Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ACHA_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ACHA_HUMAN
GO:0046872 metal ion binding 41.9355 4 no
GO:0003779 actin binding 22.5806 4 no
GO:0005509 calcium ion binding 22.5806 5 no
GO:0019900 kinase binding 22.5806 4 no
GO:0019901 protein kinase binding 22.5806 5 no
GO:0098960 postsynaptic neurotransmitter receptor activity 19.3548 4 yes
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 19.3548 5 yes
GO:0005216 ion channel activity 16.1290 4 yes
GO:0005230 extracellular ligand-gated ion channel activity 16.1290 6 yes
GO:0005231 excitatory extracellular ligand-gated ion channel activity 16.1290 7 yes
GO:0005261 cation channel activity 16.1290 5 yes
GO:0008324 cation transmembrane transporter activity 16.1290 4 yes
GO:0015267 channel activity 16.1290 4 yes
GO:0015276 ligand-gated ion channel activity 16.1290 5 yes
GO:0015464 acetylcholine receptor activity 16.1290 4 yes
GO:0022824 transmitter-gated ion channel activity 16.1290 5 yes
GO:0022834 ligand-gated channel activity 16.1290 6 yes
GO:0022835 transmitter-gated channel activity 16.1290 4 yes
GO:0022836 gated channel activity 16.1290 5 yes
GO:0022848 acetylcholine-gated cation-selective channel activity 16.1290 7 yes
GO:0022890 inorganic cation transmembrane transporter activity 16.1290 4 yes
GO:0099094 ligand-gated cation channel activity 16.1290 6 yes
GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential 16.1290 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ACHA_HUMAN
GO:0048522 positive regulation of cellular process 54.8387 4 no
GO:0010646 regulation of cell communication 38.7097 4 no
GO:0034330 cell junction organization 35.4839 4 yes
GO:0048523 negative regulation of cellular process 35.4839 4 no
GO:0010941 regulation of cell death 35.4839 4 no
GO:0042981 regulation of apoptotic process 35.4839 6 no
GO:0043067 regulation of programmed cell death 35.4839 5 no
GO:0006996 organelle organization 32.2581 4 no
GO:0009966 regulation of signal transduction 32.2581 4 no
GO:0031323 regulation of cellular metabolic process 32.2581 4 no
GO:0043085 positive regulation of catalytic activity 32.2581 4 no
GO:0051128 regulation of cellular component organization 32.2581 4 no
GO:0022603 regulation of anatomical structure morphogenesis 29.0323 4 no
GO:0030334 regulation of cell migration 29.0323 5 no
GO:0044087 regulation of cellular component biogenesis 29.0323 4 no
GO:0051171 regulation of nitrogen compound metabolic process 29.0323 4 no
GO:0060255 regulation of macromolecule metabolic process 29.0323 4 no
GO:0080090 regulation of primary metabolic process 29.0323 4 no
GO:2000145 regulation of cell motility 29.0323 4 no
GO:0022607 cellular component assembly 29.0323 4 no
GO:0099537 trans-synaptic signaling 25.8065 4 yes
GO:0007010 cytoskeleton organization 25.8065 5 no
GO:0009893 positive regulation of metabolic process 25.8065 4 no
GO:0010604 positive regulation of macromolecule metabolic process 25.8065 5 no
GO:0030030 cell projection organization 25.8065 4 no
GO:0031325 positive regulation of cellular metabolic process 25.8065 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 25.8065 5 no
GO:0051240 positive regulation of multicellular organismal process 25.8065 4 no
GO:0010942 positive regulation of cell death 25.8065 5 no
GO:0043065 positive regulation of apoptotic process 25.8065 7 no
GO:0043068 positive regulation of programmed cell death 25.8065 6 no
GO:0051336 regulation of hydrolase activity 25.8065 4 no
GO:0006811 ion transport 22.5806 4 yes
GO:0007268 chemical synaptic transmission 22.5806 6 yes
GO:0098916 anterograde trans-synaptic signaling 22.5806 5 yes
GO:0001932 regulation of protein phosphorylation 22.5806 7 no
GO:0010243 response to organonitrogen compound 22.5806 4 no
GO:0019220 regulation of phosphate metabolic process 22.5806 6 no
GO:0031399 regulation of protein modification process 22.5806 6 no
GO:0042325 regulation of phosphorylation 22.5806 7 no
GO:0043549 regulation of kinase activity 22.5806 5 no
GO:0045859 regulation of protein kinase activity 22.5806 6 no
GO:0051094 positive regulation of developmental process 22.5806 4 no
GO:0051130 positive regulation of cellular component organization 22.5806 5 no
GO:0051174 regulation of phosphorus metabolic process 22.5806 5 no
GO:0051246 regulation of protein metabolic process 22.5806 5 no
GO:0051338 regulation of transferase activity 22.5806 4 no
GO:0120036 plasma membrane bounded cell projection organization 22.5806 5 no
GO:1902531 regulation of intracellular signal transduction 22.5806 5 no
GO:0006796 phosphate-containing compound metabolic process 22.5806 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 22.5806 4 no
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 22.5806 5 no
GO:0030335 positive regulation of cell migration 22.5806 6 no
GO:0040017 positive regulation of locomotion 22.5806 4 no
GO:0048584 positive regulation of response to stimulus 22.5806 4 no
GO:0080134 regulation of response to stress 22.5806 4 no
GO:2000147 positive regulation of cell motility 22.5806 5 no
GO:0010647 positive regulation of cell communication 22.5806 5 no
GO:0023056 positive regulation of signaling 22.5806 4 no
GO:0033043 regulation of organelle organization 22.5806 5 no
GO:0006936 muscle contraction 19.3548 4 yes
GO:0050808 synapse organization 16.1290 5 yes
GO:0060249 anatomical structure homeostasis 12.9032 4 yes
GO:0001508 action potential 9.6774 4 yes
GO:0003009 skeletal muscle contraction 9.6774 6 yes
GO:0006941 striated muscle contraction 9.6774 5 yes
GO:0007274 neuromuscular synaptic transmission 9.6774 7 yes
GO:0007528 neuromuscular junction development 9.6774 6 yes
GO:0050905 neuromuscular process 9.6774 4 yes
GO:0019228 neuronal action potential 6.4516 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
STAU1_HUMAN [view entry] [view interactions] Low throughput yes yes
RER1_HUMAN [view interactions] Low throughput no yes
ITA7_HUMAN [view interactions] Low throughput no yes
ACHA_HUMAN [view entry] [view interactions] Low throughput yes no
ACTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
CALX_HUMAN [view entry] [view interactions] Low throughput yes yes
RAPSN_HUMAN [view entry] [view interactions] Low throughput yes no
ACHE_HUMAN [view entry] [view interactions] Low throughput yes no
ACHD_HUMAN [view entry] [view interactions] Low throughput yes no
ACHG_HUMAN [view entry] [view interactions] Low throughput yes no
LIRA6_HUMAN [view interactions] High throughput no no
TBL2_HUMAN [view interactions] High throughput no no
GOLM1_HUMAN [view interactions] High throughput no yes
DYST_HUMAN [view entry] [view interactions] High throughput yes yes
S27A2_HUMAN [view interactions] High throughput no no
IPIL2_HUMAN [view interactions] High throughput no no
PREB_HUMAN [view interactions] High throughput no yes
SCNNA_HUMAN [view interactions] High throughput no yes
GBF1_HUMAN [view interactions] High throughput no yes
SYVN1_HUMAN [view interactions] High throughput no yes
RETST_HUMAN [view interactions] High throughput no yes
AGRG6_HUMAN [view interactions] High throughput no no
MAN1_HUMAN [view interactions] High throughput no yes
EXTL3_HUMAN [view interactions] High throughput no yes
CSCL2_HUMAN [view interactions] High throughput no yes
RDH11_HUMAN [view interactions] High throughput no no
UBE4A_HUMAN [view entry] [view interactions] High throughput yes yes
S27A1_HUMAN [view entry] [view interactions] High throughput yes no
GLT12_HUMAN [view interactions] High throughput no yes
SCD5_HUMAN [view entry] [view interactions] High throughput yes yes
TAP2_HUMAN [view interactions] High throughput no no
DIK2A_HUMAN [view interactions] High throughput no yes
S38AA_HUMAN [view interactions] High throughput no yes
DJC16_HUMAN [view interactions] High throughput no no
FA8A1_HUMAN [view interactions] High throughput no yes
ZDHC9_HUMAN [view interactions] High throughput no yes
TM201_HUMAN [view interactions] High throughput no no
UBAC2_HUMAN [view interactions] High throughput no yes
GPX8_HUMAN [view interactions] High throughput no no
FZD6_HUMAN [view interactions] High throughput no yes
ZDHC6_HUMAN [view interactions] High throughput no no
S27A4_HUMAN [view entry] [view interactions] High throughput yes yes
ESYT2_HUMAN [view entry] [view interactions] High throughput yes yes
ZNT7_HUMAN [view interactions] High throughput no no
TAP1_HUMAN [view interactions] High throughput no yes
CSK_HUMAN [view interactions] High throughput no yes
LAMC1_HUMAN [view interactions] Computational no yes
ARHG7_HUMAN [view entry] [view interactions] Computational yes yes
SRC_HUMAN [view entry] [view interactions] Computational yes no
LAMA3_HUMAN [view interactions] Computational no no
LAMB3_HUMAN [view interactions] Computational no yes
GIT2_HUMAN [view interactions] Computational no yes
PAK4_HUMAN [view interactions] Computational no yes
LAMA2_HUMAN [view interactions] Computational no no
LAMA1_HUMAN [view interactions] Computational no no
LAMC3_HUMAN [view interactions] Computational no no
PAK5_HUMAN [view interactions] Computational no yes
ACTS_HUMAN [view interactions] Computational no no
GNAQ_HUMAN [view entry] [view interactions] Computational yes yes
LAMA5_HUMAN [view entry] [view interactions] Computational yes no
GBG1_HUMAN [view interactions] Computational no no
PAK1_HUMAN [view entry] [view interactions] Computational yes yes
LAMB2_HUMAN [view interactions] Computational no yes
SP1_HUMAN [view interactions] Computational no yes
LAMC2_HUMAN [view interactions] Computational no no
ARHG6_HUMAN [view interactions] Computational no no
LAMB1_HUMAN [view interactions] Computational no yes
AGRIN_HUMAN [view entry] [view interactions] Computational yes yes
JUN_HUMAN [view interactions] Computational no yes
PLCG1_HUMAN [view entry] [view interactions] Computational yes yes
ACM1_HUMAN [view entry] [view interactions] Computational yes yes
SRC8_HUMAN [view entry] [view interactions] Computational yes yes
GBB1_HUMAN [view entry] [view interactions] Computational yes yes
DAG1_HUMAN [view entry] [view interactions] Computational yes no
UTRN_HUMAN [view entry] [view interactions] Computational yes yes
ITB1_HUMAN [view entry] [view interactions] Computational yes no
ITA1_HUMAN [view interactions] Computational no yes
FAK1_HUMAN [view entry] [view interactions] Computational yes yes
PAK2_HUMAN [view entry] [view interactions] Computational yes no
PAXI_HUMAN [view interactions] Computational no yes
PAK3_HUMAN [view entry] [view interactions] Computational yes no