FRYL_HUMAN
Evidence for PS localization
Functions
Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching . May function as a transcriptional activator. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in FRYL_HUMAN |
|---|---|---|---|---|
| GO:0045296 | cadherin binding | 30.4348 | 4 | no |
| GO:0019900 | kinase binding | 26.0870 | 4 | no |
| GO:0019901 | protein kinase binding | 26.0870 | 5 | no |
| GO:0017076 | purine nucleotide binding | 26.0870 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 26.0870 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.0870 | 4 | no |
| GO:0046872 | metal ion binding | 21.7391 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in FRYL_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 60.8696 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 56.5217 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 52.1739 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 52.1739 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 52.1739 | 4 | no |
| GO:0010646 | regulation of cell communication | 52.1739 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 52.1739 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 52.1739 | 4 | no |
| GO:0009966 | regulation of signal transduction | 47.8261 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 47.8261 | 4 | no |
| GO:0006996 | organelle organization | 43.4783 | 4 | no |
| GO:0051049 | regulation of transport | 39.1304 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 34.7826 | 5 | no |
| GO:0007010 | cytoskeleton organization | 34.7826 | 5 | no |
| GO:0030030 | cell projection organization | 34.7826 | 4 | yes |
| GO:0022607 | cellular component assembly | 34.7826 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 34.7826 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 34.7826 | 6 | no |
| GO:0009892 | negative regulation of metabolic process | 34.7826 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 30.4348 | 5 | no |
| GO:0071702 | organic substance transport | 30.4348 | 4 | no |
| GO:0071705 | nitrogen compound transport | 30.4348 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 30.4348 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 30.4348 | 4 | no |
| GO:0043269 | regulation of ion transport | 30.4348 | 5 | no |
| GO:0006886 | intracellular protein transport | 30.4348 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 30.4348 | 5 | no |
| GO:0015031 | protein transport | 30.4348 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 30.4348 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 30.4348 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 30.4348 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 26.0870 | 5 | no |
| GO:0010468 | regulation of gene expression | 26.0870 | 5 | no |
| GO:0010975 | regulation of neuron projection development | 26.0870 | 7 | no |
| GO:0033043 | regulation of organelle organization | 26.0870 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 26.0870 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 26.0870 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 26.0870 | 6 | no |
| GO:0036211 | protein modification process | 26.0870 | 4 | no |
| GO:0043412 | macromolecule modification | 26.0870 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 26.0870 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 26.0870 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 26.0870 | 5 | no |
| GO:0010959 | regulation of metal ion transport | 26.0870 | 6 | no |
| GO:0023056 | positive regulation of signaling | 26.0870 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 26.0870 | 4 | no |
| GO:0050807 | regulation of synapse organization | 26.0870 | 5 | no |
| GO:0006605 | protein targeting | 26.0870 | 5 | no |
| GO:0031399 | regulation of protein modification process | 26.0870 | 6 | no |
| GO:0051338 | regulation of transferase activity | 21.7391 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 21.7391 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 21.7391 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.7391 | 5 | no |
| GO:0021762 | substantia nigra development | 21.7391 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 21.7391 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 21.7391 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 21.7391 | 5 | no |
| GO:0016055 | Wnt signaling pathway | 21.7391 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 21.7391 | 5 | no |
| GO:0045597 | positive regulation of cell differentiation | 21.7391 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 21.7391 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 21.7391 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 21.7391 | 5 | no |
| GO:1905114 | cell surface receptor signaling pathway involved in cell-cell signaling | 21.7391 | 4 | no |
| GO:0060284 | regulation of cell development | 21.7391 | 5 | no |
| GO:0006468 | protein phosphorylation | 21.7391 | 5 | no |
| GO:0016310 | phosphorylation | 21.7391 | 5 | no |
| GO:0031175 | neuron projection development | 21.7391 | 6 | yes |
| GO:0022898 | regulation of transmembrane transporter activity | 21.7391 | 4 | no |
| GO:0032412 | regulation of ion transmembrane transporter activity | 21.7391 | 5 | no |
| GO:0034762 | regulation of transmembrane transport | 21.7391 | 4 | no |
| GO:0034765 | regulation of ion transmembrane transport | 21.7391 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 21.7391 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 21.7391 | 4 | no |
| GO:1904062 | regulation of cation transmembrane transport | 21.7391 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 21.7391 | 7 | no |
| GO:0043549 | regulation of kinase activity | 21.7391 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SLMAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDC10_HUMAN | [view interactions] | High throughput | no | yes |
| PRR35_HUMAN | [view interactions] | High throughput | no | no |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| GRK5_HUMAN | [view interactions] | High throughput | no | yes |
| MMS19_HUMAN | [view interactions] | High throughput | no | yes |
| K0930_HUMAN | [view interactions] | High throughput | no | yes |
| NHRF3_HUMAN | [view interactions] | High throughput | no | no |
| FLNC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RN138_HUMAN | [view interactions] | High throughput | no | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| ZUP1_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| LRC31_HUMAN | [view interactions] | High throughput | no | no |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
| CCD71_HUMAN | [view interactions] | High throughput | no | no |
| PI51A_HUMAN | [view interactions] | High throughput | no | yes |
| NHRF2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARI4A_HUMAN | [view interactions] | High throughput | no | no |
| SLU7_HUMAN | [view interactions] | High throughput | no | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STK26_HUMAN | [view interactions] | High throughput | no | no |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABCF1_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PELI2_HUMAN | [view interactions] | High throughput | no | yes |
| TACC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| MD2BP_HUMAN | [view interactions] | High throughput | no | no |
| HOME1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEP44_HUMAN | [view interactions] | High throughput | no | yes |
| POLH_HUMAN | [view interactions] | High throughput | no | yes |
| NOTC1_HUMAN | [view interactions] | High throughput | no | yes |
| MAML1_HUMAN | [view interactions] | High throughput | no | yes |
| PDZ1P_HUMAN | [view interactions] | High throughput | no | no |
| FA78B_HUMAN | [view interactions] | High throughput | no | no |
| FRY_HUMAN | [view interactions] | High throughput | no | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAK_HUMAN | [view interactions] | High throughput | no | no |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HOME3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PACN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STK38_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ST38L_HUMAN | [view entry] [view interactions] | Computational | yes | yes |