GOSR1_HUMAN
Evidence for PS localization
Functions
Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GOSR1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 35.8974 | 4 | no |
| GO:0000166 | nucleotide binding | 33.3333 | 4 | no |
| GO:0017076 | purine nucleotide binding | 33.3333 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 33.3333 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 33.3333 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 28.2051 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 28.2051 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 28.2051 | 6 | no |
| GO:0005525 | GTP binding | 25.6410 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 25.6410 | 6 | no |
| GO:0032561 | guanyl ribonucleotide binding | 25.6410 | 5 | no |
| GO:0003924 | GTPase activity | 23.0769 | 7 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GOSR1_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 61.5385 | 4 | yes |
| GO:0008104 | protein localization | 61.5385 | 4 | yes |
| GO:0071702 | organic substance transport | 53.8462 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 53.8462 | 4 | yes |
| GO:0015031 | protein transport | 51.2821 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 51.2821 | 4 | no |
| GO:0061024 | membrane organization | 46.1538 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 43.5897 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 38.4615 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 38.4615 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 38.4615 | 4 | no |
| GO:0010646 | regulation of cell communication | 38.4615 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 38.4615 | 4 | no |
| GO:0016050 | vesicle organization | 35.8974 | 5 | yes |
| GO:0022607 | cellular component assembly | 35.8974 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 35.8974 | 4 | no |
| GO:0023056 | positive regulation of signaling | 35.8974 | 4 | no |
| GO:0051049 | regulation of transport | 35.8974 | 4 | no |
| GO:0061025 | membrane fusion | 33.3333 | 5 | yes |
| GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | no |
| GO:0006886 | intracellular protein transport | 33.3333 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 30.7692 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.7692 | 6 | no |
| GO:0009966 | regulation of signal transduction | 30.7692 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 30.7692 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 30.7692 | 4 | no |
| GO:0048284 | organelle fusion | 28.2051 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 28.2051 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 28.2051 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 28.2051 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 28.2051 | 5 | no |
| GO:0006906 | vesicle fusion | 25.6410 | 6 | yes |
| GO:0090174 | organelle membrane fusion | 25.6410 | 6 | yes |
| GO:0009892 | negative regulation of metabolic process | 25.6410 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.6410 | 5 | no |
| GO:0043933 | protein-containing complex organization | 25.6410 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 25.6410 | 5 | no |
| GO:0010468 | regulation of gene expression | 25.6410 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.6410 | 5 | no |
| GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport | 23.0769 | 4 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 23.0769 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 23.0769 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 23.0769 | 6 | no |
| GO:0042127 | regulation of cell population proliferation | 23.0769 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 23.0769 | 6 | no |
| GO:0032880 | regulation of protein localization | 23.0769 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 23.0769 | 4 | no |
| GO:0060341 | regulation of cellular localization | 23.0769 | 4 | no |
| GO:0031399 | regulation of protein modification process | 20.5128 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 20.5128 | 7 | no |
| GO:0065003 | protein-containing complex assembly | 20.5128 | 5 | no |
| GO:0010628 | positive regulation of gene expression | 20.5128 | 7 | no |
| GO:0006891 | intra-Golgi vesicle-mediated transport | 10.2564 | 4 | yes |
| GO:0016482 | cytosolic transport | 10.2564 | 4 | yes |
| GO:0042147 | retrograde transport, endosome to Golgi | 10.2564 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ATAD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| USO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STX5_HUMAN | [view interactions] | Low throughput | no | yes |
| YKT6_HUMAN | [view interactions] | Low throughput | no | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BET1L_HUMAN | [view interactions] | Low throughput | no | yes |
| SNTG2_HUMAN | [view interactions] | Low throughput | no | no |
| SNP25_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NSF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC22B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SCFD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOSR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKP1_HUMAN | [view interactions] | High throughput | no | no |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| MSPD2_HUMAN | [view interactions] | High throughput | no | yes |
| ATG2A_HUMAN | [view interactions] | High throughput | no | yes |
| BET1_HUMAN | [view interactions] | High throughput | no | no |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| TM216_HUMAN | [view interactions] | High throughput | no | no |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FHI2A_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| DSC1_HUMAN | [view interactions] | High throughput | no | no |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CL12A_HUMAN | [view interactions] | High throughput | no | no |
| STX3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TNF11_HUMAN | [view interactions] | High throughput | no | no |
| PTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RENR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMR1A_HUMAN | [view interactions] | High throughput | no | no |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMED2_HUMAN | [view interactions] | High throughput | no | yes |
| RBM8A_HUMAN | [view interactions] | High throughput | no | yes |
| MIC60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX11_HUMAN | [view interactions] | High throughput | no | yes |
| CGAT2_HUMAN | [view interactions] | High throughput | no | yes |
| T200A_HUMAN | [view interactions] | High throughput | no | yes |
| VAMP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MRAP2_HUMAN | [view interactions] | High throughput | no | no |
| SRPRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| T150A_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| UN93B_HUMAN | [view interactions] | High throughput | no | yes |
| SNAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAMP5_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| KI2L1_HUMAN | [view interactions] | High throughput | no | no |
| CHST7_HUMAN | [view interactions] | High throughput | no | yes |
| BSCL2_HUMAN | [view interactions] | High throughput | no | yes |
| TTYH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PDE3A_HUMAN | [view interactions] | High throughput | no | no |
| CTLA4_HUMAN | [view interactions] | High throughput | no | no |
| MARH1_HUMAN | [view interactions] | High throughput | no | yes |
| EDAR_HUMAN | [view interactions] | High throughput | no | yes |
| PCDG6_HUMAN | [view interactions] | High throughput | no | yes |
| STX8_HUMAN | [view interactions] | High throughput | no | yes |
| KCNA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMM59_HUMAN | [view interactions] | High throughput | no | yes |
| TMM74_HUMAN | [view interactions] | High throughput | no | no |
| SAAL1_HUMAN | [view interactions] | High throughput | no | yes |
| RN149_HUMAN | [view interactions] | High throughput | no | no |
| PLPP4_HUMAN | [view interactions] | High throughput | no | yes |
| FAM9C_HUMAN | [view interactions] | High throughput | no | no |
| KCP3_HUMAN | [view interactions] | High throughput | no | yes |
| BTNL9_HUMAN | [view interactions] | High throughput | no | no |
| KCNE3_HUMAN | [view interactions] | High throughput | no | yes |
| SNP29_HUMAN | [view interactions] | High throughput | no | yes |
| USE1_HUMAN | [view interactions] | High throughput | no | yes |
| P2RY2_HUMAN | [view interactions] | High throughput | no | no |
| PTCA_HUMAN | [view interactions] | High throughput | no | no |
| WIPI1_HUMAN | [view interactions] | High throughput | no | yes |
| VAMP3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SEC20_HUMAN | [view interactions] | High throughput | no | yes |
| STX18_HUMAN | [view interactions] | High throughput | no | yes |
| FNTB_HUMAN | [view interactions] | High throughput | no | no |
| NBAS_HUMAN | [view interactions] | High throughput | no | yes |
| ZW10_HUMAN | [view interactions] | High throughput | no | yes |
| GOSR2_HUMAN | [view interactions] | High throughput | no | yes |
| MIF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RER1_HUMAN | [view interactions] | High throughput | no | yes |
| S35E1_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| CDK7_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTAR1_HUMAN | [view interactions] | High throughput | no | yes |
| TPC13_HUMAN | [view interactions] | High throughput | no | yes |
| ATG12_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| ELOV5_HUMAN | [view interactions] | High throughput | no | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| SAR1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| ARL1_HUMAN | [view interactions] | High throughput | no | yes |
| TP4A2_HUMAN | [view interactions] | High throughput | no | yes |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |