DSRAD_HUMAN
Evidence for PS localization
Functions
Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed, PubMed, PubMed). This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1). Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1). Impairs HCV replication via RNA editing at multiple sites. Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function. Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5UTR and the Rev and Tat coding sequence. Can enhance viral replication of HDV via A-to-I editing at a site designated as amber/W, thereby changing an UAG amber stop codon to an UIG tryptophan (W) codon that permits synthesis of the large delta antigen (L-HDAg) which has a key role in the assembly of viral particles. However, high levels of ADAR1 inhibit HDV replication. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DSRAD_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 64.6154 | 4 | yes |
| GO:0000166 | nucleotide binding | 29.2308 | 4 | no |
| GO:0017076 | purine nucleotide binding | 27.6923 | 5 | no |
| GO:0043168 | anion binding | 27.6923 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 26.1538 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.1538 | 4 | no |
| GO:0003677 | DNA binding | 23.0769 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 23.0769 | 6 | no |
| GO:0003729 | mRNA binding | 23.0769 | 5 | no |
| GO:0005524 | ATP binding | 21.5385 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 21.5385 | 5 | no |
| GO:0043169 | cation binding | 20.0000 | 4 | yes |
| GO:0046872 | metal ion binding | 20.0000 | 5 | yes |
| GO:0003725 | double-stranded RNA binding | 13.8462 | 5 | yes |
| GO:0003726 | double-stranded RNA adenosine deaminase activity | 3.0769 | 6 | yes |
| GO:0004000 | adenosine deaminase activity | 3.0769 | 5 | yes |
| GO:0008251 | tRNA-specific adenosine deaminase activity | 3.0769 | 6 | yes |
| GO:0016814 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines | 3.0769 | 4 | yes |
| GO:0019239 | deaminase activity | 3.0769 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DSRAD_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 66.1538 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 66.1538 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 63.0769 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 61.5385 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 55.3846 | 4 | yes |
| GO:0010468 | regulation of gene expression | 55.3846 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 55.3846 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 55.3846 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 52.3077 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 52.3077 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 50.7692 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 49.2308 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 46.1538 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 46.1538 | 5 | yes |
| GO:0051252 | regulation of RNA metabolic process | 46.1538 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 44.6154 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 43.0769 | 5 | yes |
| GO:0090304 | nucleic acid metabolic process | 43.0769 | 4 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 41.5385 | 5 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 41.5385 | 6 | yes |
| GO:0022607 | cellular component assembly | 41.5385 | 4 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 41.5385 | 6 | yes |
| GO:0051246 | regulation of protein metabolic process | 41.5385 | 5 | yes |
| GO:0010646 | regulation of cell communication | 38.4615 | 4 | yes |
| GO:0016070 | RNA metabolic process | 36.9231 | 5 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 35.3846 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 35.3846 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 35.3846 | 6 | no |
| GO:0009966 | regulation of signal transduction | 33.8462 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 33.8462 | 7 | no |
| GO:0051128 | regulation of cellular component organization | 33.8462 | 4 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 33.8462 | 6 | no |
| GO:0010628 | positive regulation of gene expression | 32.3077 | 7 | yes |
| GO:0043933 | protein-containing complex organization | 32.3077 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 32.3077 | 4 | no |
| GO:0006396 | RNA processing | 30.7692 | 6 | yes |
| GO:0006996 | organelle organization | 30.7692 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 29.2308 | 5 | yes |
| GO:0043067 | regulation of programmed cell death | 29.2308 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 29.2308 | 5 | yes |
| GO:0031399 | regulation of protein modification process | 27.6923 | 6 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 27.6923 | 8 | no |
| GO:0009059 | macromolecule biosynthetic process | 27.6923 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 27.6923 | 6 | no |
| GO:0008104 | protein localization | 26.1538 | 4 | yes |
| GO:0071702 | organic substance transport | 24.6154 | 4 | yes |
| GO:0080134 | regulation of response to stress | 24.6154 | 4 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 24.6154 | 5 | no |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 24.6154 | 5 | no |
| GO:0010629 | negative regulation of gene expression | 24.6154 | 7 | no |
| GO:1902531 | regulation of intracellular signal transduction | 24.6154 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 24.6154 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 24.6154 | 5 | no |
| GO:0023056 | positive regulation of signaling | 24.6154 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 23.0769 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 23.0769 | 4 | yes |
| GO:0043412 | macromolecule modification | 23.0769 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 23.0769 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 23.0769 | 5 | no |
| GO:0051253 | negative regulation of RNA metabolic process | 23.0769 | 6 | no |
| GO:0042127 | regulation of cell population proliferation | 23.0769 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 21.5385 | 5 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 21.5385 | 6 | yes |
| GO:0048585 | negative regulation of response to stimulus | 21.5385 | 4 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 21.5385 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 21.5385 | 4 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 21.5385 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 21.5385 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 20.0000 | 7 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 20.0000 | 6 | yes |
| GO:0016071 | mRNA metabolic process | 18.4615 | 6 | yes |
| GO:0032101 | regulation of response to external stimulus | 18.4615 | 4 | yes |
| GO:0140546 | defense response to symbiont | 18.4615 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 16.9231 | 7 | yes |
| GO:0031347 | regulation of defense response | 16.9231 | 5 | yes |
| GO:0043066 | negative regulation of apoptotic process | 16.9231 | 6 | yes |
| GO:0043069 | negative regulation of programmed cell death | 16.9231 | 5 | yes |
| GO:0002831 | regulation of response to biotic stimulus | 15.3846 | 4 | yes |
| GO:0015031 | protein transport | 15.3846 | 4 | yes |
| GO:0045088 | regulation of innate immune response | 15.3846 | 5 | yes |
| GO:0050776 | regulation of immune response | 15.3846 | 4 | yes |
| GO:0006397 | mRNA processing | 13.8462 | 7 | yes |
| GO:0006913 | nucleocytoplasmic transport | 13.8462 | 5 | yes |
| GO:0006915 | apoptotic process | 13.8462 | 4 | yes |
| GO:0033365 | protein localization to organelle | 13.8462 | 5 | yes |
| GO:0034097 | response to cytokine | 13.8462 | 4 | yes |
| GO:0051169 | nuclear transport | 13.8462 | 4 | yes |
| GO:0051338 | regulation of transferase activity | 13.8462 | 4 | yes |
| GO:0022618 | protein-RNA complex assembly | 12.3077 | 6 | yes |
| GO:0031400 | negative regulation of protein modification process | 12.3077 | 7 | yes |
| GO:0043549 | regulation of kinase activity | 12.3077 | 5 | yes |
| GO:0051168 | nuclear export | 12.3077 | 6 | yes |
| GO:0071826 | protein-RNA complex organization | 12.3077 | 5 | yes |
| GO:0010563 | negative regulation of phosphorus metabolic process | 10.7692 | 6 | yes |
| GO:0043086 | negative regulation of catalytic activity | 10.7692 | 4 | yes |
| GO:0045936 | negative regulation of phosphate metabolic process | 10.7692 | 7 | yes |
| GO:0001933 | negative regulation of protein phosphorylation | 9.2308 | 8 | yes |
| GO:0001959 | regulation of cytokine-mediated signaling pathway | 9.2308 | 5 | yes |
| GO:0006886 | intracellular protein transport | 9.2308 | 4 | yes |
| GO:0031054 | pre-miRNA processing | 9.2308 | 9 | yes |
| GO:0035196 | miRNA processing | 9.2308 | 8 | yes |
| GO:0042326 | negative regulation of phosphorylation | 9.2308 | 8 | yes |
| GO:0045859 | regulation of protein kinase activity | 9.2308 | 6 | yes |
| GO:0051607 | defense response to virus | 9.2308 | 4 | yes |
| GO:0060759 | regulation of response to cytokine stimulus | 9.2308 | 4 | yes |
| GO:0070918 | regulatory ncRNA processing | 9.2308 | 7 | yes |
| GO:1903900 | regulation of viral life cycle | 9.2308 | 4 | yes |
| GO:0001649 | osteoblast differentiation | 7.6923 | 4 | yes |
| GO:0006469 | negative regulation of protein kinase activity | 7.6923 | 7 | yes |
| GO:0033673 | negative regulation of kinase activity | 7.6923 | 6 | yes |
| GO:0045069 | regulation of viral genome replication | 7.6923 | 5 | yes |
| GO:0048524 | positive regulation of viral process | 7.6923 | 4 | yes |
| GO:0051348 | negative regulation of transferase activity | 7.6923 | 5 | yes |
| GO:0060966 | regulation of gene silencing by regulatory ncRNA | 7.6923 | 7 | yes |
| GO:0070922 | RISC complex assembly | 7.6923 | 7 | yes |
| GO:0072594 | establishment of protein localization to organelle | 7.6923 | 4 | yes |
| GO:0002683 | negative regulation of immune system process | 6.1538 | 4 | yes |
| GO:0030099 | myeloid cell differentiation | 6.1538 | 4 | yes |
| GO:0032102 | negative regulation of response to external stimulus | 6.1538 | 5 | yes |
| GO:0034504 | protein localization to nucleus | 6.1538 | 6 | yes |
| GO:0045070 | positive regulation of viral genome replication | 6.1538 | 5 | yes |
| GO:0051170 | import into nucleus | 6.1538 | 6 | yes |
| GO:0060147 | regulation of post-transcriptional gene silencing | 6.1538 | 7 | yes |
| GO:0060149 | negative regulation of post-transcriptional gene silencing | 6.1538 | 4 | yes |
| GO:0060967 | negative regulation of gene silencing by regulatory ncRNA | 6.1538 | 4 | yes |
| GO:1900368 | regulation of post-transcriptional gene silencing by regulatory ncRNA | 6.1538 | 8 | yes |
| GO:1900369 | negative regulation of post-transcriptional gene silencing by regulatory ncRNA | 6.1538 | 5 | yes |
| GO:0001960 | negative regulation of cytokine-mediated signaling pathway | 4.6154 | 6 | yes |
| GO:0002244 | hematopoietic progenitor cell differentiation | 4.6154 | 4 | yes |
| GO:0002832 | negative regulation of response to biotic stimulus | 4.6154 | 5 | yes |
| GO:0006606 | protein import into nucleus | 4.6154 | 5 | yes |
| GO:0006611 | protein export from nucleus | 4.6154 | 5 | yes |
| GO:0030218 | erythrocyte differentiation | 4.6154 | 5 | yes |
| GO:0031348 | negative regulation of defense response | 4.6154 | 5 | yes |
| GO:0035455 | response to interferon-alpha | 4.6154 | 5 | yes |
| GO:0044387 | negative regulation of protein kinase activity by regulation of protein phosphorylation | 4.6154 | 8 | yes |
| GO:0045824 | negative regulation of innate immune response | 4.6154 | 6 | yes |
| GO:0050777 | negative regulation of immune response | 4.6154 | 5 | yes |
| GO:0060338 | regulation of type I interferon-mediated signaling pathway | 4.6154 | 6 | yes |
| GO:0060761 | negative regulation of response to cytokine stimulus | 4.6154 | 5 | yes |
| GO:0098586 | cellular response to virus | 4.6154 | 4 | yes |
| GO:0006382 | adenosine to inosine editing | 3.0769 | 7 | yes |
| GO:0009451 | RNA modification | 3.0769 | 5 | yes |
| GO:0016553 | base conversion or substitution editing | 3.0769 | 6 | yes |
| GO:0030097 | hemopoiesis | 3.0769 | 4 | yes |
| GO:0060216 | definitive hemopoiesis | 3.0769 | 5 | yes |
| GO:0060339 | negative regulation of type I interferon-mediated signaling pathway | 3.0769 | 7 | yes |
| GO:0061484 | hematopoietic stem cell homeostasis | 3.0769 | 4 | yes |
| GO:0097284 | hepatocyte apoptotic process | 3.0769 | 6 | yes |
| GO:1903943 | regulation of hepatocyte apoptotic process | 3.0769 | 7 | yes |
| GO:1903944 | negative regulation of hepatocyte apoptotic process | 3.0769 | 8 | yes |
| GO:1904019 | epithelial cell apoptotic process | 3.0769 | 5 | yes |
| GO:1904035 | regulation of epithelial cell apoptotic process | 3.0769 | 6 | yes |
| GO:1904036 | negative regulation of epithelial cell apoptotic process | 3.0769 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DICER_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RENT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRBP2_HUMAN | [view interactions] | Low throughput | no | yes |
| E2AK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DSRAD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VIGLN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RSMN_HUMAN | [view interactions] | Low throughput | no | yes |
| RSMB_HUMAN | [view interactions] | Low throughput | no | yes |
| FBW1A_HUMAN | [view interactions] | Low throughput | no | yes |
| ILF3_HUMAN | [view interactions] | Low throughput | no | yes |
| PRKRA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SMUF2_HUMAN | [view interactions] | Low throughput | no | yes |
| RNC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| XPO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBC9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KNOP1_HUMAN | [view interactions] | High throughput | no | yes |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| POTEE_HUMAN | [view interactions] | High throughput | no | no |
| POTEF_HUMAN | [view interactions] | High throughput | no | no |
| POTEI_HUMAN | [view interactions] | High throughput | no | no |
| POTEJ_HUMAN | [view interactions] | High throughput | no | no |
| RS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SFPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STRBP_HUMAN | [view interactions] | High throughput | no | yes |
| TRM1L_HUMAN | [view interactions] | High throughput | no | yes |
| WRN_HUMAN | [view interactions] | High throughput | no | yes |
| XRN2_HUMAN | [view interactions] | High throughput | no | yes |
| ZFR_HUMAN | [view interactions] | High throughput | no | yes |
| TGM2_HUMAN | [view interactions] | High throughput | no | no |
| ACINU_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC9_HUMAN | [view interactions] | High throughput | no | yes |
| CHD5_HUMAN | [view interactions] | High throughput | no | no |
| INT1_HUMAN | [view interactions] | High throughput | no | yes |
| AGO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELAV4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AIM2_HUMAN | [view interactions] | High throughput | no | no |
| EP400_HUMAN | [view interactions] | High throughput | no | yes |
| TACC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCN1_HUMAN | [view interactions] | High throughput | no | yes |
| RL35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RACK1_HUMAN | [view interactions] | High throughput | no | yes |
| THOC2_HUMAN | [view interactions] | High throughput | no | yes |
| TF3C4_HUMAN | [view interactions] | High throughput | no | no |
| THOC1_HUMAN | [view interactions] | High throughput | no | yes |
| HCFC1_HUMAN | [view interactions] | High throughput | no | yes |
| ZC3H1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRDL_HUMAN | [view interactions] | High throughput | no | yes |
| THOC7_HUMAN | [view interactions] | High throughput | no | yes |
| KTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RRBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDC1_HUMAN | [view interactions] | High throughput | no | yes |
| MATR3_HUMAN | [view interactions] | High throughput | no | yes |
| MRE11_HUMAN | [view interactions] | High throughput | no | yes |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MSH6_HUMAN | [view interactions] | High throughput | no | yes |
| SESN2_HUMAN | [view interactions] | High throughput | no | no |
| NUCL_HUMAN | [view interactions] | High throughput | no | yes |
| FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOL6_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOS4_HUMAN | [view interactions] | High throughput | no | yes |
| NUMA1_HUMAN | [view interactions] | High throughput | no | yes |
| JUNB_HUMAN | [view interactions] | High throughput | no | yes |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XRCC3_HUMAN | [view interactions] | High throughput | no | no |
| POGZ_HUMAN | [view interactions] | High throughput | no | yes |
| EMC5_HUMAN | [view interactions] | High throughput | no | yes |
| PUF60_HUMAN | [view interactions] | High throughput | no | yes |
| SRSF1_HUMAN | [view interactions] | High throughput | no | yes |
| RBP2_HUMAN | [view interactions] | High throughput | no | yes |
| DDX41_HUMAN | [view interactions] | High throughput | no | yes |
| RBM10_HUMAN | [view interactions] | High throughput | no | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| RL18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| RL21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYLK2_HUMAN | [view interactions] | High throughput | no | no |
| RL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCBP3_HUMAN | [view interactions] | High throughput | no | yes |
| RUVB2_HUMAN | [view interactions] | High throughput | no | yes |
| NCBP1_HUMAN | [view interactions] | High throughput | no | yes |
| SF3B3_HUMAN | [view interactions] | High throughput | no | yes |
| NCBP2_HUMAN | [view interactions] | High throughput | no | yes |
| SIN3B_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
| RU2A_HUMAN | [view interactions] | High throughput | no | yes |
| GRHL1_HUMAN | [view interactions] | High throughput | no | yes |
| SPTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFP11_HUMAN | [view interactions] | High throughput | no | no |
| COX15_HUMAN | [view interactions] | High throughput | no | yes |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOP2A_HUMAN | [view interactions] | High throughput | no | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOP2B_HUMAN | [view interactions] | High throughput | no | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBAL3_HUMAN | [view interactions] | High throughput | no | no |
| ZMYM2_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| ZN318_HUMAN | [view interactions] | High throughput | no | yes |
| HTRA4_HUMAN | [view interactions] | High throughput | no | no |
| ZN638_HUMAN | [view interactions] | High throughput | no | yes |
| TBK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLK1_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| PAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WWTR1_HUMAN | [view interactions] | High throughput | no | yes |
| CDKL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| LN28A_HUMAN | [view interactions] | High throughput | no | no |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| TADBP_HUMAN | [view interactions] | High throughput | no | yes |
| CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FOXA2_HUMAN | [view interactions] | High throughput | no | no |
| FOXA3_HUMAN | [view interactions] | High throughput | no | yes |
| FOXB1_HUMAN | [view interactions] | High throughput | no | no |
| FOXG1_HUMAN | [view interactions] | High throughput | no | no |
| FOXH1_HUMAN | [view interactions] | High throughput | no | no |
| FOXI2_HUMAN | [view interactions] | High throughput | no | no |
| FOXL1_HUMAN | [view interactions] | High throughput | no | no |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| FOXS1_HUMAN | [view interactions] | High throughput | no | yes |
| SUH_HUMAN | [view interactions] | High throughput | no | yes |
| SWAP1_HUMAN | [view interactions] | High throughput | no | no |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| DHX9_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| ERG_HUMAN | [view interactions] | High throughput | no | yes |
| STAU2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| SUZ12_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| UBP38_HUMAN | [view interactions] | High throughput | no | no |
| FBW1B_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| IF16_HUMAN | [view interactions] | High throughput | no | no |
| CRY2_HUMAN | [view interactions] | High throughput | no | yes |
| MEX3C_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| FOXA1_HUMAN | [view interactions] | High throughput | no | no |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2A_HUMAN | [view interactions] | High throughput | no | no |
| RMD5A_HUMAN | [view interactions] | High throughput | no | yes |
| CHD3_HUMAN | [view interactions] | High throughput | no | yes |
| CHD4_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| GRWD1_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBX1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| RU17_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ZCH18_HUMAN | [view interactions] | High throughput | no | yes |
| SNIP1_HUMAN | [view interactions] | High throughput | no | no |
| ARGAL_HUMAN | [view interactions] | High throughput | no | yes |
| DEP1B_HUMAN | [view interactions] | High throughput | no | yes |
| SMC1A_HUMAN | [view interactions] | High throughput | no | yes |
| SMC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAG2_HUMAN | [view interactions] | High throughput | no | yes |
| SCC4_HUMAN | [view interactions] | High throughput | no | no |
| RAD21_HUMAN | [view interactions] | High throughput | no | yes |
| STAG1_HUMAN | [view interactions] | High throughput | no | yes |
| WAPL_HUMAN | [view interactions] | High throughput | no | yes |
| PDS5A_HUMAN | [view interactions] | High throughput | no | yes |
| NIPBL_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| RIN3_HUMAN | [view interactions] | High throughput | no | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| PAGE4_HUMAN | [view interactions] | High throughput | no | no |
| MAGA8_HUMAN | [view interactions] | High throughput | no | no |
| NPAS1_HUMAN | [view interactions] | High throughput | no | no |
| AQP3_HUMAN | [view interactions] | High throughput | no | no |
| LY86_HUMAN | [view interactions] | High throughput | no | no |
| I13R2_HUMAN | [view interactions] | High throughput | no | no |
| S10A2_HUMAN | [view interactions] | High throughput | no | no |
| RNAS1_HUMAN | [view interactions] | High throughput | no | yes |
| ILF2_HUMAN | [view interactions] | High throughput | no | yes |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| FSCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| SIR6_HUMAN | [view interactions] | High throughput | no | yes |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPSF6_HUMAN | [view interactions] | High throughput | no | yes |
| DDX21_HUMAN | [view interactions] | High throughput | no | yes |
| G3BP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| PSPC1_HUMAN | [view interactions] | High throughput | no | yes |
| RBM14_HUMAN | [view interactions] | High throughput | no | yes |
| RS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNRPA_HUMAN | [view interactions] | High throughput | no | yes |
| RU1C_HUMAN | [view interactions] | High throughput | no | yes |
| SRP09_HUMAN | [view interactions] | High throughput | no | no |
| SSRP1_HUMAN | [view interactions] | High throughput | no | yes |
| TOP1_HUMAN | [view interactions] | High throughput | no | yes |
| ANM1_HUMAN | [view interactions] | High throughput | no | yes |
| MYCN_HUMAN | [view interactions] | High throughput | no | no |
| TLS1_HUMAN | [view interactions] | High throughput | no | yes |
| AIMP2_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| DOT1L_HUMAN | [view interactions] | High throughput | no | yes |
| MEN1_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| AATF_HUMAN | [view interactions] | High throughput | no | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG24_HUMAN | [view interactions] | High throughput | no | yes |
| GCSP_HUMAN | [view interactions] | High throughput | no | yes |
| PIAS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET14_HUMAN | [view interactions] | High throughput | no | yes |
| SMC5_HUMAN | [view interactions] | High throughput | no | yes |
| GRM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP36_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| DDX17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMC2_HUMAN | [view interactions] | High throughput | no | yes |
| HELZ2_HUMAN | [view interactions] | High throughput | no | no |
| IFT1B_HUMAN | [view interactions] | High throughput | no | no |
| IFIT1_HUMAN | [view interactions] | High throughput | no | no |
| IFIT3_HUMAN | [view interactions] | High throughput | no | yes |
| LG3BP_HUMAN | [view interactions] | High throughput | no | no |
| OAS3_HUMAN | [view interactions] | High throughput | no | no |
| XRCC6_HUMAN | [view interactions] | High throughput | no | yes |
| XRCC5_HUMAN | [view interactions] | High throughput | no | yes |
| RBMX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKDC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TTC9C_HUMAN | [view interactions] | High throughput | no | yes |
| PTGR2_HUMAN | [view interactions] | High throughput | no | yes |
| NEK7_HUMAN | [view interactions] | High throughput | no | yes |
| CELF1_HUMAN | [view interactions] | High throughput | no | yes |
| MK14_HUMAN | [view interactions] | High throughput | no | yes |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| MK67I_HUMAN | [view interactions] | High throughput | no | yes |
| RS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RED1_HUMAN | [view interactions] | High throughput | no | no |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DHX15_HUMAN | [view interactions] | High throughput | no | yes |
| EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TASO2_HUMAN | [view interactions] | High throughput | no | yes |
| SPB1_HUMAN | [view interactions] | High throughput | no | yes |
| GLYR1_HUMAN | [view interactions] | High throughput | no | yes |
| NOG2_HUMAN | [view interactions] | High throughput | no | yes |
| T2EB_HUMAN | [view interactions] | High throughput | no | yes |