Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

HOME2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (PubMed). Required for normal hearing (PubMed). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in HOME2_HUMAN
GO:0019900 kinase binding 34.7826 4 no
GO:0019901 protein kinase binding 30.4348 5 no
GO:0003779 actin binding 26.0870 4 yes
GO:0001664 G protein-coupled receptor binding 21.7391 4 yes
GO:0035254 glutamate receptor binding 21.7391 4 yes
GO:0043168 anion binding 21.7391 4 no
GO:0043169 cation binding 21.7391 4 no
GO:0046872 metal ion binding 21.7391 5 no
GO:0035256 G protein-coupled glutamate receptor binding 13.0435 5 yes
GO:0030159 signaling receptor complex adaptor activity 8.6957 4 yes
GO:0030160 synaptic receptor adaptor activity 8.6957 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in HOME2_HUMAN
GO:0048523 negative regulation of cellular process 69.5652 4 yes
GO:0048522 positive regulation of cellular process 69.5652 4 no
GO:0010646 regulation of cell communication 65.2174 4 yes
GO:0009966 regulation of signal transduction 56.5217 4 yes
GO:0031323 regulation of cellular metabolic process 56.5217 4 yes
GO:0060255 regulation of macromolecule metabolic process 56.5217 4 yes
GO:0051128 regulation of cellular component organization 52.1739 4 no
GO:0006996 organelle organization 47.8261 4 no
GO:0009893 positive regulation of metabolic process 47.8261 4 no
GO:0080090 regulation of primary metabolic process 47.8261 4 no
GO:0051049 regulation of transport 43.4783 4 yes
GO:0010647 positive regulation of cell communication 43.4783 5 no
GO:0023056 positive regulation of signaling 43.4783 4 no
GO:0031325 positive regulation of cellular metabolic process 43.4783 5 no
GO:0031344 regulation of cell projection organization 43.4783 5 no
GO:0010604 positive regulation of macromolecule metabolic process 43.4783 5 no
GO:0009892 negative regulation of metabolic process 39.1304 4 yes
GO:1902531 regulation of intracellular signal transduction 39.1304 5 yes
GO:0009967 positive regulation of signal transduction 39.1304 5 no
GO:0048584 positive regulation of response to stimulus 39.1304 4 no
GO:0050804 modulation of chemical synaptic transmission 39.1304 5 no
GO:0099177 regulation of trans-synaptic signaling 39.1304 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 39.1304 6 no
GO:0022607 cellular component assembly 39.1304 4 no
GO:0009889 regulation of biosynthetic process 34.7826 4 yes
GO:0010468 regulation of gene expression 34.7826 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 34.7826 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 34.7826 5 yes
GO:0031324 negative regulation of cellular metabolic process 34.7826 5 yes
GO:0031326 regulation of cellular biosynthetic process 34.7826 5 yes
GO:0044087 regulation of cellular component biogenesis 34.7826 4 no
GO:0050807 regulation of synapse organization 34.7826 5 no
GO:0001932 regulation of protein phosphorylation 34.7826 7 no
GO:0001934 positive regulation of protein phosphorylation 34.7826 8 no
GO:0010562 positive regulation of phosphorus metabolic process 34.7826 6 no
GO:0019220 regulation of phosphate metabolic process 34.7826 6 no
GO:0031399 regulation of protein modification process 34.7826 6 no
GO:0031401 positive regulation of protein modification process 34.7826 7 no
GO:0042325 regulation of phosphorylation 34.7826 7 no
GO:0042327 positive regulation of phosphorylation 34.7826 8 no
GO:0045937 positive regulation of phosphate metabolic process 34.7826 7 no
GO:0051174 regulation of phosphorus metabolic process 34.7826 5 no
GO:0051246 regulation of protein metabolic process 34.7826 5 no
GO:0051247 positive regulation of protein metabolic process 34.7826 6 no
GO:0009890 negative regulation of biosynthetic process 30.4348 5 yes
GO:0007010 cytoskeleton organization 30.4348 5 no
GO:0051130 positive regulation of cellular component organization 30.4348 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.4348 5 no
GO:0008104 protein localization 30.4348 4 no
GO:0007215 glutamate receptor signaling pathway 26.0870 4 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 26.0870 6 yes
GO:0031327 negative regulation of cellular biosynthetic process 26.0870 6 yes
GO:0048585 negative regulation of response to stimulus 26.0870 4 yes
GO:1902533 positive regulation of intracellular signal transduction 26.0870 6 no
GO:0022603 regulation of anatomical structure morphogenesis 26.0870 4 no
GO:0030334 regulation of cell migration 26.0870 5 no
GO:0033043 regulation of organelle organization 26.0870 5 no
GO:0051129 negative regulation of cellular component organization 26.0870 5 no
GO:0099175 regulation of postsynapse organization 26.0870 6 no
GO:2000145 regulation of cell motility 26.0870 4 no
GO:0043933 protein-containing complex organization 26.0870 4 no
GO:0097435 supramolecular fiber organization 26.0870 4 no
GO:1902903 regulation of supramolecular fiber organization 26.0870 5 no
GO:0048168 regulation of neuronal synaptic plasticity 26.0870 4 no
GO:0071310 cellular response to organic substance 26.0870 4 no
GO:0034330 cell junction organization 26.0870 4 no
GO:0043549 regulation of kinase activity 26.0870 5 no
GO:0045595 regulation of cell differentiation 26.0870 4 no
GO:0045859 regulation of protein kinase activity 26.0870 6 no
GO:0051338 regulation of transferase activity 26.0870 4 no
GO:0001817 regulation of cytokine production 21.7391 4 yes
GO:0007216 G protein-coupled glutamate receptor signaling pathway 21.7391 4 yes
GO:0009968 negative regulation of signal transduction 21.7391 5 yes
GO:0010629 negative regulation of gene expression 21.7391 7 yes
GO:0010648 negative regulation of cell communication 21.7391 5 yes
GO:0023057 negative regulation of signaling 21.7391 4 yes
GO:0051241 negative regulation of multicellular organismal process 21.7391 4 yes
GO:0007268 chemical synaptic transmission 21.7391 7 no
GO:0044057 regulation of system process 21.7391 4 no
GO:0051966 regulation of synaptic transmission, glutamatergic 21.7391 6 no
GO:0098916 anterograde trans-synaptic signaling 21.7391 6 no
GO:0099536 synaptic signaling 21.7391 4 no
GO:0099537 trans-synaptic signaling 21.7391 5 no
GO:0010975 regulation of neuron projection development 21.7391 7 no
GO:0007015 actin filament organization 21.7391 5 no
GO:0030030 cell projection organization 21.7391 4 no
GO:0031175 neuron projection development 21.7391 6 no
GO:0032956 regulation of actin cytoskeleton organization 21.7391 5 no
GO:0032970 regulation of actin filament-based process 21.7391 4 no
GO:0051493 regulation of cytoskeleton organization 21.7391 6 no
GO:0065003 protein-containing complex assembly 21.7391 5 no
GO:0110053 regulation of actin filament organization 21.7391 6 no
GO:0120036 plasma membrane bounded cell projection organization 21.7391 5 no
GO:0048169 regulation of long-term neuronal synaptic plasticity 21.7391 5 no
GO:0033674 positive regulation of kinase activity 21.7391 6 no
GO:0034329 cell junction assembly 21.7391 5 no
GO:0043085 positive regulation of catalytic activity 21.7391 4 no
GO:0045860 positive regulation of protein kinase activity 21.7391 7 no
GO:0051094 positive regulation of developmental process 21.7391 4 no
GO:0051240 positive regulation of multicellular organismal process 21.7391 4 no
GO:0051252 regulation of RNA metabolic process 21.7391 5 no
GO:0051347 positive regulation of transferase activity 21.7391 5 no
GO:0060284 regulation of cell development 21.7391 5 no
GO:2000026 regulation of multicellular organismal development 21.7391 4 no
GO:0001818 negative regulation of cytokine production 17.3913 5 yes
GO:0043269 regulation of monoatomic ion transport 17.3913 5 yes
GO:0050848 regulation of calcium-mediated signaling 17.3913 6 yes
GO:0008277 regulation of G protein-coupled receptor signaling pathway 13.0435 5 yes
GO:0010959 regulation of metal ion transport 13.0435 6 yes
GO:0050849 negative regulation of calcium-mediated signaling 13.0435 7 yes
GO:0051924 regulation of calcium ion transport 13.0435 7 yes
GO:1902532 negative regulation of intracellular signal transduction 13.0435 6 yes
GO:2001256 regulation of store-operated calcium entry 13.0435 8 yes
GO:0007600 sensory perception 8.6957 4 yes
GO:0032663 regulation of interleukin-2 production 8.6957 5 yes
GO:0032703 negative regulation of interleukin-2 production 8.6957 6 yes
GO:0048148 behavioral response to cocaine 8.6957 4 yes
GO:0070884 regulation of calcineurin-NFAT signaling cascade 8.6957 8 yes
GO:0070885 negative regulation of calcineurin-NFAT signaling cascade 8.6957 9 yes
GO:0106056 regulation of calcineurin-mediated signaling 8.6957 7 yes
GO:0106057 negative regulation of calcineurin-mediated signaling 8.6957 8 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
AGAP2_HUMAN [view entry] [view interactions] Low throughput yes yes
RNF41_HUMAN [view interactions] Low throughput no yes
UBXN1_HUMAN [view interactions] Low throughput no no
RYR1_HUMAN [view interactions] Low throughput no no
RHOA_HUMAN [view entry] [view interactions] Low throughput yes yes
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
CDC42_HUMAN [view entry] [view interactions] Low throughput yes yes
CAZA1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRM1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRM5_HUMAN [view entry] [view interactions] Low throughput yes no
DREB_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
ITPR1_HUMAN [view entry] [view interactions] Low throughput yes yes
SYPH_HUMAN [view entry] [view interactions] Low throughput yes yes
IMA1_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
HXB2_HUMAN [view interactions] High throughput no no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
LZTS2_HUMAN [view interactions] High throughput no no
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
VKOR1_HUMAN [view interactions] High throughput no yes
ABI3_HUMAN [view entry] [view interactions] High throughput yes no
PALLD_HUMAN [view interactions] High throughput no yes
HOME1_HUMAN [view entry] [view interactions] High throughput yes yes
HOME3_HUMAN [view entry] [view interactions] High throughput yes yes
CSPP1_HUMAN [view interactions] High throughput no no
IFT57_HUMAN [view interactions] High throughput no yes
SPOPL_HUMAN [view interactions] High throughput no yes
MYPN_HUMAN [view interactions] High throughput no no
INSY1_HUMAN [view entry] [view interactions] High throughput yes yes
SYCE1_HUMAN [view interactions] High throughput no no
TPM3_HUMAN [view entry] [view interactions] High throughput yes yes
CD6_HUMAN [view interactions] High throughput no no
UBE2H_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
SMUF1_HUMAN [view interactions] High throughput no yes
PJA1_HUMAN [view interactions] High throughput no yes