UBE4A_HUMAN
Evidence for PS localization
Functions
Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates Lys-48-linked polyubiquitination of substrates. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in UBE4A_HUMAN |
|---|---|---|---|---|
| GO:0005216 | ion channel activity | 30.0000 | 4 | no |
| GO:0008324 | cation transmembrane transporter activity | 30.0000 | 4 | no |
| GO:0015267 | channel activity | 30.0000 | 4 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 30.0000 | 4 | no |
| GO:0005261 | cation channel activity | 25.0000 | 5 | no |
| GO:0022836 | gated channel activity | 25.0000 | 5 | no |
| GO:0046873 | metal ion transmembrane transporter activity | 25.0000 | 5 | no |
| GO:0003723 | RNA binding | 25.0000 | 4 | no |
| GO:0004842 | ubiquitin-protein transferase activity | 20.0000 | 4 | yes |
| GO:0034450 | ubiquitin-ubiquitin ligase activity | 15.0000 | 6 | yes |
| GO:0061630 | ubiquitin protein ligase activity | 15.0000 | 5 | yes |
| GO:0061659 | ubiquitin-like protein ligase activity | 15.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in UBE4A_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
| GO:0034976 | response to endoplasmic reticulum stress | 40.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 40.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 40.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 40.0000 | 4 | no |
| GO:0006508 | proteolysis | 35.0000 | 4 | yes |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 35.0000 | 7 | yes |
| GO:0009057 | macromolecule catabolic process | 35.0000 | 4 | yes |
| GO:0010498 | proteasomal protein catabolic process | 35.0000 | 5 | yes |
| GO:0019941 | modification-dependent protein catabolic process | 35.0000 | 6 | yes |
| GO:0030163 | protein catabolic process | 35.0000 | 4 | yes |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 35.0000 | 6 | yes |
| GO:0043632 | modification-dependent macromolecule catabolic process | 35.0000 | 5 | yes |
| GO:0044265 | cellular macromolecule catabolic process | 35.0000 | 4 | yes |
| GO:0051603 | proteolysis involved in protein catabolic process | 35.0000 | 5 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 35.0000 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 35.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.0000 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 35.0000 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 35.0000 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 35.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 35.0000 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 30.0000 | 4 | yes |
| GO:0030433 | ubiquitin-dependent ERAD pathway | 30.0000 | 6 | yes |
| GO:0036211 | protein modification process | 30.0000 | 4 | yes |
| GO:0036503 | ERAD pathway | 30.0000 | 5 | yes |
| GO:0043412 | macromolecule modification | 30.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 30.0000 | 4 | no |
| GO:0008104 | protein localization | 30.0000 | 4 | no |
| GO:0009894 | regulation of catabolic process | 30.0000 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.0000 | 5 | no |
| GO:0031329 | regulation of cellular catabolic process | 30.0000 | 5 | no |
| GO:0016567 | protein ubiquitination | 25.0000 | 7 | yes |
| GO:0032446 | protein modification by small protein conjugation | 25.0000 | 6 | yes |
| GO:0070647 | protein modification by small protein conjugation or removal | 25.0000 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 25.0000 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.0000 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 25.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 25.0000 | 4 | no |
| GO:0006811 | ion transport | 25.0000 | 4 | no |
| GO:0043933 | protein-containing complex organization | 25.0000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 25.0000 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0000209 | protein polyubiquitination | 15.0000 | 8 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in UBE4A_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 15.0000 | 3 | no |
| DOID:1289 | neurodegenerative disease | 10.0000 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| UB2D3_HUMAN | [view interactions] | Low throughput | no | yes |
| DNJC7_HUMAN | [view interactions] | Low throughput | no | yes |
| ITPR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SLAP1_HUMAN | [view interactions] | Low throughput | no | yes |
| FAM3C_HUMAN | [view interactions] | Low throughput | no | yes |
| MTA1_HUMAN | [view interactions] | Low throughput | no | yes |
| TP53B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RSAD2_HUMAN | [view interactions] | Low throughput | no | yes |
| CASP6_HUMAN | [view interactions] | Low throughput | no | no |
| GRAB_HUMAN | [view interactions] | Low throughput | no | no |
| PTTG1_HUMAN | [view interactions] | Low throughput | no | no |
| UBE4A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EPHA2_HUMAN | [view interactions] | Low throughput | no | no |
| MAVS_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| SH2D3_HUMAN | [view interactions] | High throughput | no | no |
| CWC25_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P2RY6_HUMAN | [view interactions] | High throughput | no | no |
| UBXN4_HUMAN | [view interactions] | High throughput | no | yes |
| SELS_HUMAN | [view interactions] | High throughput | no | yes |
| TP4A3_HUMAN | [view interactions] | High throughput | no | no |
| UB2D1_HUMAN | [view interactions] | High throughput | no | yes |
| UB2D2_HUMAN | [view interactions] | High throughput | no | yes |
| UB2D4_HUMAN | [view interactions] | High throughput | no | yes |
| IP6K1_HUMAN | [view interactions] | High throughput | no | yes |
| CBX7_HUMAN | [view interactions] | High throughput | no | yes |
| FOXB1_HUMAN | [view interactions] | High throughput | no | no |
| FOXI2_HUMAN | [view interactions] | High throughput | no | no |
| FOXL1_HUMAN | [view interactions] | High throughput | no | no |
| FOXL2_HUMAN | [view interactions] | High throughput | no | no |
| FOXQ1_HUMAN | [view interactions] | High throughput | no | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAR16_HUMAN | [view interactions] | High throughput | no | yes |
| IL9R_HUMAN | [view interactions] | High throughput | no | no |
| B4GT3_HUMAN | [view interactions] | High throughput | no | yes |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| VSIG1_HUMAN | [view interactions] | High throughput | no | no |
| FGFR2_HUMAN | [view interactions] | High throughput | no | yes |
| GLPB_HUMAN | [view interactions] | High throughput | no | no |
| SIGL1_HUMAN | [view interactions] | High throughput | no | no |
| CD70_HUMAN | [view interactions] | High throughput | no | no |
| SV2C_HUMAN | [view interactions] | High throughput | no | no |
| LRRT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDM1_HUMAN | [view interactions] | High throughput | no | yes |
| PCBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TEDC2_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| BMP7_HUMAN | [view interactions] | High throughput | no | no |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| CUL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| EDEM1_HUMAN | [view interactions] | High throughput | no | yes |
| SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
| TM134_HUMAN | [view interactions] | High throughput | no | yes |
| GLPA_HUMAN | [view interactions] | High throughput | no | no |
| CF062_HUMAN | [view interactions] | High throughput | no | yes |
| EFNB1_HUMAN | [view interactions] | High throughput | no | yes |
| LRC25_HUMAN | [view interactions] | High throughput | no | yes |
| KCNA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HIDE1_HUMAN | [view interactions] | High throughput | no | no |
| GPR17_HUMAN | [view interactions] | High throughput | no | no |
| F234A_HUMAN | [view interactions] | High throughput | no | yes |
| TTMP_HUMAN | [view interactions] | High throughput | no | no |
| TTYH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CC018_HUMAN | [view interactions] | High throughput | no | yes |
| KI2L1_HUMAN | [view interactions] | High throughput | no | no |
| CA210_HUMAN | [view interactions] | High throughput | no | yes |
| SEM4C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCMB3_HUMAN | [view interactions] | High throughput | no | no |
| SPSB4_HUMAN | [view interactions] | High throughput | no | no |
| AT1B3_HUMAN | [view interactions] | High throughput | no | yes |
| ACHA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZDH12_HUMAN | [view interactions] | High throughput | no | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| H2AX_HUMAN | [view interactions] | High throughput | no | yes |
| BAG6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCAF7_HUMAN | [view interactions] | High throughput | no | yes |
| TPR_HUMAN | [view interactions] | High throughput | no | yes |
| DPPA3_HUMAN | [view interactions] | High throughput | no | no |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| ST7_HUMAN | [view interactions] | High throughput | no | yes |
| PTN1_HUMAN | [view interactions] | High throughput | no | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| DNJC1_HUMAN | [view interactions] | High throughput | no | yes |
| UN45B_HUMAN | [view interactions] | Computational | no | no |
| CHIP_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PLAP_HUMAN | [view interactions] | Computational | no | yes |
| NPL4_HUMAN | [view interactions] | Computational | no | yes |
| UFD1_HUMAN | [view interactions] | Computational | no | no |
| RD23A_HUMAN | [view interactions] | Computational | no | yes |
| TRIPC_HUMAN | [view interactions] | Computational | no | yes |
| CHIN_HUMAN | [view interactions] | Computational | no | no |
| RD23B_HUMAN | [view interactions] | Computational | no | yes |
| UBQL1_HUMAN | [view interactions] | Computational | no | yes |