SNP25_HUMAN
Evidence for PS localization
Functions
t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SNP25_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 31.1111 | 4 | no |
| GO:0043169 | cation binding | 26.6667 | 4 | no |
| GO:0046872 | metal ion binding | 26.6667 | 5 | no |
| GO:0000166 | nucleotide binding | 25.5556 | 4 | no |
| GO:0017076 | purine nucleotide binding | 25.5556 | 5 | no |
| GO:0019900 | kinase binding | 23.3333 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 23.3333 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.2222 | 4 | no |
| GO:0019905 | syntaxin binding | 17.7778 | 4 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 13.3333 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 13.3333 | 4 | yes |
| GO:0017075 | syntaxin-1 binding | 11.1111 | 5 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 8.8889 | 5 | yes |
| GO:0005216 | monoatomic ion channel activity | 5.5556 | 4 | yes |
| GO:0015079 | potassium ion transmembrane transporter activity | 5.5556 | 6 | yes |
| GO:0015267 | channel activity | 5.5556 | 4 | yes |
| GO:0017022 | myosin binding | 5.5556 | 4 | yes |
| GO:0005261 | monoatomic cation channel activity | 4.4444 | 5 | yes |
| GO:0022836 | gated channel activity | 4.4444 | 5 | yes |
| GO:0005244 | voltage-gated monoatomic ion channel activity | 3.3333 | 5 | yes |
| GO:0005249 | voltage-gated potassium channel activity | 3.3333 | 7 | yes |
| GO:0005267 | potassium channel activity | 3.3333 | 6 | yes |
| GO:0022832 | voltage-gated channel activity | 3.3333 | 6 | yes |
| GO:0022843 | voltage-gated monoatomic cation channel activity | 3.3333 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SNP25_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 52.2222 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 47.7778 | 4 | yes |
| GO:0008104 | protein localization | 47.7778 | 4 | no |
| GO:0006996 | organelle organization | 47.7778 | 4 | yes |
| GO:0010646 | regulation of cell communication | 47.7778 | 4 | yes |
| GO:0051049 | regulation of transport | 44.4444 | 4 | yes |
| GO:0071702 | organic substance transport | 40.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 40.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 40.0000 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 36.6667 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 36.6667 | 4 | yes |
| GO:0015031 | protein transport | 36.6667 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 33.3333 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 32.2222 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 32.2222 | 4 | no |
| GO:0046903 | secretion | 30.0000 | 4 | yes |
| GO:0030030 | cell projection organization | 30.0000 | 4 | yes |
| GO:0061024 | membrane organization | 28.8889 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 28.8889 | 4 | no |
| GO:0051046 | regulation of secretion | 27.7778 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 27.7778 | 4 | yes |
| GO:1903530 | regulation of secretion by cell | 26.6667 | 4 | yes |
| GO:0006886 | intracellular protein transport | 26.6667 | 4 | no |
| GO:0043933 | protein-containing complex organization | 26.6667 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 26.6667 | 4 | yes |
| GO:0051050 | positive regulation of transport | 25.5556 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 25.5556 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 25.5556 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 25.5556 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 25.5556 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 24.4444 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 23.3333 | 5 | no |
| GO:0060341 | regulation of cellular localization | 22.2222 | 4 | yes |
| GO:0017157 | regulation of exocytosis | 22.2222 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 22.2222 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.2222 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 22.2222 | 4 | no |
| GO:0098657 | import into cell | 21.1111 | 4 | yes |
| GO:0010468 | regulation of gene expression | 21.1111 | 6 | no |
| GO:0016050 | vesicle organization | 21.1111 | 5 | yes |
| GO:0032880 | regulation of protein localization | 21.1111 | 5 | yes |
| GO:0065003 | protein-containing complex assembly | 20.0000 | 5 | yes |
| GO:0031344 | regulation of cell projection organization | 20.0000 | 5 | yes |
| GO:0050806 | positive regulation of synaptic transmission | 18.8889 | 5 | yes |
| GO:0099536 | synaptic signaling | 18.8889 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 18.8889 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 18.8889 | 6 | yes |
| GO:0023061 | signal release | 18.8889 | 4 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 17.7778 | 6 | yes |
| GO:0099643 | signal release from synapse | 17.7778 | 5 | yes |
| GO:0007268 | chemical synaptic transmission | 17.7778 | 7 | yes |
| GO:0051047 | positive regulation of secretion | 16.6667 | 5 | yes |
| GO:0061025 | membrane fusion | 16.6667 | 5 | yes |
| GO:0045055 | regulated exocytosis | 16.6667 | 4 | yes |
| GO:0048278 | vesicle docking | 15.5556 | 4 | yes |
| GO:0050890 | cognition | 15.5556 | 4 | yes |
| GO:1903532 | positive regulation of secretion by cell | 15.5556 | 5 | yes |
| GO:0010975 | regulation of neuron projection development | 15.5556 | 7 | yes |
| GO:0048284 | organelle fusion | 14.4444 | 5 | yes |
| GO:0090174 | organelle membrane fusion | 14.4444 | 6 | yes |
| GO:0006906 | vesicle fusion | 14.4444 | 6 | yes |
| GO:0016079 | synaptic vesicle exocytosis | 14.4444 | 4 | yes |
| GO:0048812 | neuron projection morphogenesis | 13.3333 | 5 | yes |
| GO:0050807 | regulation of synapse organization | 13.3333 | 5 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 13.3333 | 4 | yes |
| GO:0006836 | neurotransmitter transport | 13.3333 | 4 | yes |
| GO:0007612 | learning | 13.3333 | 4 | yes |
| GO:0017156 | calcium-ion regulated exocytosis | 13.3333 | 5 | yes |
| GO:0051650 | establishment of vesicle localization | 12.2222 | 4 | yes |
| GO:0070201 | regulation of establishment of protein localization | 12.2222 | 6 | yes |
| GO:1903829 | positive regulation of protein localization | 12.2222 | 5 | yes |
| GO:0051223 | regulation of protein transport | 11.1111 | 5 | yes |
| GO:0006898 | receptor-mediated endocytosis | 10.0000 | 4 | yes |
| GO:0048499 | synaptic vesicle membrane organization | 8.8889 | 5 | yes |
| GO:0060291 | long-term synaptic potentiation | 8.8889 | 4 | yes |
| GO:1901888 | regulation of cell junction assembly | 8.8889 | 5 | yes |
| GO:0031623 | receptor internalization | 8.8889 | 5 | yes |
| GO:0051963 | regulation of synapse assembly | 7.7778 | 6 | yes |
| GO:0031629 | synaptic vesicle fusion to presynaptic active zone membrane | 7.7778 | 4 | yes |
| GO:0035493 | SNARE complex assembly | 7.7778 | 6 | yes |
| GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter | 6.6667 | 5 | yes |
| GO:0050708 | regulation of protein secretion | 6.6667 | 5 | yes |
| GO:1904951 | positive regulation of establishment of protein localization | 6.6667 | 6 | yes |
| GO:0007409 | axonogenesis | 6.6667 | 6 | yes |
| GO:0008306 | associative learning | 6.6667 | 5 | yes |
| GO:0050796 | regulation of insulin secretion | 5.5556 | 6 | yes |
| GO:0051222 | positive regulation of protein transport | 5.5556 | 5 | yes |
| GO:0090087 | regulation of peptide transport | 5.5556 | 5 | yes |
| GO:0090276 | regulation of peptide hormone secretion | 5.5556 | 5 | yes |
| GO:0002791 | regulation of peptide secretion | 5.5556 | 6 | yes |
| GO:0007613 | memory | 5.5556 | 4 | yes |
| GO:0032252 | secretory granule localization | 5.5556 | 4 | yes |
| GO:0032253 | dense core granule localization | 5.5556 | 5 | yes |
| GO:0046883 | regulation of hormone secretion | 5.5556 | 4 | yes |
| GO:0098967 | exocytic insertion of neurotransmitter receptor to postsynaptic membrane | 4.4444 | 4 | yes |
| GO:1990504 | dense core granule exocytosis | 4.4444 | 5 | yes |
| GO:0001504 | neurotransmitter uptake | 4.4444 | 5 | yes |
| GO:0050714 | positive regulation of protein secretion | 3.3333 | 6 | yes |
| GO:0090277 | positive regulation of peptide hormone secretion | 3.3333 | 6 | yes |
| GO:0099011 | neuronal dense core vesicle exocytosis | 3.3333 | 6 | yes |
| GO:0099525 | presynaptic dense core vesicle exocytosis | 3.3333 | 6 | yes |
| GO:0002793 | positive regulation of peptide secretion | 3.3333 | 6 | yes |
| GO:0016081 | synaptic vesicle docking | 3.3333 | 4 | yes |
| GO:0032024 | positive regulation of insulin secretion | 3.3333 | 7 | yes |
| GO:0046887 | positive regulation of hormone secretion | 3.3333 | 5 | yes |
| GO:0007616 | long-term memory | 2.2222 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| HGS_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ITSN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STX1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RP3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VAMP8_HUMAN | [view interactions] | Low throughput | no | no |
| VAMP1_HUMAN | [view interactions] | Low throughput | no | no |
| SNAPN_HUMAN | [view interactions] | Low throughput | no | yes |
| ADCY6_HUMAN | [view interactions] | Low throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MTR1A_HUMAN | [view interactions] | Low throughput | no | no |
| STX3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CPLX1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CPLX2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VAMP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| VAMP7_HUMAN | [view interactions] | Low throughput | no | yes |
| SYT2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| STX12_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STX6_HUMAN | [view interactions] | Low throughput | no | yes |
| KINH_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SYPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DNJC5_HUMAN | [view interactions] | Low throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| STX1B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STXB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ZDH17_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNP25_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STXB5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRRT2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MTR1B_HUMAN | [view interactions] | Low throughput | no | yes |
| CAPS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STX4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| VAMP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SNAA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STX2_HUMAN | [view interactions] | Low throughput | no | no |
| TRIM9_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ZWINT_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| APBA1_HUMAN | [view interactions] | Low throughput | no | no |
| GOSR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STX5_HUMAN | [view interactions] | Low throughput | no | yes |
| KCNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYT3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SCAM1_HUMAN | [view interactions] | Low throughput | no | no |
| OSBL2_HUMAN | [view interactions] | Low throughput | no | yes |
| UN13B_HUMAN | [view interactions] | Low throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UT2_HUMAN | [view interactions] | High throughput | no | no |
| RD23B_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| VAMP5_HUMAN | [view interactions] | High throughput | no | no |
| SPTCS_HUMAN | [view interactions] | High throughput | no | yes |
| VA0D1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCKP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PACS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFHX3_HUMAN | [view interactions] | High throughput | no | yes |
| MAP6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGBM_HUMAN | [view interactions] | High throughput | no | no |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NSF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNP29_HUMAN | [view interactions] | High throughput | no | yes |
| SYN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPG_HUMAN | [view interactions] | High throughput | no | yes |
| TTYH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VAS1_HUMAN | [view interactions] | High throughput | no | yes |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPB_HUMAN | [view interactions] | High throughput | no | yes |
| AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FHL1_HUMAN | [view interactions] | High throughput | no | no |
| RAB6B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEPT5_HUMAN | [view interactions] | High throughput | no | no |
| GGYF1_HUMAN | [view interactions] | High throughput | no | yes |
| WASC3_HUMAN | [view interactions] | High throughput | no | yes |
| STX11_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UQCC2_HUMAN | [view interactions] | High throughput | no | yes |
| STX19_HUMAN | [view interactions] | High throughput | no | yes |
| ZN177_HUMAN | [view interactions] | High throughput | no | no |
| SGTA_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLP1R_HUMAN | [view interactions] | High throughput | no | no |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SEGN_HUMAN | [view interactions] | High throughput | no | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| OSBP1_HUMAN | [view interactions] | High throughput | no | yes |
| OSBL5_HUMAN | [view interactions] | High throughput | no | yes |
| OSBL8_HUMAN | [view interactions] | High throughput | no | yes |
| OSB10_HUMAN | [view interactions] | High throughput | no | no |
| OSB11_HUMAN | [view interactions] | High throughput | no | no |
| NDUS5_HUMAN | [view interactions] | High throughput | no | yes |
| NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCS1N_HUMAN | [view interactions] | High throughput | no | no |
| SCG1_HUMAN | [view interactions] | High throughput | no | no |
| CX6A1_HUMAN | [view interactions] | High throughput | no | yes |
| ENOG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STMN3_HUMAN | [view interactions] | High throughput | no | yes |
| CPLX3_HUMAN | [view interactions] | High throughput | no | no |
| NDUBA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEGR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALDOC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNAB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEC2_HUMAN | [view interactions] | High throughput | no | no |
| MYPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNP47_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR6L_HUMAN | [view interactions] | High throughput | no | yes |
| QCR6_HUMAN | [view interactions] | High throughput | no | yes |
| CX6B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CNTP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NRX1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTRK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |
| NBEA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |