Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ACL6B_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion, and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth . Essential for neuronal maturation and dendrite development (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ACL6B_HUMAN
GO:0043169 cation binding 35.7143 4 no
GO:0046872 metal ion binding 35.7143 5 no
GO:0000166 nucleotide binding 28.5714 4 no
GO:0017076 purine nucleotide binding 28.5714 5 no
GO:0031625 ubiquitin protein ligase binding 21.4286 5 no
GO:0044389 ubiquitin-like protein ligase binding 21.4286 4 no
GO:0030554 adenyl nucleotide binding 21.4286 6 no
GO:0032555 purine ribonucleotide binding 21.4286 4 no
GO:0035639 purine ribonucleoside triphosphate binding 21.4286 4 no
GO:0043168 anion binding 21.4286 4 no
GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 21.4286 5 no
GO:0140297 DNA-binding transcription factor binding 21.4286 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in ACL6B_HUMAN
GO:0048523 negative regulation of cellular process 64.2857 4 yes
GO:0051128 regulation of cellular component organization 57.1429 4 yes
GO:0009889 regulation of biosynthetic process 50.0000 4 yes
GO:0010468 regulation of gene expression 50.0000 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 yes
GO:0031323 regulation of cellular metabolic process 50.0000 4 yes
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 yes
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 yes
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0031324 negative regulation of cellular metabolic process 42.8571 5 no
GO:0031327 negative regulation of cellular biosynthetic process 42.8571 6 no
GO:0036211 protein modification process 42.8571 4 no
GO:0043412 macromolecule modification 42.8571 4 no
GO:1902531 regulation of intracellular signal transduction 42.8571 5 no
GO:0043933 protein-containing complex organization 42.8571 4 yes
GO:0048522 positive regulation of cellular process 42.8571 4 yes
GO:0080090 regulation of primary metabolic process 42.8571 4 yes
GO:0009890 negative regulation of biosynthetic process 42.8571 5 no
GO:0009892 negative regulation of metabolic process 42.8571 4 no
GO:0009966 regulation of signal transduction 42.8571 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 42.8571 6 no
GO:0010605 negative regulation of macromolecule metabolic process 42.8571 5 no
GO:0006796 phosphate-containing compound metabolic process 35.7143 4 no
GO:0006355 regulation of DNA-templated transcription 35.7143 7 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 35.7143 5 yes
GO:0030030 cell projection organization 35.7143 4 yes
GO:0051093 negative regulation of developmental process 35.7143 4 yes
GO:0051252 regulation of RNA metabolic process 35.7143 5 yes
GO:2001141 regulation of RNA biosynthetic process 35.7143 6 yes
GO:0050804 modulation of chemical synaptic transmission 35.7143 5 no
GO:0099177 regulation of trans-synaptic signaling 35.7143 4 no
GO:0006996 organelle organization 35.7143 4 no
GO:0044087 regulation of cellular component biogenesis 28.5714 4 no
GO:0050890 cognition 28.5714 4 no
GO:0051049 regulation of transport 28.5714 4 no
GO:0051129 negative regulation of cellular component organization 28.5714 5 no
GO:0051130 positive regulation of cellular component organization 28.5714 5 no
GO:0071310 cellular response to organic substance 28.5714 4 no
GO:0006468 protein phosphorylation 28.5714 5 no
GO:0016310 phosphorylation 28.5714 5 no
GO:0006357 regulation of transcription by RNA polymerase II 28.5714 8 yes
GO:0009893 positive regulation of metabolic process 28.5714 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 28.5714 5 yes
GO:0031175 neuron projection development 28.5714 6 yes
GO:0042127 regulation of cell population proliferation 28.5714 4 yes
GO:0045595 regulation of cell differentiation 28.5714 4 yes
GO:0045596 negative regulation of cell differentiation 28.5714 5 yes
GO:0048584 positive regulation of response to stimulus 28.5714 4 yes
GO:0080134 regulation of response to stress 28.5714 4 yes
GO:0120036 plasma membrane bounded cell projection organization 28.5714 5 yes
GO:0007612 learning 28.5714 4 no
GO:0008104 protein localization 28.5714 4 no
GO:0010243 response to organonitrogen compound 28.5714 4 no
GO:0010629 negative regulation of gene expression 28.5714 7 no
GO:0022607 cellular component assembly 28.5714 4 no
GO:0023057 negative regulation of signaling 21.4286 4 no
GO:0030111 regulation of Wnt signaling pathway 21.4286 5 no
GO:0030163 protein catabolic process 21.4286 4 no
GO:0031325 positive regulation of cellular metabolic process 21.4286 5 no
GO:0031328 positive regulation of cellular biosynthetic process 21.4286 6 no
GO:0031329 regulation of cellular catabolic process 21.4286 5 no
GO:0031331 positive regulation of cellular catabolic process 21.4286 6 no
GO:0031399 regulation of protein modification process 21.4286 6 no
GO:0031401 positive regulation of protein modification process 21.4286 7 no
GO:0032092 positive regulation of protein binding 21.4286 5 no
GO:0032880 regulation of protein localization 21.4286 5 no
GO:0042981 regulation of apoptotic process 21.4286 5 no
GO:0043066 negative regulation of apoptotic process 21.4286 6 no
GO:0043067 regulation of programmed cell death 21.4286 4 no
GO:0043069 negative regulation of programmed cell death 21.4286 5 no
GO:0043393 regulation of protein binding 21.4286 4 no
GO:0043408 regulation of MAPK cascade 21.4286 6 no
GO:0045892 negative regulation of DNA-templated transcription 21.4286 8 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 21.4286 5 no
GO:0048585 negative regulation of response to stimulus 21.4286 4 no
GO:0048638 regulation of developmental growth 21.4286 4 no
GO:0050905 neuromuscular process 21.4286 4 no
GO:0051099 positive regulation of binding 21.4286 4 no
GO:0051174 regulation of phosphorus metabolic process 21.4286 5 no
GO:0051223 regulation of protein transport 21.4286 5 no
GO:0051246 regulation of protein metabolic process 21.4286 5 no
GO:0051247 positive regulation of protein metabolic process 21.4286 6 no
GO:0051253 negative regulation of RNA metabolic process 21.4286 6 no
GO:0051338 regulation of transferase activity 21.4286 4 no
GO:0060341 regulation of cellular localization 21.4286 4 no
GO:0065003 protein-containing complex assembly 21.4286 5 no
GO:0070201 regulation of establishment of protein localization 21.4286 6 no
GO:0071417 cellular response to organonitrogen compound 21.4286 4 no
GO:0071702 organic substance transport 21.4286 4 no
GO:0071705 nitrogen compound transport 21.4286 4 no
GO:0097435 supramolecular fiber organization 21.4286 4 no
GO:0098657 import into cell 21.4286 4 no
GO:1901565 organonitrogen compound catabolic process 21.4286 4 no
GO:1901699 cellular response to nitrogen compound 21.4286 4 no
GO:1901701 cellular response to oxygen-containing compound 21.4286 4 no
GO:1902532 negative regulation of intracellular signal transduction 21.4286 6 no
GO:1902533 positive regulation of intracellular signal transduction 21.4286 6 no
GO:1902679 negative regulation of RNA biosynthetic process 21.4286 7 no
GO:1902903 regulation of supramolecular fiber organization 21.4286 5 no
GO:0018193 peptidyl-amino acid modification 21.4286 5 no
GO:0034097 response to cytokine 21.4286 4 no
GO:0051241 negative regulation of multicellular organismal process 21.4286 4 no
GO:0006915 apoptotic process 21.4286 4 no
GO:0008306 associative learning 21.4286 5 no
GO:0008542 visual learning 21.4286 4 no
GO:0009416 response to light stimulus 21.4286 4 no
GO:0034330 cell junction organization 21.4286 4 no
GO:0048812 neuron projection morphogenesis 21.4286 5 no
GO:0050808 synapse organization 21.4286 5 no
GO:0051402 neuron apoptotic process 21.4286 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 21.4286 4 no
GO:0008285 negative regulation of cell population proliferation 21.4286 5 no
GO:0030334 regulation of cell migration 21.4286 5 no
GO:2000145 regulation of cell motility 21.4286 4 no
GO:0010970 transport along microtubule 21.4286 4 no
GO:0030705 cytoskeleton-dependent intracellular transport 21.4286 4 no
GO:0099111 microtubule-based transport 21.4286 4 no
GO:0033043 regulation of organelle organization 21.4286 5 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 21.4286 5 yes
GO:0051094 positive regulation of developmental process 21.4286 4 yes
GO:0051726 regulation of cell cycle 21.4286 4 yes
GO:0060284 regulation of cell development 21.4286 5 yes
GO:0080135 regulation of cellular response to stress 21.4286 4 yes
GO:0006109 regulation of carbohydrate metabolic process 21.4286 5 no
GO:0006508 proteolysis 21.4286 4 no
GO:0008344 adult locomotory behavior 21.4286 4 no
GO:0009057 macromolecule catabolic process 21.4286 4 no
GO:0009891 positive regulation of biosynthetic process 21.4286 5 no
GO:0009894 regulation of catabolic process 21.4286 4 no
GO:0009896 positive regulation of catabolic process 21.4286 5 no
GO:0009967 positive regulation of signal transduction 21.4286 5 no
GO:0009968 negative regulation of signal transduction 21.4286 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 21.4286 6 no
GO:0010628 positive regulation of gene expression 21.4286 7 no
GO:0010647 positive regulation of cell communication 21.4286 5 no
GO:0010648 negative regulation of cell communication 21.4286 5 no
GO:0019220 regulation of phosphate metabolic process 21.4286 6 no
GO:0022411 cellular component disassembly 21.4286 4 no
GO:0022603 regulation of anatomical structure morphogenesis 21.4286 4 no
GO:0023056 positive regulation of signaling 21.4286 4 no
GO:0002684 positive regulation of immune system process 14.2857 4 yes
GO:0007346 regulation of mitotic cell cycle 14.2857 5 yes
GO:0010564 regulation of cell cycle process 14.2857 5 yes
GO:0030155 regulation of cell adhesion 14.2857 4 yes
GO:0042551 neuron maturation 14.2857 4 yes
GO:0045597 positive regulation of cell differentiation 14.2857 5 yes
GO:0045785 positive regulation of cell adhesion 14.2857 5 yes
GO:0051240 positive regulation of multicellular organismal process 14.2857 4 yes
GO:1901987 regulation of cell cycle phase transition 14.2857 6 yes
GO:1901990 regulation of mitotic cell cycle phase transition 14.2857 6 yes
GO:2000026 regulation of multicellular organismal development 14.2857 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SMCA2_HUMAN [view interactions] Low throughput no yes
CTBP1_HUMAN [view entry] [view interactions] Low throughput yes yes
SMCA4_HUMAN [view interactions] Low throughput no yes
ANXA7_HUMAN [view entry] [view interactions] High throughput yes yes
CDN1A_HUMAN [view interactions] High throughput no no
CSK2B_HUMAN [view entry] [view interactions] High throughput yes yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
PLK1_HUMAN [view interactions] High throughput no yes
SMN_HUMAN [view interactions] High throughput no yes
KITH_HUMAN [view interactions] High throughput no yes
H2B1A_HUMAN [view interactions] High throughput no no
REQU_HUMAN [view interactions] High throughput no yes
RUVB2_HUMAN [view interactions] High throughput no yes
RUVB1_HUMAN [view interactions] High throughput no yes
YETS4_HUMAN [view interactions] High throughput no no
ACHG_HUMAN [view entry] [view interactions] High throughput yes no
S35A5_HUMAN [view interactions] High throughput no no
S38A7_HUMAN [view interactions] High throughput no yes
CDC73_HUMAN [view interactions] High throughput no yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
ARI1B_HUMAN [view interactions] High throughput no yes
ATM_HUMAN [view interactions] High throughput no yes
COQ9_HUMAN [view interactions] High throughput no yes
DPF3_HUMAN [view interactions] High throughput no yes
SSXT_HUMAN [view interactions] High throughput no yes
SMRD1_HUMAN [view interactions] High throughput no yes
SMRC2_HUMAN [view interactions] High throughput no yes
BCL7C_HUMAN [view interactions] High throughput no yes
BCL7A_HUMAN [view interactions] High throughput no yes
EP400_HUMAN [view interactions] High throughput no yes
MAX_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
CHM4C_HUMAN [view interactions] High throughput no yes
H2B1C_HUMAN [view interactions] High throughput no yes
SELN_HUMAN [view interactions] High throughput no yes
CR1L_HUMAN [view interactions] High throughput no yes
SNF5_HUMAN [view interactions] High throughput no yes
DPF1_HUMAN [view interactions] High throughput no yes
LMO3_HUMAN [view interactions] High throughput no no
LGMN_HUMAN [view interactions] High throughput no yes
ZNHI1_HUMAN [view interactions] High throughput no yes
S18L2_HUMAN [view interactions] High throughput no no
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
HCFC1_HUMAN [view interactions] High throughput no yes
TBB8_HUMAN [view interactions] High throughput no no
BLT3A_HUMAN [view interactions] High throughput no no
DMAP1_HUMAN [view interactions] High throughput no yes
EFMT2_HUMAN [view interactions] High throughput no yes
H2AZ_HUMAN [view interactions] High throughput no yes
INO80_HUMAN [view interactions] High throughput no no
H2B3B_HUMAN [view interactions] High throughput no yes
RM27_HUMAN [view interactions] High throughput no yes
SPRE2_HUMAN [view interactions] High throughput no yes
IQEC1_HUMAN [view entry] [view interactions] High throughput yes yes
RING1_HUMAN [view interactions] High throughput no yes
IQGA3_HUMAN [view interactions] High throughput no no
TEP1_HUMAN [view interactions] High throughput no no
NDUS5_HUMAN [view interactions] High throughput no yes
PRLD1_HUMAN [view interactions] High throughput no yes
SMG8_HUMAN [view interactions] High throughput no yes
SETX_HUMAN [view interactions] High throughput no yes
MAP7_HUMAN [view interactions] High throughput no yes
FRMD5_HUMAN [view interactions] High throughput no no
RIT1_HUMAN [view interactions] High throughput no yes
ZNG1C_HUMAN [view interactions] High throughput no yes
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
VATC2_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
MARH7_HUMAN [view interactions] High throughput no yes
PKHA3_HUMAN [view interactions] High throughput no yes
DDX28_HUMAN [view interactions] High throughput no yes
HJURP_HUMAN [view interactions] High throughput no yes
GBP3_HUMAN [view interactions] High throughput no yes
ETV3_HUMAN [view interactions] High throughput no yes
PAPD1_HUMAN [view interactions] High throughput no yes
SENP5_HUMAN [view entry] [view interactions] High throughput yes no
WRP73_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
MED14_HUMAN [view interactions] High throughput no no
GRIA2_HUMAN [view entry] [view interactions] High throughput yes yes