HOME3_HUMAN
Evidence for PS localization
Functions
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in HOME3_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 23.4043 | 4 | no |
| GO:0001664 | G protein-coupled receptor binding | 19.1489 | 4 | yes |
| GO:0035254 | glutamate receptor binding | 17.0213 | 4 | yes |
| GO:0035256 | G protein-coupled glutamate receptor binding | 8.5106 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in HOME3_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 65.9574 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 57.4468 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 55.3191 | 4 | yes |
| GO:0010646 | regulation of cell communication | 53.1915 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 53.1915 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 51.0638 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 44.6809 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 42.5532 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 42.5532 | 4 | yes |
| GO:0010468 | regulation of gene expression | 40.4255 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 40.4255 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 40.4255 | 5 | yes |
| GO:0022607 | cellular component assembly | 38.2979 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 36.1702 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 36.1702 | 5 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 34.0426 | 5 | yes |
| GO:0051049 | regulation of transport | 34.0426 | 4 | yes |
| GO:0006996 | organelle organization | 34.0426 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 34.0426 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 34.0426 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 31.9149 | 5 | yes |
| GO:0031344 | regulation of cell projection organization | 31.9149 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 31.9149 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 31.9149 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 31.9149 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 29.7872 | 6 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 29.7872 | 6 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 29.7872 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.7872 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 29.7872 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 29.7872 | 6 | no |
| GO:0023056 | positive regulation of signaling | 29.7872 | 4 | no |
| GO:0030030 | cell projection organization | 29.7872 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 29.7872 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 29.7872 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 29.7872 | 6 | no |
| GO:0008104 | protein localization | 27.6596 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 27.6596 | 5 | no |
| GO:0033043 | regulation of organelle organization | 27.6596 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 27.6596 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 27.6596 | 4 | no |
| GO:0031399 | regulation of protein modification process | 25.5319 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 25.5319 | 7 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.5319 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 25.5319 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 23.4043 | 5 | no |
| GO:0010629 | negative regulation of gene expression | 21.2766 | 7 | yes |
| GO:0048585 | negative regulation of response to stimulus | 21.2766 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 21.2766 | 7 | no |
| GO:0051247 | positive regulation of protein metabolic process | 21.2766 | 6 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 21.2766 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 21.2766 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 21.2766 | 6 | no |
| GO:0009968 | negative regulation of signal transduction | 19.1489 | 5 | yes |
| GO:0010648 | negative regulation of cell communication | 19.1489 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 19.1489 | 4 | yes |
| GO:0043269 | regulation of monoatomic ion transport | 19.1489 | 5 | yes |
| GO:0007215 | glutamate receptor signaling pathway | 17.0213 | 4 | yes |
| GO:0010959 | regulation of metal ion transport | 17.0213 | 6 | yes |
| GO:0051924 | regulation of calcium ion transport | 14.8936 | 7 | yes |
| GO:1902532 | negative regulation of intracellular signal transduction | 14.8936 | 6 | yes |
| GO:0007216 | G protein-coupled glutamate receptor signaling pathway | 12.7660 | 4 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 12.7660 | 4 | yes |
| GO:0001817 | regulation of cytokine production | 10.6383 | 4 | yes |
| GO:0050848 | regulation of calcium-mediated signaling | 10.6383 | 6 | yes |
| GO:0001818 | negative regulation of cytokine production | 8.5106 | 5 | yes |
| GO:0006605 | protein targeting | 8.5106 | 4 | yes |
| GO:0050849 | negative regulation of calcium-mediated signaling | 8.5106 | 7 | yes |
| GO:2001256 | regulation of store-operated calcium entry | 8.5106 | 8 | yes |
| GO:0032663 | regulation of interleukin-2 production | 6.3830 | 5 | yes |
| GO:0032703 | negative regulation of interleukin-2 production | 6.3830 | 6 | yes |
| GO:0070884 | regulation of calcineurin-NFAT signaling cascade | 6.3830 | 8 | yes |
| GO:0070885 | negative regulation of calcineurin-NFAT signaling cascade | 6.3830 | 9 | yes |
| GO:0106056 | regulation of calcineurin-mediated signaling | 6.3830 | 7 | yes |
| GO:0106057 | negative regulation of calcineurin-mediated signaling | 6.3830 | 8 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SHAN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HOME3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| WBP2_HUMAN | [view interactions] | Low throughput | no | yes |
| PRS8_HUMAN | [view interactions] | Low throughput | no | yes |
| IKKB_HUMAN | [view interactions] | Low throughput | no | yes |
| TRI59_HUMAN | [view interactions] | Low throughput | no | no |
| TRPC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RYR1_HUMAN | [view interactions] | Low throughput | no | no |
| GRM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALX_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FRPD4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PAX6_HUMAN | [view interactions] | Low throughput | no | no |
| PSA2_HUMAN | [view interactions] | Low throughput | no | yes |
| FAT1_HUMAN | [view interactions] | Low throughput | no | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| TRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABI3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3D_HUMAN | [view interactions] | High throughput | no | yes |
| WIPF1_HUMAN | [view interactions] | High throughput | no | no |
| UBP2_HUMAN | [view interactions] | High throughput | no | yes |
| NEBL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PSA1_HUMAN | [view interactions] | High throughput | no | yes |
| RUXF_HUMAN | [view interactions] | High throughput | no | no |
| PPR18_HUMAN | [view interactions] | High throughput | no | no |
| P121A_HUMAN | [view interactions] | High throughput | no | yes |
| PRCC_HUMAN | [view interactions] | High throughput | no | yes |
| C19L2_HUMAN | [view interactions] | High throughput | no | yes |
| CC120_HUMAN | [view interactions] | High throughput | no | no |
| DVL3_HUMAN | [view interactions] | High throughput | no | yes |
| RBM22_HUMAN | [view interactions] | High throughput | no | yes |
| SMR3B_HUMAN | [view interactions] | High throughput | no | no |
| DRC4_HUMAN | [view interactions] | High throughput | no | yes |
| HXB5_HUMAN | [view interactions] | High throughput | no | no |
| NTAQ1_HUMAN | [view interactions] | High throughput | no | yes |
| KANK4_HUMAN | [view interactions] | High throughput | no | no |
| LHX2_HUMAN | [view interactions] | High throughput | no | no |
| PS1C2_HUMAN | [view interactions] | High throughput | no | no |
| SDCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBTB4_HUMAN | [view interactions] | High throughput | no | yes |
| LNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM14_HUMAN | [view interactions] | High throughput | no | yes |
| F161B_HUMAN | [view interactions] | High throughput | no | yes |
| SCNM1_HUMAN | [view interactions] | High throughput | no | no |
| MFAP1_HUMAN | [view interactions] | High throughput | no | yes |
| CDK18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDM1_HUMAN | [view interactions] | High throughput | no | yes |
| PRR35_HUMAN | [view interactions] | High throughput | no | no |
| CC141_HUMAN | [view interactions] | High throughput | no | no |
| ZN414_HUMAN | [view interactions] | High throughput | no | yes |
| DYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GGN_HUMAN | [view interactions] | High throughput | no | no |
| SARG_HUMAN | [view interactions] | High throughput | no | yes |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| F90A1_HUMAN | [view interactions] | High throughput | no | no |
| DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZNF35_HUMAN | [view interactions] | High throughput | no | no |
| MEOX1_HUMAN | [view interactions] | High throughput | no | no |
| SAXO1_HUMAN | [view interactions] | High throughput | no | no |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| KANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TB22B_HUMAN | [view interactions] | High throughput | no | no |
| POLI_HUMAN | [view interactions] | High throughput | no | yes |
| MSS51_HUMAN | [view interactions] | High throughput | no | no |
| INCA1_HUMAN | [view interactions] | High throughput | no | no |
| FBX28_HUMAN | [view interactions] | High throughput | no | yes |
| SLAI1_HUMAN | [view interactions] | High throughput | no | no |
| AR13B_HUMAN | [view interactions] | High throughput | no | yes |
| TGO1_HUMAN | [view interactions] | High throughput | no | yes |
| KR197_HUMAN | [view interactions] | High throughput | no | no |
| ZNF19_HUMAN | [view interactions] | High throughput | no | no |
| CD017_HUMAN | [view interactions] | High throughput | no | no |
| ZN655_HUMAN | [view interactions] | High throughput | no | yes |
| EFHC1_HUMAN | [view interactions] | High throughput | no | yes |
| FRYL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| CDC16_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| PAX7_HUMAN | [view interactions] | High throughput | no | no |
| LRRC7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TOX2_HUMAN | [view interactions] | High throughput | no | no |
| PALLD_HUMAN | [view interactions] | High throughput | no | yes |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LS14B_HUMAN | [view interactions] | High throughput | no | yes |
| SAXO4_HUMAN | [view interactions] | High throughput | no | no |
| OTX2_HUMAN | [view interactions] | High throughput | no | yes |
| PLAT5_HUMAN | [view interactions] | High throughput | no | no |
| TRPC4_HUMAN | [view interactions] | High throughput | no | no |
| TRPC5_HUMAN | [view interactions] | High throughput | no | no |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRM5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HOME2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFT57_HUMAN | [view interactions] | High throughput | no | yes |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOX17_HUMAN | [view interactions] | High throughput | no | no |
| SPF27_HUMAN | [view interactions] | High throughput | no | yes |
| IFIT2_HUMAN | [view interactions] | High throughput | no | no |
| PALS1_HUMAN | [view interactions] | High throughput | no | no |
| INADL_HUMAN | [view interactions] | High throughput | no | no |
| HNRLL_HUMAN | [view interactions] | High throughput | no | yes |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| NUP54_HUMAN | [view interactions] | High throughput | no | yes |
| WASF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPOG2_HUMAN | [view interactions] | High throughput | no | yes |
| NCKP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF4E2_HUMAN | [view interactions] | High throughput | no | no |
| CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| MYPN_HUMAN | [view interactions] | High throughput | no | no |
| SPOPL_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DSN1_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITPR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STRBP_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTG8_HUMAN | [view interactions] | High throughput | no | yes |
| PKN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EAF1_HUMAN | [view interactions] | High throughput | no | yes |
| MOS_HUMAN | [view interactions] | High throughput | no | no |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| HOME1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| CEP44_HUMAN | [view interactions] | High throughput | no | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| TENS3_HUMAN | [view interactions] | High throughput | no | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |