UBE4A_HUMAN
Evidence for PS localization
Functions
Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates Lys-48-linked polyubiquitination of substrates. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in UBE4A_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 30.4348 | 4 | no |
| GO:0005216 | monoatomic ion channel activity | 26.0870 | 4 | no |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 26.0870 | 4 | no |
| GO:0015267 | channel activity | 26.0870 | 4 | no |
| GO:0043169 | cation binding | 26.0870 | 4 | no |
| GO:0005261 | monoatomic cation channel activity | 21.7391 | 5 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 21.7391 | 4 | no |
| GO:0046873 | metal ion transmembrane transporter activity | 21.7391 | 5 | no |
| GO:0046872 | metal ion binding | 21.7391 | 5 | no |
| GO:0022836 | gated channel activity | 21.7391 | 5 | no |
| GO:0004842 | ubiquitin-protein transferase activity | 17.3913 | 4 | yes |
| GO:0016755 | aminoacyltransferase activity | 17.3913 | 4 | yes |
| GO:0061630 | ubiquitin protein ligase activity | 13.0435 | 5 | yes |
| GO:0061659 | ubiquitin-like protein ligase activity | 13.0435 | 4 | yes |
| GO:0034450 | ubiquitin-ubiquitin ligase activity | 8.6957 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in UBE4A_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 52.1739 | 4 | no |
| GO:0022607 | cellular component assembly | 39.1304 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 39.1304 | 4 | no |
| GO:0008104 | protein localization | 34.7826 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 34.7826 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 34.7826 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 34.7826 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 34.7826 | 4 | no |
| GO:0006508 | proteolysis | 30.4348 | 4 | yes |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 30.4348 | 7 | yes |
| GO:0009057 | macromolecule catabolic process | 30.4348 | 4 | yes |
| GO:0019941 | modification-dependent protein catabolic process | 30.4348 | 6 | yes |
| GO:0036211 | protein modification process | 30.4348 | 4 | yes |
| GO:0043412 | macromolecule modification | 30.4348 | 4 | yes |
| GO:0043632 | modification-dependent macromolecule catabolic process | 30.4348 | 5 | yes |
| GO:0051603 | proteolysis involved in protein catabolic process | 30.4348 | 5 | yes |
| GO:0009894 | regulation of catabolic process | 30.4348 | 4 | no |
| GO:0010646 | regulation of cell communication | 30.4348 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 30.4348 | 4 | no |
| GO:0043933 | protein-containing complex organization | 30.4348 | 4 | no |
| GO:0009966 | regulation of signal transduction | 26.0870 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.0870 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 26.0870 | 4 | no |
| GO:0051049 | regulation of transport | 26.0870 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 26.0870 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 26.0870 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 26.0870 | 6 | no |
| GO:0006996 | organelle organization | 26.0870 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 26.0870 | 5 | no |
| GO:0023056 | positive regulation of signaling | 26.0870 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 26.0870 | 4 | no |
| GO:0016567 | protein ubiquitination | 21.7391 | 8 | yes |
| GO:0032446 | protein modification by small protein conjugation | 21.7391 | 7 | yes |
| GO:0043687 | post-translational protein modification | 21.7391 | 5 | yes |
| GO:0070647 | protein modification by small protein conjugation or removal | 21.7391 | 6 | yes |
| GO:0009889 | regulation of biosynthetic process | 21.7391 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 21.7391 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 21.7391 | 4 | no |
| GO:0009896 | positive regulation of catabolic process | 21.7391 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.7391 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.7391 | 5 | no |
| GO:0033365 | protein localization to organelle | 21.7391 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 21.7391 | 5 | no |
| GO:0080134 | regulation of response to stress | 21.7391 | 4 | no |
| GO:0080135 | regulation of cellular response to stress | 21.7391 | 4 | no |
| GO:0034976 | response to endoplasmic reticulum stress | 21.7391 | 4 | no |
| GO:0000209 | protein polyubiquitination | 13.0435 | 9 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MDM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| P53_HUMAN | [view interactions] | Low throughput | no | no |
| CASP6_HUMAN | [view interactions] | Low throughput | no | no |
| GRAB_HUMAN | [view interactions] | Low throughput | no | no |
| PTTG1_HUMAN | [view interactions] | Low throughput | no | no |
| UBE4A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EPHA2_HUMAN | [view interactions] | Low throughput | no | no |
| UB2D3_HUMAN | [view interactions] | Low throughput | no | yes |
| DNJC7_HUMAN | [view interactions] | Low throughput | no | yes |
| ITPR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SLAP1_HUMAN | [view interactions] | Low throughput | no | yes |
| FAM3C_HUMAN | [view interactions] | Low throughput | no | yes |
| MTA1_HUMAN | [view interactions] | Low throughput | no | yes |
| TP53B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RSAD2_HUMAN | [view interactions] | Low throughput | no | yes |
| SPSB4_HUMAN | [view interactions] | High throughput | no | no |
| AT1B3_HUMAN | [view interactions] | High throughput | no | yes |
| ACHA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZDH12_HUMAN | [view interactions] | High throughput | no | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| TLS1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| GOLI_HUMAN | [view interactions] | High throughput | no | yes |
| RN149_HUMAN | [view interactions] | High throughput | no | no |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| H2AX_HUMAN | [view interactions] | High throughput | no | yes |
| BAG6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCAF7_HUMAN | [view interactions] | High throughput | no | yes |
| TPR_HUMAN | [view interactions] | High throughput | no | yes |
| WDHD1_HUMAN | [view interactions] | High throughput | no | no |
| GLU2B_HUMAN | [view interactions] | High throughput | no | yes |
| ACTZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHD4_HUMAN | [view interactions] | High throughput | no | yes |
| P4R3A_HUMAN | [view interactions] | High throughput | no | yes |
| SMC4_HUMAN | [view interactions] | High throughput | no | yes |
| DPPA3_HUMAN | [view interactions] | High throughput | no | no |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| ST7_HUMAN | [view interactions] | High throughput | no | yes |
| PTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| DNJC1_HUMAN | [view interactions] | High throughput | no | yes |
| MAVS_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| SH2D3_HUMAN | [view interactions] | High throughput | no | no |
| CWC25_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P2RY6_HUMAN | [view interactions] | High throughput | no | no |
| UBXN4_HUMAN | [view interactions] | High throughput | no | yes |
| SELS_HUMAN | [view interactions] | High throughput | no | yes |
| TP4A3_HUMAN | [view interactions] | High throughput | no | no |
| UB2D1_HUMAN | [view interactions] | High throughput | no | yes |
| UB2D2_HUMAN | [view interactions] | High throughput | no | yes |
| UB2D4_HUMAN | [view interactions] | High throughput | no | yes |
| IP6K1_HUMAN | [view interactions] | High throughput | no | yes |
| CBX7_HUMAN | [view interactions] | High throughput | no | yes |
| FOXB1_HUMAN | [view interactions] | High throughput | no | no |
| FOXI2_HUMAN | [view interactions] | High throughput | no | no |
| FOXL1_HUMAN | [view interactions] | High throughput | no | no |
| FOXL2_HUMAN | [view interactions] | High throughput | no | no |
| FOXQ1_HUMAN | [view interactions] | High throughput | no | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLIC6_HUMAN | [view interactions] | High throughput | no | no |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAR16_HUMAN | [view interactions] | High throughput | no | yes |
| IL9R_HUMAN | [view interactions] | High throughput | no | no |
| B4GT3_HUMAN | [view interactions] | High throughput | no | yes |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| VSIG1_HUMAN | [view interactions] | High throughput | no | no |
| FGFR2_HUMAN | [view interactions] | High throughput | no | yes |
| GLPB_HUMAN | [view interactions] | High throughput | no | no |
| SIGL1_HUMAN | [view interactions] | High throughput | no | no |
| CD70_HUMAN | [view interactions] | High throughput | no | no |
| SV2C_HUMAN | [view interactions] | High throughput | no | no |
| LRRT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDM1_HUMAN | [view interactions] | High throughput | no | yes |
| PCBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TEDC2_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| BMP7_HUMAN | [view interactions] | High throughput | no | no |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| CUL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| EDEM1_HUMAN | [view interactions] | High throughput | no | yes |
| SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
| TM134_HUMAN | [view interactions] | High throughput | no | yes |
| GLPA_HUMAN | [view interactions] | High throughput | no | no |
| CF062_HUMAN | [view interactions] | High throughput | no | yes |
| EFNB1_HUMAN | [view interactions] | High throughput | no | yes |
| LRC25_HUMAN | [view interactions] | High throughput | no | yes |
| KCNA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HIDE1_HUMAN | [view interactions] | High throughput | no | no |
| GPR17_HUMAN | [view interactions] | High throughput | no | no |
| F234A_HUMAN | [view interactions] | High throughput | no | yes |
| TTMP_HUMAN | [view interactions] | High throughput | no | no |
| TTYH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CC018_HUMAN | [view interactions] | High throughput | no | yes |
| KI2L1_HUMAN | [view interactions] | High throughput | no | no |
| CA210_HUMAN | [view interactions] | High throughput | no | yes |
| SEM4C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCMB3_HUMAN | [view interactions] | High throughput | no | no |