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ZDH17_HUMAN

Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PubMed, PubMed, PubMed, PubMed, PubMed). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA . Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT (PubMed, PubMed, PubMed, PubMed). Also palmitoylates neuronal protein GPM6A as well as SPRED1 and SPRED3 (PubMed). Could also play a role in axonogenesis through the regulation of NTRK1 and the downstream ERK1/ERK2 signaling cascade . May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane (PubMed). May play a role in Mg(2+) transport (PubMed). Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane . Palmitoylates CASP6, thereby preventing its dimerization and subsequent activation (PubMed). [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in ZDH17_HUMAN
GO:0043168 anion binding 24.4898 4 no
GO:0000166 nucleotide binding 22.4490 4 no
GO:0043169 cation binding 22.4490 4 no
GO:0046872 metal ion binding 22.4490 5 no
GO:0016417 S-acyltransferase activity 4.0816 5 yes
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4.0816 4 yes
GO:0019107 myristoyltransferase activity 4.0816 5 yes
GO:0019705 protein-cysteine S-myristoyltransferase activity 4.0816 4 yes
GO:0019706 protein-cysteine S-palmitoyltransferase activity 4.0816 4 yes
GO:0140439 protein-cysteine S-stearoyltransferase activity 4.0816 4 yes
GO:0016409 palmitoyltransferase activity 4.0816 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ZDH17_HUMAN
GO:0048522 positive regulation of cellular process 65.3061 4 yes
GO:0010646 regulation of cell communication 51.0204 4 yes
GO:0010647 positive regulation of cell communication 44.8980 5 yes
GO:0023056 positive regulation of signaling 44.8980 4 yes
GO:0048523 negative regulation of cellular process 44.8980 4 no
GO:0009966 regulation of signal transduction 40.8163 4 yes
GO:0048584 positive regulation of response to stimulus 38.7755 4 yes
GO:0051128 regulation of cellular component organization 38.7755 4 no
GO:0031323 regulation of cellular metabolic process 38.7755 4 no
GO:0060255 regulation of macromolecule metabolic process 38.7755 4 no
GO:0080090 regulation of primary metabolic process 36.7347 4 no
GO:0009967 positive regulation of signal transduction 34.6939 5 yes
GO:0006996 organelle organization 34.6939 4 no
GO:0009893 positive regulation of metabolic process 34.6939 4 no
GO:0022607 cellular component assembly 34.6939 4 no
GO:0031325 positive regulation of cellular metabolic process 32.6531 5 no
GO:0051049 regulation of transport 30.6122 4 no
GO:0009889 regulation of biosynthetic process 30.6122 4 no
GO:0010556 regulation of macromolecule biosynthetic process 30.6122 5 no
GO:0031326 regulation of cellular biosynthetic process 30.6122 5 no
GO:0051130 positive regulation of cellular component organization 28.5714 5 no
GO:0010604 positive regulation of macromolecule metabolic process 28.5714 5 no
GO:0033043 regulation of organelle organization 28.5714 5 no
GO:0008104 protein localization 26.5306 4 yes
GO:1902531 regulation of intracellular signal transduction 26.5306 5 yes
GO:0051246 regulation of protein metabolic process 26.5306 5 no
GO:0010468 regulation of gene expression 26.5306 6 no
GO:0043067 regulation of programmed cell death 24.4898 4 yes
GO:0044087 regulation of cellular component biogenesis 24.4898 4 no
GO:0043933 protein-containing complex organization 24.4898 4 no
GO:0030030 cell projection organization 22.4490 4 yes
GO:0065003 protein-containing complex assembly 22.4490 5 no
GO:0019220 regulation of phosphate metabolic process 22.4490 6 no
GO:0051174 regulation of phosphorus metabolic process 22.4490 5 no
GO:0071702 organic substance transport 20.4082 4 yes
GO:0071705 nitrogen compound transport 20.4082 4 yes
GO:0009891 positive regulation of biosynthetic process 20.4082 5 no
GO:0009892 negative regulation of metabolic process 20.4082 4 no
GO:0031324 negative regulation of cellular metabolic process 20.4082 5 no
GO:0031328 positive regulation of cellular biosynthetic process 20.4082 6 no
GO:0031399 regulation of protein modification process 20.4082 6 no
GO:0051247 positive regulation of protein metabolic process 20.4082 6 no
GO:0051094 positive regulation of developmental process 20.4082 4 no
GO:0042325 regulation of phosphorylation 20.4082 7 no
GO:0010648 negative regulation of cell communication 20.4082 5 no
GO:0023057 negative regulation of signaling 20.4082 4 no
GO:1902533 positive regulation of intracellular signal transduction 18.3673 6 yes
GO:0015031 protein transport 16.3265 4 yes
GO:0043408 regulation of MAPK cascade 16.3265 6 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 16.3265 4 yes
GO:0036211 protein modification process 14.2857 4 yes
GO:0043412 macromolecule modification 14.2857 4 yes
GO:0048812 neuron projection morphogenesis 14.2857 5 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 14.2857 7 yes
GO:0007409 axonogenesis 10.2041 6 yes
GO:0043122 regulation of canonical NF-kappaB signal transduction 10.2041 6 yes
GO:0090287 regulation of cellular response to growth factor stimulus 10.2041 4 yes
GO:0043123 positive regulation of canonical NF-kappaB signal transduction 8.1633 7 yes
GO:0006497 protein lipidation 4.0816 5 yes
GO:0018345 protein palmitoylation 4.0816 6 yes
GO:0042953 lipoprotein transport 4.0816 5 yes
GO:0043543 protein acylation 4.0816 5 yes
GO:0044872 lipoprotein localization 4.0816 5 yes
GO:0051386 regulation of neurotrophin TRK receptor signaling pathway 4.0816 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DNJC5_HUMAN [view interactions] Low throughput no yes
SPRE3_HUMAN [view interactions] Low throughput no no
SPRE1_HUMAN [view interactions] Low throughput no yes
OPTN_HUMAN [view interactions] Low throughput no yes
GPM6A_HUMAN [view entry] [view interactions] Low throughput yes no
SNP25_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
SYT1_HUMAN [view entry] [view interactions] Low throughput yes no
MP2K4_HUMAN [view interactions] Low throughput no yes
MP2K7_HUMAN [view entry] [view interactions] Low throughput yes yes
HD_HUMAN [view entry] [view interactions] Low throughput yes yes
ZDH17_HUMAN [view entry] [view interactions] Low throughput yes yes
UBAC1_HUMAN [view interactions] High throughput no yes
THAP7_HUMAN [view interactions] High throughput no no
WAC_HUMAN [view interactions] High throughput no yes
BEX2_HUMAN [view interactions] High throughput no yes
LMA2L_HUMAN [view interactions] High throughput no yes
GLP3L_HUMAN [view interactions] High throughput no no
STN1_HUMAN [view interactions] High throughput no no
LN28A_HUMAN [view interactions] High throughput no no
ARFG3_HUMAN [view entry] [view interactions] High throughput yes no
IFT57_HUMAN [view interactions] High throughput no yes
DAXX_HUMAN [view interactions] High throughput no yes
RCAN3_HUMAN [view interactions] High throughput no no
UBP18_HUMAN [view interactions] High throughput no yes
FUT9_HUMAN [view interactions] High throughput no no
MSRB2_HUMAN [view interactions] High throughput no no
SKAP_HUMAN [view interactions] High throughput no yes
WASF2_HUMAN [view entry] [view interactions] High throughput yes yes
SL9A9_HUMAN [view interactions] High throughput no yes
ASF1A_HUMAN [view interactions] High throughput no no
SPY2_HUMAN [view interactions] High throughput no yes
SPY3_HUMAN [view interactions] High throughput no no
WFS1_HUMAN [view entry] [view interactions] High throughput yes yes
ZHX1R_HUMAN [view interactions] High throughput no yes
GDAP1_HUMAN [view entry] [view interactions] High throughput yes yes
NFYC_HUMAN [view interactions] High throughput no no
SRBP2_HUMAN [view interactions] High throughput no yes
STK3_HUMAN [view interactions] High throughput no yes
RIMS3_HUMAN [view entry] [view interactions] High throughput yes no
ADDA_HUMAN [view entry] [view interactions] High throughput yes yes
CN37_HUMAN [view entry] [view interactions] High throughput yes no
LASP1_HUMAN [view entry] [view interactions] High throughput yes yes
P85A_HUMAN [view interactions] High throughput no yes
CIP4_HUMAN [view interactions] High throughput no no
BAIP2_HUMAN [view entry] [view interactions] High throughput yes yes
BTF3_HUMAN [view interactions] High throughput no yes
KC1D_HUMAN [view entry] [view interactions] High throughput yes yes
GABP1_HUMAN [view interactions] High throughput no yes
GATA1_HUMAN [view interactions] High throughput no no
HBG1_HUMAN [view interactions] High throughput no no
DRB1_HUMAN [view interactions] High throughput no no
SHIP1_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
ODFP2_HUMAN [view interactions] High throughput no no
OTX2_HUMAN [view interactions] High throughput no yes
PDE4D_HUMAN [view entry] [view interactions] High throughput yes yes
PDPK1_HUMAN [view entry] [view interactions] High throughput yes yes
PTMA_HUMAN [view interactions] High throughput no yes
SHOX2_HUMAN [view interactions] High throughput no no
SP2_HUMAN [view interactions] High throughput no yes
FKBP6_HUMAN [view interactions] High throughput no no
STX16_HUMAN [view interactions] High throughput no yes
PA24B_HUMAN [view interactions] High throughput no no
DYH11_HUMAN [view interactions] High throughput no no
DLK1_HUMAN [view interactions] High throughput no no
CCNE2_HUMAN [view interactions] High throughput no no
K0408_HUMAN [view entry] [view interactions] High throughput yes no
SETB1_HUMAN [view interactions] High throughput no yes
TPGS2_HUMAN [view interactions] High throughput no yes
MLH3_HUMAN [view interactions] High throughput no no
MOG1_HUMAN [view interactions] High throughput no yes
EVL_HUMAN [view entry] [view interactions] High throughput yes yes
BCAS3_HUMAN [view interactions] High throughput no yes
DALD3_HUMAN [view interactions] High throughput no yes
PB1_HUMAN [view interactions] High throughput no yes
ASIC4_HUMAN [view interactions] High throughput no no
ANR50_HUMAN [view interactions] High throughput no no
ZN624_HUMAN [view interactions] High throughput no yes
SEM4G_HUMAN [view interactions] High throughput no yes
PKHB1_HUMAN [view interactions] High throughput no no
RIC8A_HUMAN [view entry] [view interactions] High throughput yes no
H1BP3_HUMAN [view interactions] High throughput no yes
TTC23_HUMAN [view interactions] High throughput no yes
TUT7_HUMAN [view interactions] High throughput no yes
TTLL7_HUMAN [view interactions] High throughput no yes
PACER_HUMAN [view interactions] High throughput no yes
COG3_HUMAN [view entry] [view interactions] High throughput yes yes
TMTC1_HUMAN [view interactions] High throughput no no
DIXC1_HUMAN [view entry] [view interactions] High throughput yes no
IFT20_HUMAN [view interactions] High throughput no yes
WDR20_HUMAN [view interactions] High throughput no no
PPR21_HUMAN [view interactions] High throughput no yes
PBIR3_HUMAN [view interactions] High throughput no no
ZC3H1_HUMAN [view interactions] High throughput no yes
ALKB3_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
NRG1_HUMAN [view entry] [view interactions] High throughput yes no
NRSN2_HUMAN [view interactions] High throughput no yes
PLS4_HUMAN [view interactions] High throughput no no
TRM9B_HUMAN [view interactions] High throughput no yes
LPAR6_HUMAN [view interactions] High throughput no no
B4GT3_HUMAN [view interactions] High throughput no yes
BSCL2_HUMAN [view interactions] High throughput no yes
LPAR1_HUMAN [view entry] [view interactions] High throughput yes no
HERC2_HUMAN [view interactions] High throughput no yes
DHX57_HUMAN [view interactions] High throughput no no
C3AR_HUMAN [view interactions] High throughput no no
IPPK_HUMAN [view interactions] High throughput no yes
AMPO_HUMAN [view interactions] High throughput no yes
TNR19_HUMAN [view interactions] High throughput no no
S39A8_HUMAN [view interactions] High throughput no yes
FUT3_HUMAN [view interactions] High throughput no yes
FA8A1_HUMAN [view interactions] High throughput no yes
SRPRA_HUMAN [view interactions] High throughput no no
AMGO3_HUMAN [view interactions] High throughput no no
LMBRL_HUMAN [view interactions] High throughput no no
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
NK3R_HUMAN [view interactions] High throughput no no
HCST_HUMAN [view interactions] High throughput no no
IDD_HUMAN [view interactions] High throughput no no
ITA8_HUMAN [view entry] [view interactions] High throughput yes no
GABR1_HUMAN [view entry] [view interactions] High throughput yes yes
LCTL_HUMAN [view interactions] High throughput no no
TA2R_HUMAN [view interactions] High throughput no no
PTH2R_HUMAN [view interactions] High throughput no no
TSN15_HUMAN [view interactions] High throughput no yes
MDFI_HUMAN [view interactions] High throughput no no
PL8L1_HUMAN [view interactions] High throughput no no
SCAP_HUMAN [view interactions] High throughput no yes
ARSL_HUMAN [view interactions] High throughput no no
ANM5_HUMAN [view entry] [view interactions] High throughput yes yes
GPR35_HUMAN [view interactions] High throughput no no
SOX14_HUMAN [view interactions] High throughput no no
ACRBP_HUMAN [view interactions] High throughput no no
KLK8_HUMAN [view interactions] High throughput no no
LPAR2_HUMAN [view interactions] High throughput no yes
TXD12_HUMAN [view interactions] High throughput no no
P2RY8_HUMAN [view interactions] High throughput no no
FRIL_HUMAN [view interactions] High throughput no yes
VIPR1_HUMAN [view interactions] High throughput no yes
MANF_HUMAN [view interactions] High throughput no yes
PAR2_HUMAN [view entry] [view interactions] High throughput yes yes
RAD51_HUMAN [view interactions] High throughput no yes
JAM1_HUMAN [view interactions] High throughput no yes
EIF3E_HUMAN [view entry] [view interactions] High throughput yes yes
DNJ5B_HUMAN [view interactions] High throughput no no
SRSF4_HUMAN [view interactions] High throughput no yes
TMEM9_HUMAN [view interactions] High throughput no no
PDZ1I_HUMAN [view interactions] High throughput no no
VIPR2_HUMAN [view interactions] High throughput no no
FX4L6_HUMAN [view interactions] High throughput no no
LRAD1_HUMAN [view interactions] High throughput no no
BACD2_HUMAN [view interactions] High throughput no no
GP182_HUMAN [view interactions] High throughput no no
CA216_HUMAN [view interactions] High throughput no yes
TYOBP_HUMAN [view interactions] High throughput no no
FBH1_HUMAN [view interactions] High throughput no no
GPR55_HUMAN [view interactions] High throughput no no
KR111_HUMAN [view interactions] High throughput no no
TMC6_HUMAN [view interactions] High throughput no yes
KRA92_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
RNF38_HUMAN [view interactions] High throughput no yes
EXD2_HUMAN [view interactions] High throughput no yes
KAD3_HUMAN [view entry] [view interactions] High throughput yes yes
TMPS2_HUMAN [view interactions] High throughput no no
CT141_HUMAN [view interactions] High throughput no no
STING_HUMAN [view interactions] High throughput no yes
M3K19_HUMAN [view interactions] High throughput no no
MBPHL_HUMAN [view interactions] High throughput no no
E2F8_HUMAN [view interactions] High throughput no yes
STK25_HUMAN [view interactions] High throughput no no
SNP23_HUMAN [view entry] [view interactions] High throughput yes no
TOX_HUMAN [view interactions] High throughput no yes
LY66C_HUMAN [view interactions] High throughput no no
ATF2_HUMAN [view interactions] High throughput no yes
EAA1_HUMAN [view entry] [view interactions] High throughput yes no
RBM5_HUMAN [view interactions] High throughput no yes
HBG2_HUMAN [view interactions] High throughput no no
VSX2_HUMAN [view interactions] High throughput no no
DRB3_HUMAN [view interactions] High throughput no no
NC2B_HUMAN [view interactions] High throughput no yes
SNF5_HUMAN [view interactions] High throughput no yes
TM115_HUMAN [view interactions] High throughput no yes
GRB10_HUMAN [view entry] [view interactions] High throughput yes yes
CDSN_HUMAN [view interactions] High throughput no no
QRIC1_HUMAN [view interactions] High throughput no yes
F135B_HUMAN [view interactions] High throughput no no
MIIP_HUMAN [view interactions] High throughput no yes
HECD3_HUMAN [view interactions] High throughput no yes
ZN333_HUMAN [view interactions] High throughput no no
LEG9C_HUMAN [view interactions] High throughput no no
OTU7B_HUMAN [view interactions] High throughput no yes
YTHD3_HUMAN [view interactions] High throughput no no
ZFP2_HUMAN [view interactions] High throughput no no
SPRE2_HUMAN [view interactions] High throughput no yes
KHDC4_HUMAN [view interactions] High throughput no yes
TAF8_HUMAN [view interactions] High throughput no yes
SKA3_HUMAN [view interactions] High throughput no no
GP135_HUMAN [view interactions] High throughput no no
OFCC1_HUMAN [view interactions] High throughput no no
FAM9A_HUMAN [view interactions] High throughput no no
DTX3_HUMAN [view interactions] High throughput no yes
PPTC7_HUMAN [view interactions] High throughput no yes
SUMF2_HUMAN [view interactions] High throughput no yes
CTCFL_HUMAN [view interactions] High throughput no no
GABP2_HUMAN [view interactions] High throughput no yes
AIDA_HUMAN [view interactions] High throughput no yes
TM186_HUMAN [view interactions] High throughput no no
H2B1H_HUMAN [view interactions] High throughput no yes
RB39B_HUMAN [view interactions] High throughput no no
TXD15_HUMAN [view interactions] High throughput no yes
CC120_HUMAN [view interactions] High throughput no no
SCNM1_HUMAN [view interactions] High throughput no no
EYA3_HUMAN [view interactions] High throughput no no
MK67I_HUMAN [view interactions] High throughput no yes
ZN341_HUMAN [view interactions] High throughput no no
ADT4_HUMAN [view entry] [view interactions] High throughput yes no
SPY4_HUMAN [view interactions] High throughput no yes
ABCG4_HUMAN [view interactions] High throughput no no
CHM1A_HUMAN [view entry] [view interactions] High throughput yes no
ZCC17_HUMAN [view interactions] High throughput no yes
MYOZ2_HUMAN [view interactions] High throughput no no
SLX9_HUMAN [view interactions] High throughput no yes
FEZ2_HUMAN [view interactions] High throughput no yes
TEAD1_HUMAN [view interactions] High throughput no no
MOFA1_HUMAN [view interactions] High throughput no yes
HXA3_HUMAN [view interactions] High throughput no no
ZSC9_HUMAN [view interactions] High throughput no yes
HYPM_HUMAN [view interactions] High throughput no no
NEBL_HUMAN [view entry] [view interactions] High throughput yes no
TMCC1_HUMAN [view interactions] High throughput no yes
YIF1A_HUMAN [view interactions] High throughput no yes
LCA5L_HUMAN [view interactions] High throughput no no
CYTA_HUMAN [view interactions] High throughput no no
HLAA_HUMAN [view interactions] High throughput no no
JMJD7_HUMAN [view interactions] High throughput no yes
HEM3_HUMAN [view interactions] High throughput no yes
CAN2_HUMAN [view entry] [view interactions] High throughput yes no
EF1G_HUMAN [view entry] [view interactions] High throughput yes yes
TTP_HUMAN [view interactions] High throughput no yes
CBS_HUMAN [view interactions] High throughput no yes
ACTY_HUMAN [view entry] [view interactions] High throughput yes no
GSK3A_HUMAN [view interactions] High throughput no yes
TNF10_HUMAN [view interactions] High throughput no no
ANX11_HUMAN [view entry] [view interactions] High throughput yes yes
UBE2K_HUMAN [view interactions] High throughput no yes
RAP1B_HUMAN [view entry] [view interactions] High throughput yes no
EF1A1_HUMAN [view entry] [view interactions] High throughput yes yes
H31_HUMAN [view interactions] High throughput no yes
K1C17_HUMAN [view interactions] High throughput no no
EXOS9_HUMAN [view interactions] High throughput no yes
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
NCBP1_HUMAN [view interactions] High throughput no yes
FUT2_HUMAN [view interactions] High throughput no yes
SF3A3_HUMAN [view interactions] High throughput no yes
SNW1_HUMAN [view interactions] High throughput no yes
DELE1_HUMAN [view interactions] High throughput no yes
2A5E_HUMAN [view interactions] High throughput no yes
ERC6L_HUMAN [view interactions] High throughput no yes
EDRF1_HUMAN [view interactions] High throughput no no
NPFF_HUMAN [view interactions] High throughput no no
AHDC1_HUMAN [view interactions] High throughput no yes
BRE1A_HUMAN [view interactions] High throughput no yes
RSBNL_HUMAN [view interactions] High throughput no yes
PHF5A_HUMAN [view interactions] High throughput no yes
UBP32_HUMAN [view interactions] High throughput no yes
AB1IP_HUMAN [view interactions] High throughput no no
NF2IP_HUMAN [view interactions] High throughput no no
CLRN3_HUMAN [view interactions] High throughput no no
CNKR1_HUMAN [view interactions] High throughput no no
CTHR1_HUMAN [view interactions] High throughput no yes
LRC45_HUMAN [view interactions] High throughput no yes
MSD3_HUMAN [view interactions] High throughput no no
MR1L1_HUMAN [view interactions] High throughput no no
ANCHR_HUMAN [view interactions] High throughput no yes
CNDP2_HUMAN [view entry] [view interactions] High throughput yes yes
ZN597_HUMAN [view interactions] High throughput no yes
CCDC7_HUMAN [view interactions] High throughput no no
TIGD1_HUMAN [view interactions] High throughput no yes
CIB1_HUMAN [view interactions] High throughput no no