LANC1_HUMAN
Evidence for PS localization
Functions
Functions as glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism . May play a role in EPS8 signaling. Binds glutathione (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in LANC1_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 27.7778 | 4 | yes |
| GO:0019900 | kinase binding | 22.2222 | 4 | no |
| GO:0008270 | zinc ion binding | 8.3333 | 6 | yes |
| GO:0017124 | SH3 domain binding | 8.3333 | 4 | yes |
| GO:0046914 | transition metal ion binding | 8.3333 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in LANC1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 66.6667 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 55.5556 | 4 | no |
| GO:0010646 | regulation of cell communication | 55.5556 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | no |
| GO:0006996 | organelle organization | 50.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 50.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 47.2222 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 47.2222 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 47.2222 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 44.4444 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 41.6667 | 4 | no |
| GO:0010468 | regulation of gene expression | 41.6667 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 38.8889 | 5 | no |
| GO:0022607 | cellular component assembly | 38.8889 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 36.1111 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 33.3333 | 5 | no |
| GO:0051049 | regulation of transport | 33.3333 | 4 | no |
| GO:0010941 | regulation of cell death | 33.3333 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 33.3333 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 30.5556 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 30.5556 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 30.5556 | 6 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.5556 | 5 | no |
| GO:0008104 | protein localization | 30.5556 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 30.5556 | 6 | yes |
| GO:0043067 | regulation of programmed cell death | 30.5556 | 5 | yes |
| GO:0030030 | cell projection organization | 30.5556 | 4 | no |
| GO:0033043 | regulation of organelle organization | 30.5556 | 5 | no |
| GO:0036211 | protein modification process | 30.5556 | 4 | no |
| GO:0043412 | macromolecule modification | 30.5556 | 4 | no |
| GO:0071310 | cellular response to organic substance | 27.7778 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 27.7778 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 27.7778 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 27.7778 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 27.7778 | 5 | no |
| GO:0007010 | cytoskeleton organization | 27.7778 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 27.7778 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 25.0000 | 6 | no |
| GO:0010648 | negative regulation of cell communication | 25.0000 | 5 | no |
| GO:0023057 | negative regulation of signaling | 25.0000 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 25.0000 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 25.0000 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 25.0000 | 6 | no |
| GO:0071702 | organic substance transport | 25.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 25.0000 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 25.0000 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0031399 | regulation of protein modification process | 25.0000 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.0000 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 22.2222 | 5 | no |
| GO:0060341 | regulation of cellular localization | 22.2222 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 22.2222 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 22.2222 | 4 | no |
| GO:0015031 | protein transport | 22.2222 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 22.2222 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 22.2222 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 22.2222 | 4 | no |
| GO:0023056 | positive regulation of signaling | 22.2222 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.2222 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 22.2222 | 4 | no |
| GO:0031346 | positive regulation of cell projection organization | 22.2222 | 6 | no |
| GO:0080134 | regulation of response to stress | 13.8889 | 4 | yes |
| GO:1901214 | regulation of neuron death | 13.8889 | 5 | yes |
| GO:0043523 | regulation of neuron apoptotic process | 11.1111 | 6 | yes |
| GO:0080135 | regulation of cellular response to stress | 11.1111 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in LANC1_HUMAN |
|---|---|---|---|---|
| DOID:10595 | Charcot-Marie-Tooth disease | 8.3333 | 6 | no |
| DOID:440 | neuromuscular disease | 8.3333 | 5 | no |
| DOID:574 | peripheral nervous system disease | 8.3333 | 3 | no |
| DOID:870 | neuropathy | 8.3333 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| EPS8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| PRP8_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| SPDLY_HUMAN | [view interactions] | High throughput | no | yes |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| PPT1_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| TET2_HUMAN | [view interactions] | High throughput | no | yes |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| SET1A_HUMAN | [view interactions] | High throughput | no | yes |
| RHG21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG25_HUMAN | [view interactions] | High throughput | no | no |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TULP3_HUMAN | [view interactions] | High throughput | no | yes |
| T22D4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NRBP_HUMAN | [view interactions] | High throughput | no | yes |
| NRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| THB_HUMAN | [view interactions] | High throughput | no | no |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| CATL1_HUMAN | [view interactions] | High throughput | no | yes |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| TM11B_HUMAN | [view interactions] | High throughput | no | no |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SERPH_HUMAN | [view interactions] | High throughput | no | no |
| ALDOC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NEGR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BROMI_HUMAN | [view interactions] | High throughput | no | no |
| T106B_HUMAN | [view interactions] | High throughput | no | yes |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADIP_HUMAN | [view interactions] | High throughput | no | yes |
| IPP_HUMAN | [view interactions] | High throughput | no | yes |
| DEOC_HUMAN | [view interactions] | High throughput | no | no |
| A16A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBCD9_HUMAN | [view interactions] | High throughput | no | yes |
| FIGN_HUMAN | [view interactions] | High throughput | no | yes |
| FGD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFTAP_HUMAN | [view interactions] | High throughput | no | no |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPRH_HUMAN | [view interactions] | High throughput | no | no |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| SNF5_HUMAN | [view interactions] | High throughput | no | yes |
| ST38L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APBB1_HUMAN | [view interactions] | High throughput | no | yes |
| ERBB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MERTK_HUMAN | [view interactions] | High throughput | no | yes |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA1_HUMAN | [view interactions] | High throughput | no | yes |
| EPHB6_HUMAN | [view interactions] | High throughput | no | no |
| FGFR2_HUMAN | [view interactions] | High throughput | no | yes |
| VGFR1_HUMAN | [view interactions] | High throughput | no | no |
| FLT3_HUMAN | [view interactions] | High throughput | no | no |
| TIE2_HUMAN | [view interactions] | High throughput | no | no |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGLN_HUMAN | [view interactions] | High throughput | no | no |
| BI2L1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| CSAG2_HUMAN | [view interactions] | High throughput | no | no |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIR1_HUMAN | [view interactions] | High throughput | no | yes |
| ERG_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| TBC9B_HUMAN | [view interactions] | High throughput | no | yes |
| MYO7A_HUMAN | [view interactions] | High throughput | no | yes |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| UBN2_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| MCM5_HUMAN | [view interactions] | High throughput | no | no |
| STOM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |