TACC3_HUMAN
Evidence for PS localization
Functions
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors . Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed, PubMed). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in TACC3_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 43.2432 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 37.8378 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 37.8378 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 29.7297 | 5 | no |
| GO:0003723 | RNA binding | 24.3243 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 24.3243 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 24.3243 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 24.3243 | 6 | no |
| GO:0005524 | ATP binding | 24.3243 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 24.3243 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in TACC3_HUMAN |
|---|---|---|---|---|
| GO:0051128 | regulation of cellular component organization | 51.3514 | 4 | yes |
| GO:0006996 | organelle organization | 43.2432 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 40.5405 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 40.5405 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 40.5405 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 40.5405 | 4 | no |
| GO:0033043 | regulation of organelle organization | 37.8378 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 35.1351 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 35.1351 | 4 | no |
| GO:0022607 | cellular component assembly | 35.1351 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 32.4324 | 5 | no |
| GO:0007010 | cytoskeleton organization | 29.7297 | 5 | yes |
| GO:0010646 | regulation of cell communication | 29.7297 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 29.7297 | 4 | no |
| GO:0043933 | protein-containing complex organization | 29.7297 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 29.7297 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.7297 | 5 | no |
| GO:0032886 | regulation of microtubule-based process | 27.0270 | 4 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 27.0270 | 6 | yes |
| GO:0009892 | negative regulation of metabolic process | 27.0270 | 4 | no |
| GO:0009966 | regulation of signal transduction | 27.0270 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.0270 | 5 | no |
| GO:0031399 | regulation of protein modification process | 27.0270 | 6 | no |
| GO:0008104 | protein localization | 27.0270 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 27.0270 | 5 | no |
| GO:0010468 | regulation of gene expression | 27.0270 | 5 | no |
| GO:0070507 | regulation of microtubule cytoskeleton organization | 24.3243 | 5 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 24.3243 | 5 | no |
| GO:0071702 | organic substance transport | 24.3243 | 4 | no |
| GO:0071705 | nitrogen compound transport | 24.3243 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 24.3243 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 24.3243 | 5 | no |
| GO:0010628 | positive regulation of gene expression | 24.3243 | 6 | no |
| GO:0051726 | regulation of cell cycle | 21.6216 | 4 | yes |
| GO:0051129 | negative regulation of cellular component organization | 21.6216 | 5 | no |
| GO:0015031 | protein transport | 21.6216 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 21.6216 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 21.6216 | 5 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 21.6216 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 21.6216 | 6 | no |
| GO:0045595 | regulation of cell differentiation | 21.6216 | 4 | no |
| GO:0010564 | regulation of cell cycle process | 18.9189 | 5 | yes |
| GO:0060236 | regulation of mitotic spindle organization | 13.5135 | 7 | yes |
| GO:0090224 | regulation of spindle organization | 13.5135 | 6 | yes |
| GO:1902850 | microtubule cytoskeleton organization involved in mitosis | 13.5135 | 4 | yes |
| GO:0007052 | mitotic spindle organization | 10.8108 | 4 | yes |
| GO:0051983 | regulation of chromosome segregation | 10.8108 | 4 | yes |
| GO:0010965 | regulation of mitotic sister chromatid separation | 8.1081 | 6 | yes |
| GO:0033044 | regulation of chromosome organization | 8.1081 | 6 | yes |
| GO:0033045 | regulation of sister chromatid segregation | 8.1081 | 5 | yes |
| GO:0044772 | mitotic cell cycle phase transition | 8.1081 | 4 | yes |
| GO:1905818 | regulation of chromosome separation | 8.1081 | 5 | yes |
| GO:0007091 | metaphase/anaphase transition of mitotic cell cycle | 5.4054 | 5 | yes |
| GO:0044784 | metaphase/anaphase transition of cell cycle | 5.4054 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in TACC3_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 8.1081 | 3 | no |
| DOID:936 | brain disease | 8.1081 | 4 | no |
| DOID:0050701 | electroclinical syndrome | 5.4054 | 6 | no |
| DOID:0112202 | developmental and epileptic encephalopathy | 5.4054 | 7 | no |
| DOID:1826 | epilepsy | 5.4054 | 5 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| FOG1_HUMAN | [view interactions] | Low throughput | no | yes |
| TTF2_HUMAN | [view interactions] | Low throughput | no | yes |
| TACC3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CKAP5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AURKA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CLCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NDEL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AKAP9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MBD2_HUMAN | [view interactions] | Low throughput | no | yes |
| FZR1_HUMAN | [view interactions] | Low throughput | no | no |
| KAT2B_HUMAN | [view interactions] | Low throughput | no | yes |
| RAE1L_HUMAN | [view interactions] | Low throughput | no | no |
| CDC27_HUMAN | [view interactions] | Low throughput | no | yes |
| ARNT_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BRCA1_HUMAN | [view interactions] | Low throughput | no | yes |
| KAT2A_HUMAN | [view interactions] | Low throughput | no | no |
| CLH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CEP55_HUMAN | [view interactions] | High throughput | no | yes |
| ZER1_HUMAN | [view interactions] | High throughput | no | no |
| VASP_HUMAN | [view interactions] | High throughput | no | yes |
| M3K21_HUMAN | [view interactions] | High throughput | no | yes |
| PCDH7_HUMAN | [view interactions] | High throughput | no | no |
| DSRAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DEFM_HUMAN | [view interactions] | High throughput | no | yes |
| RN135_HUMAN | [view interactions] | High throughput | no | yes |
| SLAI2_HUMAN | [view interactions] | High throughput | no | no |
| RN168_HUMAN | [view interactions] | High throughput | no | no |
| WDR90_HUMAN | [view interactions] | High throughput | no | yes |
| KIF11_HUMAN | [view interactions] | High throughput | no | yes |
| FRYL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SLBP_HUMAN | [view interactions] | High throughput | no | yes |
| TGO1_HUMAN | [view interactions] | High throughput | no | yes |
| ENAH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPR1_HUMAN | [view interactions] | High throughput | no | yes |
| ANM9_HUMAN | [view interactions] | High throughput | no | no |
| CB069_HUMAN | [view interactions] | High throughput | no | yes |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| MET14_HUMAN | [view interactions] | High throughput | no | yes |
| ARX_HUMAN | [view interactions] | High throughput | no | no |
| BD1L1_HUMAN | [view interactions] | High throughput | no | yes |
| T2EB_HUMAN | [view interactions] | High throughput | no | yes |
| ZC3H1_HUMAN | [view interactions] | High throughput | no | yes |
| HPBP1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MS18B_HUMAN | [view interactions] | High throughput | no | no |
| SNP29_HUMAN | [view interactions] | High throughput | no | yes |
| BORC6_HUMAN | [view interactions] | High throughput | no | yes |
| CRIS2_HUMAN | [view interactions] | High throughput | no | no |
| KIME_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| VP37C_HUMAN | [view interactions] | High throughput | no | yes |
| KIZ_HUMAN | [view interactions] | High throughput | no | no |
| SNX20_HUMAN | [view interactions] | High throughput | no | no |
| CIB3_HUMAN | [view interactions] | High throughput | no | no |
| ASPC1_HUMAN | [view interactions] | High throughput | no | yes |
| TB22B_HUMAN | [view interactions] | High throughput | no | no |
| ARNT2_HUMAN | [view interactions] | High throughput | no | yes |
| BRE1A_HUMAN | [view interactions] | High throughput | no | yes |
| C2CD6_HUMAN | [view interactions] | High throughput | no | no |
| NUP54_HUMAN | [view interactions] | High throughput | no | yes |
| KLH38_HUMAN | [view interactions] | High throughput | no | no |
| GDIR3_HUMAN | [view interactions] | High throughput | no | no |
| MIEAP_HUMAN | [view interactions] | High throughput | no | no |
| BEX2_HUMAN | [view interactions] | High throughput | no | yes |
| GDF15_HUMAN | [view interactions] | High throughput | no | no |
| BEX3_HUMAN | [view interactions] | High throughput | no | yes |
| CDKL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZWINT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RON_HUMAN | [view interactions] | High throughput | no | yes |
| CLIP4_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOD2_HUMAN | [view interactions] | High throughput | no | yes |
| KLC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CD20B_HUMAN | [view interactions] | High throughput | no | no |
| DRC10_HUMAN | [view interactions] | High throughput | no | no |
| CCHCR_HUMAN | [view interactions] | High throughput | no | no |
| PKHO2_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NFS1_HUMAN | [view interactions] | High throughput | no | yes |
| DHRS2_HUMAN | [view interactions] | High throughput | no | no |
| ORC3_HUMAN | [view interactions] | High throughput | no | yes |
| PANK2_HUMAN | [view interactions] | High throughput | no | yes |
| DEPD7_HUMAN | [view interactions] | High throughput | no | no |
| PR14L_HUMAN | [view interactions] | High throughput | no | no |
| F111B_HUMAN | [view interactions] | High throughput | no | no |
| CORO6_HUMAN | [view interactions] | High throughput | no | no |
| CBY2_HUMAN | [view interactions] | High throughput | no | no |
| EVL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| BAG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SVIP_HUMAN | [view interactions] | High throughput | no | yes |
| GNAQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIM8A_HUMAN | [view interactions] | High throughput | no | yes |
| MPDZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUP62_HUMAN | [view interactions] | High throughput | no | yes |
| IPP_HUMAN | [view interactions] | High throughput | no | yes |
| CLP1_HUMAN | [view interactions] | High throughput | no | yes |
| SLAI1_HUMAN | [view interactions] | High throughput | no | no |
| PRP19_HUMAN | [view interactions] | High throughput | no | yes |
| K1522_HUMAN | [view interactions] | High throughput | no | yes |
| KXDL1_HUMAN | [view interactions] | High throughput | no | yes |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TUSC1_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLH12_HUMAN | [view interactions] | High throughput | no | no |
| AF17_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SAHH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRXN1_HUMAN | [view interactions] | High throughput | no | no |
| SC23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RD23B_HUMAN | [view interactions] | High throughput | no | yes |
| CPLX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAE2_HUMAN | [view interactions] | High throughput | no | yes |
| RD23A_HUMAN | [view interactions] | High throughput | no | yes |
| RAB14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZNRD2_HUMAN | [view interactions] | High throughput | no | yes |
| PUR6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC24A_HUMAN | [view interactions] | High throughput | no | no |
| MRE11_HUMAN | [view interactions] | High throughput | no | yes |
| DCA15_HUMAN | [view interactions] | High throughput | no | no |
| K1C18_HUMAN | [view interactions] | High throughput | no | no |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| NOTC3_HUMAN | [view interactions] | Computational | no | yes |
| AURKB_HUMAN | [view interactions] | Computational | no | yes |
| CCNA2_HUMAN | [view interactions] | Computational | no | no |
| CDC20_HUMAN | [view interactions] | Computational | no | no |
| CDCA3_HUMAN | [view interactions] | Computational | no | no |
| CENPE_HUMAN | [view interactions] | Computational | no | no |
| CCNB2_HUMAN | [view interactions] | Computational | no | yes |
| GTSE1_HUMAN | [view interactions] | Computational | no | no |
| NUSAP_HUMAN | [view interactions] | Computational | no | no |
| CCNB1_HUMAN | [view interactions] | Computational | no | no |
| PLK1_HUMAN | [view interactions] | Computational | no | yes |
| NOTC4_HUMAN | [view interactions] | Computational | no | no |
| MD2L1_HUMAN | [view interactions] | Computational | no | no |
| ILK_HUMAN | [view interactions] | Computational | no | no |
| KIF2C_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| DLGP5_HUMAN | [view interactions] | Computational | no | no |
| FGFR3_HUMAN | [view interactions] | Computational | no | yes |
| ASPM_HUMAN | [view interactions] | Computational | no | no |
| TTK_HUMAN | [view interactions] | Computational | no | yes |
| CND1_HUMAN | [view interactions] | Computational | no | yes |
| EPHB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NUF2_HUMAN | [view interactions] | Computational | no | no |
| CND3_HUMAN | [view interactions] | Computational | no | yes |
| BOREA_HUMAN | [view interactions] | Computational | no | yes |
| CE120_HUMAN | [view interactions] | Computational | no | no |
| TPX2_HUMAN | [view interactions] | Computational | no | yes |
| PRC1_HUMAN | [view interactions] | Computational | no | yes |
| CDK1_HUMAN | [view interactions] | Computational | no | no |
| NDC80_HUMAN | [view interactions] | Computational | no | no |