ACHA_HUMAN
Evidence for PS localization
Functions
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. [View more on UniProt]
Protein features
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 37%
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Close ✖
ACHA_HUMAN has binary interactions with 14 proteins
Isoforms
Interacting regions
Canonical [ACHA_HUMAN]
Isoform [F8WDS3] alignment
Isoform [A0A1B0GV17] alignment
Isoform [B8ZZD3] alignment
Isoform [G5E9G9] alignment
Isoform [E7ENE5] alignment
Isoform [P02708-1] alignment
LOADING 27%
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ACHA_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 60.0000 | 4 | yes |
| GO:0046872 | metal ion binding | 40.0000 | 5 | no |
| GO:0005216 | monoatomic ion channel activity | 33.3333 | 4 | yes |
| GO:0005230 | extracellular ligand-gated monoatomic ion channel activity | 33.3333 | 6 | yes |
| GO:0005231 | excitatory extracellular ligand-gated monoatomic ion channel activity | 33.3333 | 7 | yes |
| GO:0005261 | monoatomic cation channel activity | 33.3333 | 5 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 33.3333 | 4 | yes |
| GO:0015267 | channel activity | 33.3333 | 4 | yes |
| GO:0015276 | ligand-gated monoatomic ion channel activity | 33.3333 | 5 | yes |
| GO:0022824 | transmitter-gated monoatomic ion channel activity | 33.3333 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 33.3333 | 6 | yes |
| GO:0022835 | transmitter-gated channel activity | 33.3333 | 4 | yes |
| GO:0022836 | gated channel activity | 33.3333 | 5 | yes |
| GO:0022848 | acetylcholine-gated monoatomic cation-selective channel activity | 33.3333 | 7 | yes |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 33.3333 | 4 | yes |
| GO:0099094 | ligand-gated monoatomic cation channel activity | 33.3333 | 6 | yes |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 33.3333 | 5 | yes |
| GO:1904315 | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | 33.3333 | 6 | yes |
| GO:0015464 | acetylcholine receptor activity | 26.6667 | 4 | yes |
| GO:0005509 | calcium ion binding | 26.6667 | 6 | no |
| GO:0042166 | acetylcholine binding | 20.0000 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ACHA_HUMAN |
|---|---|---|---|---|
| GO:0006936 | muscle contraction | 33.3333 | 4 | yes |
| GO:0034330 | cell junction organization | 33.3333 | 4 | yes |
| GO:0007268 | chemical synaptic transmission | 26.6667 | 7 | yes |
| GO:0007271 | synaptic transmission, cholinergic | 26.6667 | 8 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 26.6667 | 6 | yes |
| GO:0099536 | synaptic signaling | 26.6667 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 26.6667 | 5 | yes |
| GO:0048522 | positive regulation of cellular process | 26.6667 | 4 | no |
| GO:0071702 | organic substance transport | 26.6667 | 4 | no |
| GO:0098657 | import into cell | 26.6667 | 4 | no |
| GO:0003009 | skeletal muscle contraction | 20.0000 | 6 | yes |
| GO:0006941 | striated muscle contraction | 20.0000 | 5 | yes |
| GO:0050808 | synapse organization | 20.0000 | 5 | yes |
| GO:0050905 | neuromuscular process | 20.0000 | 4 | yes |
| GO:0001508 | action potential | 13.3333 | 4 | yes |
| GO:0007274 | neuromuscular synaptic transmission | 13.3333 | 8 | yes |
| GO:0007528 | neuromuscular junction development | 13.3333 | 6 | yes |
| GO:0019228 | neuronal action potential | 13.3333 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ACHA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACHD_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACHE_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACHG_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AGRG6_HUMAN | [view interactions] | High throughput | no | no |
| CALX_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CSCL2_HUMAN | [view interactions] | High throughput | no | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| DIK2A_HUMAN | [view interactions] | High throughput | no | yes |
| DJC16_HUMAN | [view interactions] | High throughput | no | no |
| DYST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESYT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXTL3_HUMAN | [view interactions] | High throughput | no | yes |
| FA8A1_HUMAN | [view interactions] | High throughput | no | yes |
| FZD6_HUMAN | [view interactions] | High throughput | no | yes |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| GLT12_HUMAN | [view interactions] | High throughput | no | yes |
| GOLM1_HUMAN | [view interactions] | High throughput | no | yes |
| GPX8_HUMAN | [view interactions] | High throughput | no | no |
| IPIL2_HUMAN | [view interactions] | High throughput | no | no |
| ITA7_HUMAN | [view interactions] | Low throughput | no | yes |
| LIRA6_HUMAN | [view interactions] | High throughput | no | no |
| MAN1_HUMAN | [view interactions] | High throughput | no | yes |
| PREB_HUMAN | [view interactions] | High throughput | no | yes |