FRYL_HUMAN
Evidence for PS localization
Functions
Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching . May function as a transcriptional activator. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in FRYL_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 26.9231 | 4 | no |
| GO:0019901 | protein kinase binding | 26.9231 | 5 | no |
| GO:0000166 | nucleotide binding | 26.9231 | 4 | no |
| GO:0017076 | purine nucleotide binding | 26.9231 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 26.9231 | 4 | no |
| GO:0043168 | anion binding | 26.9231 | 4 | no |
| GO:0045296 | cadherin binding | 26.9231 | 4 | no |
| GO:0003723 | RNA binding | 23.0769 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 23.0769 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in FRYL_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 61.5385 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 57.6923 | 4 | no |
| GO:0008104 | protein localization | 57.6923 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 57.6923 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 57.6923 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 57.6923 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 53.8462 | 4 | no |
| GO:0010646 | regulation of cell communication | 53.8462 | 4 | no |
| GO:0006996 | organelle organization | 50.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 50.0000 | 4 | no |
| GO:0051049 | regulation of transport | 46.1538 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 42.3077 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 42.3077 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 38.4615 | 4 | no |
| GO:0010468 | regulation of gene expression | 38.4615 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 38.4615 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 38.4615 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 38.4615 | 5 | no |
| GO:0022607 | cellular component assembly | 38.4615 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 38.4615 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 38.4615 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 38.4615 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 34.6154 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 34.6154 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 34.6154 | 5 | no |
| GO:0023056 | positive regulation of signaling | 34.6154 | 4 | no |
| GO:0030030 | cell projection organization | 30.7692 | 4 | yes |
| GO:0007010 | cytoskeleton organization | 30.7692 | 5 | no |
| GO:0033043 | regulation of organelle organization | 30.7692 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 30.7692 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 30.7692 | 7 | no |
| GO:0009890 | negative regulation of biosynthetic process | 30.7692 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 30.7692 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 30.7692 | 6 | no |
| GO:0009893 | positive regulation of metabolic process | 30.7692 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.7692 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 30.7692 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 30.7692 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 30.7692 | 5 | no |
| GO:0060284 | regulation of cell development | 30.7692 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 30.7692 | 6 | no |
| GO:2000026 | regulation of multicellular organismal development | 30.7692 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 30.7692 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 30.7692 | 5 | no |
| GO:0023057 | negative regulation of signaling | 30.7692 | 4 | no |
| GO:0031399 | regulation of protein modification process | 30.7692 | 6 | no |
| GO:0048585 | negative regulation of response to stimulus | 30.7692 | 4 | no |
| GO:0071310 | cellular response to organic substance | 30.7692 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 30.7692 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 30.7692 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 26.9231 | 5 | yes |
| GO:0051726 | regulation of cell cycle | 26.9231 | 4 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 26.9231 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 26.9231 | 6 | no |
| GO:0043269 | regulation of monoatomic ion transport | 26.9231 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 26.9231 | 4 | no |
| GO:0045597 | positive regulation of cell differentiation | 26.9231 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.9231 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 26.9231 | 5 | no |
| GO:0031175 | neuron projection development | 23.0769 | 6 | yes |
| GO:0034762 | regulation of transmembrane transport | 23.0769 | 4 | no |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 23.0769 | 5 | no |
| GO:0141124 | intracellular signaling cassette | 23.0769 | 4 | no |
| GO:0010975 | regulation of neuron projection development | 23.0769 | 7 | no |
| GO:0016055 | Wnt signaling pathway | 23.0769 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.0769 | 4 | no |
| GO:0050807 | regulation of synapse organization | 23.0769 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 23.0769 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 23.0769 | 6 | no |
| GO:0031400 | negative regulation of protein modification process | 23.0769 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.0769 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 23.0769 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 23.0769 | 5 | no |
| GO:0043066 | negative regulation of apoptotic process | 23.0769 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 23.0769 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 23.0769 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SLU7_HUMAN | [view interactions] | High throughput | no | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STK26_HUMAN | [view interactions] | High throughput | no | no |
| ANM1_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| ABCF1_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PELI2_HUMAN | [view interactions] | High throughput | no | yes |
| TACC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| MD2BP_HUMAN | [view interactions] | High throughput | no | no |
| HOME1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEP44_HUMAN | [view interactions] | High throughput | no | yes |
| POLH_HUMAN | [view interactions] | High throughput | no | yes |
| NOTC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAML1_HUMAN | [view interactions] | High throughput | no | yes |
| PDZ1P_HUMAN | [view interactions] | High throughput | no | no |
| FA78B_HUMAN | [view interactions] | High throughput | no | no |
| FRY_HUMAN | [view interactions] | High throughput | no | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAK_HUMAN | [view interactions] | High throughput | no | no |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HOME3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PACN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SLMAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDC10_HUMAN | [view interactions] | High throughput | no | yes |
| PRR35_HUMAN | [view interactions] | High throughput | no | no |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| GRK5_HUMAN | [view interactions] | High throughput | no | yes |
| MMS19_HUMAN | [view interactions] | High throughput | no | yes |
| K0930_HUMAN | [view interactions] | High throughput | no | yes |
| NHRF3_HUMAN | [view interactions] | High throughput | no | no |
| FLNC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RN138_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| ZUP1_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| LRC31_HUMAN | [view interactions] | High throughput | no | no |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
| CCD71_HUMAN | [view interactions] | High throughput | no | no |
| PI51A_HUMAN | [view interactions] | High throughput | no | yes |
| NHRF2_HUMAN | [view interactions] | High throughput | no | no |
| ARI4A_HUMAN | [view interactions] | High throughput | no | no |