EVL_HUMAN
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in EVL_HUMAN |
---|---|---|---|---|
GO:0003779 | actin binding | 35.4839 | 4 | yes |
GO:0017124 | SH3 domain binding | 29.0323 | 4 | yes |
GO:0045296 | cadherin binding | 29.0323 | 4 | no |
GO:0003723 | RNA binding | 25.8065 | 4 | no |
GO:0017076 | purine nucleotide binding | 22.5806 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 22.5806 | 5 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in EVL_HUMAN |
---|---|---|---|---|
GO:0051128 | regulation of cellular component organization | 77.4194 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 70.9677 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 67.7419 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 58.0645 | 4 | no |
GO:0033043 | regulation of organelle organization | 54.8387 | 5 | yes |
GO:0044087 | regulation of cellular component biogenesis | 54.8387 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 54.8387 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 51.6129 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 51.6129 | 4 | no |
GO:0031344 | regulation of cell projection organization | 48.3871 | 5 | yes |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 48.3871 | 6 | yes |
GO:0006996 | organelle organization | 48.3871 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 45.1613 | 5 | yes |
GO:0009893 | positive regulation of metabolic process | 45.1613 | 4 | no |
GO:0022607 | cellular component assembly | 41.9355 | 4 | yes |
GO:0051493 | regulation of cytoskeleton organization | 41.9355 | 6 | yes |
GO:0010468 | regulation of gene expression | 41.9355 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 41.9355 | 4 | no |
GO:0010638 | positive regulation of organelle organization | 38.7097 | 6 | yes |
GO:0032956 | regulation of actin cytoskeleton organization | 38.7097 | 5 | yes |
GO:0032970 | regulation of actin filament-based process | 38.7097 | 4 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 38.7097 | 5 | no |
GO:0044089 | positive regulation of cellular component biogenesis | 35.4839 | 5 | yes |
GO:0110053 | regulation of actin filament organization | 35.4839 | 6 | yes |
GO:1902903 | regulation of supramolecular fiber organization | 35.4839 | 5 | yes |
GO:0010646 | regulation of cell communication | 35.4839 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 35.4839 | 5 | no |
GO:0030334 | regulation of cell migration | 32.2581 | 5 | yes |
GO:0060491 | regulation of cell projection assembly | 32.2581 | 5 | yes |
GO:2000145 | regulation of cell motility | 32.2581 | 4 | yes |
GO:0007010 | cytoskeleton organization | 32.2581 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 32.2581 | 4 | no |
GO:0009966 | regulation of signal transduction | 32.2581 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 32.2581 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 32.2581 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 32.2581 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 32.2581 | 5 | no |
GO:0051252 | regulation of RNA metabolic process | 32.2581 | 5 | no |
GO:0051049 | regulation of transport | 32.2581 | 4 | no |
GO:0043254 | regulation of protein-containing complex assembly | 29.0323 | 5 | yes |
GO:0051129 | negative regulation of cellular component organization | 29.0323 | 5 | yes |
GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 29.0323 | 6 | yes |
GO:0008104 | protein localization | 29.0323 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 29.0323 | 4 | no |
GO:0009894 | regulation of catabolic process | 29.0323 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 29.0323 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 29.0323 | 5 | no |
GO:0031329 | regulation of cellular catabolic process | 29.0323 | 5 | no |
GO:0031399 | regulation of protein modification process | 29.0323 | 6 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 29.0323 | 5 | no |
GO:0071310 | cellular response to organic substance | 29.0323 | 4 | no |
GO:0030030 | cell projection organization | 29.0323 | 4 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 29.0323 | 5 | no |
GO:0032231 | regulation of actin filament bundle assembly | 25.8065 | 5 | yes |
GO:0032271 | regulation of protein polymerization | 25.8065 | 6 | yes |
GO:0032535 | regulation of cellular component size | 25.8065 | 4 | yes |
GO:0051495 | positive regulation of cytoskeleton organization | 25.8065 | 7 | yes |
GO:1902905 | positive regulation of supramolecular fiber organization | 25.8065 | 6 | yes |
GO:0006355 | regulation of DNA-templated transcription | 25.8065 | 6 | no |
GO:0009967 | positive regulation of signal transduction | 25.8065 | 5 | no |
GO:0010647 | positive regulation of cell communication | 25.8065 | 5 | no |
GO:0023056 | positive regulation of signaling | 25.8065 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 25.8065 | 5 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 25.8065 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 25.8065 | 6 | no |
GO:0001932 | regulation of protein phosphorylation | 25.8065 | 7 | no |
GO:0019220 | regulation of phosphate metabolic process | 25.8065 | 6 | no |
GO:0042325 | regulation of phosphorylation | 25.8065 | 7 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.8065 | 5 | no |
GO:0051174 | regulation of phosphorus metabolic process | 25.8065 | 5 | no |
GO:0080134 | regulation of response to stress | 25.8065 | 4 | no |
GO:0016192 | vesicle-mediated transport | 25.8065 | 4 | no |
GO:0010941 | regulation of cell death | 25.8065 | 4 | no |
GO:0042981 | regulation of apoptotic process | 25.8065 | 6 | no |
GO:0043067 | regulation of programmed cell death | 25.8065 | 5 | no |
GO:0007015 | actin filament organization | 22.5806 | 5 | yes |
GO:0008064 | regulation of actin polymerization or depolymerization | 22.5806 | 6 | yes |
GO:0030832 | regulation of actin filament length | 22.5806 | 5 | yes |
GO:0030833 | regulation of actin filament polymerization | 22.5806 | 7 | yes |
GO:0031334 | positive regulation of protein-containing complex assembly | 22.5806 | 6 | yes |
GO:0051492 | regulation of stress fiber assembly | 22.5806 | 6 | yes |
GO:0097435 | supramolecular fiber organization | 22.5806 | 4 | yes |
GO:0110020 | regulation of actomyosin structure organization | 22.5806 | 6 | yes |
GO:0022603 | regulation of anatomical structure morphogenesis | 22.5806 | 4 | no |
GO:0051248 | negative regulation of protein metabolic process | 22.5806 | 6 | no |
GO:0071702 | organic substance transport | 22.5806 | 4 | no |
GO:0071705 | nitrogen compound transport | 22.5806 | 4 | no |
GO:0001934 | positive regulation of protein phosphorylation | 22.5806 | 8 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 22.5806 | 6 | no |
GO:0031401 | positive regulation of protein modification process | 22.5806 | 7 | no |
GO:0042327 | positive regulation of phosphorylation | 22.5806 | 8 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 22.5806 | 7 | no |
GO:0051247 | positive regulation of protein metabolic process | 22.5806 | 6 | no |
GO:0031346 | positive regulation of cell projection organization | 22.5806 | 6 | no |
GO:0034330 | cell junction organization | 22.5806 | 4 | no |
GO:0007167 | enzyme-linked receptor protein signaling pathway | 22.5806 | 4 | no |
GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 22.5806 | 5 | no |
GO:0036211 | protein modification process | 22.5806 | 4 | no |
GO:0043412 | macromolecule modification | 22.5806 | 4 | no |
GO:0010632 | regulation of epithelial cell migration | 19.3548 | 4 | yes |
GO:0030838 | positive regulation of actin filament polymerization | 19.3548 | 7 | yes |
GO:0032273 | positive regulation of protein polymerization | 19.3548 | 7 | yes |
GO:0043933 | protein-containing complex organization | 19.3548 | 4 | yes |
GO:0008154 | actin polymerization or depolymerization | 16.1290 | 6 | yes |
GO:0032233 | positive regulation of actin filament bundle assembly | 16.1290 | 6 | yes |
GO:0065003 | protein-containing complex assembly | 16.1290 | 5 | yes |
GO:1900027 | regulation of ruffle assembly | 16.1290 | 7 | yes |
GO:0031345 | negative regulation of cell projection organization | 12.9032 | 6 | yes |
GO:0051241 | negative regulation of multicellular organismal process | 12.9032 | 4 | yes |
GO:0051496 | positive regulation of stress fiber assembly | 12.9032 | 7 | yes |
GO:0120033 | negative regulation of plasma membrane bounded cell projection assembly | 12.9032 | 7 | yes |
GO:1900028 | negative regulation of ruffle assembly | 12.9032 | 8 | yes |
GO:0007399 | nervous system development | 9.6774 | 4 | yes |
GO:0010633 | negative regulation of epithelial cell migration | 9.6774 | 5 | yes |
GO:0030336 | negative regulation of cell migration | 9.6774 | 6 | yes |
GO:0040013 | negative regulation of locomotion | 9.6774 | 4 | yes |
GO:0051259 | protein complex oligomerization | 9.6774 | 6 | yes |
GO:0051260 | protein homooligomerization | 9.6774 | 7 | yes |
GO:2000146 | negative regulation of cell motility | 9.6774 | 5 | yes |
GO:0045010 | actin nucleation | 6.4516 | 6 | yes |
GO:0051262 | protein tetramerization | 6.4516 | 7 | yes |
GO:0051289 | protein homotetramerization | 6.4516 | 8 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
DNMBP_HUMAN | [view interactions] | Low throughput | no | no |
XIRP1_HUMAN | [view interactions] | Low throughput | no | no |
SEM6A_HUMAN | [view interactions] | Low throughput | no | yes |
VASP_HUMAN | [view interactions] | Low throughput | no | yes |
ENAH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PROF2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ABL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
LYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
APBB1_HUMAN | [view interactions] | Low throughput | no | yes |
TES_HUMAN | [view interactions] | Low throughput | no | yes |
SPTA1_HUMAN | [view interactions] | Low throughput | no | no |
SPTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RAD51_HUMAN | [view interactions] | Low throughput | no | yes |
TRIM9_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
EVL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
FYB1_HUMAN | [view interactions] | Low throughput | no | no |
ZDH17_HUMAN | [view interactions] | High throughput | no | yes |
SH3R1_HUMAN | [view interactions] | High throughput | no | yes |
ZYX_HUMAN | [view interactions] | High throughput | no | no |
ZN655_HUMAN | [view interactions] | High throughput | no | yes |
RAD21_HUMAN | [view interactions] | High throughput | no | yes |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NECT4_HUMAN | [view interactions] | High throughput | no | no |
NP1L5_HUMAN | [view interactions] | High throughput | no | yes |
U2AF2_HUMAN | [view interactions] | High throughput | no | yes |
TRM61_HUMAN | [view interactions] | High throughput | no | no |
UBIP1_HUMAN | [view interactions] | High throughput | no | no |
DDX49_HUMAN | [view interactions] | High throughput | no | no |
NUCG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TACC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EXD2_HUMAN | [view interactions] | High throughput | no | yes |
LTMD1_HUMAN | [view interactions] | High throughput | no | no |
RL23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRAF7_HUMAN | [view interactions] | High throughput | no | yes |
FBLI1_HUMAN | [view interactions] | High throughput | no | yes |
ETFR1_HUMAN | [view interactions] | High throughput | no | no |
WASF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AKT3_HUMAN | [view interactions] | High throughput | no | yes |
TRI67_HUMAN | [view interactions] | High throughput | no | no |
K1522_HUMAN | [view interactions] | High throughput | no | yes |
UTP4_HUMAN | [view interactions] | High throughput | no | yes |
CDK7_HUMAN | [view interactions] | High throughput | no | yes |
MOFA1_HUMAN | [view interactions] | High throughput | no | yes |
PKHH2_HUMAN | [view interactions] | High throughput | no | no |
ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TCRG1_HUMAN | [view interactions] | High throughput | no | yes |
PR40A_HUMAN | [view interactions] | High throughput | no | yes |
WIPF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BAIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DNJC3_HUMAN | [view interactions] | High throughput | no | yes |
CRKL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AB1IP_HUMAN | [view interactions] | High throughput | no | no |
G3BP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
PAPS1_HUMAN | [view interactions] | High throughput | no | yes |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
P53_HUMAN | [view interactions] | High throughput | no | no |
HCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IF4H_HUMAN | [view interactions] | High throughput | no | yes |
GRAP2_HUMAN | [view interactions] | High throughput | no | no |
ABI3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TERF1_HUMAN | [view interactions] | High throughput | no | no |
POTE1_HUMAN | [view interactions] | High throughput | no | no |
HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |