signaling 37.5000 4 yes
GO:0060627 regulation of vesicle-mediated transport 37.5000 4 yes
GO:0017157 regulation of exocytosis 34.3750 5 yes
GO:0023061 signal release 34.3750 4 yes
GO:0045055 regulated exocytosis 34.3750 5 yes
GO:0061025 membrane fusion 34.3750 5 yes
GO:0010647 positive regulation of cell communication 31.2500 5 yes
GO:0016079 synaptic vesicle exocytosis 31.2500 4 yes
GO:0044087 regulation of cellular component biogenesis 31.2500 4 yes
GO:0048278 vesicle docking 31.2500 4 yes
GO:0060255 regulation of macromolecule metabolic process 31.2500 4 yes
GO:0099003 vesicle-mediated transport in synapse 31.2500 5 yes
GO:0099643 signal release from synapse 31.2500 5 yes
GO:0006906 vesicle fusion 28.1250 6 yes
GO:0048284 organelle fusion 28.1250 5 yes
GO:0090174 organelle membrane fusion 28.1250 6 yes
GO:0048193 Golgi vesicle transport 25.0000 5 no
GO:0006886 intracellular protein transport 25.0000 4 yes
GO:0017156 calcium-ion regulated exocytosis 25.0000 6 yes
GO:0048523 negative regulation of cellular process 25.0000 4 yes
GO:0050806 positive regulation of synaptic transmission 25.0000 5 yes
GO:0051050 positive regulation of transport 25.0000 4 yes
GO:0032880 regulation of protein localization 25.0000 5 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0060341 regulation of cellular localization 25.0000 4 no
GO:0007268 chemical synaptic transmission 25.0000 6 no
GO:0098916 anterograde trans-synaptic signaling 25.0000 5 no
GO:0099537 trans-synaptic signaling 25.0000 4 no
GO:0009893 positive regulation of metabolic process 21.8750 4 no
GO:0031323 regulation of cellular metabolic process 21.8750 4 no
GO:0009966 regulation of signal transduction 21.8750 4 yes
GO:0046928 regulation of neurotransmitter secretion 21.8750 4 yes
GO:0048584 positive regulation of response to stimulus 21.8750 4 yes
GO:0051588 regulation of neurotransmitter transport 21.8750 5 yes
GO:0051171 regulation of nitrogen compound metabolic process 21.8750 4 no
GO:0080090 regulation of primary metabolic process 21.8750 4 no
GO:0043269 regulation of ion transport 21.8750 5 no
GO:0010807 regulation of synaptic vesicle priming 18.7500 6 yes
GO:0031344 regulation of cell projection organization 18.7500 5 yes
GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane 18.7500 4 yes
GO:0043254 regulation of protein-containing complex assembly 18.7500 5 yes
GO:0048499 synaptic vesicle membrane organization 18.7500 5 yes
GO:0051047 positive regulation of secretion 18.7500 5 yes
GO:1903532 positive regulation of secretion by cell 18.7500 5 yes
GO:0006836 neurotransmitter transport 15.6250 4 yes
GO:0009967 positive regulation of signal transduction 15.6250 5 yes
GO:0048791 calcium ion-regulated exocytosis of neurotransmitter 15.6250 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 15.6250 6 yes
GO:0001956 positive regulation of neurotransmitter secretion 12.5000 5 yes
GO:0007269 neurotransmitter secretion 12.5000 4 yes
GO:0016081 synaptic vesicle docking 12.5000 4 yes
GO:0051129 negative regulation of cellular component organization 12.5000 5 yes
GO:0051590 positive regulation of neurotransmitter transport 12.5000 5 yes
GO:0010975 regulation of neuron projection development 9.3750 7 yes
GO:0031644 regulation of nervous system process 9.3750 5 yes
GO:0044057 regulation of system process 9.3750 4 yes
GO:0051051 negative regulation of transport 9.3750 4 yes
GO:0098815 modulation of excitatory postsynaptic potential 9.3750 4 yes
GO:0098967 exocytic insertion of neurotransmitter receptor to postsynaptic membrane 9.3750 4 yes
GO:2000463 positive regulation of excitatory postsynaptic potential 9.3750 5 yes
GO:0010468 regulation of gene expression 6.2500 5 yes
GO:0030100 regulation of endocytosis 6.2500 5 yes
GO:0045806 negative regulation of endocytosis 6.2500 5 yes
GO:0061669 spontaneous neurotransmitter secretion 6.2500 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in STX1B_HUMAN
DOID:331 central nervous system disease 9.3750 3 yes
DOID:1826 epilepsy 6.2500 5 yes
DOID:936 brain disease 6.2500 4 yes

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
BRE1B_HUMAN [view interactions] Low throughput no yes
SNP23_HUMAN [view entry] [view interactions] Low throughput yes no
VAMP2_HUMAN [view entry] [view interactions] Low throughput yes no
SNP25_HUMAN [view entry] [view interactions] Low throughput yes yes
STXB1_HUMAN [view entry] [view interactions] Low throughput yes yes
UN13B_HUMAN [view interactions] Low throughput no no
VAMP1_HUMAN [view interactions] Low throughput no no
STX1A_HUMAN [view entry] [view interactions] High throughput yes yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
NUFP1_HUMAN [view interactions] High throughput no yes
ARMC1_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
DJC11_HUMAN [view entry] [view interactions] High throughput yes no
SNP47_HUMAN [view entry] [view interactions] High throughput yes yes
SNAB_HUMAN [view entry] [view interactions] High throughput yes yes
TXLNA_HUMAN [view interactions] High throughput no yes
VAMP5_HUMAN [view interactions] High throughput no no
BET1_HUMAN [view interactions] High throughput no no
STX4_HUMAN [view entry] [view interactions] High throughput yes no
SNP29_HUMAN [view interactions] High throughput no yes
F161B_HUMAN [view interactions] High throughput no yes
FBX28_HUMAN [view interactions] High throughput no yes
ABHGA_HUMAN [view entry] [view interactions] High throughput yes yes
FA81A_HUMAN [view entry] [view interactions] High throughput yes yes
AQP6_HUMAN [view interactions] High throughput no no
KCNN4_HUMAN [view interactions] High throughput no no
ERGI3_HUMAN [view interactions] High throughput no yes
CXA8_HUMAN [view interactions] High throughput no no
EMC5_HUMAN [view interactions] High throughput no yes
GP152_HUMAN [view interactions] High throughput no no
EBP_HUMAN [view interactions] High throughput no no
KISHB_HUMAN [view interactions] High throughput no no
F209A_HUMAN [view interactions] High throughput no no
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
UBC9_HUMAN [view interactions] High throughput no yes
ACBD5_HUMAN [view entry] [view interactions] High throughput yes yes
STX2_HUMAN [view interactions] High throughput no no
FIBA_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
VAPB_HUMAN [view entry] [view interactions] High throughput yes yes
HAX1_HUMAN [view interactions] High throughput no no
DGUOK_HUMAN [view interactions] High throughput no yes
KTU_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
TIA1_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
DX39A_HUMAN [view interactions] High throughput no yes
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
SC22B_HUMAN [view entry] [view interactions] Computational yes no
STB5L_HUMAN [view interactions] Computational no no
SYT2_HUMAN [view entry] [view interactions] Computational yes no
VAMP7_HUMAN [view interactions] Computational no yes
STXB2_HUMAN [view interactions] Computational no no
UN13A_HUMAN [view entry] [view interactions] Computational yes no
STX6_HUMAN [view interactions] Computational no yes
SYT1_HUMAN [view entry] [view interactions] Computational yes no
STXB5_HUMAN [view entry] [view interactions] Computational yes yes
YKT6_HUMAN [view interactions] Computational no yes
VAMP4_HUMAN [view interactions] Computational no yes
VAMP8_HUMAN [view interactions] Computational no no
SCG1_HUMAN [view interactions] Computational no no
CMGA_HUMAN [view interactions] Computational no yes
VAMP3_HUMAN [view entry] [view interactions] Computational yes no
CPLX2_HUMAN [view entry] [view interactions] Computational yes yes
SNAA_HUMAN [view entry] [view interactions] Computational yes yes
CPLX1_HUMAN [view entry] [view interactions] Computational yes yes
NSF_HUMAN [view entry] [view interactions] Computational yes yes
STX5_HUMAN [view interactions] Computational no yes