SYPH_HUMAN
Evidence for PS localization
Functions
Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SYPH_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 26.4706 | 4 | no |
| GO:0019900 | kinase binding | 20.5882 | 4 | no |
| GO:0042169 | SH2 domain binding | 4.4118 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SYPH_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 61.7647 | 4 | no |
| GO:0051049 | regulation of transport | 54.4118 | 4 | yes |
| GO:0010646 | regulation of cell communication | 47.0588 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 38.2353 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 38.2353 | 4 | no |
| GO:0009966 | regulation of signal transduction | 36.7647 | 4 | yes |
| GO:0051050 | positive regulation of transport | 36.7647 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 35.2941 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 35.2941 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 35.2941 | 4 | no |
| GO:0006996 | organelle organization | 32.3529 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 32.3529 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 32.3529 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 32.3529 | 4 | no |
| GO:0043269 | regulation of ion transport | 32.3529 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.4118 | 5 | no |
| GO:0022607 | cellular component assembly | 29.4118 | 4 | no |
| GO:0051046 | regulation of secretion | 27.9412 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 27.9412 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 26.4706 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.4706 | 5 | no |
| GO:0006897 | endocytosis | 25.0000 | 5 | yes |
| GO:0043085 | positive regulation of catalytic activity | 25.0000 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 25.0000 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 25.0000 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.0000 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 23.5294 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 23.5294 | 4 | yes |
| GO:1903530 | regulation of secretion by cell | 23.5294 | 4 | yes |
| GO:0071702 | organic substance transport | 23.5294 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 23.5294 | 7 | no |
| GO:0031399 | regulation of protein modification process | 23.5294 | 6 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 22.0588 | 4 | yes |
| GO:0008104 | protein localization | 22.0588 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.0588 | 4 | no |
| GO:0071705 | nitrogen compound transport | 22.0588 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.0588 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 22.0588 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.0588 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.0588 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.0588 | 6 | no |
| GO:0009892 | negative regulation of metabolic process | 22.0588 | 4 | no |
| GO:0034762 | regulation of transmembrane transport | 22.0588 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 20.5882 | 5 | no |
| GO:0023057 | negative regulation of signaling | 20.5882 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 20.5882 | 5 | no |
| GO:0043933 | protein-containing complex organization | 20.5882 | 4 | no |
| GO:0032880 | regulation of protein localization | 20.5882 | 5 | no |
| GO:0060341 | regulation of cellular localization | 20.5882 | 4 | no |
| GO:0043549 | regulation of kinase activity | 20.5882 | 5 | no |
| GO:0051338 | regulation of transferase activity | 20.5882 | 4 | no |
| GO:0061024 | membrane organization | 17.6471 | 4 | yes |
| GO:0017157 | regulation of exocytosis | 16.1765 | 5 | yes |
| GO:0071310 | cellular response to organic substance | 16.1765 | 4 | yes |
| GO:0099003 | vesicle-mediated transport in synapse | 14.7059 | 5 | yes |
| GO:0016050 | vesicle organization | 13.2353 | 5 | yes |
| GO:0048488 | synaptic vesicle endocytosis | 11.7647 | 5 | yes |
| GO:0140238 | presynaptic endocytosis | 11.7647 | 4 | yes |
| GO:1903305 | regulation of regulated secretory pathway | 11.7647 | 6 | yes |
| GO:0046928 | regulation of neurotransmitter secretion | 10.2941 | 4 | yes |
| GO:0051588 | regulation of neurotransmitter transport | 10.2941 | 5 | yes |
| GO:0008277 | regulation of G protein-coupled receptor signaling pathway | 8.8235 | 5 | yes |
| GO:0048168 | regulation of neuronal synaptic plasticity | 8.8235 | 4 | yes |
| GO:0048169 | regulation of long-term neuronal synaptic plasticity | 7.3529 | 5 | yes |
| GO:2000300 | regulation of synaptic vesicle exocytosis | 7.3529 | 5 | yes |
| GO:0048499 | synaptic vesicle membrane organization | 4.4118 | 5 | yes |
| GO:0048172 | regulation of short-term neuronal synaptic plasticity | 2.9412 | 5 | yes |
| GO:2000474 | regulation of opioid receptor signaling pathway | 2.9412 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in SYPH_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 2.9412 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 2.9412 | 5 | no |
| DOID:114 | heart disease | 2.9412 | 3 | no |
| DOID:2843 | long QT syndrome | 2.9412 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ARFP2_HUMAN | [view interactions] | Low throughput | no | no |
| CDK16_HUMAN | [view interactions] | Low throughput | no | yes |
| CALX_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DNJC5_HUMAN | [view interactions] | Low throughput | no | yes |
| SIAH1_HUMAN | [view interactions] | Low throughput | no | yes |
| SIAH2_HUMAN | [view interactions] | Low throughput | no | no |
| STX1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PARK7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNG3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| VINEX_HUMAN | [view interactions] | Low throughput | no | no |
| IRS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAB26_HUMAN | [view interactions] | Low throughput | no | no |
| PRIO_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GAB1_HUMAN | [view interactions] | Low throughput | no | yes |
| SCAM1_HUMAN | [view interactions] | Low throughput | no | no |
| STMN3_HUMAN | [view interactions] | Low throughput | no | yes |
| RND2_HUMAN | [view interactions] | Low throughput | no | no |
| HOME2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HGS_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ZNT10_HUMAN | [view interactions] | Low throughput | no | yes |
| ZNT3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| OPRM_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SYUA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MYO5B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAB3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRAF1_HUMAN | [view interactions] | Low throughput | no | yes |
| VAMP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SNP25_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SPN90_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FXL20_HUMAN | [view interactions] | Low throughput | no | no |
| AP1G1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SH3K1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHLB1_HUMAN | [view interactions] | High throughput | no | yes |
| MYG1_HUMAN | [view interactions] | High throughput | no | yes |
| JOS2_HUMAN | [view interactions] | High throughput | no | no |
| PLIN3_HUMAN | [view interactions] | High throughput | no | yes |
| CAND2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DBLOH_HUMAN | [view interactions] | High throughput | no | no |
| SYFM_HUMAN | [view interactions] | High throughput | no | yes |
| PTN9_HUMAN | [view interactions] | High throughput | no | yes |
| HSFX1_HUMAN | [view interactions] | High throughput | no | no |
| PTCD1_HUMAN | [view interactions] | High throughput | no | yes |
| MRM1_HUMAN | [view interactions] | High throughput | no | no |
| SPG21_HUMAN | [view interactions] | High throughput | no | yes |
| STAR4_HUMAN | [view interactions] | High throughput | no | yes |
| RBFA_HUMAN | [view interactions] | High throughput | no | yes |
| THAP4_HUMAN | [view interactions] | High throughput | no | yes |
| SMG9_HUMAN | [view interactions] | High throughput | no | yes |
| WDFY2_HUMAN | [view interactions] | High throughput | no | no |
| PNKP_HUMAN | [view interactions] | High throughput | no | yes |
| TBB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDRG4_HUMAN | [view interactions] | High throughput | no | no |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| PITC1_HUMAN | [view interactions] | High throughput | no | yes |
| WIPI2_HUMAN | [view interactions] | High throughput | no | yes |
| SSX5_HUMAN | [view interactions] | High throughput | no | no |
| PBX3_HUMAN | [view interactions] | High throughput | no | yes |
| GDNF_HUMAN | [view interactions] | High throughput | no | yes |
| MID49_HUMAN | [view interactions] | High throughput | no | yes |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| BOREA_HUMAN | [view interactions] | High throughput | no | yes |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| S35B2_HUMAN | [view interactions] | High throughput | no | no |
| TMTC4_HUMAN | [view interactions] | High throughput | no | yes |
| ERD23_HUMAN | [view interactions] | High throughput | no | yes |
| JIP4_HUMAN | [view interactions] | High throughput | no | yes |
| MBOA7_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS4_HUMAN | [view interactions] | High throughput | no | yes |
| BSCL2_HUMAN | [view interactions] | High throughput | no | yes |
| MTCH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PARL_HUMAN | [view interactions] | High throughput | no | yes |
| LPAR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLN3_HUMAN | [view interactions] | High throughput | no | no |
| AOFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHC24_HUMAN | [view interactions] | High throughput | no | yes |
| S27A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTSS2_HUMAN | [view interactions] | High throughput | no | yes |
| EXTL3_HUMAN | [view interactions] | High throughput | no | yes |
| GPAT4_HUMAN | [view interactions] | High throughput | no | yes |
| TMCO1_HUMAN | [view interactions] | High throughput | no | yes |
| SPG7_HUMAN | [view interactions] | High throughput | no | no |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HIP1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S61A2_HUMAN | [view interactions] | High throughput | no | no |
| SURF1_HUMAN | [view interactions] | High throughput | no | yes |
| NCTR1_HUMAN | [view interactions] | High throughput | no | no |
| MACOI_HUMAN | [view interactions] | High throughput | no | no |
| LRC15_HUMAN | [view interactions] | High throughput | no | no |
| ORNT1_HUMAN | [view interactions] | High throughput | no | yes |
| VSIG8_HUMAN | [view interactions] | High throughput | no | no |
| SNH28_HUMAN | [view interactions] | High throughput | no | no |
| HYAS3_HUMAN | [view interactions] | High throughput | no | no |
| FDFT_HUMAN | [view interactions] | High throughput | no | yes |
| PMGT1_HUMAN | [view interactions] | High throughput | no | yes |
| PCAT2_HUMAN | [view interactions] | High throughput | no | yes |
| ALG11_HUMAN | [view interactions] | High throughput | no | yes |
| SRPRA_HUMAN | [view interactions] | High throughput | no | no |
| DHR13_HUMAN | [view interactions] | High throughput | no | yes |
| B3GA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTX3_HUMAN | [view interactions] | High throughput | no | yes |
| NDUF4_HUMAN | [view interactions] | High throughput | no | yes |
| ECM29_HUMAN | [view interactions] | High throughput | no | no |
| SFXN2_HUMAN | [view interactions] | High throughput | no | no |
| S10A3_HUMAN | [view interactions] | High throughput | no | no |
| HPHL1_HUMAN | [view interactions] | High throughput | no | no |
| DJC11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYRM_HUMAN | [view interactions] | High throughput | no | yes |
| LBR_HUMAN | [view interactions] | High throughput | no | yes |
| TSYL1_HUMAN | [view interactions] | High throughput | no | yes |
| DSG4_HUMAN | [view interactions] | High throughput | no | no |
| S27A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S20A1_HUMAN | [view interactions] | High throughput | no | yes |
| TPC_HUMAN | [view interactions] | High throughput | no | no |
| ETV3_HUMAN | [view interactions] | High throughput | no | yes |
| T184B_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS5_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDUBA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEGR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALDOC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| QCR6L_HUMAN | [view interactions] | High throughput | no | yes |
| QCR6_HUMAN | [view interactions] | High throughput | no | yes |
| CX6B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LANC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| MRS2_HUMAN | [view interactions] | High throughput | no | no |
| RN5A_HUMAN | [view interactions] | High throughput | no | yes |
| S38AA_HUMAN | [view interactions] | High throughput | no | yes |
| ARV1_HUMAN | [view interactions] | High throughput | no | yes |
| SGPP1_HUMAN | [view interactions] | High throughput | no | no |
| SFXN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCMC3_HUMAN | [view interactions] | High throughput | no | yes |
| ARL5B_HUMAN | [view interactions] | High throughput | no | yes |
| TM186_HUMAN | [view interactions] | High throughput | no | no |
| TM87A_HUMAN | [view interactions] | High throughput | no | yes |
| T183A_HUMAN | [view interactions] | High throughput | no | no |
| TM164_HUMAN | [view interactions] | High throughput | no | yes |
| EXT1_HUMAN | [view interactions] | High throughput | no | yes |
| S20A2_HUMAN | [view interactions] | High throughput | no | yes |
| PTPS_HUMAN | [view interactions] | High throughput | no | yes |
| GLPK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GDC_HUMAN | [view interactions] | High throughput | no | no |
| ATP9A_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APBB1_HUMAN | [view interactions] | High throughput | no | yes |
| VATL_HUMAN | [view interactions] | High throughput | no | no |
| TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
| EAA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GNAT2_HUMAN | [view interactions] | High throughput | no | no |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1C_HUMAN | [view interactions] | High throughput | no | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTEF3_HUMAN | [view interactions] | High throughput | no | no |
| PPIF_HUMAN | [view interactions] | High throughput | no | no |
| MID51_HUMAN | [view interactions] | High throughput | no | no |
| RRFM_HUMAN | [view interactions] | High throughput | no | yes |
| BY55_HUMAN | [view interactions] | High throughput | no | no |
| PTN6_HUMAN | [view interactions] | Computational | no | no |
| VGLU1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RFOX3_HUMAN | [view interactions] | Computational | no | yes |
| K2C7_HUMAN | [view interactions] | Computational | no | no |
| SV2A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CMGA_HUMAN | [view interactions] | Computational | no | yes |
| MTAP2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ENOG_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SYN1_HUMAN | [view entry] [view interactions] | Computational | yes | no |