Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ACHG_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ACHG_HUMAN
GO:0005216 ion channel activity 50.0000 4 yes
GO:0005230 extracellular ligand-gated ion channel activity 50.0000 6 yes
GO:0005231 excitatory extracellular ligand-gated ion channel activity 50.0000 7 yes
GO:0005261 cation channel activity 50.0000 5 yes
GO:0008324 cation transmembrane transporter activity 50.0000 4 yes
GO:0015267 channel activity 50.0000 4 yes
GO:0015276 ligand-gated ion channel activity 50.0000 5 yes
GO:0015464 acetylcholine receptor activity 50.0000 4 yes
GO:0022824 transmitter-gated ion channel activity 50.0000 5 yes
GO:0022834 ligand-gated channel activity 50.0000 6 yes
GO:0022835 transmitter-gated channel activity 50.0000 4 yes
GO:0022836 gated channel activity 50.0000 5 yes
GO:0022848 acetylcholine-gated cation-selective channel activity 50.0000 7 yes
GO:0022890 inorganic cation transmembrane transporter activity 50.0000 4 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 50.0000 4 yes
GO:0099094 ligand-gated cation channel activity 50.0000 6 yes
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 50.0000 5 yes
GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential 50.0000 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ACHG_HUMAN
GO:0006811 ion transport 50.0000 4 yes
GO:0006936 muscle contraction 50.0000 4 yes
GO:0007268 chemical synaptic transmission 50.0000 6 yes
GO:0098916 anterograde trans-synaptic signaling 50.0000 5 yes
GO:0099537 trans-synaptic signaling 50.0000 4 yes
GO:0030030 cell projection organization 50.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 50.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0120036 plasma membrane bounded cell projection organization 50.0000 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ACHA_HUMAN [view entry] [view interactions] Low throughput yes no
ACL6B_HUMAN [view entry] [view interactions] High throughput yes no
KR107_HUMAN [view interactions] High throughput no no
KR108_HUMAN [view interactions] High throughput no no
KR109_HUMAN [view interactions] High throughput no no
K1H1_HUMAN [view interactions] High throughput no no
NT2NA_HUMAN [view interactions] High throughput no no
KR103_HUMAN [view interactions] High throughput no no
ATL4_HUMAN [view interactions] High throughput no yes
MDFI_HUMAN [view interactions] High throughput no no
MEOX2_HUMAN [view interactions] High throughput no no
SPY2_HUMAN [view interactions] High throughput no yes
SNX1_HUMAN [view entry] [view interactions] High throughput yes yes
SGTA_HUMAN [view interactions] High throughput no yes
KRT34_HUMAN [view interactions] High throughput no no
KRA11_HUMAN [view interactions] High throughput no no
CRTP1_HUMAN [view interactions] High throughput no yes
KRA93_HUMAN [view interactions] High throughput no no
KR123_HUMAN [view interactions] High throughput no no
KRA13_HUMAN [view interactions] High throughput no no
KRA59_HUMAN [view interactions] High throughput no no