ACHE_HUMAN
Evidence for PS localization
Functions
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ACHE_HUMAN |
|---|---|---|---|---|
| GO:0005216 | monoatomic ion channel activity | 50.0000 | 4 | yes |
| GO:0005230 | extracellular ligand-gated monoatomic ion channel activity | 50.0000 | 6 | yes |
| GO:0005231 | excitatory extracellular ligand-gated monoatomic ion channel activity | 50.0000 | 7 | yes |
| GO:0005261 | monoatomic cation channel activity | 50.0000 | 5 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 50.0000 | 4 | yes |
| GO:0015267 | channel activity | 50.0000 | 4 | yes |
| GO:0015276 | ligand-gated monoatomic ion channel activity | 50.0000 | 5 | yes |
| GO:0015464 | acetylcholine receptor activity | 50.0000 | 4 | yes |
| GO:0022824 | transmitter-gated monoatomic ion channel activity | 50.0000 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 50.0000 | 6 | yes |
| GO:0022835 | transmitter-gated channel activity | 50.0000 | 4 | yes |
| GO:0022836 | gated channel activity | 50.0000 | 5 | yes |
| GO:0022848 | acetylcholine-gated monoatomic cation-selective channel activity | 50.0000 | 7 | yes |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 50.0000 | 4 | yes |
| GO:0099094 | ligand-gated monoatomic cation channel activity | 50.0000 | 6 | yes |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 50.0000 | 5 | yes |
| GO:1904315 | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | 50.0000 | 6 | yes |
| GO:0043169 | cation binding | 50.0000 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ACHE_HUMAN |
|---|---|---|---|---|
| GO:0099536 | synaptic signaling | 75.0000 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 75.0000 | 5 | yes |
| GO:0006936 | muscle contraction | 50.0000 | 4 | yes |
| GO:0007268 | chemical synaptic transmission | 50.0000 | 7 | yes |
| GO:0007271 | synaptic transmission, cholinergic | 50.0000 | 8 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 50.0000 | 6 | yes |
| GO:0071702 | organic substance transport | 50.0000 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ACHA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RBM3_HUMAN | [view interactions] | High throughput | no | no |
| DIK1A_HUMAN | [view interactions] | High throughput | no | yes |
| TM59L_HUMAN | [view interactions] | High throughput | no | yes |
| TTC17_HUMAN | [view interactions] | High throughput | no | yes |
| ITA6_HUMAN | [view interactions] | High throughput | no | yes |
| SPP2B_HUMAN | [view interactions] | High throughput | no | yes |
| SIA4C_HUMAN | [view interactions] | High throughput | no | yes |
| TM131_HUMAN | [view interactions] | High throughput | no | yes |
| TMUB2_HUMAN | [view interactions] | High throughput | no | yes |
| NB5R1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LTBP1_HUMAN | [view interactions] | High throughput | no | no |
| CNNM1_HUMAN | [view interactions] | High throughput | no | yes |
| PXYP1_HUMAN | [view interactions] | High throughput | no | yes |
| SC11C_HUMAN | [view interactions] | High throughput | no | no |
| NXPE3_HUMAN | [view interactions] | High throughput | no | no |
| CC50A_HUMAN | [view interactions] | High throughput | no | yes |
| TPST2_HUMAN | [view interactions] | High throughput | no | yes |
| POMT2_HUMAN | [view interactions] | High throughput | no | yes |
| NMU_HUMAN | [view interactions] | High throughput | no | no |
| SGCB_HUMAN | [view interactions] | High throughput | no | no |
| DAG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IPRI_HUMAN | [view interactions] | High throughput | no | no |
| TM219_HUMAN | [view interactions] | High throughput | no | yes |
| UD3A2_HUMAN | [view interactions] | High throughput | no | no |
| TUSC3_HUMAN | [view interactions] | High throughput | no | yes |
| ICAM4_HUMAN | [view interactions] | High throughput | no | no |
| LRP12_HUMAN | [view interactions] | High throughput | no | yes |
| PODXL_HUMAN | [view interactions] | High throughput | no | no |