Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DSRAD_HUMAN

Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing (PubMed, PubMed, PubMed). This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1). Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1). Impairs HCV replication via RNA editing at multiple sites. Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function. Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5UTR and the Rev and Tat coding sequence. Can enhance viral replication of HDV via A-to-I editing at a site designated as amber/W, thereby changing an UAG amber stop codon to an UIG tryptophan (W) codon that permits synthesis of the large delta antigen (L-HDAg) which has a key role in the assembly of viral particles. However, high levels of ADAR1 inhibit HDV replication. [View more on UniProt]

01002003004005006007008009001,0001,1001,200
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 73%

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

01002003004005006007008009001,0001,1001,200
DSRAD_HUMAN
LOADING 67%

DSRAD_HUMAN has binary interactions with 50 proteins

DSRAD_HUMANHS71A_HUMANPTEN_HUMANHS71B_HUMANDSRAD_HUMANPHB1_HUMANSRPK2_HUMANAGO2_HUMANCOPB2_HUMANRBMX_HUMANSTIP1_HUMANSTAU2_HUMANXPO1_HUMANODPA_HUMANPAK2_HUMANPRKRA_HUMANCTRO_HUMANRL35_HUMANELAV1_HUMANRENT1_HUMANCHM4B_HUMANG3BP2_HUMANTACC3_HUMANUBC9_HUMANDDRGK_HUMANGRM2_HUMANVIGLN_HUMANRASK_HUMANFMR1_HUMANSMC3_HUMANCUL3_HUMANRS16_HUMANTOLIP_HUMANRS6_HUMANPIAS1_HUMANFUS_HUMANCAND1_HUMANCAC1C_HUMANPRKDC_HUMANSTAU1_HUMANRBX1_HUMANCAPZB_HUMANCDKL2_HUMANE2AK2_HUMANHNRPM_HUMANRNC_HUMANDICER_HUMANDDX17_HUMANROA1_HUMANFSCN1_HUMANRRBP1_HUMANDSRAD_HUMANHS71A_HUMANPTEN_HUMANHS71B_HUMANDSRAD_HUMANPHB1_HUMANSRPK2_HUMANAGO2_HUMANCOPB2_HUMANRBMX_HUMANSTIP1_HUMANSTAU2_HUMANXPO1_HUMANODPA_HUMANPAK2_HUMANPRKRA_HUMANCTRO_HUMANRL35_HUMANELAV1_HUMANRENT1_HUMANCHM4B_HUMANG3BP2_HUMANTACC3_HUMANUBC9_HUMANDDRGK_HUMANGRM2_HUMANVIGLN_HUMANRASK_HUMANFMR1_HUMANSMC3_HUMANCUL3_HUMANRS16_HUMANTOLIP_HUMANRS6_HUMANPIAS1_HUMANFUS_HUMANCAND1_HUMANCAC1C_HUMANPRKDC_HUMANSTAU1_HUMANRBX1_HUMANCAPZB_HUMANCDKL2_HUMANE2AK2_HUMANHNRPM_HUMANRNC_HUMANDICER_HUMANDDX17_HUMANROA1_HUMANFSCN1_HUMANRRBP1_HUMAN
Download full PS network for entry.
01002003004005006007008009001,0001,1001,200
Interacting regions
Canonical [DSRAD_HUMAN]
Isoform [A0A7P0TA14] alignment
Isoform [A0A7P0Z4K3] alignment
Isoform [A0A7P0Z4F9] alignment
Isoform [A0A3B3IRQ9] alignment
Isoform [A0A3B3ISU1] alignment
Isoform [A0A3B3ISX1] alignment
Isoform [A0A3B3ITG9] alignment
Isoform [A2IBT1] alignment
Isoform [P55265-2] alignment
Isoform [P55265-3] alignment
Isoform [P55265-4] alignment
Isoform [P55265-5] alignment
LOADING 30%

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Biological process

Disease

No data found.

[GDPR]

By using PSINDB you accept the Privacy Notice in compliance with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018. Read the

Privacy notes
Understood