HOME3_HUMAN
Evidence for PS localization
Functions
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in HOME3_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 22.7273 | 4 | no |
| GO:0001664 | G protein-coupled receptor binding | 18.1818 | 4 | yes |
| GO:0035254 | glutamate receptor binding | 18.1818 | 4 | yes |
| GO:0035256 | G protein-coupled glutamate receptor binding | 9.0909 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in HOME3_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 59.0909 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 59.0909 | 4 | no |
| GO:0010646 | regulation of cell communication | 52.2727 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 47.7273 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 45.4545 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 45.4545 | 4 | no |
| GO:0010468 | regulation of gene expression | 40.9091 | 5 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 40.9091 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 40.9091 | 4 | no |
| GO:0022607 | cellular component assembly | 36.3636 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 34.0909 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 34.0909 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 34.0909 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 31.8182 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 31.8182 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 31.8182 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 31.8182 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 31.8182 | 5 | no |
| GO:0030030 | cell projection organization | 31.8182 | 4 | no |
| GO:0008104 | protein localization | 29.5455 | 4 | yes |
| GO:0051049 | regulation of transport | 29.5455 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 29.5455 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 29.5455 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 29.5455 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 29.5455 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 27.2727 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 27.2727 | 5 | no |
| GO:0006996 | organelle organization | 27.2727 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 27.2727 | 5 | no |
| GO:0043269 | regulation of ion transport | 25.0000 | 5 | yes |
| GO:0071702 | organic substance transport | 25.0000 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 25.0000 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0033043 | regulation of organelle organization | 25.0000 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.0000 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 25.0000 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 25.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 25.0000 | 6 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.0000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 25.0000 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 25.0000 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 22.7273 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 22.7273 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 22.7273 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 22.7273 | 7 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 22.7273 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 20.4545 | 5 | yes |
| GO:0048585 | negative regulation of response to stimulus | 20.4545 | 4 | yes |
| GO:0032956 | regulation of actin cytoskeleton organization | 20.4545 | 5 | no |
| GO:0032970 | regulation of actin filament-based process | 20.4545 | 4 | no |
| GO:0050807 | regulation of synapse organization | 20.4545 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 20.4545 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 20.4545 | 5 | no |
| GO:0006468 | protein phosphorylation | 20.4545 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 20.4545 | 4 | no |
| GO:0016310 | phosphorylation | 20.4545 | 5 | no |
| GO:0036211 | protein modification process | 20.4545 | 4 | no |
| GO:0043412 | macromolecule modification | 20.4545 | 4 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 20.4545 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 20.4545 | 7 | no |
| GO:0009890 | negative regulation of biosynthetic process | 20.4545 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 20.4545 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 20.4545 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 20.4545 | 6 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 20.4545 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 20.4545 | 6 | no |
| GO:0032990 | cell part morphogenesis | 20.4545 | 4 | no |
| GO:0048858 | cell projection morphogenesis | 20.4545 | 5 | no |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 20.4545 | 6 | no |
| GO:0007215 | glutamate receptor signaling pathway | 18.1818 | 4 | yes |
| GO:0010629 | negative regulation of gene expression | 18.1818 | 6 | yes |
| GO:0015031 | protein transport | 18.1818 | 4 | yes |
| GO:0006886 | intracellular protein transport | 15.9091 | 4 | yes |
| GO:0010959 | regulation of metal ion transport | 15.9091 | 6 | yes |
| GO:0007216 | G protein-coupled glutamate receptor signaling pathway | 13.6364 | 4 | yes |
| GO:0051924 | regulation of calcium ion transport | 13.6364 | 7 | yes |
| GO:1902532 | negative regulation of intracellular signal transduction | 13.6364 | 6 | yes |
| GO:0006605 | protein targeting | 11.3636 | 5 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 11.3636 | 4 | yes |
| GO:0001817 | regulation of cytokine production | 9.0909 | 4 | yes |
| GO:0050848 | regulation of calcium-mediated signaling | 9.0909 | 6 | yes |
| GO:0050849 | negative regulation of calcium-mediated signaling | 9.0909 | 7 | yes |
| GO:2001256 | regulation of store-operated calcium entry | 9.0909 | 8 | yes |
| GO:0001818 | negative regulation of cytokine production | 6.8182 | 5 | yes |
| GO:0032663 | regulation of interleukin-2 production | 6.8182 | 5 | yes |
| GO:0032703 | negative regulation of interleukin-2 production | 6.8182 | 6 | yes |
| GO:0070884 | regulation of calcineurin-NFAT signaling cascade | 6.8182 | 8 | yes |
| GO:0070885 | negative regulation of calcineurin-NFAT signaling cascade | 6.8182 | 9 | yes |
| GO:0106056 | regulation of calcineurin-mediated signaling | 6.8182 | 7 | yes |
| GO:0106057 | negative regulation of calcineurin-mediated signaling | 6.8182 | 8 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in HOME3_HUMAN |
|---|---|---|---|---|
| DOID:0050753 | cerebellar ataxia | 4.5455 | 6 | no |
| DOID:0050951 | hereditary ataxia | 4.5455 | 5 | no |
| DOID:1289 | neurodegenerative disease | 4.5455 | 4 | no |
| DOID:1441 | autosomal dominant cerebellar ataxia | 4.5455 | 7 | no |
| DOID:331 | central nervous system disease | 4.5455 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PSA2_HUMAN | [view interactions] | Low throughput | no | yes |
| FAT1_HUMAN | [view interactions] | Low throughput | no | yes |
| SHAN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HOME3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| WBP2_HUMAN | [view interactions] | Low throughput | no | yes |
| PRS8_HUMAN | [view interactions] | Low throughput | no | yes |
| IKKB_HUMAN | [view interactions] | Low throughput | no | yes |
| TRI59_HUMAN | [view interactions] | Low throughput | no | no |
| TRPC1_HUMAN | [view interactions] | Low throughput | no | yes |
| RYR1_HUMAN | [view interactions] | Low throughput | no | no |
| GRM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALX_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FRPD4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PAX6_HUMAN | [view interactions] | Low throughput | no | no |
| MOS_HUMAN | [view interactions] | High throughput | no | no |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| HOME1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| CEP44_HUMAN | [view interactions] | High throughput | no | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| TENS3_HUMAN | [view interactions] | High throughput | no | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| TRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABI3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3D_HUMAN | [view interactions] | High throughput | no | yes |
| WIPF1_HUMAN | [view interactions] | High throughput | no | no |
| UBP2_HUMAN | [view interactions] | High throughput | no | yes |
| NEBL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PSA1_HUMAN | [view interactions] | High throughput | no | yes |
| RUXF_HUMAN | [view interactions] | High throughput | no | no |
| PPR18_HUMAN | [view interactions] | High throughput | no | no |
| P121A_HUMAN | [view interactions] | High throughput | no | yes |
| PRCC_HUMAN | [view interactions] | High throughput | no | yes |
| C19L2_HUMAN | [view interactions] | High throughput | no | yes |
| CC120_HUMAN | [view interactions] | High throughput | no | no |
| DVL3_HUMAN | [view interactions] | High throughput | no | yes |
| SMR3B_HUMAN | [view interactions] | High throughput | no | no |
| RBM22_HUMAN | [view interactions] | High throughput | no | yes |
| DRC4_HUMAN | [view interactions] | High throughput | no | yes |
| HXB5_HUMAN | [view interactions] | High throughput | no | no |
| NTAQ1_HUMAN | [view interactions] | High throughput | no | yes |
| KANK4_HUMAN | [view interactions] | High throughput | no | no |
| LHX2_HUMAN | [view interactions] | High throughput | no | no |
| PS1C2_HUMAN | [view interactions] | High throughput | no | no |
| SDCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBTB4_HUMAN | [view interactions] | High throughput | no | yes |
| LNX1_HUMAN | [view interactions] | High throughput | no | yes |
| RBM14_HUMAN | [view interactions] | High throughput | no | yes |
| F161B_HUMAN | [view interactions] | High throughput | no | yes |
| SCNM1_HUMAN | [view interactions] | High throughput | no | no |
| MFAP1_HUMAN | [view interactions] | High throughput | no | yes |
| CDK18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDM1_HUMAN | [view interactions] | High throughput | no | yes |
| PRR35_HUMAN | [view interactions] | High throughput | no | no |
| CC141_HUMAN | [view interactions] | High throughput | no | no |
| ZN414_HUMAN | [view interactions] | High throughput | no | yes |
| DYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GGN_HUMAN | [view interactions] | High throughput | no | no |
| SARG_HUMAN | [view interactions] | High throughput | no | yes |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| F90A1_HUMAN | [view interactions] | High throughput | no | no |
| DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZNF35_HUMAN | [view interactions] | High throughput | no | no |
| MEOX1_HUMAN | [view interactions] | High throughput | no | no |
| SAXO1_HUMAN | [view interactions] | High throughput | no | no |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| KANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TB22B_HUMAN | [view interactions] | High throughput | no | no |
| POLI_HUMAN | [view interactions] | High throughput | no | yes |
| MSS51_HUMAN | [view interactions] | High throughput | no | no |
| INCA1_HUMAN | [view interactions] | High throughput | no | no |
| FBX28_HUMAN | [view interactions] | High throughput | no | yes |
| SLAI1_HUMAN | [view interactions] | High throughput | no | no |
| AR13B_HUMAN | [view interactions] | High throughput | no | yes |
| TGO1_HUMAN | [view interactions] | High throughput | no | yes |
| KR197_HUMAN | [view interactions] | High throughput | no | no |
| ZNF19_HUMAN | [view interactions] | High throughput | no | no |
| CD017_HUMAN | [view interactions] | High throughput | no | no |
| ZN655_HUMAN | [view interactions] | High throughput | no | yes |
| EFHC1_HUMAN | [view interactions] | High throughput | no | yes |
| FRYL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC16_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| PAX7_HUMAN | [view interactions] | High throughput | no | no |
| LRRC7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TOX2_HUMAN | [view interactions] | High throughput | no | no |
| PALLD_HUMAN | [view interactions] | High throughput | no | yes |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LS14B_HUMAN | [view interactions] | High throughput | no | yes |
| PPR32_HUMAN | [view interactions] | High throughput | no | no |
| OTX2_HUMAN | [view interactions] | High throughput | no | yes |
| PLAT5_HUMAN | [view interactions] | High throughput | no | no |
| TRPC4_HUMAN | [view interactions] | High throughput | no | no |
| TRPC5_HUMAN | [view interactions] | High throughput | no | no |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRM5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HOME2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFT57_HUMAN | [view interactions] | High throughput | no | yes |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOX17_HUMAN | [view interactions] | High throughput | no | no |
| SPF27_HUMAN | [view interactions] | High throughput | no | yes |
| IFIT2_HUMAN | [view interactions] | High throughput | no | no |
| PALS1_HUMAN | [view interactions] | High throughput | no | no |
| INADL_HUMAN | [view interactions] | High throughput | no | no |
| HNRLL_HUMAN | [view interactions] | High throughput | no | yes |
| NUP54_HUMAN | [view interactions] | High throughput | no | yes |
| WASF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPOG2_HUMAN | [view interactions] | High throughput | no | yes |
| NCKP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF4E2_HUMAN | [view interactions] | High throughput | no | no |
| CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| MYPN_HUMAN | [view interactions] | High throughput | no | no |
| SPOPL_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITPR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| MTG8_HUMAN | [view interactions] | High throughput | no | yes |
| PKN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EAF1_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |