SNP25_HUMAN
t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in SNP25_HUMAN |
---|---|---|---|---|
GO:0046872 | metal ion binding | 27.0270 | 4 | no |
GO:0017076 | purine nucleotide binding | 21.6216 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 21.6216 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 20.7207 | 4 | no |
GO:0019905 | syntaxin binding | 18.9189 | 4 | yes |
GO:0008324 | cation transmembrane transporter activity | 12.6126 | 4 | yes |
GO:0022890 | inorganic cation transmembrane transporter activity | 12.6126 | 4 | yes |
GO:0046873 | metal ion transmembrane transporter activity | 10.8108 | 5 | yes |
GO:0017075 | syntaxin-1 binding | 9.9099 | 5 | yes |
GO:0005216 | ion channel activity | 7.2072 | 4 | yes |
GO:0015267 | channel activity | 7.2072 | 4 | yes |
GO:0005261 | cation channel activity | 6.3063 | 5 | yes |
GO:0022836 | gated channel activity | 6.3063 | 5 | yes |
GO:0005244 | voltage-gated ion channel activity | 5.4054 | 4 | yes |
GO:0022832 | voltage-gated channel activity | 5.4054 | 6 | yes |
GO:0022843 | voltage-gated cation channel activity | 5.4054 | 5 | yes |
GO:0015079 | potassium ion transmembrane transporter activity | 4.5045 | 6 | yes |
GO:0005249 | voltage-gated potassium channel activity | 2.7027 | 6 | yes |
GO:0005267 | potassium channel activity | 2.7027 | 6 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in SNP25_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 52.2523 | 4 | yes |
GO:0016192 | vesicle-mediated transport | 48.6486 | 4 | yes |
GO:0051049 | regulation of transport | 47.7477 | 4 | yes |
GO:0008104 | protein localization | 47.7477 | 4 | no |
GO:0010646 | regulation of cell communication | 44.1441 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 43.2432 | 4 | yes |
GO:0071702 | organic substance transport | 43.2432 | 4 | no |
GO:0006996 | organelle organization | 42.3423 | 4 | yes |
GO:0071705 | nitrogen compound transport | 42.3423 | 4 | no |
GO:0015031 | protein transport | 39.6396 | 4 | no |
GO:0046903 | secretion | 36.9369 | 4 | yes |
GO:0022607 | cellular component assembly | 35.1351 | 4 | yes |
GO:0050804 | modulation of chemical synaptic transmission | 35.1351 | 5 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 35.1351 | 4 | yes |
GO:0006887 | exocytosis | 33.3333 | 4 | yes |
GO:0051046 | regulation of secretion | 31.5315 | 5 | yes |
GO:0060627 | regulation of vesicle-mediated transport | 30.6306 | 4 | no |
GO:1903530 | regulation of secretion by cell | 29.7297 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 27.9279 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 27.0270 | 4 | no |
GO:0023061 | signal release | 26.1261 | 4 | yes |
GO:0043933 | protein-containing complex organization | 26.1261 | 4 | yes |
GO:0061024 | membrane organization | 26.1261 | 4 | yes |
GO:0006886 | intracellular protein transport | 26.1261 | 4 | no |
GO:0043269 | regulation of ion transport | 25.2252 | 5 | no |
GO:0051050 | positive regulation of transport | 25.2252 | 4 | no |
GO:0017157 | regulation of exocytosis | 25.2252 | 5 | no |
GO:0023056 | positive regulation of signaling | 23.4234 | 4 | yes |
GO:0060341 | regulation of cellular localization | 23.4234 | 4 | yes |
GO:0099643 | signal release from synapse | 23.4234 | 5 | yes |
GO:0016050 | vesicle organization | 22.5225 | 5 | yes |
GO:0032880 | regulation of protein localization | 22.5225 | 5 | yes |
GO:0031323 | regulation of cellular metabolic process | 22.5225 | 4 | no |
GO:0010647 | positive regulation of cell communication | 21.6216 | 5 | yes |
GO:0045055 | regulated exocytosis | 21.6216 | 5 | yes |
GO:0080090 | regulation of primary metabolic process | 21.6216 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 21.6216 | 4 | no |
GO:0065003 | protein-containing complex assembly | 20.7207 | 5 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 20.7207 | 4 | no |
GO:0009966 | regulation of signal transduction | 20.7207 | 4 | no |
GO:0099003 | vesicle-mediated transport in synapse | 19.8198 | 5 | yes |
GO:0099537 | trans-synaptic signaling | 19.8198 | 4 | yes |
GO:0061025 | membrane fusion | 18.9189 | 5 | yes |
GO:0007268 | chemical synaptic transmission | 18.0180 | 6 | yes |
GO:0098916 | anterograde trans-synaptic signaling | 18.0180 | 5 | yes |
GO:0006836 | neurotransmitter transport | 17.1171 | 4 | yes |
GO:0016079 | synaptic vesicle exocytosis | 16.2162 | 4 | yes |
GO:0006906 | vesicle fusion | 15.3153 | 6 | yes |
GO:0048284 | organelle fusion | 15.3153 | 5 | yes |
GO:0090174 | organelle membrane fusion | 15.3153 | 6 | yes |
GO:0006897 | endocytosis | 14.4144 | 5 | yes |
GO:0031344 | regulation of cell projection organization | 14.4144 | 5 | yes |
GO:0048278 | vesicle docking | 14.4144 | 4 | yes |
GO:0050806 | positive regulation of synaptic transmission | 14.4144 | 5 | yes |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 13.5135 | 6 | yes |
GO:0070201 | regulation of establishment of protein localization | 12.6126 | 6 | yes |
GO:0051223 | regulation of protein transport | 11.7117 | 5 | yes |
GO:0050890 | cognition | 10.8108 | 4 | yes |
GO:0010975 | regulation of neuron projection development | 9.9099 | 7 | yes |
GO:0007612 | learning | 9.0090 | 4 | yes |
GO:0048499 | synaptic vesicle membrane organization | 9.0090 | 5 | yes |
GO:0031629 | synaptic vesicle fusion to presynaptic active zone membrane | 8.1081 | 4 | yes |
GO:0050708 | regulation of protein secretion | 8.1081 | 5 | yes |
GO:0006898 | receptor-mediated endocytosis | 7.2072 | 6 | yes |
GO:0046883 | regulation of hormone secretion | 6.3063 | 4 | yes |
GO:0060291 | long-term synaptic potentiation | 6.3063 | 4 | yes |
GO:0002791 | regulation of peptide secretion | 5.4054 | 6 | yes |
GO:0008306 | associative learning | 5.4054 | 5 | yes |
GO:0031623 | receptor internalization | 5.4054 | 7 | yes |
GO:0050796 | regulation of insulin secretion | 5.4054 | 6 | yes |
GO:0090087 | regulation of peptide transport | 5.4054 | 5 | yes |
GO:0090276 | regulation of peptide hormone secretion | 5.4054 | 5 | yes |
GO:0098657 | import into cell | 5.4054 | 4 | yes |
GO:0016081 | synaptic vesicle docking | 4.5045 | 4 | yes |
GO:0098967 | exocytic insertion of neurotransmitter receptor to postsynaptic membrane | 4.5045 | 4 | yes |
GO:0001504 | neurotransmitter uptake | 3.6036 | 4 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in SNP25_HUMAN |
---|---|---|---|---|
DOID:331 | central nervous system disease | 4.5045 | 3 | no |
DOID:936 | brain disease | 4.5045 | 4 | no |
DOID:1826 | epilepsy | 3.6036 | 5 | no |
DOID:0050701 | electroclinical syndrome | 2.7027 | 6 | no |
DOID:0112202 | developmental and epileptic encephalopathy | 1.8018 | 7 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
HGS_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ITSN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SRCN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DCTN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SYT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
DYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
STX1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RP3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
VAMP1_HUMAN | [view interactions] | Low throughput | no | no |
VAMP8_HUMAN | [view interactions] | Low throughput | no | no |
SNAPN_HUMAN | [view interactions] | Low throughput | no | yes |
ADCY6_HUMAN | [view interactions] | Low throughput | no | yes |
HD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MTR1A_HUMAN | [view interactions] | Low throughput | no | no |
STX3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CPLX1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CPLX2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
VAMP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
VAMP7_HUMAN | [view interactions] | Low throughput | no | yes |
SYT2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
STX6_HUMAN | [view interactions] | Low throughput | no | yes |
STX12_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SYPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KINH_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
SYUA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
DNJC5_HUMAN | [view interactions] | Low throughput | no | yes |
ARF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
STXB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
STX1B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ZDH17_HUMAN | [view interactions] | Low throughput | no | yes |
SNP25_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
STXB5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PRRT2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
MTR1B_HUMAN | [view interactions] | Low throughput | no | yes |
CAPS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
STX4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
VAMP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
SNAA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
STX2_HUMAN | [view interactions] | Low throughput | no | no |
TRIM9_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ZWINT_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
APBA1_HUMAN | [view interactions] | Low throughput | no | no |
GOSR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
STX5_HUMAN | [view interactions] | Low throughput | no | yes |
KCNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SYT3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
SCAM1_HUMAN | [view interactions] | Low throughput | no | no |
OSBL2_HUMAN | [view interactions] | Low throughput | no | yes |
UN13B_HUMAN | [view interactions] | Low throughput | no | no |
SNAB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NEC2_HUMAN | [view interactions] | High throughput | no | no |
MYPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SC6A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SNP47_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
QCR6L_HUMAN | [view interactions] | High throughput | no | yes |
QCR6_HUMAN | [view interactions] | High throughput | no | yes |
CX6B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NBEA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UT2_HUMAN | [view interactions] | High throughput | no | no |
RD23B_HUMAN | [view interactions] | High throughput | no | yes |
LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
VAMP5_HUMAN | [view interactions] | High throughput | no | no |
AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PGBM_HUMAN | [view interactions] | High throughput | no | no |
TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBB2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AT1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MAP6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZFHX3_HUMAN | [view interactions] | High throughput | no | yes |
KIF5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PACS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NCKP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBB5_HUMAN | [view interactions] | High throughput | no | yes |
VA0D1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
RAB6B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FHL1_HUMAN | [view interactions] | High throughput | no | no |
AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ATPB_HUMAN | [view interactions] | High throughput | no | yes |
MAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATPA_HUMAN | [view interactions] | High throughput | no | yes |
RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VAS1_HUMAN | [view interactions] | High throughput | no | yes |
TTYH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ATPG_HUMAN | [view interactions] | High throughput | no | yes |
RAB3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SNP29_HUMAN | [view interactions] | High throughput | no | yes |
NSF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SEPT5_HUMAN | [view interactions] | High throughput | no | no |
WASC3_HUMAN | [view interactions] | High throughput | no | yes |
STX11_HUMAN | [view interactions] | High throughput | no | yes |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UQCC2_HUMAN | [view interactions] | High throughput | no | yes |
STX19_HUMAN | [view interactions] | High throughput | no | yes |
ZN177_HUMAN | [view interactions] | High throughput | no | no |
SGTA_HUMAN | [view interactions] | High throughput | no | yes |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
KTU_HUMAN | [view interactions] | High throughput | no | yes |
NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GLP1R_HUMAN | [view interactions] | High throughput | no | no |
TIA1_HUMAN | [view interactions] | High throughput | no | no |
GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SEGN_HUMAN | [view interactions] | High throughput | no | no |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FBX7_HUMAN | [view interactions] | High throughput | no | yes |
OSBP1_HUMAN | [view interactions] | High throughput | no | yes |
OSBL5_HUMAN | [view interactions] | High throughput | no | yes |
OSBL8_HUMAN | [view interactions] | High throughput | no | yes |
OSB10_HUMAN | [view interactions] | High throughput | no | no |
OSB11_HUMAN | [view interactions] | High throughput | no | no |
NDUS5_HUMAN | [view interactions] | High throughput | no | yes |
NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PCS1N_HUMAN | [view interactions] | High throughput | no | no |
SCG1_HUMAN | [view interactions] | High throughput | no | no |
CX6A1_HUMAN | [view interactions] | High throughput | no | yes |
ENOG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DCE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SDCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STMN3_HUMAN | [view interactions] | High throughput | no | yes |
CPLX3_HUMAN | [view interactions] | High throughput | no | no |
NDUBA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NEGR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ALDOC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CNTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GNAO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DCE2_HUMAN | [view interactions] | Computational | no | yes |
SNX4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SV2A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
STX16_HUMAN | [view interactions] | Computational | no | yes |
STX17_HUMAN | [view interactions] | Computational | no | yes |
CPLX4_HUMAN | [view interactions] | Computational | no | no |
VGLU1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
RAB28_HUMAN | [view interactions] | Computational | no | yes |
SYT4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
LIN7A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SYN2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
RBGPR_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SYT9_HUMAN | [view interactions] | Computational | no | no |
EXOC6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CACB3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
CAV1_HUMAN | [view interactions] | Computational | no | no |
INS_HUMAN | [view interactions] | Computational | no | no |
EXOC3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
SYNPR_HUMAN | [view interactions] | Computational | no | no |
CA2D2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
LIN7B_HUMAN | [view entry] [view interactions] | Computational | yes | no |
SYT7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RPGF4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SYT11_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
STXB6_HUMAN | [view interactions] | Computational | no | yes |
SNP23_HUMAN | [view entry] [view interactions] | Computational | yes | no |
GOSR2_HUMAN | [view interactions] | Computational | no | yes |
RIMS2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
STB5L_HUMAN | [view interactions] | Computational | no | no |
SYT5_HUMAN | [view entry] [view interactions] | Computational | yes | no |
RIMS1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GNAI1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
STXB2_HUMAN | [view interactions] | Computational | no | no |
TXLNA_HUMAN | [view interactions] | Computational | no | yes |
OTOF_HUMAN | [view interactions] | Computational | no | yes |
UN13A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
GNAI2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SYN3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CACB2_HUMAN | [view interactions] | Computational | no | yes |
LIN7C_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
YKT6_HUMAN | [view interactions] | Computational | no | yes |
STX18_HUMAN | [view interactions] | Computational | no | yes |
VIAAT_HUMAN | [view interactions] | Computational | no | yes |
CAC1C_HUMAN | [view entry] [view interactions] | Computational | yes | no |
VAPA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
VAMP4_HUMAN | [view interactions] | Computational | no | yes |
CAC1D_HUMAN | [view interactions] | Computational | no | yes |