EVL_HUMAN
Evidence for PS localization
Functions
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in EVL_HUMAN |
|---|---|---|---|---|
| GO:0003779 | actin binding | 34.2105 | 4 | yes |
| GO:0017124 | SH3 domain binding | 28.9474 | 4 | yes |
| GO:0045296 | cadherin binding | 26.3158 | 4 | no |
| GO:0043168 | anion binding | 23.6842 | 4 | no |
| GO:0003723 | RNA binding | 23.6842 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in EVL_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 68.4211 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 68.4211 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 60.5263 | 4 | yes |
| GO:0006996 | organelle organization | 55.2632 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 52.6316 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 47.3684 | 4 | no |
| GO:0033043 | regulation of organelle organization | 47.3684 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 47.3684 | 4 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 44.7368 | 6 | yes |
| GO:0080090 | regulation of primary metabolic process | 44.7368 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 44.7368 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 42.1053 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 42.1053 | 5 | no |
| GO:0022607 | cellular component assembly | 42.1053 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 42.1053 | 5 | yes |
| GO:0010646 | regulation of cell communication | 39.4737 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 34.2105 | 4 | no |
| GO:0010468 | regulation of gene expression | 34.2105 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 34.2105 | 5 | no |
| GO:0030030 | cell projection organization | 34.2105 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 34.2105 | 5 | no |
| GO:0010638 | positive regulation of organelle organization | 34.2105 | 6 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 34.2105 | 6 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 31.5789 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 31.5789 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 31.5789 | 5 | no |
| GO:0051049 | regulation of transport | 31.5789 | 4 | no |
| GO:0007010 | cytoskeleton organization | 31.5789 | 5 | no |
| GO:0008104 | protein localization | 31.5789 | 4 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 31.5789 | 5 | yes |
| GO:0032970 | regulation of actin filament-based process | 31.5789 | 4 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 31.5789 | 5 | yes |
| GO:0110053 | regulation of actin filament organization | 31.5789 | 6 | yes |
| GO:0043067 | regulation of programmed cell death | 28.9474 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.9474 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 28.9474 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.9474 | 5 | no |
| GO:2000145 | regulation of cell motility | 26.3158 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 26.3158 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 26.3158 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 26.3158 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.3158 | 5 | no |
| GO:0030334 | regulation of cell migration | 26.3158 | 5 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 26.3158 | 5 | yes |
| GO:0051129 | negative regulation of cellular component organization | 26.3158 | 5 | yes |
| GO:0060491 | regulation of cell projection assembly | 26.3158 | 5 | yes |
| GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 23.6842 | 6 | yes |
| GO:1902905 | positive regulation of supramolecular fiber organization | 23.6842 | 6 | yes |
| GO:0001932 | regulation of protein phosphorylation | 23.6842 | 7 | no |
| GO:0009892 | negative regulation of metabolic process | 23.6842 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 23.6842 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 23.6842 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 23.6842 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 23.6842 | 6 | no |
| GO:0023056 | positive regulation of signaling | 23.6842 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 23.6842 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 23.6842 | 7 | no |
| GO:0048585 | negative regulation of response to stimulus | 23.6842 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.6842 | 5 | no |
| GO:0009894 | regulation of catabolic process | 23.6842 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 23.6842 | 5 | no |
| GO:0007015 | actin filament organization | 23.6842 | 5 | yes |
| GO:0032271 | regulation of protein polymerization | 23.6842 | 6 | yes |
| GO:0032535 | regulation of cellular component size | 23.6842 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 23.6842 | 4 | yes |
| GO:0051495 | positive regulation of cytoskeleton organization | 23.6842 | 7 | yes |
| GO:0097435 | supramolecular fiber organization | 23.6842 | 4 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 21.0526 | 8 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 21.0526 | 6 | no |
| GO:0010975 | regulation of neuron projection development | 21.0526 | 7 | no |
| GO:0031346 | positive regulation of cell projection organization | 21.0526 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 21.0526 | 7 | no |
| GO:0036211 | protein modification process | 21.0526 | 4 | no |
| GO:0042327 | positive regulation of phosphorylation | 21.0526 | 8 | no |
| GO:0043412 | macromolecule modification | 21.0526 | 4 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 21.0526 | 7 | no |
| GO:0051247 | positive regulation of protein metabolic process | 21.0526 | 6 | no |
| GO:0071310 | cellular response to organic substance | 21.0526 | 4 | no |
| GO:0071702 | organic substance transport | 21.0526 | 4 | no |
| GO:0071705 | nitrogen compound transport | 21.0526 | 4 | no |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 21.0526 | 4 | no |
| GO:0008064 | regulation of actin polymerization or depolymerization | 21.0526 | 6 | yes |
| GO:0030832 | regulation of actin filament length | 21.0526 | 5 | yes |
| GO:0030833 | regulation of actin filament polymerization | 21.0526 | 7 | yes |
| GO:0031334 | positive regulation of protein-containing complex assembly | 21.0526 | 6 | yes |
| GO:0032231 | regulation of actin filament bundle assembly | 21.0526 | 5 | yes |
| GO:0030838 | positive regulation of actin filament polymerization | 18.4211 | 7 | yes |
| GO:0032273 | positive regulation of protein polymerization | 18.4211 | 7 | yes |
| GO:0051492 | regulation of stress fiber assembly | 18.4211 | 6 | yes |
| GO:0065003 | protein-containing complex assembly | 18.4211 | 5 | yes |
| GO:0110020 | regulation of actomyosin structure organization | 18.4211 | 6 | yes |
| GO:0008154 | actin polymerization or depolymerization | 15.7895 | 6 | yes |
| GO:0010632 | regulation of epithelial cell migration | 15.7895 | 4 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 15.7895 | 4 | yes |
| GO:1900027 | regulation of ruffle assembly | 13.1579 | 7 | yes |
| GO:0031345 | negative regulation of cell projection organization | 13.1579 | 6 | yes |
| GO:0032233 | positive regulation of actin filament bundle assembly | 13.1579 | 6 | yes |
| GO:0120033 | negative regulation of plasma membrane bounded cell projection assembly | 10.5263 | 7 | yes |
| GO:1900028 | negative regulation of ruffle assembly | 10.5263 | 8 | yes |
| GO:0051259 | protein complex oligomerization | 10.5263 | 6 | yes |
| GO:0051260 | protein homooligomerization | 10.5263 | 7 | yes |
| GO:0051496 | positive regulation of stress fiber assembly | 10.5263 | 7 | yes |
| GO:2000146 | negative regulation of cell motility | 7.8947 | 5 | yes |
| GO:0007399 | nervous system development | 7.8947 | 4 | yes |
| GO:0010633 | negative regulation of epithelial cell migration | 7.8947 | 5 | yes |
| GO:0030336 | negative regulation of cell migration | 7.8947 | 6 | yes |
| GO:0040013 | negative regulation of locomotion | 7.8947 | 4 | yes |
| GO:0051262 | protein tetramerization | 7.8947 | 7 | yes |
| GO:0051289 | protein homotetramerization | 7.8947 | 8 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SPTA1_HUMAN | [view interactions] | Low throughput | no | no |
| SPTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAD51_HUMAN | [view interactions] | Low throughput | no | yes |
| TRIM9_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EVL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FYB1_HUMAN | [view interactions] | Low throughput | no | no |
| DNMBP_HUMAN | [view interactions] | Low throughput | no | no |
| XIRP1_HUMAN | [view interactions] | Low throughput | no | no |
| SEM6A_HUMAN | [view interactions] | Low throughput | no | yes |
| VASP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ENAH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PROF2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ABL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| APBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TES_HUMAN | [view interactions] | Low throughput | no | yes |
| PAPS1_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| HCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF4H_HUMAN | [view interactions] | High throughput | no | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABI3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| POTE1_HUMAN | [view interactions] | High throughput | no | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDH17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH3R1_HUMAN | [view interactions] | High throughput | no | yes |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| ZN655_HUMAN | [view interactions] | High throughput | no | yes |
| RAD21_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NECT4_HUMAN | [view interactions] | High throughput | no | no |
| NP1L5_HUMAN | [view interactions] | High throughput | no | yes |
| U2AF2_HUMAN | [view interactions] | High throughput | no | yes |
| TRM61_HUMAN | [view interactions] | High throughput | no | no |
| UBIP1_HUMAN | [view interactions] | High throughput | no | no |
| DDX49_HUMAN | [view interactions] | High throughput | no | no |
| NUCG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TACC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXD2_HUMAN | [view interactions] | High throughput | no | yes |
| LTMD1_HUMAN | [view interactions] | High throughput | no | no |
| RL23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAF7_HUMAN | [view interactions] | High throughput | no | yes |
| FBLI1_HUMAN | [view interactions] | High throughput | no | yes |
| ETFR1_HUMAN | [view interactions] | High throughput | no | no |
| WASF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKT3_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| NHSL3_HUMAN | [view interactions] | High throughput | no | yes |
| UTP4_HUMAN | [view interactions] | High throughput | no | yes |
| CDK7_HUMAN | [view interactions] | High throughput | no | yes |
| MOFA1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHH2_HUMAN | [view interactions] | High throughput | no | no |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCRG1_HUMAN | [view interactions] | High throughput | no | yes |
| PR40A_HUMAN | [view interactions] | High throughput | no | no |
| WIPF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC3_HUMAN | [view interactions] | High throughput | no | yes |
| CRKL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AB1IP_HUMAN | [view interactions] | High throughput | no | no |
| G3BP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MSS4_HUMAN | [view interactions] | High throughput | no | yes |
| RS23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ES8L2_HUMAN | [view interactions] | High throughput | no | yes |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| GEPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |