TACC3_HUMAN
Evidence for PS localization
Functions
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors . Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed, PubMed). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in TACC3_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 30.7692 | 4 | no |
| GO:0017076 | purine nucleotide binding | 30.7692 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 30.7692 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 30.7692 | 4 | no |
| GO:0043168 | anion binding | 30.7692 | 4 | no |
| GO:0003723 | RNA binding | 23.0769 | 4 | no |
| GO:0031625 | ubiquitin protein ligase binding | 23.0769 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 23.0769 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in TACC3_HUMAN |
|---|---|---|---|---|
| GO:0051128 | regulation of cellular component organization | 53.8462 | 4 | yes |
| GO:0006996 | organelle organization | 46.1538 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 46.1538 | 4 | no |
| GO:0033043 | regulation of organelle organization | 43.5897 | 5 | yes |
| GO:0022607 | cellular component assembly | 41.0256 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 41.0256 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 41.0256 | 4 | no |
| GO:0043933 | protein-containing complex organization | 35.8974 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 35.8974 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 35.8974 | 4 | no |
| GO:0010646 | regulation of cell communication | 33.3333 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 33.3333 | 5 | no |
| GO:0007010 | cytoskeleton organization | 30.7692 | 5 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 30.7692 | 6 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 30.7692 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 30.7692 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 30.7692 | 5 | no |
| GO:0008104 | protein localization | 30.7692 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 30.7692 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.7692 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.7692 | 5 | no |
| GO:0071702 | organic substance transport | 28.2051 | 4 | no |
| GO:0071705 | nitrogen compound transport | 28.2051 | 4 | no |
| GO:0009966 | regulation of signal transduction | 28.2051 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 28.2051 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 28.2051 | 5 | no |
| GO:0031399 | regulation of protein modification process | 28.2051 | 6 | no |
| GO:0009892 | negative regulation of metabolic process | 28.2051 | 4 | no |
| GO:0010468 | regulation of gene expression | 28.2051 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 28.2051 | 5 | no |
| GO:0032886 | regulation of microtubule-based process | 25.6410 | 4 | yes |
| GO:0010638 | positive regulation of organelle organization | 25.6410 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.6410 | 6 | no |
| GO:0070507 | regulation of microtubule cytoskeleton organization | 23.0769 | 5 | yes |
| GO:0097435 | supramolecular fiber organization | 23.0769 | 4 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 23.0769 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 23.0769 | 5 | no |
| GO:0015031 | protein transport | 23.0769 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 23.0769 | 5 | no |
| GO:0010564 | regulation of cell cycle process | 20.5128 | 5 | yes |
| GO:0051726 | regulation of cell cycle | 20.5128 | 4 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 20.5128 | 5 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 20.5128 | 5 | no |
| GO:0030030 | cell projection organization | 20.5128 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 20.5128 | 5 | no |
| GO:0006886 | intracellular protein transport | 20.5128 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 20.5128 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 20.5128 | 6 | no |
| GO:0010628 | positive regulation of gene expression | 20.5128 | 7 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 20.5128 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 20.5128 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 20.5128 | 4 | no |
| GO:0009894 | regulation of catabolic process | 20.5128 | 4 | no |
| GO:1902850 | microtubule cytoskeleton organization involved in mitosis | 15.3846 | 4 | yes |
| GO:0060236 | regulation of mitotic spindle organization | 12.8205 | 7 | yes |
| GO:0090224 | regulation of spindle organization | 12.8205 | 6 | yes |
| GO:0007052 | mitotic spindle organization | 10.2564 | 4 | yes |
| GO:0033044 | regulation of chromosome organization | 10.2564 | 6 | yes |
| GO:0033045 | regulation of sister chromatid segregation | 10.2564 | 7 | yes |
| GO:0044772 | mitotic cell cycle phase transition | 10.2564 | 4 | yes |
| GO:0051983 | regulation of chromosome segregation | 10.2564 | 6 | yes |
| GO:0007091 | metaphase/anaphase transition of mitotic cell cycle | 5.1282 | 5 | yes |
| GO:0044784 | metaphase/anaphase transition of cell cycle | 5.1282 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| FOG1_HUMAN | [view interactions] | Low throughput | no | yes |
| TTF2_HUMAN | [view interactions] | Low throughput | no | yes |
| TACC3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CKAP5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AURKA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| CLCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NDEL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AKAP9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MBD2_HUMAN | [view interactions] | Low throughput | no | yes |
| FZR1_HUMAN | [view interactions] | Low throughput | no | no |
| KAT2B_HUMAN | [view interactions] | Low throughput | no | yes |
| RAE1L_HUMAN | [view interactions] | Low throughput | no | no |
| CDC27_HUMAN | [view interactions] | Low throughput | no | yes |
| ARNT_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BRCA1_HUMAN | [view interactions] | Low throughput | no | yes |
| KAT2A_HUMAN | [view interactions] | Low throughput | no | no |
| CLH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CEP55_HUMAN | [view interactions] | High throughput | no | yes |
| MET14_HUMAN | [view interactions] | High throughput | no | yes |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| CB069_HUMAN | [view interactions] | High throughput | no | yes |
| ANM9_HUMAN | [view interactions] | High throughput | no | no |
| S53A1_HUMAN | [view interactions] | High throughput | no | yes |
| ENAH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZER1_HUMAN | [view interactions] | High throughput | no | no |
| TGO1_HUMAN | [view interactions] | High throughput | no | yes |
| SLBP_HUMAN | [view interactions] | High throughput | no | yes |
| FRYL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF11_HUMAN | [view interactions] | High throughput | no | yes |
| WDR90_HUMAN | [view interactions] | High throughput | no | yes |
| RN168_HUMAN | [view interactions] | High throughput | no | no |
| SLAI2_HUMAN | [view interactions] | High throughput | no | no |
| RN135_HUMAN | [view interactions] | High throughput | no | yes |
| DEFM_HUMAN | [view interactions] | High throughput | no | yes |
| DSRAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCDH7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| M3K21_HUMAN | [view interactions] | High throughput | no | yes |
| VASP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARX_HUMAN | [view interactions] | High throughput | no | no |
| BD1L1_HUMAN | [view interactions] | High throughput | no | yes |
| T2EB_HUMAN | [view interactions] | High throughput | no | yes |
| ZC3H1_HUMAN | [view interactions] | High throughput | no | yes |
| HPBP1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MS18B_HUMAN | [view interactions] | High throughput | no | no |
| SNP29_HUMAN | [view interactions] | High throughput | no | yes |
| BORC6_HUMAN | [view interactions] | High throughput | no | yes |
| CRIS2_HUMAN | [view interactions] | High throughput | no | no |
| KIME_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| VP37C_HUMAN | [view interactions] | High throughput | no | yes |
| KIZ_HUMAN | [view interactions] | High throughput | no | no |
| SNX20_HUMAN | [view interactions] | High throughput | no | no |
| CIB3_HUMAN | [view interactions] | High throughput | no | no |
| ASPC1_HUMAN | [view interactions] | High throughput | no | yes |
| TB22B_HUMAN | [view interactions] | High throughput | no | no |
| ARNT2_HUMAN | [view interactions] | High throughput | no | yes |
| BRE1A_HUMAN | [view interactions] | High throughput | no | yes |
| CTSRT_HUMAN | [view interactions] | High throughput | no | no |
| NUP54_HUMAN | [view interactions] | High throughput | no | yes |
| KLH38_HUMAN | [view interactions] | High throughput | no | no |
| GDIR3_HUMAN | [view interactions] | High throughput | no | no |
| MIEAP_HUMAN | [view interactions] | High throughput | no | no |
| BEX2_HUMAN | [view interactions] | High throughput | no | yes |
| GDF15_HUMAN | [view interactions] | High throughput | no | no |
| BEX3_HUMAN | [view interactions] | High throughput | no | yes |
| CDKL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZWINT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RON_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| CLIP4_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOD2_HUMAN | [view interactions] | High throughput | no | yes |
| KLC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CD20B_HUMAN | [view interactions] | High throughput | no | no |
| DRC10_HUMAN | [view interactions] | High throughput | no | no |
| CCHCR_HUMAN | [view interactions] | High throughput | no | no |
| PKHO2_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NFS1_HUMAN | [view interactions] | High throughput | no | yes |
| DHRS2_HUMAN | [view interactions] | High throughput | no | no |
| ORC3_HUMAN | [view interactions] | High throughput | no | yes |
| PANK2_HUMAN | [view interactions] | High throughput | no | yes |
| DEPD7_HUMAN | [view interactions] | High throughput | no | no |
| PR14L_HUMAN | [view interactions] | High throughput | no | no |
| F111B_HUMAN | [view interactions] | High throughput | no | no |
| CORO6_HUMAN | [view interactions] | High throughput | no | no |
| CBY2_HUMAN | [view interactions] | High throughput | no | no |
| EVL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| BAG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SVIP_HUMAN | [view interactions] | High throughput | no | yes |
| GNAQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIM8A_HUMAN | [view interactions] | High throughput | no | yes |
| MPDZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUP62_HUMAN | [view interactions] | High throughput | no | yes |
| IPP_HUMAN | [view interactions] | High throughput | no | yes |
| CLP1_HUMAN | [view interactions] | High throughput | no | yes |
| SLAI1_HUMAN | [view interactions] | High throughput | no | no |
| PRP19_HUMAN | [view interactions] | High throughput | no | yes |
| NHSL3_HUMAN | [view interactions] | High throughput | no | yes |
| KXDL1_HUMAN | [view interactions] | High throughput | no | yes |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TUSC1_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLH12_HUMAN | [view interactions] | High throughput | no | no |
| AF17_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SAHH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRXN1_HUMAN | [view interactions] | High throughput | no | no |
| SC23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RD23B_HUMAN | [view interactions] | High throughput | no | yes |
| CPLX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAE2_HUMAN | [view interactions] | High throughput | no | yes |
| RD23A_HUMAN | [view interactions] | High throughput | no | yes |
| RAB14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZNRD2_HUMAN | [view interactions] | High throughput | no | yes |
| PUR6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC24A_HUMAN | [view interactions] | High throughput | no | no |
| MRE11_HUMAN | [view interactions] | High throughput | no | yes |
| DCA15_HUMAN | [view interactions] | High throughput | no | no |
| K1C18_HUMAN | [view interactions] | High throughput | no | no |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| ARL8B_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| PF21A_HUMAN | [view interactions] | High throughput | no | yes |
| KBTB4_HUMAN | [view interactions] | High throughput | no | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| WWTR1_HUMAN | [view interactions] | High throughput | no | yes |