NEGR1_HUMAN
Evidence for PS localization
Functions
May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NEGR1_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 26.0870 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NEGR1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 60.8696 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 52.1739 | 4 | yes |
| GO:0051049 | regulation of transport | 43.4783 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 39.1304 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 39.1304 | 6 | yes |
| GO:0010646 | regulation of cell communication | 30.4348 | 4 | no |
| GO:0022607 | cellular component assembly | 30.4348 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 30.4348 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 30.4348 | 4 | no |
| GO:0043269 | regulation of ion transport | 30.4348 | 5 | no |
| GO:0010975 | regulation of neuron projection development | 26.0870 | 7 | yes |
| GO:0031346 | positive regulation of cell projection organization | 26.0870 | 6 | yes |
| GO:0051130 | positive regulation of cellular component organization | 26.0870 | 5 | yes |
| GO:0016192 | vesicle-mediated transport | 26.0870 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 26.0870 | 5 | no |
| GO:0051046 | regulation of secretion | 26.0870 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 26.0870 | 4 | no |
| GO:1903530 | regulation of secretion by cell | 26.0870 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.0870 | 5 | no |
| GO:0051050 | positive regulation of transport | 26.0870 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 21.7391 | 4 | yes |
| GO:0050807 | regulation of synapse organization | 21.7391 | 5 | yes |
| GO:0050890 | cognition | 21.7391 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 21.7391 | 7 | no |
| GO:0010468 | regulation of gene expression | 21.7391 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 21.7391 | 6 | no |
| GO:0030030 | cell projection organization | 21.7391 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 21.7391 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 21.7391 | 5 | no |
| GO:0031399 | regulation of protein modification process | 21.7391 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 21.7391 | 7 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 21.7391 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 21.7391 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 21.7391 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 21.7391 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 21.7391 | 5 | no |
| GO:0010941 | regulation of cell death | 21.7391 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 21.7391 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 21.7391 | 5 | no |
| GO:0043270 | positive regulation of ion transport | 21.7391 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 21.7391 | 4 | no |
| GO:0010976 | positive regulation of neuron projection development | 17.3913 | 7 | yes |
| GO:0007420 | brain development | 13.0435 | 4 | yes |
| GO:0051963 | regulation of synapse assembly | 8.6957 | 6 | yes |
| GO:1901888 | regulation of cell junction assembly | 8.6957 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NPC2_HUMAN | [view interactions] | Low throughput | no | yes |
| NEGR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IGLO5_HUMAN | [view interactions] | Low throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LSAMP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTRI_HUMAN | [view interactions] | High throughput | no | yes |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GLMN_HUMAN | [view interactions] | High throughput | no | no |
| CX6A1_HUMAN | [view interactions] | High throughput | no | yes |
| DIRA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUBA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALDOC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CX6B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNP25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| QCR6L_HUMAN | [view interactions] | High throughput | no | yes |
| QCR6_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS5_HUMAN | [view interactions] | High throughput | no | yes |
| LANC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNPI2_HUMAN | [view interactions] | Computational | no | yes |
| TMM18_HUMAN | [view interactions] | Computational | no | yes |
| KCD15_HUMAN | [view interactions] | Computational | no | no |
| MTCH2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SH2B1_HUMAN | [view interactions] | Computational | no | yes |