Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SNP25_HUMAN

t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in SNP25_HUMAN
GO:0046872 metal ion binding 27.0270 4 no
GO:0017076 purine nucleotide binding 21.6216 4 no
GO:0032555 purine ribonucleotide binding 21.6216 4 no
GO:0035639 purine ribonucleoside triphosphate binding 20.7207 4 no
GO:0019905 syntaxin binding 18.9189 4 yes
GO:0008324 cation transmembrane transporter activity 12.6126 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 12.6126 4 yes
GO:0046873 metal ion transmembrane transporter activity 10.8108 5 yes
GO:0017075 syntaxin-1 binding 9.9099 5 yes
GO:0005216 ion channel activity 7.2072 4 yes
GO:0015267 channel activity 7.2072 4 yes
GO:0005261 cation channel activity 6.3063 5 yes
GO:0022836 gated channel activity 6.3063 5 yes
GO:0005244 voltage-gated ion channel activity 5.4054 4 yes
GO:0022832 voltage-gated channel activity 5.4054 6 yes
GO:0022843 voltage-gated cation channel activity 5.4054 5 yes
GO:0015079 potassium ion transmembrane transporter activity 4.5045 6 yes
GO:0005249 voltage-gated potassium channel activity 2.7027 6 yes
GO:0005267 potassium channel activity 2.7027 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SNP25_HUMAN
GO:0048522 positive regulation of cellular process 52.2523 4 yes
GO:0016192 vesicle-mediated transport 48.6486 4 yes
GO:0051049 regulation of transport 47.7477 4 yes
GO:0008104 protein localization 47.7477 4 no
GO:0010646 regulation of cell communication 44.1441 4 yes
GO:0051128 regulation of cellular component organization 43.2432 4 yes
GO:0071702 organic substance transport 43.2432 4 no
GO:0006996 organelle organization 42.3423 4 yes
GO:0071705 nitrogen compound transport 42.3423 4 no
GO:0015031 protein transport 39.6396 4 no
GO:0046903 secretion 36.9369 4 yes
GO:0022607 cellular component assembly 35.1351 4 yes
GO:0050804 modulation of chemical synaptic transmission 35.1351 5 yes
GO:0099177 regulation of trans-synaptic signaling 35.1351 4 yes
GO:0006887 exocytosis 33.3333 4 yes
GO:0051046 regulation of secretion 31.5315 5 yes
GO:0060627 regulation of vesicle-mediated transport 30.6306 4 no
GO:1903530 regulation of secretion by cell 29.7297 4 yes
GO:0048523 negative regulation of cellular process 27.9279 4 no
GO:0060255 regulation of macromolecule metabolic process 27.0270 4 no
GO:0023061 signal release 26.1261 4 yes
GO:0043933 protein-containing complex organization 26.1261 4 yes
GO:0061024 membrane organization 26.1261 4 yes
GO:0006886 intracellular protein transport 26.1261 4 no
GO:0043269 regulation of ion transport 25.2252 5 no
GO:0051050 positive regulation of transport 25.2252 4 no
GO:0017157 regulation of exocytosis 25.2252 5 no
GO:0023056 positive regulation of signaling 23.4234 4 yes
GO:0060341 regulation of cellular localization 23.4234 4 yes
GO:0099643 signal release from synapse 23.4234 5 yes
GO:0016050 vesicle organization 22.5225 5 yes
GO:0032880 regulation of protein localization 22.5225 5 yes
GO:0031323 regulation of cellular metabolic process 22.5225 4 no
GO:0010647 positive regulation of cell communication 21.6216 5 yes
GO:0045055 regulated exocytosis 21.6216 5 yes
GO:0080090 regulation of primary metabolic process 21.6216 4 no
GO:0009893 positive regulation of metabolic process 21.6216 4 no
GO:0065003 protein-containing complex assembly 20.7207 5 yes
GO:0051171 regulation of nitrogen compound metabolic process 20.7207 4 no
GO:0009966 regulation of signal transduction 20.7207 4 no
GO:0099003 vesicle-mediated transport in synapse 19.8198 5 yes
GO:0099537 trans-synaptic signaling 19.8198 4 yes
GO:0061025 membrane fusion 18.9189 5 yes
GO:0007268 chemical synaptic transmission 18.0180 6 yes
GO:0098916 anterograde trans-synaptic signaling 18.0180 5 yes
GO:0006836 neurotransmitter transport 17.1171 4 yes
GO:0016079 synaptic vesicle exocytosis 16.2162 4 yes
GO:0006906 vesicle fusion 15.3153 6 yes
GO:0048284 organelle fusion 15.3153 5 yes
GO:0090174 organelle membrane fusion 15.3153 6 yes
GO:0006897 endocytosis 14.4144 5 yes
GO:0031344 regulation of cell projection organization 14.4144 5 yes
GO:0048278 vesicle docking 14.4144 4 yes
GO:0050806 positive regulation of synaptic transmission 14.4144 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 13.5135 6 yes
GO:0070201 regulation of establishment of protein localization 12.6126 6 yes
GO:0051223 regulation of protein transport 11.7117 5 yes
GO:0050890 cognition 10.8108 4 yes
GO:0010975 regulation of neuron projection development 9.9099 7 yes
GO:0007612 learning 9.0090 4 yes
GO:0048499 synaptic vesicle membrane organization 9.0090 5 yes
GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane 8.1081 4 yes
GO:0050708 regulation of protein secretion 8.1081 5 yes
GO:0006898 receptor-mediated endocytosis 7.2072 6 yes
GO:0046883 regulation of hormone secretion 6.3063 4 yes
GO:0060291 long-term synaptic potentiation 6.3063 4 yes
GO:0002791 regulation of peptide secretion 5.4054 6 yes
GO:0008306 associative learning 5.4054 5 yes
GO:0031623 receptor internalization 5.4054 7 yes
GO:0050796 regulation of insulin secretion 5.4054 6 yes
GO:0090087 regulation of peptide transport 5.4054 5 yes
GO:0090276 regulation of peptide hormone secretion 5.4054 5 yes
GO:0098657 import into cell 5.4054 4 yes
GO:0016081 synaptic vesicle docking 4.5045 4 yes
GO:0098967 exocytic insertion of neurotransmitter receptor to postsynaptic membrane 4.5045 4 yes
GO:0001504 neurotransmitter uptake 3.6036 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in SNP25_HUMAN
DOID:331 central nervous system disease 4.5045 3 no
DOID:936 brain disease 4.5045 4 no
DOID:1826 epilepsy 3.6036 5 no
DOID:0050701 electroclinical syndrome 2.7027 6 no
DOID:0112202 developmental and epileptic encephalopathy 1.8018 7 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
HGS_HUMAN [view entry] [view interactions] Low throughput yes yes
ITSN1_HUMAN [view entry] [view interactions] Low throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] Low throughput yes yes
DCTN2_HUMAN [view entry] [view interactions] Low throughput yes yes
SYT1_HUMAN [view entry] [view interactions] Low throughput yes no
DYN1_HUMAN [view entry] [view interactions] Low throughput yes yes
STX1A_HUMAN [view entry] [view interactions] Low throughput yes yes
RP3A_HUMAN [view entry] [view interactions] Low throughput yes yes
VAMP1_HUMAN [view interactions] Low throughput no no
VAMP8_HUMAN [view interactions] Low throughput no no
SNAPN_HUMAN [view interactions] Low throughput no yes
ADCY6_HUMAN [view interactions] Low throughput no yes
HD_HUMAN [view entry] [view interactions] Low throughput yes yes
MTR1A_HUMAN [view interactions] Low throughput no no
STX3_HUMAN [view entry] [view interactions] Low throughput yes no
CPLX1_HUMAN [view entry] [view interactions] Low throughput yes yes
CPLX2_HUMAN [view entry] [view interactions] Low throughput yes yes
VAMP2_HUMAN [view entry] [view interactions] Low throughput yes no
VAMP7_HUMAN [view interactions] Low throughput no yes
SYT2_HUMAN [view entry] [view interactions] Low throughput yes no
STX6_HUMAN [view interactions] Low throughput no yes
STX12_HUMAN [view entry] [view interactions] Low throughput yes yes
SYPH_HUMAN [view entry] [view interactions] Low throughput yes yes
KINH_HUMAN [view entry] [view interactions] Low throughput yes no
SYUA_HUMAN [view entry] [view interactions] Low throughput yes no
DNJC5_HUMAN [view interactions] Low throughput no yes
ARF1_HUMAN [view entry] [view interactions] Low throughput yes yes
STXB1_HUMAN [view entry] [view interactions] Low throughput yes yes
STX1B_HUMAN [view entry] [view interactions] Low throughput yes yes
ZDH17_HUMAN [view interactions] Low throughput no yes
SNP25_HUMAN [view entry] [view interactions] Low throughput yes yes
STXB5_HUMAN [view entry] [view interactions] Low throughput yes yes
PRRT2_HUMAN [view entry] [view interactions] Low throughput yes no
MTR1B_HUMAN [view interactions] Low throughput no yes
CAPS1_HUMAN [view entry] [view interactions] Low throughput yes yes
STX4_HUMAN [view entry] [view interactions] Low throughput yes no
VAMP3_HUMAN [view entry] [view interactions] Low throughput yes no
SNAA_HUMAN [view entry] [view interactions] Low throughput yes yes
STX2_HUMAN [view interactions] Low throughput no no
TRIM9_HUMAN [view entry] [view interactions] Low throughput yes no
ZWINT_HUMAN [view entry] [view interactions] Low throughput yes no
APBA1_HUMAN [view interactions] Low throughput no no
GOSR1_HUMAN [view entry] [view interactions] Low throughput yes yes
STX5_HUMAN [view interactions] Low throughput no yes
KCNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
SYT3_HUMAN [view entry] [view interactions] Low throughput yes no
SCAM1_HUMAN [view interactions] Low throughput no no
OSBL2_HUMAN [view interactions] Low throughput no yes
UN13B_HUMAN [view interactions] Low throughput no no
SNAB_HUMAN [view entry] [view interactions] High throughput yes yes
NEC2_HUMAN [view interactions] High throughput no no
MYPR_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A1_HUMAN [view entry] [view interactions] High throughput yes no
SNP47_HUMAN [view entry] [view interactions] High throughput yes yes
QCR6L_HUMAN [view interactions] High throughput no yes
QCR6_HUMAN [view interactions] High throughput no yes
CX6B1_HUMAN [view entry] [view interactions] High throughput yes yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
NBEA_HUMAN [view entry] [view interactions] High throughput yes yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
UT2_HUMAN [view interactions] High throughput no no
RD23B_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
VAMP5_HUMAN [view interactions] High throughput no no
AP2B1_HUMAN [view entry] [view interactions] High throughput yes yes
PGBM_HUMAN [view interactions] High throughput no no
TBA1B_HUMAN [view entry] [view interactions] High throughput yes yes
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
AP2A1_HUMAN [view entry] [view interactions] High throughput yes yes
TBB2A_HUMAN [view entry] [view interactions] High throughput yes yes
TBB2B_HUMAN [view entry] [view interactions] High throughput yes yes
AT1A1_HUMAN [view entry] [view interactions] High throughput yes no
MAP6_HUMAN [view entry] [view interactions] High throughput yes yes
ZFHX3_HUMAN [view interactions] High throughput no yes
KIF5C_HUMAN [view entry] [view interactions] High throughput yes yes
G3P_HUMAN [view entry] [view interactions] High throughput yes yes
PACS1_HUMAN [view entry] [view interactions] High throughput yes yes
NCKP1_HUMAN [view entry] [view interactions] High throughput yes yes
TBA4A_HUMAN [view entry] [view interactions] High throughput yes yes
TBB5_HUMAN [view interactions] High throughput no yes
VA0D1_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
RAB6B_HUMAN [view entry] [view interactions] High throughput yes yes
FHL1_HUMAN [view interactions] High throughput no no
AT1B1_HUMAN [view entry] [view interactions] High throughput yes no
ATPB_HUMAN [view interactions] High throughput no yes
MAP1B_HUMAN [view entry] [view interactions] High throughput yes yes
ATPA_HUMAN [view interactions] High throughput no yes
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
VAS1_HUMAN [view interactions] High throughput no yes
TTYH1_HUMAN [view entry] [view interactions] High throughput yes no
ATPG_HUMAN [view interactions] High throughput no yes
RAB3A_HUMAN [view entry] [view interactions] High throughput yes yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
SYN1_HUMAN [view entry] [view interactions] High throughput yes no
SNP29_HUMAN [view interactions] High throughput no yes
NSF_HUMAN [view entry] [view interactions] High throughput yes yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
SEPT5_HUMAN [view interactions] High throughput no no
WASC3_HUMAN [view interactions] High throughput no yes
STX11_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
UQCC2_HUMAN [view interactions] High throughput no yes
STX19_HUMAN [view interactions] High throughput no yes
ZN177_HUMAN [view interactions] High throughput no no
SGTA_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
NUFP1_HUMAN [view interactions] High throughput no yes
DGUOK_HUMAN [view interactions] High throughput no yes
KTU_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
GLP1R_HUMAN [view interactions] High throughput no no
TIA1_HUMAN [view interactions] High throughput no no
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
SEGN_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
FBX7_HUMAN [view interactions] High throughput no yes
OSBP1_HUMAN [view interactions] High throughput no yes
OSBL5_HUMAN [view interactions] High throughput no yes
OSBL8_HUMAN [view interactions] High throughput no yes
OSB10_HUMAN [view interactions] High throughput no no
OSB11_HUMAN [view interactions] High throughput no no
NDUS5_HUMAN [view interactions] High throughput no yes
NDUV1_HUMAN [view entry] [view interactions] High throughput yes yes
PCS1N_HUMAN [view interactions] High throughput no no
SCG1_HUMAN [view interactions] High throughput no no
CX6A1_HUMAN [view interactions] High throughput no yes
ENOG_HUMAN [view entry] [view interactions] High throughput yes yes
DCE1_HUMAN [view entry] [view interactions] High throughput yes yes
SDCB1_HUMAN [view entry] [view interactions] High throughput yes yes
STMN3_HUMAN [view interactions] High throughput no yes
CPLX3_HUMAN [view interactions] High throughput no no
NDUBA_HUMAN [view entry] [view interactions] High throughput yes yes
NEGR1_HUMAN [view entry] [view interactions] High throughput yes yes
NPTN_HUMAN [view entry] [view interactions] High throughput yes yes
ALDOC_HUMAN [view entry] [view interactions] High throughput yes yes
CNTN1_HUMAN [view entry] [view interactions] High throughput yes yes
GNAO_HUMAN [view entry] [view interactions] High throughput yes yes
DCE2_HUMAN [view interactions] Computational no yes
SNX4_HUMAN [view entry] [view interactions] Computational yes yes
SV2A_HUMAN [view entry] [view interactions] Computational yes yes
STX16_HUMAN [view interactions] Computational no yes
STX17_HUMAN [view interactions] Computational no yes
CPLX4_HUMAN [view interactions] Computational no no
VGLU1_HUMAN [view entry] [view interactions] Computational yes no
RAB28_HUMAN [view interactions] Computational no yes
SYT4_HUMAN [view entry] [view interactions] Computational yes yes
LIN7A_HUMAN [view entry] [view interactions] Computational yes yes
SYN2_HUMAN [view entry] [view interactions] Computational yes no
RBGPR_HUMAN [view entry] [view interactions] Computational yes yes
SYT9_HUMAN [view interactions] Computational no no
EXOC6_HUMAN [view entry] [view interactions] Computational yes yes
CACB3_HUMAN [view entry] [view interactions] Computational yes no
CAV1_HUMAN [view interactions] Computational no no
INS_HUMAN [view interactions] Computational no no
EXOC3_HUMAN [view entry] [view interactions] Computational yes no
SYNPR_HUMAN [view interactions] Computational no no
CA2D2_HUMAN [view entry] [view interactions] Computational yes yes
LIN7B_HUMAN [view entry] [view interactions] Computational yes no
SYT7_HUMAN [view entry] [view interactions] Computational yes yes
RPGF4_HUMAN [view entry] [view interactions] Computational yes yes
SYT11_HUMAN [view entry] [view interactions] Computational yes yes
STXB6_HUMAN [view interactions] Computational no yes
SNP23_HUMAN [view entry] [view interactions] Computational yes no
GOSR2_HUMAN [view interactions] Computational no yes
RIMS2_HUMAN [view entry] [view interactions] Computational yes no
STB5L_HUMAN [view interactions] Computational no no
SYT5_HUMAN [view entry] [view interactions] Computational yes no
RIMS1_HUMAN [view entry] [view interactions] Computational yes yes
GNAI1_HUMAN [view entry] [view interactions] Computational yes yes
STXB2_HUMAN [view interactions] Computational no no
TXLNA_HUMAN [view interactions] Computational no yes
OTOF_HUMAN [view interactions] Computational no yes
UN13A_HUMAN [view entry] [view interactions] Computational yes no
GNAI2_HUMAN [view entry] [view interactions] Computational yes yes
SYN3_HUMAN [view entry] [view interactions] Computational yes yes
CACB2_HUMAN [view interactions] Computational no yes
LIN7C_HUMAN [view entry] [view interactions] Computational yes yes
YKT6_HUMAN [view interactions] Computational no yes
STX18_HUMAN [view interactions] Computational no yes
VIAAT_HUMAN [view interactions] Computational no yes
CAC1C_HUMAN [view entry] [view interactions] Computational yes no
VAPA_HUMAN [view entry] [view interactions] Computational yes yes
VAMP4_HUMAN [view interactions] Computational no yes
CAC1D_HUMAN [view interactions] Computational no yes