GOSR1_HUMAN
Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in GOSR1_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 29.7297 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 29.7297 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 29.7297 | 4 | no |
GO:0019905 | syntaxin binding | 24.3243 | 4 | no |
GO:0016462 | pyrophosphatase activity | 24.3243 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 24.3243 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 24.3243 | 6 | no |
GO:0005525 | GTP binding | 21.6216 | 5 | no |
GO:0019001 | guanyl nucleotide binding | 21.6216 | 5 | no |
GO:0032561 | guanyl ribonucleotide binding | 21.6216 | 5 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in GOSR1_HUMAN |
---|---|---|---|---|
GO:0008104 | protein localization | 67.5676 | 4 | yes |
GO:0016192 | vesicle-mediated transport | 62.1622 | 4 | yes |
GO:0071702 | organic substance transport | 62.1622 | 4 | yes |
GO:0071705 | nitrogen compound transport | 62.1622 | 4 | yes |
GO:0006996 | organelle organization | 59.4595 | 4 | yes |
GO:0015031 | protein transport | 59.4595 | 4 | yes |
GO:0061024 | membrane organization | 51.3514 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 51.3514 | 4 | no |
GO:0061025 | membrane fusion | 43.2432 | 5 | yes |
GO:0048193 | Golgi vesicle transport | 40.5405 | 5 | yes |
GO:0051049 | regulation of transport | 40.5405 | 4 | no |
GO:0016050 | vesicle organization | 37.8378 | 5 | yes |
GO:0006886 | intracellular protein transport | 37.8378 | 4 | no |
GO:0010646 | regulation of cell communication | 37.8378 | 4 | no |
GO:0022607 | cellular component assembly | 37.8378 | 4 | no |
GO:0023056 | positive regulation of signaling | 37.8378 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 37.8378 | 4 | no |
GO:0048523 | negative regulation of cellular process | 35.1351 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 35.1351 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 35.1351 | 5 | no |
GO:0006906 | vesicle fusion | 32.4324 | 6 | yes |
GO:0048284 | organelle fusion | 32.4324 | 5 | yes |
GO:0090174 | organelle membrane fusion | 32.4324 | 6 | yes |
GO:0031323 | regulation of cellular metabolic process | 32.4324 | 4 | no |
GO:0051128 | regulation of cellular component organization | 32.4324 | 4 | no |
GO:0010647 | positive regulation of cell communication | 32.4324 | 5 | no |
GO:0080090 | regulation of primary metabolic process | 32.4324 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 29.7297 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 29.7297 | 4 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 29.7297 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 29.7297 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 29.7297 | 6 | no |
GO:0043933 | protein-containing complex organization | 27.0270 | 4 | no |
GO:0009966 | regulation of signal transduction | 27.0270 | 4 | no |
GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport | 24.3243 | 4 | yes |
GO:0065003 | protein-containing complex assembly | 24.3243 | 5 | no |
GO:0009967 | positive regulation of signal transduction | 24.3243 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 24.3243 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 24.3243 | 5 | no |
GO:0009892 | negative regulation of metabolic process | 21.6216 | 4 | no |
GO:0032880 | regulation of protein localization | 21.6216 | 5 | no |
GO:0060341 | regulation of cellular localization | 21.6216 | 4 | no |
GO:0048278 | vesicle docking | 21.6216 | 4 | no |
GO:0010468 | regulation of gene expression | 21.6216 | 5 | no |
GO:0010628 | positive regulation of gene expression | 21.6216 | 6 | no |
GO:0042127 | regulation of cell population proliferation | 21.6216 | 4 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 21.6216 | 6 | no |
GO:0006891 | intra-Golgi vesicle-mediated transport | 18.9189 | 6 | yes |
GO:0016197 | endosomal transport | 16.2162 | 4 | yes |
GO:0016482 | cytosolic transport | 13.5135 | 4 | yes |
GO:0042147 | retrograde transport, endosome to Golgi | 13.5135 | 5 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
SNTG2_HUMAN | [view interactions] | Low throughput | no | no |
SNP25_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ATAD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
USO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
STX5_HUMAN | [view interactions] | Low throughput | no | yes |
BET1L_HUMAN | [view interactions] | Low throughput | no | yes |
GOGA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
YKT6_HUMAN | [view interactions] | Low throughput | no | yes |
DSC1_HUMAN | [view interactions] | High throughput | no | no |
STX6_HUMAN | [view interactions] | High throughput | no | yes |
STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STX12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CL12A_HUMAN | [view interactions] | High throughput | no | no |
STX3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TNF11_HUMAN | [view interactions] | High throughput | no | no |
PTN1_HUMAN | [view interactions] | High throughput | no | yes |
RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RENR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BMR1A_HUMAN | [view interactions] | High throughput | no | no |
MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TMED2_HUMAN | [view interactions] | High throughput | no | yes |
RBM8A_HUMAN | [view interactions] | High throughput | no | yes |
MIC60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STX11_HUMAN | [view interactions] | High throughput | no | yes |
CGAT2_HUMAN | [view interactions] | High throughput | no | yes |
T200A_HUMAN | [view interactions] | High throughput | no | yes |
VAMP4_HUMAN | [view interactions] | High throughput | no | yes |
MRAP2_HUMAN | [view interactions] | High throughput | no | no |
SRPRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
T150A_HUMAN | [view interactions] | High throughput | no | yes |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
H4_HUMAN | [view interactions] | High throughput | no | yes |
APEX1_HUMAN | [view interactions] | High throughput | no | yes |
UN93B_HUMAN | [view interactions] | High throughput | no | yes |
SNAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VAMP5_HUMAN | [view interactions] | High throughput | no | no |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
KI2L1_HUMAN | [view interactions] | High throughput | no | no |
CHST7_HUMAN | [view interactions] | High throughput | no | yes |
BSCL2_HUMAN | [view interactions] | High throughput | no | yes |
TTYH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PDE3A_HUMAN | [view interactions] | High throughput | no | no |
CTLA4_HUMAN | [view interactions] | High throughput | no | no |
MARH1_HUMAN | [view interactions] | High throughput | no | yes |
EDAR_HUMAN | [view interactions] | High throughput | no | yes |
PCDG6_HUMAN | [view interactions] | High throughput | no | yes |
STX8_HUMAN | [view interactions] | High throughput | no | yes |
KCNA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TMM59_HUMAN | [view interactions] | High throughput | no | yes |
TMM74_HUMAN | [view interactions] | High throughput | no | no |
SAAL1_HUMAN | [view interactions] | High throughput | no | yes |
RN149_HUMAN | [view interactions] | High throughput | no | no |
PLPP4_HUMAN | [view interactions] | High throughput | no | yes |
FAM9C_HUMAN | [view interactions] | High throughput | no | no |
KCP3_HUMAN | [view interactions] | High throughput | no | yes |
BTNL9_HUMAN | [view interactions] | High throughput | no | no |
KCNE3_HUMAN | [view interactions] | High throughput | no | yes |
SNP29_HUMAN | [view interactions] | High throughput | no | yes |
USE1_HUMAN | [view interactions] | High throughput | no | yes |
P2RY2_HUMAN | [view interactions] | High throughput | no | no |
PTCA_HUMAN | [view interactions] | High throughput | no | no |
WIPI1_HUMAN | [view interactions] | High throughput | no | yes |
VAMP3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SEC20_HUMAN | [view interactions] | High throughput | no | yes |
STX18_HUMAN | [view interactions] | High throughput | no | yes |
FNTB_HUMAN | [view interactions] | High throughput | no | no |
NBAS_HUMAN | [view interactions] | High throughput | no | yes |
ZW10_HUMAN | [view interactions] | High throughput | no | yes |
GOSR2_HUMAN | [view interactions] | High throughput | no | yes |
MIF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RER1_HUMAN | [view interactions] | High throughput | no | yes |
S35E1_HUMAN | [view interactions] | High throughput | no | yes |
RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTAR1_HUMAN | [view interactions] | High throughput | no | yes |
TPC13_HUMAN | [view interactions] | High throughput | no | yes |
ATG12_HUMAN | [view interactions] | High throughput | no | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OTULL_HUMAN | [view interactions] | High throughput | no | no |
RN183_HUMAN | [view interactions] | High throughput | no | no |
B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
CAV1_HUMAN | [view interactions] | High throughput | no | no |
RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
ELOV5_HUMAN | [view interactions] | High throughput | no | yes |
CXD3_HUMAN | [view interactions] | High throughput | no | no |
3BHS7_HUMAN | [view interactions] | High throughput | no | no |
LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PKP1_HUMAN | [view interactions] | High throughput | no | no |
GOSR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SCFD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SC22B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NSF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OCRL_HUMAN | [view interactions] | High throughput | no | yes |
MSPD2_HUMAN | [view interactions] | High throughput | no | yes |
ATG2A_HUMAN | [view interactions] | High throughput | no | yes |
BET1_HUMAN | [view interactions] | High throughput | no | no |
INSR_HUMAN | [view interactions] | High throughput | no | yes |
GP182_HUMAN | [view interactions] | High throughput | no | no |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
TMM17_HUMAN | [view interactions] | High throughput | no | yes |
TM216_HUMAN | [view interactions] | High throughput | no | no |
TGON2_HUMAN | [view interactions] | High throughput | no | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FHI2A_HUMAN | [view interactions] | High throughput | no | yes |
COG8_HUMAN | [view interactions] | Computational | no | no |
MA2A1_HUMAN | [view interactions] | Computational | no | no |
VAMP2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
GOLI4_HUMAN | [view interactions] | Computational | no | yes |
COG1_HUMAN | [view interactions] | Computational | no | yes |
RB33B_HUMAN | [view interactions] | Computational | no | no |
COG6_HUMAN | [view interactions] | Computational | no | yes |
SNAG_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
COG7_HUMAN | [view interactions] | Computational | no | yes |
STX16_HUMAN | [view interactions] | Computational | no | yes |
STX10_HUMAN | [view interactions] | Computational | no | yes |
COG3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SURF4_HUMAN | [view interactions] | Computational | no | yes |
VTI1B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
COG2_HUMAN | [view interactions] | Computational | no | no |
GOGA5_HUMAN | [view interactions] | Computational | no | yes |
VTI1A_HUMAN | [view interactions] | Computational | no | yes |
VAMP7_HUMAN | [view interactions] | Computational | no | yes |
COG5_HUMAN | [view interactions] | Computational | no | yes |
STX17_HUMAN | [view interactions] | Computational | no | yes |