DSRAD_HUMAN
Evidence for PS localization
Functions
Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed, PubMed, PubMed). This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1). Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1). Impairs HCV replication via RNA editing at multiple sites. Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function. Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5UTR and the Rev and Tat coding sequence. Can enhance viral replication of HDV via A-to-I editing at a site designated as amber/W, thereby changing an UAG amber stop codon to an UIG tryptophan (W) codon that permits synthesis of the large delta antigen (L-HDAg) which has a key role in the assembly of viral particles. However, high levels of ADAR1 inhibit HDV replication. [View more on UniProt]
Protein features
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Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
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Network
DSRAD_HUMAN has binary interactions with 50 proteins
Isoforms
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Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in DSRAD_HUMAN |
---|---|---|---|---|
GO:0003723 | RNA binding | 64.6154 | 4 | yes |
GO:0000166 | nucleotide binding | 29.2308 | 4 | no |
GO:0017076 | purine nucleotide binding | 27.6923 | 5 | no |
GO:0043168 | anion binding | 27.6923 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 26.1538 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 26.1538 | 4 | no |
GO:0003677 | DNA binding | 23.0769 | 4 | yes |
GO:0030554 | adenyl nucleotide binding | 23.0769 | 6 | no |
GO:0003729 | mRNA binding | 23.0769 | 5 | no |
GO:0005524 | ATP binding | 21.5385 | 5 | no |
GO:0032559 | adenyl ribonucleotide binding | 21.5385 | 5 | no |
GO:0043169 | cation binding | 20.0000 | 4 | yes |
GO:0046872 | metal ion binding | 20.0000 | 5 | yes |
GO:0003725 | double-stranded RNA binding | 13.8462 | 5 | yes |
GO:0003726 | double-stranded RNA adenosine deaminase activity | 3.0769 | 6 | yes |
GO:0004000 | adenosine deaminase activity | 3.0769 | 5 | yes |
GO:0008251 | tRNA-specific adenosine deaminase activity | 3.0769 | 6 | yes |
GO:0016814 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines | 3.0769 | 4 | yes |
GO:0019239 | deaminase activity | 3.0769 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in DSRAD_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 66.1538 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 66.1538 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 63.0769 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 61.5385 | 4 | yes |
GO:0009889 | regulation of biosynthetic process | 55.3846 | 4 | yes |
GO:0010468 | regulation of gene expression | 55.3846 | 6 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 55.3846 | 5 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 55.3846 | 5 | yes |
GO:0009893 | positive regulation of metabolic process | 52.3077 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 52.3077 | 4 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 50.7692 | 5 | yes |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 49.2308 | 5 | no |
GO:0009892 | negative regulation of metabolic process | 46.1538 | 4 | yes |
GO:0010605 | negative regulation of macromolecule metabolic process | 46.1538 | 5 | yes |
GO:0051252 | regulation of RNA metabolic process | 46.1538 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 44.6154 | 5 | yes |
GO:0031324 | negative regulation of cellular metabolic process | 43.0769 | 5 | yes |
GO:0090304 | nucleic acid metabolic process | 43.0769 | 4 | yes |
GO:0009891 | positive regulation of biosynthetic process | 41.5385 | 5 | yes |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 41.5385 | 6 | yes |
GO:0022607 | cellular component assembly | 41.5385 | 4 | yes |
GO:0031328 | positive regulation of cellular biosynthetic process | 41.5385 | 6 | yes |
GO:0051246 | regulation of protein metabolic process | 41.5385 | 5 | yes |
GO:0010646 | regulation of cell communication | 38.4615 | 4 | yes |
GO:0016070 | RNA metabolic process | 36.9231 | 5 | yes |
Disease
No data found.
All partners
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
AATF_HUMAN | [view interactions] | High throughput | no | yes |
ACE2_HUMAN | [view interactions] | High throughput | no | no |
ACINU_HUMAN | [view interactions] | High throughput | no | yes |
AGO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AIM2_HUMAN | [view interactions] | High throughput | no | no |
AIMP2_HUMAN | [view interactions] | High throughput | no | yes |
ANDR_HUMAN | [view interactions] | High throughput | no | no |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
ANM1_HUMAN | [view interactions] | High throughput | no | yes |
APEX1_HUMAN | [view interactions] | High throughput | no | yes |
AQP3_HUMAN | [view interactions] | High throughput | no | no |
ARGAL_HUMAN | [view interactions] | High throughput | no | yes |
BAP1_HUMAN | [view interactions] | High throughput | no | yes |
BIRC3_HUMAN | [view interactions] | High throughput | no | no |
BMI1_HUMAN | [view interactions] | High throughput | no | yes |
BRD4_HUMAN | [view interactions] | High throughput | no | yes |
BTF3_HUMAN | [view interactions] | High throughput | no | yes |
CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CCNF_HUMAN | [view interactions] | High throughput | no | no |
CDK9_HUMAN | [view interactions] | High throughput | no | yes |
CDKL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CELF1_HUMAN | [view interactions] | High throughput | no | yes |