SYPH_HUMAN
Evidence for PS localization
Functions
Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SYPH_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 26.1538 | 4 | no |
| GO:0046872 | metal ion binding | 26.1538 | 5 | no |
| GO:0043168 | anion binding | 24.6154 | 4 | no |
| GO:0042169 | SH2 domain binding | 4.6154 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SYPH_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 64.6154 | 4 | no |
| GO:0051049 | regulation of transport | 50.7692 | 4 | yes |
| GO:0010646 | regulation of cell communication | 46.1538 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 41.5385 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 38.4615 | 4 | no |
| GO:0006996 | organelle organization | 36.9231 | 4 | yes |
| GO:0098657 | import into cell | 36.9231 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 36.9231 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 36.9231 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 35.3846 | 4 | no |
| GO:0009966 | regulation of signal transduction | 33.8462 | 4 | yes |
| GO:0022607 | cellular component assembly | 33.8462 | 4 | no |
| GO:0051050 | positive regulation of transport | 32.3077 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.7692 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 30.7692 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.2308 | 5 | no |
| GO:0071702 | organic substance transport | 27.6923 | 4 | no |
| GO:0008104 | protein localization | 26.1538 | 4 | no |
| GO:0071705 | nitrogen compound transport | 26.1538 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 26.1538 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 26.1538 | 4 | no |
| GO:0030030 | cell projection organization | 26.1538 | 4 | no |
| GO:0051046 | regulation of secretion | 24.6154 | 5 | yes |
| GO:0061024 | membrane organization | 24.6154 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 24.6154 | 5 | no |
| GO:0023056 | positive regulation of signaling | 24.6154 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 24.6154 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 24.6154 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 24.6154 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 23.0769 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 23.0769 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 23.0769 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 21.5385 | 4 | yes |
| GO:1903530 | regulation of secretion by cell | 21.5385 | 4 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 21.5385 | 5 | no |
| GO:0010468 | regulation of gene expression | 21.5385 | 6 | no |
| GO:0051246 | regulation of protein metabolic process | 21.5385 | 5 | no |
| GO:0016050 | vesicle organization | 16.9231 | 5 | yes |
| GO:0071310 | cellular response to organic substance | 16.9231 | 4 | yes |
| GO:0048488 | synaptic vesicle endocytosis | 15.3846 | 5 | yes |
| GO:0140238 | presynaptic endocytosis | 15.3846 | 4 | yes |
| GO:0017157 | regulation of exocytosis | 13.8462 | 5 | yes |
| GO:0048168 | regulation of neuronal synaptic plasticity | 9.2308 | 4 | yes |
| GO:0051588 | regulation of neurotransmitter transport | 9.2308 | 5 | yes |
| GO:1903305 | regulation of regulated secretory pathway | 9.2308 | 6 | yes |
| GO:0046928 | regulation of neurotransmitter secretion | 7.6923 | 5 | yes |
| GO:0048169 | regulation of long-term neuronal synaptic plasticity | 7.6923 | 5 | yes |
| GO:0008277 | regulation of G protein-coupled receptor signaling pathway | 6.1538 | 5 | yes |
| GO:0048499 | synaptic vesicle membrane organization | 6.1538 | 5 | yes |
| GO:2000300 | regulation of synaptic vesicle exocytosis | 4.6154 | 6 | yes |
| GO:0048172 | regulation of short-term neuronal synaptic plasticity | 3.0769 | 5 | yes |
| GO:2000474 | regulation of opioid receptor signaling pathway | 3.0769 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GAB1_HUMAN | [view interactions] | Low throughput | no | yes |
| SCAM1_HUMAN | [view interactions] | Low throughput | no | no |
| STMN3_HUMAN | [view interactions] | Low throughput | no | yes |
| RND2_HUMAN | [view interactions] | Low throughput | no | no |
| HOME2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HGS_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ZNT10_HUMAN | [view interactions] | Low throughput | no | yes |
| ZNT3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| OPRM_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SYUA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MYO5B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VAMP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PRAF1_HUMAN | [view interactions] | Low throughput | no | yes |
| RAB3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNP25_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SPN90_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FXL20_HUMAN | [view interactions] | Low throughput | no | no |
| AP1G1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SH3K1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARFP2_HUMAN | [view interactions] | Low throughput | no | no |
| CDK16_HUMAN | [view interactions] | Low throughput | no | yes |
| CALX_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DNJC5_HUMAN | [view interactions] | Low throughput | no | yes |
| SIAH1_HUMAN | [view interactions] | Low throughput | no | yes |
| SIAH2_HUMAN | [view interactions] | Low throughput | no | no |
| STX1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PARK7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNG3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| VINEX_HUMAN | [view interactions] | Low throughput | no | no |
| IRS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAB26_HUMAN | [view interactions] | Low throughput | no | no |
| PRIO_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TSYL1_HUMAN | [view interactions] | High throughput | no | yes |
| DSG4_HUMAN | [view interactions] | High throughput | no | no |
| S27A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S20A1_HUMAN | [view interactions] | High throughput | no | yes |
| TPC_HUMAN | [view interactions] | High throughput | no | no |
| ETV3_HUMAN | [view interactions] | High throughput | no | yes |
| T184B_HUMAN | [view interactions] | High throughput | no | yes |
| PRRT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS5_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDUBA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEGR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALDOC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| QCR6L_HUMAN | [view interactions] | High throughput | no | yes |
| QCR6_HUMAN | [view interactions] | High throughput | no | yes |
| CX6B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LANC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNTP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBPZ_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| ATP9A_HUMAN | [view interactions] | High throughput | no | yes |
| GDC_HUMAN | [view interactions] | High throughput | no | no |
| GLPK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTPS_HUMAN | [view interactions] | High throughput | no | yes |
| RN5A_HUMAN | [view interactions] | High throughput | no | yes |
| S20A2_HUMAN | [view interactions] | High throughput | no | yes |
| EXT1_HUMAN | [view interactions] | High throughput | no | yes |
| TM164_HUMAN | [view interactions] | High throughput | no | yes |
| T183A_HUMAN | [view interactions] | High throughput | no | no |
| TM87A_HUMAN | [view interactions] | High throughput | no | yes |
| TM186_HUMAN | [view interactions] | High throughput | no | no |
| ARL5B_HUMAN | [view interactions] | High throughput | no | yes |
| SCMC3_HUMAN | [view interactions] | High throughput | no | yes |
| SFXN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SGPP1_HUMAN | [view interactions] | High throughput | no | no |
| ARV1_HUMAN | [view interactions] | High throughput | no | yes |
| S38AA_HUMAN | [view interactions] | High throughput | no | yes |
| MRS2_HUMAN | [view interactions] | High throughput | no | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATL_HUMAN | [view interactions] | High throughput | no | no |
| TBA1C_HUMAN | [view interactions] | High throughput | no | yes |
| VPP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAT2_HUMAN | [view interactions] | High throughput | no | no |
| EAA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| SNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTEF3_HUMAN | [view interactions] | High throughput | no | no |
| PPIF_HUMAN | [view interactions] | High throughput | no | no |
| MID51_HUMAN | [view interactions] | High throughput | no | no |
| RRFM_HUMAN | [view interactions] | High throughput | no | yes |
| BY55_HUMAN | [view interactions] | High throughput | no | no |
| SHLB1_HUMAN | [view interactions] | High throughput | no | yes |
| MYG1_HUMAN | [view interactions] | High throughput | no | yes |
| JOS2_HUMAN | [view interactions] | High throughput | no | no |
| PLIN3_HUMAN | [view interactions] | High throughput | no | yes |
| CAND2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DBLOH_HUMAN | [view interactions] | High throughput | no | no |
| SYFM_HUMAN | [view interactions] | High throughput | no | yes |
| PTN9_HUMAN | [view interactions] | High throughput | no | yes |
| HSFX1_HUMAN | [view interactions] | High throughput | no | no |
| PTCD1_HUMAN | [view interactions] | High throughput | no | yes |
| MRM1_HUMAN | [view interactions] | High throughput | no | no |
| SPG21_HUMAN | [view interactions] | High throughput | no | yes |
| STAR4_HUMAN | [view interactions] | High throughput | no | yes |
| RBFA_HUMAN | [view interactions] | High throughput | no | yes |
| THAP4_HUMAN | [view interactions] | High throughput | no | yes |
| SMG9_HUMAN | [view interactions] | High throughput | no | yes |
| WDFY2_HUMAN | [view interactions] | High throughput | no | no |
| PNKP_HUMAN | [view interactions] | High throughput | no | yes |
| TBB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| NDRG4_HUMAN | [view interactions] | High throughput | no | no |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| PITC1_HUMAN | [view interactions] | High throughput | no | yes |
| WIPI2_HUMAN | [view interactions] | High throughput | no | yes |
| SSX5_HUMAN | [view interactions] | High throughput | no | no |
| PBX3_HUMAN | [view interactions] | High throughput | no | yes |
| GDNF_HUMAN | [view interactions] | High throughput | no | yes |
| MID49_HUMAN | [view interactions] | High throughput | no | yes |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| BOREA_HUMAN | [view interactions] | High throughput | no | yes |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| S35B2_HUMAN | [view interactions] | High throughput | no | no |
| TMTC4_HUMAN | [view interactions] | High throughput | no | yes |
| ERD23_HUMAN | [view interactions] | High throughput | no | yes |
| JIP4_HUMAN | [view interactions] | High throughput | no | yes |
| MBOA7_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS4_HUMAN | [view interactions] | High throughput | no | yes |
| BSCL2_HUMAN | [view interactions] | High throughput | no | yes |
| MTCH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PARL_HUMAN | [view interactions] | High throughput | no | yes |
| LPAR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLN3_HUMAN | [view interactions] | High throughput | no | no |
| AOFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHC24_HUMAN | [view interactions] | High throughput | no | yes |
| S27A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTSS2_HUMAN | [view interactions] | High throughput | no | yes |
| EXTL3_HUMAN | [view interactions] | High throughput | no | yes |
| GPAT4_HUMAN | [view interactions] | High throughput | no | yes |
| TMCO1_HUMAN | [view interactions] | High throughput | no | yes |
| SPG7_HUMAN | [view interactions] | High throughput | no | no |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HIP1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S61A2_HUMAN | [view interactions] | High throughput | no | no |
| SURF1_HUMAN | [view interactions] | High throughput | no | yes |
| NCTR1_HUMAN | [view interactions] | High throughput | no | no |
| MACOI_HUMAN | [view interactions] | High throughput | no | no |
| LRC15_HUMAN | [view interactions] | High throughput | no | no |
| ORNT1_HUMAN | [view interactions] | High throughput | no | yes |
| VSIG8_HUMAN | [view interactions] | High throughput | no | no |
| SNH28_HUMAN | [view interactions] | High throughput | no | no |
| HYAS3_HUMAN | [view interactions] | High throughput | no | no |
| FDFT_HUMAN | [view interactions] | High throughput | no | yes |
| PMGT1_HUMAN | [view interactions] | High throughput | no | yes |
| PCAT2_HUMAN | [view interactions] | High throughput | no | yes |
| ALG11_HUMAN | [view interactions] | High throughput | no | yes |
| SRPRA_HUMAN | [view interactions] | High throughput | no | no |
| DHR13_HUMAN | [view interactions] | High throughput | no | yes |
| B3GA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTX3_HUMAN | [view interactions] | High throughput | no | yes |
| NDUF4_HUMAN | [view interactions] | High throughput | no | yes |
| ECM29_HUMAN | [view interactions] | High throughput | no | no |
| SFXN2_HUMAN | [view interactions] | High throughput | no | no |
| S10A3_HUMAN | [view interactions] | High throughput | no | no |
| HPHL1_HUMAN | [view interactions] | High throughput | no | no |
| DJC11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYRM_HUMAN | [view interactions] | High throughput | no | yes |
| LBR_HUMAN | [view interactions] | High throughput | no | yes |