KCNA2_HUMAN
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the cardiovascular system. Prevents aberrant action potential firing and regulates neuronal output. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed, PubMed, PubMed, PubMed). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, KCNA6, KCNA7, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed, PubMed). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA2 forms a delayed-rectifier potassium channel that opens in response to membrane depolarization, followed by slow spontaneous channel closure (PubMed, PubMed). In contrast, a heteromultimer formed by KCNA2 and KCNA4 shows rapid inactivation (PubMed). Regulates neuronal excitability and plays a role as pacemaker in the regulation of neuronal action potentials . KCNA2-containing channels play a presynaptic role and prevent hyperexcitability and aberrant action potential firing . Response to toxins that are selective for KCNA2-containing potassium channels suggests that in Purkinje cells, dendritic subthreshold KCNA2-containing potassium channels prevent random spontaneous calcium spikes, suppressing dendritic hyperexcitability without hindering the generation of somatic action potentials, and thereby play an important role in motor coordination . Plays a role in the induction of long-term potentiation of neuron excitability in the CA3 layer of the hippocampus . May function as down-stream effector for G protein-coupled receptors and inhibit GABAergic inputs to basolateral amygdala neurons . May contribute to the regulation of neurotransmitter release, such as gamma-aminobutyric acid (GABA) . Contributes to the regulation of the axonal release of the neurotransmitter dopamine . Reduced KCNA2 expression plays a role in the perception of neuropathic pain after peripheral nerve injury, but not acute pain . Plays a role in the regulation of the time spent in non-rapid eye movement (NREM) sleep . [View more on UniProt]
Interacting region for partners were not defined.
Position | Amino acid | Mutation | Disease | Overlap with binding region |
---|---|---|---|---|
263 | Ile | Thr | Developmentalandepilepticencephalopathy32(DEE32) | - |
297 | Arg | Gln | Developmentalandepilepticencephalopathy32(DEE32) | - |
298 | Leu | Phe | Developmentalandepilepticencephalopathy32(DEE32) | - |
405 | Pro | Leu | Developmentalandepilepticencephalopathy32(DEE32) | - |
324 | Ser | Thr | - | - |
236 | Glu | Lys | Developmentalandepilepticencephalopathy32(DEE32) | - |
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in KCNA2_HUMAN |
---|---|---|---|---|
GO:0005216 | ion channel activity | 37.9310 | 4 | yes |
GO:0005244 | voltage-gated ion channel activity | 37.9310 | 4 | yes |
GO:0005261 | cation channel activity | 37.9310 | 5 | yes |
GO:0008324 | cation transmembrane transporter activity | 37.9310 | 4 | yes |
GO:0015267 | channel activity | 37.9310 | 4 | yes |
GO:0022832 | voltage-gated channel activity | 37.9310 | 6 | yes |
GO:0022836 | gated channel activity | 37.9310 | 5 | yes |
GO:0022890 | inorganic cation transmembrane transporter activity | 37.9310 | 4 | yes |
GO:0046873 | metal ion transmembrane transporter activity | 34.4828 | 5 | yes |
GO:0022843 | voltage-gated cation channel activity | 31.0345 | 5 | yes |
GO:0005249 | voltage-gated potassium channel activity | 27.5862 | 6 | yes |
GO:0005267 | potassium channel activity | 27.5862 | 6 | yes |
GO:0015079 | potassium ion transmembrane transporter activity | 27.5862 | 6 | yes |
GO:0005251 | delayed rectifier potassium channel activity | 24.1379 | 7 | yes |
GO:0017076 | purine nucleotide binding | 24.1379 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 24.1379 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 24.1379 | 4 | no |
GO:0015271 | outward rectifier potassium channel activity | 13.7931 | 7 | yes |
GO:0019894 | kinesin binding | 10.3448 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in KCNA2_HUMAN |
---|---|---|---|---|
GO:0022607 | cellular component assembly | 48.2759 | 4 | yes |
GO:0043269 | regulation of ion transport | 48.2759 | 5 | yes |
GO:0051049 | regulation of transport | 48.2759 | 4 | yes |
GO:0034762 | regulation of transmembrane transport | 44.8276 | 4 | yes |
GO:0034765 | regulation of ion transmembrane transport | 44.8276 | 5 | yes |
GO:0043933 | protein-containing complex organization | 41.3793 | 4 | yes |
GO:0065003 | protein-containing complex assembly | 37.9310 | 5 | yes |
GO:0006811 | ion transport | 37.9310 | 4 | yes |
GO:0006812 | cation transport | 34.4828 | 5 | yes |
GO:0030001 | metal ion transport | 34.4828 | 6 | yes |
GO:0008104 | protein localization | 34.4828 | 4 | no |
GO:0098655 | cation transmembrane transport | 31.0345 | 4 | yes |
GO:0098660 | inorganic ion transmembrane transport | 31.0345 | 4 | yes |
GO:0098662 | inorganic cation transmembrane transport | 31.0345 | 5 | yes |
GO:0010646 | regulation of cell communication | 31.0345 | 4 | no |
GO:0048522 | positive regulation of cellular process | 31.0345 | 4 | no |
GO:0009966 | regulation of signal transduction | 27.5862 | 4 | no |
GO:0030030 | cell projection organization | 27.5862 | 4 | no |
GO:0051128 | regulation of cellular component organization | 27.5862 | 4 | no |
GO:0006813 | potassium ion transport | 24.1379 | 7 | yes |
GO:0051259 | protein complex oligomerization | 24.1379 | 6 | yes |
GO:0051260 | protein homooligomerization | 24.1379 | 7 | yes |
GO:0071805 | potassium ion transmembrane transport | 24.1379 | 6 | yes |
GO:0010941 | regulation of cell death | 24.1379 | 4 | no |
GO:0048523 | negative regulation of cellular process | 24.1379 | 4 | no |
GO:0006996 | organelle organization | 24.1379 | 4 | no |
GO:0001508 | action potential | 24.1379 | 4 | yes |
GO:0006796 | phosphate-containing compound metabolic process | 20.6897 | 4 | no |
GO:0042981 | regulation of apoptotic process | 20.6897 | 6 | no |
GO:0043067 | regulation of programmed cell death | 20.6897 | 5 | no |
GO:0044057 | regulation of system process | 20.6897 | 4 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 20.6897 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 20.6897 | 4 | no |
GO:0031344 | regulation of cell projection organization | 20.6897 | 5 | no |
GO:0032990 | cell part morphogenesis | 20.6897 | 4 | no |
GO:0048812 | neuron projection morphogenesis | 20.6897 | 7 | no |
GO:0048858 | cell projection morphogenesis | 20.6897 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 20.6897 | 5 | no |
GO:0120039 | plasma membrane bounded cell projection morphogenesis | 20.6897 | 6 | no |
GO:0071702 | organic substance transport | 20.6897 | 4 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 20.6897 | 5 | no |
GO:0019228 | neuronal action potential | 17.2414 | 5 | yes |
GO:0007600 | sensory perception | 10.3448 | 4 | yes |
GO:0050433 | regulation of catecholamine secretion | 10.3448 | 5 | yes |
GO:0050795 | regulation of behavior | 10.3448 | 4 | yes |
GO:0051046 | regulation of secretion | 10.3448 | 5 | yes |
GO:0051952 | regulation of amine transport | 10.3448 | 5 | yes |
GO:0097623 | potassium ion export across plasma membrane | 10.3448 | 4 | yes |
GO:1903530 | regulation of secretion by cell | 10.3448 | 4 | yes |
GO:0014059 | regulation of dopamine secretion | 6.8966 | 6 | yes |
GO:0019233 | sensory perception of pain | 6.8966 | 5 | yes |
GO:0021633 | optic nerve structural organization | 6.8966 | 4 | yes |
GO:0042749 | regulation of circadian sleep/wake cycle | 6.8966 | 4 | yes |
GO:0045187 | regulation of circadian sleep/wake cycle, sleep | 6.8966 | 5 | yes |
GO:0045188 | regulation of circadian sleep/wake cycle, non-REM sleep | 6.8966 | 6 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in KCNA2_HUMAN |
---|---|---|---|---|
DOID:331 | central nervous system disease | 20.6897 | 3 | yes |
DOID:0050701 | electroclinical syndrome | 17.2414 | 6 | yes |
DOID:0112202 | developmental and epileptic encephalopathy | 17.2414 | 7 | yes |
DOID:1826 | epilepsy | 17.2414 | 5 | yes |
DOID:936 | brain disease | 17.2414 | 4 | yes |
DOID:0080416 | developmental and epileptic encephalopathy 32 | 6.8966 | 8 | yes |
DOID:0050703 | infancy electroclinical syndrome | 6.8966 | 7 | no |
DOID:0060169 | benign familial infantile epilepsy | 6.8966 | 8 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
NEUR1_HUMAN | [view interactions] | Low throughput | no | yes |
DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SGMR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SRC8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KCAB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KCNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KCNA5_HUMAN | [view interactions] | Low throughput | no | no |
RHOA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KCNA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CNTP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RTN4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
FAK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KCNA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
KCNA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KCNA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KCAB1_HUMAN | [view interactions] | Low throughput | no | no |
PTPRA_HUMAN | [view interactions] | Low throughput | no | yes |
FYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CNTP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SARAF_HUMAN | [view interactions] | High throughput | no | no |
TM214_HUMAN | [view interactions] | High throughput | no | no |
VANG2_HUMAN | [view interactions] | High throughput | no | no |
SNX14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ST7L_HUMAN | [view interactions] | High throughput | no | no |
DOLK_HUMAN | [view interactions] | High throughput | no | no |
ABCBA_HUMAN | [view interactions] | High throughput | no | yes |
TMX2_HUMAN | [view interactions] | High throughput | no | yes |
ABHGA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ALG12_HUMAN | [view interactions] | High throughput | no | yes |
C2C2L_HUMAN | [view interactions] | High throughput | no | yes |
DJC30_HUMAN | [view interactions] | High throughput | no | no |
UBAC2_HUMAN | [view interactions] | High throughput | no | yes |
IQCB1_HUMAN | [view interactions] | High throughput | no | no |
CSCL2_HUMAN | [view interactions] | High throughput | no | yes |
SEC20_HUMAN | [view interactions] | High throughput | no | yes |
FADS1_HUMAN | [view interactions] | High throughput | no | yes |
GOLI4_HUMAN | [view interactions] | High throughput | no | yes |
INT6_HUMAN | [view interactions] | High throughput | no | yes |
B3GT6_HUMAN | [view interactions] | High throughput | no | no |
ZDHC9_HUMAN | [view interactions] | High throughput | no | yes |
TM223_HUMAN | [view interactions] | High throughput | no | yes |
ERG1_HUMAN | [view interactions] | High throughput | no | no |
TM129_HUMAN | [view interactions] | High throughput | no | no |
NB5R1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRR11_HUMAN | [view interactions] | High throughput | no | no |
GOSR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VRK2_HUMAN | [view interactions] | High throughput | no | no |
MARC1_HUMAN | [view interactions] | High throughput | no | yes |
ARF5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ATP9A_HUMAN | [view interactions] | High throughput | no | yes |
XPR1_HUMAN | [view interactions] | High throughput | no | yes |
UBP33_HUMAN | [view interactions] | High throughput | no | yes |
NGBR_HUMAN | [view interactions] | High throughput | no | no |
LTMD1_HUMAN | [view interactions] | High throughput | no | no |
NPL4_HUMAN | [view interactions] | High throughput | no | yes |
PCX3_HUMAN | [view interactions] | High throughput | no | no |
TM39B_HUMAN | [view interactions] | High throughput | no | yes |
LRC8E_HUMAN | [view interactions] | High throughput | no | no |
FBX11_HUMAN | [view interactions] | High throughput | no | no |
NAT14_HUMAN | [view interactions] | High throughput | no | no |
KCNQ5_HUMAN | [view interactions] | High throughput | no | yes |
ABCD4_HUMAN | [view interactions] | High throughput | no | yes |
KCNG1_HUMAN | [view interactions] | High throughput | no | yes |
PIGO_HUMAN | [view interactions] | High throughput | no | no |
CA043_HUMAN | [view interactions] | High throughput | no | yes |
PIGQ_HUMAN | [view interactions] | High throughput | no | yes |
ARL17_HUMAN | [view interactions] | High throughput | no | yes |
LPCT4_HUMAN | [view interactions] | High throughput | no | yes |
ZNT6_HUMAN | [view interactions] | High throughput | no | yes |
DEGS1_HUMAN | [view interactions] | High throughput | no | no |
TM38B_HUMAN | [view interactions] | High throughput | no | yes |
P121A_HUMAN | [view interactions] | High throughput | no | yes |
DCAKD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CISD2_HUMAN | [view interactions] | High throughput | no | yes |
DHR13_HUMAN | [view interactions] | High throughput | no | yes |
RNFT1_HUMAN | [view interactions] | High throughput | no | no |
PAQR4_HUMAN | [view interactions] | High throughput | no | no |
DJC18_HUMAN | [view interactions] | High throughput | no | yes |
ABD12_HUMAN | [view interactions] | High throughput | no | no |
S27A6_HUMAN | [view interactions] | High throughput | no | yes |
LRC8C_HUMAN | [view interactions] | High throughput | no | yes |
RHBL4_HUMAN | [view interactions] | High throughput | no | no |
GHDC_HUMAN | [view interactions] | High throughput | no | yes |
MYO9A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TAP2_HUMAN | [view interactions] | High throughput | no | no |
RETST_HUMAN | [view interactions] | High throughput | no | yes |
SPCS2_HUMAN | [view interactions] | High throughput | no | yes |
CD320_HUMAN | [view interactions] | High throughput | no | yes |
T120B_HUMAN | [view interactions] | High throughput | no | yes |
S38AA_HUMAN | [view interactions] | High throughput | no | yes |
S12A9_HUMAN | [view interactions] | High throughput | no | yes |
CC033_HUMAN | [view interactions] | High throughput | no | yes |
AREL1_HUMAN | [view interactions] | High throughput | no | no |
PDE3B_HUMAN | [view interactions] | High throughput | no | no |
PPM1L_HUMAN | [view interactions] | High throughput | no | yes |
SRBP2_HUMAN | [view interactions] | High throughput | no | yes |
RBP2_HUMAN | [view interactions] | High throughput | no | yes |
DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CAMLG_HUMAN | [view interactions] | High throughput | no | yes |
FAM3C_HUMAN | [view interactions] | High throughput | no | yes |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LCLT1_HUMAN | [view interactions] | High throughput | no | no |
AMFR_HUMAN | [view interactions] | High throughput | no | yes |
ADCK2_HUMAN | [view interactions] | High throughput | no | yes |
S35F5_HUMAN | [view interactions] | High throughput | no | no |
LEMD2_HUMAN | [view interactions] | High throughput | no | yes |
ABCB9_HUMAN | [view interactions] | High throughput | no | yes |
FACR2_HUMAN | [view interactions] | High throughput | no | yes |
CP51A_HUMAN | [view interactions] | High throughput | no | no |
ABHD3_HUMAN | [view interactions] | High throughput | no | yes |
TAP1_HUMAN | [view interactions] | High throughput | no | yes |
GOLM1_HUMAN | [view interactions] | High throughput | no | yes |
HACD2_HUMAN | [view interactions] | High throughput | no | yes |
DHRS7_HUMAN | [view interactions] | High throughput | no | yes |
REEP4_HUMAN | [view interactions] | High throughput | no | no |
S27A3_HUMAN | [view interactions] | High throughput | no | no |
HYEP_HUMAN | [view interactions] | High throughput | no | no |
MARC2_HUMAN | [view interactions] | High throughput | no | no |
FACE1_HUMAN | [view interactions] | High throughput | no | yes |
UBE4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SCN8A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
KCNH2_HUMAN | [view interactions] | Computational | no | no |
KCAB3_HUMAN | [view interactions] | Computational | no | no |
KCNH5_HUMAN | [view interactions] | Computational | no | no |
CXG3_HUMAN | [view interactions] | Computational | no | yes |
KCNH1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SCN2A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |