Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SCFD1_HUMAN

Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi . [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in SCFD1_HUMAN
GO:0017076 purine nucleotide binding 33.3333 4 no
GO:0032555 purine ribonucleotide binding 33.3333 4 no
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 no
GO:0016462 pyrophosphatase activity 23.4568 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 23.4568 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 23.4568 6 no
GO:0019905 syntaxin binding 11.1111 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SCFD1_HUMAN
GO:0048522 positive regulation of cellular process 53.0864 4 no
GO:0008104 protein localization 49.3827 4 yes
GO:0016192 vesicle-mediated transport 48.1481 4 yes
GO:0006996 organelle organization 46.9136 4 no
GO:0071702 organic substance transport 44.4444 4 yes
GO:0071705 nitrogen compound transport 44.4444 4 yes
GO:0015031 protein transport 41.9753 4 yes
GO:0051128 regulation of cellular component organization 35.8025 4 yes
GO:0010646 regulation of cell communication 35.8025 4 no
GO:0006886 intracellular protein transport 32.0988 4 yes
GO:0060255 regulation of macromolecule metabolic process 32.0988 4 no
GO:0061024 membrane organization 32.0988 4 no
GO:0031323 regulation of cellular metabolic process 30.8642 4 yes
GO:0022607 cellular component assembly 30.8642 4 no
GO:0009893 positive regulation of metabolic process 30.8642 4 no
GO:0048523 negative regulation of cellular process 29.6296 4 yes
GO:0009966 regulation of signal transduction 29.6296 4 no
GO:0023056 positive regulation of signaling 28.3951 4 no
GO:0051171 regulation of nitrogen compound metabolic process 28.3951 4 no
GO:0080090 regulation of primary metabolic process 28.3951 4 no
GO:0010604 positive regulation of macromolecule metabolic process 28.3951 5 no
GO:0010647 positive regulation of cell communication 27.1605 5 no
GO:0048584 positive regulation of response to stimulus 27.1605 4 no
GO:0048193 Golgi vesicle transport 25.9259 5 yes
GO:0051049 regulation of transport 24.6914 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 24.6914 5 no
GO:0031325 positive regulation of cellular metabolic process 23.4568 5 no
GO:0051246 regulation of protein metabolic process 23.4568 5 no
GO:0033043 regulation of organelle organization 22.2222 5 yes
GO:0009967 positive regulation of signal transduction 22.2222 5 no
GO:0044087 regulation of cellular component biogenesis 20.9877 4 yes
GO:0007010 cytoskeleton organization 20.9877 5 no
GO:1902531 regulation of intracellular signal transduction 20.9877 5 no
GO:0010468 regulation of gene expression 20.9877 5 no
GO:0051247 positive regulation of protein metabolic process 20.9877 6 no
GO:0060341 regulation of cellular localization 19.7531 4 yes
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 17.2840 4 yes
GO:0032880 regulation of protein localization 16.0494 5 yes
GO:0009892 negative regulation of metabolic process 13.5802 4 yes
GO:0060627 regulation of vesicle-mediated transport 13.5802 4 yes
GO:0009894 regulation of catabolic process 11.1111 4 yes
GO:0051129 negative regulation of cellular component organization 9.8765 5 yes
GO:1902115 regulation of organelle assembly 9.8765 5 yes
GO:0031324 negative regulation of cellular metabolic process 8.6420 5 yes
GO:0032386 regulation of intracellular transport 8.6420 5 yes
GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum 7.4074 6 yes
GO:0031329 regulation of cellular catabolic process 7.4074 5 yes
GO:0006892 post-Golgi vesicle-mediated transport 6.1728 6 yes
GO:0010506 regulation of autophagy 6.1728 6 yes
GO:0051223 regulation of protein transport 6.1728 5 yes
GO:0070201 regulation of establishment of protein localization 6.1728 6 yes
GO:0009895 negative regulation of catabolic process 4.9383 5 yes
GO:0010639 negative regulation of organelle organization 4.9383 6 yes
GO:0016241 regulation of macroautophagy 4.9383 7 yes
GO:0044088 regulation of vacuole organization 4.9383 6 yes
GO:2000785 regulation of autophagosome assembly 4.9383 6 yes
GO:0010507 negative regulation of autophagy 3.7037 7 yes
GO:0031330 negative regulation of cellular catabolic process 3.7037 6 yes
GO:0036293 response to decreased oxygen levels 3.7037 4 yes
GO:1901998 toxin transport 3.7037 4 yes
GO:0016242 negative regulation of macroautophagy 2.4691 8 yes
GO:1902116 negative regulation of organelle assembly 2.4691 6 yes
GO:1902902 negative regulation of autophagosome assembly 2.4691 7 yes

Disease

Term Name % Distance from top the of the tree Annotated in SCFD1_HUMAN
DOID:440 neuromuscular disease 3.7037 5 no
DOID:574 peripheral nervous system disease 3.7037 3 no
DOID:870 neuropathy 3.7037 4 no
DOID:0050700 cardiomyopathy 2.4691 4 no
DOID:0060036 intrinsic cardiomyopathy 2.4691 5 no
DOID:114 heart disease 2.4691 3 no
DOID:331 central nervous system disease 2.4691 3 no
DOID:0050539 Charcot-Marie-Tooth disease type 2 2.4691 7 no
DOID:10595 Charcot-Marie-Tooth disease 2.4691 6 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
COG7_HUMAN [view interactions] Low throughput no yes
COG4_HUMAN [view interactions] Low throughput no no
COG3_HUMAN [view entry] [view interactions] Low throughput yes yes
USO1_HUMAN [view entry] [view interactions] Low throughput yes yes
DKKL1_HUMAN [view interactions] Low throughput no no
KAT5_HUMAN [view interactions] Low throughput no yes
APBP2_HUMAN [view interactions] Low throughput no yes
TGO1_HUMAN [view interactions] Low throughput no yes
HEXI1_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
NR2C2_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
CLUA1_HUMAN [view interactions] High throughput no yes
LMBRL_HUMAN [view interactions] High throughput no no
TIF1B_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
EMC1_HUMAN [view interactions] High throughput no yes
EMC4_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
CUL4A_HUMAN [view interactions] High throughput no no
STX8_HUMAN [view interactions] High throughput no yes
RINT1_HUMAN [view interactions] High throughput no yes
SCFD2_HUMAN [view interactions] High throughput no yes
SNAG_HUMAN [view entry] [view interactions] High throughput yes yes
CS025_HUMAN [view interactions] High throughput no no
SNP29_HUMAN [view interactions] High throughput no yes
GPC5B_HUMAN [view entry] [view interactions] High throughput yes no
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
SEC20_HUMAN [view interactions] High throughput no yes
CC107_HUMAN [view interactions] High throughput no no
FSCN1_HUMAN [view entry] [view interactions] High throughput yes yes
RBCC1_HUMAN [view interactions] High throughput no no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RND2_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
AR6P1_HUMAN [view interactions] High throughput no yes
BET1L_HUMAN [view interactions] High throughput no yes
COPA_HUMAN [view entry] [view interactions] High throughput yes yes
COPB2_HUMAN [view entry] [view interactions] High throughput yes yes
COPE_HUMAN [view interactions] High throughput no yes
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
GOT1B_HUMAN [view interactions] High throughput no yes
GORS2_HUMAN [view interactions] High throughput no yes
GOSR2_HUMAN [view interactions] High throughput no yes
GP107_HUMAN [view interactions] High throughput no yes
MIF_HUMAN [view entry] [view interactions] High throughput yes yes
PGRC1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB1B_HUMAN [view entry] [view interactions] High throughput yes yes
RER1_HUMAN [view interactions] High throughput no yes
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
SAC1_HUMAN [view entry] [view interactions] High throughput yes yes
RNF25_HUMAN [view interactions] High throughput no no
NBAS_HUMAN [view interactions] High throughput no yes
YKT6_HUMAN [view interactions] High throughput no yes
GET3_HUMAN [view interactions] High throughput no yes
SC61B_HUMAN [view interactions] High throughput no yes
STX10_HUMAN [view interactions] High throughput no yes
STX16_HUMAN [view interactions] High throughput no yes
STX3_HUMAN [view entry] [view interactions] High throughput yes no
TMEDA_HUMAN [view interactions] High throughput no yes
VAPA_HUMAN [view entry] [view interactions] High throughput yes yes
VAPB_HUMAN [view entry] [view interactions] High throughput yes yes
VTI1A_HUMAN [view interactions] High throughput no yes
VTI1B_HUMAN [view entry] [view interactions] High throughput yes yes
YIPF5_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RM13_HUMAN [view interactions] High throughput no yes
VPP1_HUMAN [view entry] [view interactions] High throughput yes yes
SNP23_HUMAN [view entry] [view interactions] High throughput yes no
RM15_HUMAN [view interactions] High throughput no yes
S2546_HUMAN [view entry] [view interactions] High throughput yes yes
RM40_HUMAN [view interactions] High throughput no yes
RM49_HUMAN [view interactions] High throughput no yes
ILF2_HUMAN [view interactions] High throughput no yes
HSP76_HUMAN [view entry] [view interactions] High throughput yes yes
ODO1_HUMAN [view entry] [view interactions] High throughput yes yes
HOOK3_HUMAN [view entry] [view interactions] High throughput yes yes
MPV17_HUMAN [view interactions] High throughput no no
MPCP_HUMAN [view entry] [view interactions] High throughput yes no
DNJA3_HUMAN [view entry] [view interactions] High throughput yes yes
VAMP2_HUMAN [view entry] [view interactions] High throughput yes no
RM32_HUMAN [view interactions] High throughput no yes
RM09_HUMAN [view interactions] High throughput no yes
VPS45_HUMAN [view entry] [view interactions] High throughput yes yes
VINC_HUMAN [view entry] [view interactions] High throughput yes no
WDR1_HUMAN [view entry] [view interactions] High throughput yes yes
CUL4B_HUMAN [view interactions] High throughput no yes
PTH2_HUMAN [view interactions] High throughput no yes
GBF1_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
OTULL_HUMAN [view interactions] High throughput no no
SYVN1_HUMAN [view interactions] High throughput no yes
ST7_HUMAN [view interactions] High throughput no yes
FKBP8_HUMAN [view entry] [view interactions] High throughput yes yes
PTN1_HUMAN [view interactions] High throughput no yes
MIRO2_HUMAN [view entry] [view interactions] High throughput yes yes
RMD3_HUMAN [view interactions] High throughput no yes
SEC62_HUMAN [view interactions] High throughput no yes
RN183_HUMAN [view interactions] High throughput no no
LEG9_HUMAN [view interactions] High throughput no yes
DNJC1_HUMAN [view interactions] High throughput no yes
DJC25_HUMAN [view interactions] High throughput no yes
SEC63_HUMAN [view interactions] High throughput no yes
ACTZ_HUMAN [view entry] [view interactions] High throughput yes yes
AT2A1_HUMAN [view entry] [view interactions] High throughput yes no
B3GA1_HUMAN [view interactions] High throughput no yes
CAV1_HUMAN [view interactions] High throughput no no
CKAP4_HUMAN [view entry] [view interactions] High throughput yes yes
CXAR_HUMAN [view interactions] High throughput no yes
DERL1_HUMAN [view interactions] High throughput no yes
RCAS1_HUMAN [view interactions] High throughput no yes
ELOV5_HUMAN [view interactions] High throughput no yes
EMD_HUMAN [view interactions] High throughput no yes
ERGI2_HUMAN [view interactions] High throughput no yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
CXD3_HUMAN [view interactions] High throughput no no
DHB11_HUMAN [view interactions] High throughput no yes
3BHS7_HUMAN [view interactions] High throughput no no
LAMP2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LMNB1_HUMAN [view entry] [view interactions] High throughput yes yes
LNP_HUMAN [view interactions] High throughput no yes
LRC59_HUMAN [view entry] [view interactions] High throughput yes yes
MET7A_HUMAN [view interactions] High throughput no no
NU155_HUMAN [view interactions] High throughput no yes
PANX1_HUMAN [view interactions] High throughput no no
PEX14_HUMAN [view interactions] High throughput no yes
PXMP2_HUMAN [view interactions] High throughput no no
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RAB3B_HUMAN [view interactions] High throughput no no
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB9A_HUMAN [view interactions] High throughput no yes
REEP5_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
SSRA_HUMAN [view entry] [view interactions] High throughput yes yes
STIM1_HUMAN [view interactions] High throughput no yes
STX4_HUMAN [view entry] [view interactions] High throughput yes no
SYNE3_HUMAN [view interactions] High throughput no no
LAP2A_HUMAN [view interactions] High throughput no yes
ZFPL1_HUMAN [view interactions] High throughput no yes
TFR1_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
GLUT4_HUMAN [view interactions] High throughput no no
NSF_HUMAN [view entry] [view interactions] High throughput yes yes
GOSR1_HUMAN [view entry] [view interactions] High throughput yes yes
LRRK2_HUMAN [view interactions] High throughput no yes
RIPK4_HUMAN [view interactions] High throughput no no
ZW10_HUMAN [view interactions] High throughput no yes
RENR_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
TMED2_HUMAN [view interactions] High throughput no yes
PGFRA_HUMAN [view interactions] High throughput no no
SC22B_HUMAN [view entry] [view interactions] High throughput yes no
USE1_HUMAN [view interactions] High throughput no yes
STX18_HUMAN [view interactions] High throughput no yes
OCRL_HUMAN [view interactions] High throughput no yes
SOX2_HUMAN [view interactions] High throughput no yes
MOT11_HUMAN [view interactions] High throughput no no
BET1_HUMAN [view interactions] High throughput no no
SNAA_HUMAN [view entry] [view interactions] High throughput yes yes
P2RY6_HUMAN [view interactions] High throughput no no
UN93B_HUMAN [view interactions] High throughput no yes
VAMP5_HUMAN [view interactions] High throughput no no
ROS1_HUMAN [view interactions] High throughput no no
JUN_HUMAN [view interactions] High throughput no yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
ODO2_HUMAN [view entry] [view interactions] High throughput yes yes
UBP22_HUMAN [view interactions] High throughput no yes
CXCL7_HUMAN [view interactions] High throughput no yes
CUL5_HUMAN [view entry] [view interactions] High throughput yes yes
LBN_HUMAN [view interactions] High throughput no yes
TMM17_HUMAN [view interactions] High throughput no yes
FBF1_HUMAN [view interactions] High throughput no no
TM216_HUMAN [view interactions] High throughput no no
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP1_HUMAN [view interactions] High throughput no yes
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
PLRKT_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view interactions] High throughput no yes
KCNJ2_HUMAN [view entry] [view interactions] High throughput yes yes
ALK_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA8_HUMAN [view interactions] High throughput no no
ERBB3_HUMAN [view interactions] High throughput no yes
FGFR1_HUMAN [view interactions] High throughput no yes
FGFR4_HUMAN [view interactions] High throughput no no
VGFR3_HUMAN [view interactions] High throughput no yes
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
INSR_HUMAN [view interactions] High throughput no yes
MUSK_HUMAN [view entry] [view interactions] High throughput yes no
NTRK1_HUMAN [view interactions] High throughput no yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
PGFRB_HUMAN [view interactions] High throughput no yes
RET_HUMAN [view interactions] High throughput no yes
ROR2_HUMAN [view entry] [view interactions] High throughput yes yes
FHI2A_HUMAN [view interactions] High throughput no yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
STB5L_HUMAN [view interactions] High throughput no no
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
STX6_HUMAN [view interactions] High throughput no yes
STX5_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
VAMP4_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
CNIH1_HUMAN [view interactions] Computational no yes
A1AT_HUMAN [view interactions] Computational no no
CD59_HUMAN [view entry] [view interactions] Computational yes no
SC23A_HUMAN [view entry] [view interactions] Computational yes yes
SC22C_HUMAN [view interactions] Computational no no
TGFA_HUMAN [view interactions] Computational no yes
LMAN2_HUMAN [view interactions] Computational no yes
LMAN1_HUMAN [view interactions] Computational no yes
LMA1L_HUMAN [view interactions] Computational no no
FA5_HUMAN [view interactions] Computational no no
SC24D_HUMAN [view interactions] Computational no yes
CATZ_HUMAN [view interactions] Computational no yes
FA8_HUMAN [view interactions] Computational no yes
GRIA1_HUMAN [view entry] [view interactions] Computational yes yes
CATC_HUMAN [view interactions] Computational no yes
STX17_HUMAN [view interactions] Computational no yes
SEC13_HUMAN [view entry] [view interactions] Computational yes yes
GORS1_HUMAN [view interactions] Computational no yes
RAB28_HUMAN [view interactions] Computational no yes
AREG_HUMAN [view interactions] Computational no no
SC24C_HUMAN [view entry] [view interactions] Computational yes yes
SC24B_HUMAN [view interactions] Computational no yes
FOLR1_HUMAN [view interactions] Computational no no
LMA2L_HUMAN [view interactions] Computational no yes
CNIH3_HUMAN [view entry] [view interactions] Computational yes no
SC22A_HUMAN [view interactions] Computational no no
COPB_HUMAN [view interactions] Computational no yes
CO7A1_HUMAN [view interactions] Computational no no
CNIH2_HUMAN [view entry] [view interactions] Computational yes no
MCFD2_HUMAN [view interactions] Computational no yes