Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

HOME2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (PubMed). Required for normal hearing (PubMed). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in HOME2_HUMAN
GO:0019900 kinase binding 30.7692 4 no
GO:0019901 protein kinase binding 30.7692 5 no
GO:0001664 G protein-coupled receptor binding 26.9231 4 yes
GO:0035254 glutamate receptor binding 26.9231 4 yes
GO:0003779 actin binding 23.0769 4 yes
GO:0030159 signaling receptor complex adaptor activity 15.3846 4 yes
GO:0030160 synaptic receptor adaptor activity 15.3846 5 yes
GO:0035256 G protein-coupled glutamate receptor binding 11.5385 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in HOME2_HUMAN
GO:0048523 negative regulation of cellular process 69.2308 4 yes
GO:0010646 regulation of cell communication 65.3846 4 yes
GO:0048522 positive regulation of cellular process 65.3846 4 no
GO:0009966 regulation of signal transduction 61.5385 4 yes
GO:0051128 regulation of cellular component organization 53.8462 4 no
GO:0051049 regulation of transport 50.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 yes
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0009893 positive regulation of metabolic process 42.3077 4 no
GO:0031325 positive regulation of cellular metabolic process 42.3077 5 no
GO:0031344 regulation of cell projection organization 42.3077 5 no
GO:0010647 positive regulation of cell communication 42.3077 5 no
GO:0023056 positive regulation of signaling 42.3077 4 no
GO:0048584 positive regulation of response to stimulus 42.3077 4 no
GO:0050804 modulation of chemical synaptic transmission 42.3077 5 no
GO:0099177 regulation of trans-synaptic signaling 42.3077 4 no
GO:0051171 regulation of nitrogen compound metabolic process 42.3077 4 no
GO:0080090 regulation of primary metabolic process 42.3077 4 no
GO:1902531 regulation of intracellular signal transduction 38.4615 5 yes
GO:0044087 regulation of cellular component biogenesis 38.4615 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 38.4615 6 no
GO:0009967 positive regulation of signal transduction 38.4615 5 no
GO:0022607 cellular component assembly 38.4615 4 no
GO:0010604 positive regulation of macromolecule metabolic process 38.4615 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 38.4615 5 no
GO:0009892 negative regulation of metabolic process 34.6154 4 yes
GO:0043269 regulation of ion transport 34.6154 5 yes
GO:0033043 regulation of organelle organization 34.6154 5 no
GO:0050807 regulation of synapse organization 34.6154 5 no
GO:0051129 negative regulation of cellular component organization 34.6154 5 no
GO:0010562 positive regulation of phosphorus metabolic process 34.6154 6 no
GO:0019220 regulation of phosphate metabolic process 34.6154 6 no
GO:0042325 regulation of phosphorylation 34.6154 7 no
GO:0042327 positive regulation of phosphorylation 34.6154 8 no
GO:0045937 positive regulation of phosphate metabolic process 34.6154 7 no
GO:0051174 regulation of phosphorus metabolic process 34.6154 5 no
GO:0006996 organelle organization 34.6154 4 no
GO:0051094 positive regulation of developmental process 34.6154 4 no
GO:1902903 regulation of supramolecular fiber organization 30.7692 5 no
GO:0010468 regulation of gene expression 30.7692 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 30.7692 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 30.7692 4 no
GO:0032956 regulation of actin cytoskeleton organization 30.7692 5 no
GO:0032970 regulation of actin filament-based process 30.7692 4 no
GO:0051493 regulation of cytoskeleton organization 30.7692 6 no
GO:0008104 protein localization 30.7692 4 no
GO:0044057 regulation of system process 30.7692 4 no
GO:0001932 regulation of protein phosphorylation 30.7692 7 no
GO:0001934 positive regulation of protein phosphorylation 30.7692 8 no
GO:0031399 regulation of protein modification process 30.7692 6 no
GO:0031401 positive regulation of protein modification process 30.7692 7 no
GO:0051246 regulation of protein metabolic process 30.7692 5 no
GO:0051247 positive regulation of protein metabolic process 30.7692 6 no
GO:0030030 cell projection organization 30.7692 4 no
GO:0034330 cell junction organization 30.7692 4 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 26.9231 6 no
GO:0009968 negative regulation of signal transduction 26.9231 5 yes
GO:0010648 negative regulation of cell communication 26.9231 5 yes
GO:0023057 negative regulation of signaling 26.9231 4 yes
GO:0048585 negative regulation of response to stimulus 26.9231 4 yes
GO:0031644 regulation of nervous system process 26.9231 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 26.9231 5 no
GO:0032990 cell part morphogenesis 26.9231 4 no
GO:0033674 positive regulation of kinase activity 26.9231 6 no
GO:0043085 positive regulation of catalytic activity 26.9231 4 no
GO:0043549 regulation of kinase activity 26.9231 5 no
GO:0045595 regulation of cell differentiation 26.9231 4 no
GO:0045597 positive regulation of cell differentiation 26.9231 5 no
GO:0048812 neuron projection morphogenesis 26.9231 7 no
GO:0048858 cell projection morphogenesis 26.9231 5 no
GO:0051130 positive regulation of cellular component organization 26.9231 5 no
GO:0051338 regulation of transferase activity 26.9231 4 no
GO:0051347 positive regulation of transferase activity 26.9231 5 no
GO:0110053 regulation of actin filament organization 26.9231 6 no
GO:1902533 positive regulation of intracellular signal transduction 23.0769 6 no
GO:0007612 learning 23.0769 4 no
GO:0031175 neuron projection development 23.0769 6 no
GO:0048168 regulation of neuronal synaptic plasticity 23.0769 4 no
GO:0050808 synapse organization 23.0769 5 no
GO:0050890 cognition 23.0769 4 no
GO:0120036 plasma membrane bounded cell projection organization 23.0769 5 no
GO:0007215 glutamate receptor signaling pathway 23.0769 4 yes
GO:0097435 supramolecular fiber organization 23.0769 4 no
GO:0099175 regulation of postsynapse organization 23.0769 6 no
GO:0022898 regulation of transmembrane transporter activity 23.0769 4 no
GO:0032412 regulation of ion transmembrane transporter activity 23.0769 5 no
GO:0034762 regulation of transmembrane transport 23.0769 4 no
GO:0034765 regulation of ion transmembrane transport 23.0769 5 no
GO:0043933 protein-containing complex organization 23.0769 4 no
GO:0065003 protein-containing complex assembly 23.0769 5 no
GO:0099601 regulation of neurotransmitter receptor activity 23.0769 4 no
GO:0009889 regulation of biosynthetic process 23.0769 4 no
GO:0031326 regulation of cellular biosynthetic process 23.0769 5 no
GO:0007010 cytoskeleton organization 23.0769 5 no
GO:0034329 cell junction assembly 23.0769 5 no
GO:0045859 regulation of protein kinase activity 23.0769 6 no
GO:0045860 positive regulation of protein kinase activity 23.0769 7 no
GO:0071310 cellular response to organic substance 23.0769 4 no
GO:0007216 G protein-coupled glutamate receptor signaling pathway 19.2308 4 yes
GO:0010629 negative regulation of gene expression 19.2308 6 yes
GO:0051241 negative regulation of multicellular organismal process 19.2308 4 yes
GO:1902532 negative regulation of intracellular signal transduction 19.2308 6 yes
GO:0001817 regulation of cytokine production 15.3846 4 yes
GO:0008277 regulation of G protein-coupled receptor signaling pathway 15.3846 5 yes
GO:0010959 regulation of metal ion transport 15.3846 6 yes
GO:0048878 chemical homeostasis 15.3846 4 yes
GO:0051924 regulation of calcium ion transport 15.3846 7 yes
GO:0001818 negative regulation of cytokine production 11.5385 5 yes
GO:0019722 calcium-mediated signaling 11.5385 5 yes
GO:0019932 second-messenger-mediated signaling 11.5385 4 yes
GO:0050848 regulation of calcium-mediated signaling 11.5385 6 yes
GO:0050849 negative regulation of calcium-mediated signaling 11.5385 7 yes
GO:2001256 regulation of store-operated calcium entry 11.5385 8 yes
GO:0001894 tissue homeostasis 7.6923 5 yes
GO:0007600 sensory perception 7.6923 4 yes
GO:0032663 regulation of interleukin-2 production 7.6923 5 yes
GO:0032703 negative regulation of interleukin-2 production 7.6923 6 yes
GO:0035584 calcium-mediated signaling using intracellular calcium source 7.6923 6 yes
GO:0048148 behavioral response to cocaine 7.6923 4 yes
GO:0048875 chemical homeostasis within a tissue 7.6923 5 yes
GO:0060249 anatomical structure homeostasis 7.6923 4 yes
GO:0070884 regulation of calcineurin-NFAT signaling cascade 7.6923 8 yes
GO:0070885 negative regulation of calcineurin-NFAT signaling cascade 7.6923 9 yes
GO:0106056 regulation of calcineurin-mediated signaling 7.6923 7 yes
GO:0106057 negative regulation of calcineurin-mediated signaling 7.6923 8 yes

Disease

Term Name % Distance from top the of the tree Annotated in HOME2_HUMAN
DOID:0050753 cerebellar ataxia 7.6923 6 no
DOID:0050951 hereditary ataxia 7.6923 5 no
DOID:1289 neurodegenerative disease 7.6923 4 no
DOID:1441 autosomal dominant cerebellar ataxia 7.6923 7 no
DOID:331 central nervous system disease 7.6923 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
AGAP2_HUMAN [view entry] [view interactions] Low throughput yes yes
RNF41_HUMAN [view interactions] Low throughput no yes
UBXN1_HUMAN [view interactions] Low throughput no no
RYR1_HUMAN [view interactions] Low throughput no no
RHOA_HUMAN [view entry] [view interactions] Low throughput yes yes
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
CDC42_HUMAN [view entry] [view interactions] Low throughput yes yes
CAZA1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRM1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRM5_HUMAN [view entry] [view interactions] Low throughput yes no
DREB_HUMAN [view entry] [view interactions] Low throughput yes yes
ITPR1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
SYPH_HUMAN [view entry] [view interactions] Low throughput yes yes
IMA1_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
HXB2_HUMAN [view interactions] High throughput no no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
LZTS2_HUMAN [view interactions] High throughput no no
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
VKOR1_HUMAN [view interactions] High throughput no yes
ABI3_HUMAN [view entry] [view interactions] High throughput yes no
PALLD_HUMAN [view interactions] High throughput no yes
HOME1_HUMAN [view entry] [view interactions] High throughput yes yes
HOME3_HUMAN [view entry] [view interactions] High throughput yes yes
CSPP1_HUMAN [view interactions] High throughput no no
IFT57_HUMAN [view interactions] High throughput no yes
SPOPL_HUMAN [view interactions] High throughput no yes
MYPN_HUMAN [view interactions] High throughput no no
INSY1_HUMAN [view entry] [view interactions] High throughput yes yes
SYCE1_HUMAN [view interactions] High throughput no no
TPM3_HUMAN [view entry] [view interactions] High throughput yes yes
CD6_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
SMUF1_HUMAN [view interactions] High throughput no yes
PJA1_HUMAN [view interactions] High throughput no yes
SHAN1_HUMAN [view entry] [view interactions] Computational yes yes
DLGP1_HUMAN [view entry] [view interactions] Computational yes no
SHAN2_HUMAN [view entry] [view interactions] Computational yes yes