COG3_HUMAN
Evidence for PS localization
Functions
Involved in ER-Golgi transport. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in COG3_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 35.2941 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 35.2941 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 35.2941 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 26.4706 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 26.4706 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 26.4706 | 6 | no |
| GO:0003924 | GTPase activity | 20.5882 | 7 | no |
| GO:0005525 | GTP binding | 20.5882 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 20.5882 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 20.5882 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in COG3_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 58.8235 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 52.9412 | 4 | yes |
| GO:0006996 | organelle organization | 50.0000 | 4 | yes |
| GO:0015031 | protein transport | 50.0000 | 4 | yes |
| GO:0071702 | organic substance transport | 50.0000 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 50.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 41.1765 | 4 | no |
| GO:0006886 | intracellular protein transport | 38.2353 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 38.2353 | 4 | no |
| GO:0048193 | Golgi vesicle transport | 35.2941 | 5 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 35.2941 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 35.2941 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 32.3529 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 32.3529 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 29.4118 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.4118 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 29.4118 | 5 | no |
| GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport | 26.4706 | 4 | yes |
| GO:0033365 | protein localization to organelle | 23.5294 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 23.5294 | 4 | no |
| GO:0022607 | cellular component assembly | 23.5294 | 4 | no |
| GO:0010468 | regulation of gene expression | 23.5294 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 23.5294 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 23.5294 | 5 | no |
| GO:0036211 | protein modification process | 20.5882 | 4 | yes |
| GO:0043412 | macromolecule modification | 20.5882 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 20.5882 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 20.5882 | 4 | no |
| GO:0051049 | regulation of transport | 20.5882 | 4 | no |
| GO:0010646 | regulation of cell communication | 20.5882 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 20.5882 | 6 | no |
| GO:0007030 | Golgi organization | 17.6471 | 5 | yes |
| GO:0006890 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 14.7059 | 6 | yes |
| GO:0006891 | intra-Golgi vesicle-mediated transport | 14.7059 | 6 | yes |
| GO:0000301 | retrograde transport, vesicle recycling within Golgi | 5.8824 | 7 | yes |
| GO:0006486 | protein glycosylation | 5.8824 | 4 | yes |
| GO:0050821 | protein stabilization | 5.8824 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in COG3_HUMAN |
|---|---|---|---|---|
| DOID:0050539 | Charcot-Marie-Tooth disease type 2 | 5.8824 | 7 | no |
| DOID:10595 | Charcot-Marie-Tooth disease | 5.8824 | 6 | no |
| DOID:440 | neuromuscular disease | 5.8824 | 5 | no |
| DOID:574 | peripheral nervous system disease | 5.8824 | 3 | no |
| DOID:870 | neuropathy | 5.8824 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SCFD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| COG8_HUMAN | [view interactions] | Low throughput | no | no |
| COG1_HUMAN | [view interactions] | Low throughput | no | yes |
| COG2_HUMAN | [view interactions] | Low throughput | no | no |
| COG6_HUMAN | [view interactions] | Low throughput | no | yes |
| COG4_HUMAN | [view interactions] | Low throughput | no | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB30_HUMAN | [view interactions] | High throughput | no | yes |
| CKLF8_HUMAN | [view interactions] | High throughput | no | yes |
| FPR1_HUMAN | [view interactions] | High throughput | no | no |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLR_HUMAN | [view interactions] | High throughput | no | no |
| TACD2_HUMAN | [view interactions] | High throughput | no | no |
| P2Y10_HUMAN | [view interactions] | High throughput | no | no |
| TNR5_HUMAN | [view interactions] | High throughput | no | no |
| ACM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPR17_HUMAN | [view interactions] | High throughput | no | no |
| F234A_HUMAN | [view interactions] | High throughput | no | yes |
| EFNA4_HUMAN | [view interactions] | High throughput | no | no |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| CMTD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HACL2_HUMAN | [view interactions] | High throughput | no | yes |
| GPR45_HUMAN | [view interactions] | High throughput | no | no |
| PMVK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSA6_HUMAN | [view interactions] | High throughput | no | yes |
| RAB1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARMD3_HUMAN | [view interactions] | High throughput | no | yes |
| PTAR1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIPR1_HUMAN | [view interactions] | High throughput | no | yes |
| GET3_HUMAN | [view interactions] | High throughput | no | yes |
| VATG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COG3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LEO1_HUMAN | [view interactions] | High throughput | no | yes |
| NOL8_HUMAN | [view interactions] | High throughput | no | yes |
| NUDC_HUMAN | [view interactions] | High throughput | no | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RTF1_HUMAN | [view interactions] | High throughput | no | yes |
| SCYL1_HUMAN | [view interactions] | High throughput | no | yes |
| SC22B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S35A1_HUMAN | [view interactions] | High throughput | no | no |
| WDR7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SC24C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| AKA10_HUMAN | [view interactions] | High throughput | no | no |
| AP3B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTR9_HUMAN | [view interactions] | High throughput | no | yes |
| MYH14_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| K2C7_HUMAN | [view interactions] | High throughput | no | no |
| ML12A_HUMAN | [view interactions] | High throughput | no | no |
| RABL6_HUMAN | [view interactions] | High throughput | no | yes |
| CLIC1_HUMAN | [view interactions] | High throughput | no | no |
| ARP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| GOGA1_HUMAN | [view interactions] | High throughput | no | yes |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCN2B_HUMAN | [view interactions] | High throughput | no | no |
| COMD8_HUMAN | [view interactions] | High throughput | no | yes |
| VSIG2_HUMAN | [view interactions] | High throughput | no | no |
| PD1L1_HUMAN | [view interactions] | High throughput | no | no |
| HAUS3_HUMAN | [view interactions] | High throughput | no | yes |
| TBCC_HUMAN | [view interactions] | High throughput | no | yes |
| COG7_HUMAN | [view interactions] | High throughput | no | yes |
| UN93B_HUMAN | [view interactions] | High throughput | no | yes |
| ROS1_HUMAN | [view interactions] | High throughput | no | no |
| RIPK2_HUMAN | [view interactions] | High throughput | no | yes |
| TESK1_HUMAN | [view interactions] | High throughput | no | no |
| COQ8A_HUMAN | [view interactions] | High throughput | no | no |
| SNRK_HUMAN | [view interactions] | High throughput | no | yes |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| ZDH17_HUMAN | [view interactions] | High throughput | no | yes |
| SPG21_HUMAN | [view interactions] | High throughput | no | yes |
| CINP_HUMAN | [view interactions] | High throughput | no | no |
| TRIM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUP58_HUMAN | [view interactions] | High throughput | no | yes |
| KIFC3_HUMAN | [view interactions] | High throughput | no | no |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSH2_HUMAN | [view interactions] | High throughput | no | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HAUS1_HUMAN | [view interactions] | High throughput | no | yes |
| COG5_HUMAN | [view interactions] | High throughput | no | yes |
| CCD18_HUMAN | [view interactions] | High throughput | no | yes |
| HAUS4_HUMAN | [view interactions] | High throughput | no | yes |
| CP250_HUMAN | [view interactions] | High throughput | no | no |
| NEUA_HUMAN | [view interactions] | High throughput | no | yes |
| 5HT6R_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| OPRM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UXS1_HUMAN | [view interactions] | High throughput | no | yes |
| STX6_HUMAN | [view interactions] | Computational | no | yes |
| GOGB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| YKT6_HUMAN | [view interactions] | Computational | no | yes |
| VPS52_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GOGA3_HUMAN | [view interactions] | Computational | no | yes |
| RAB43_HUMAN | [view interactions] | Computational | no | yes |
| RAB6A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RIC1_HUMAN | [view interactions] | Computational | no | no |
| VPS54_HUMAN | [view interactions] | Computational | no | no |
| VPS53_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| STX5_HUMAN | [view interactions] | Computational | no | yes |
| GOLI4_HUMAN | [view interactions] | Computational | no | yes |
| VAMP4_HUMAN | [view interactions] | Computational | no | yes |
| NSF_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RB33B_HUMAN | [view interactions] | Computational | no | no |
| COPG1_HUMAN | [view interactions] | Computational | no | yes |
| RINT1_HUMAN | [view interactions] | Computational | no | yes |
| SYS1_HUMAN | [view interactions] | Computational | no | yes |
| STX16_HUMAN | [view interactions] | Computational | no | yes |
| BET1_HUMAN | [view interactions] | Computational | no | no |
| GOSR2_HUMAN | [view interactions] | Computational | no | yes |
| COPG2_HUMAN | [view interactions] | Computational | no | yes |
| GOGA5_HUMAN | [view interactions] | Computational | no | yes |
| COPB_HUMAN | [view interactions] | Computational | no | yes |
| VPS51_HUMAN | [view interactions] | Computational | no | yes |
| GOSR1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VTI1A_HUMAN | [view interactions] | Computational | no | yes |
| USO1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| BET1L_HUMAN | [view interactions] | Computational | no | yes |