NB5R1_HUMAN
NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in NB5R1_HUMAN |
---|---|---|---|---|
GO:0008324 | cation transmembrane transporter activity | 33.3333 | 4 | no |
GO:0022890 | inorganic cation transmembrane transporter activity | 30.9524 | 4 | no |
GO:0017076 | purine nucleotide binding | 26.1905 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 26.1905 | 4 | no |
GO:0046872 | metal ion binding | 26.1905 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 23.8095 | 4 | no |
GO:0005216 | ion channel activity | 21.4286 | 4 | no |
GO:0015267 | channel activity | 21.4286 | 4 | no |
GO:0022836 | gated channel activity | 21.4286 | 5 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in NB5R1_HUMAN |
---|---|---|---|---|
GO:0006811 | ion transport | 38.0952 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 38.0952 | 4 | no |
GO:0010646 | regulation of cell communication | 28.5714 | 4 | no |
GO:0051049 | regulation of transport | 28.5714 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 28.5714 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 28.5714 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 28.5714 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 28.5714 | 4 | no |
GO:0006812 | cation transport | 26.1905 | 5 | no |
GO:0006996 | organelle organization | 26.1905 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 23.8095 | 4 | no |
GO:0009966 | regulation of signal transduction | 23.8095 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 23.8095 | 5 | no |
GO:0010941 | regulation of cell death | 23.8095 | 4 | no |
GO:0042981 | regulation of apoptotic process | 23.8095 | 6 | no |
GO:0043067 | regulation of programmed cell death | 23.8095 | 5 | no |
GO:0048523 | negative regulation of cellular process | 23.8095 | 4 | no |
GO:0051128 | regulation of cellular component organization | 23.8095 | 4 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 23.8095 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 23.8095 | 5 | no |
GO:0022607 | cellular component assembly | 23.8095 | 4 | no |
GO:0010468 | regulation of gene expression | 21.4286 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 21.4286 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 21.4286 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 21.4286 | 5 | no |
GO:0071702 | organic substance transport | 19.0476 | 4 | yes |
GO:0006820 | anion transport | 11.9048 | 5 | yes |
GO:0008202 | steroid metabolic process | 7.1429 | 4 | yes |
GO:1901362 | organic cyclic compound biosynthetic process | 7.1429 | 4 | yes |
GO:0008610 | lipid biosynthetic process | 4.7619 | 4 | yes |
GO:0015711 | organic anion transport | 4.7619 | 5 | yes |
GO:0016125 | sterol metabolic process | 4.7619 | 4 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in NB5R1_HUMAN |
---|---|---|---|---|
DOID:331 | central nervous system disease | 7.1429 | 3 | no |
DOID:1289 | neurodegenerative disease | 4.7619 | 4 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
TCPQM_HUMAN | [view interactions] | High throughput | no | no |
RXFP1_HUMAN | [view interactions] | High throughput | no | yes |
LY66F_HUMAN | [view interactions] | High throughput | no | no |
MARH4_HUMAN | [view interactions] | High throughput | no | yes |
SG2A2_HUMAN | [view interactions] | High throughput | no | no |
PGFRA_HUMAN | [view interactions] | High throughput | no | no |
COPT1_HUMAN | [view interactions] | High throughput | no | no |
CCG1_HUMAN | [view interactions] | High throughput | no | no |
MAGA8_HUMAN | [view interactions] | High throughput | no | no |
PINK1_HUMAN | [view interactions] | High throughput | no | yes |
CCR1_HUMAN | [view interactions] | High throughput | no | no |
SSUH2_HUMAN | [view interactions] | High throughput | no | no |
MPV17_HUMAN | [view interactions] | High throughput | no | no |
CYB5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NB5R3_HUMAN | [view interactions] | High throughput | no | yes |
ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ADAS_HUMAN | [view interactions] | High throughput | no | yes |
QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SCPDL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MGST1_HUMAN | [view interactions] | High throughput | no | no |
PRDX3_HUMAN | [view interactions] | High throughput | no | yes |
ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ODO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATPB_HUMAN | [view interactions] | High throughput | no | yes |
GBG5_HUMAN | [view interactions] | High throughput | no | no |
RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
APOE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MCAT_HUMAN | [view interactions] | High throughput | no | yes |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ACOT9_HUMAN | [view interactions] | High throughput | no | yes |
PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SFXN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATPA_HUMAN | [view interactions] | High throughput | no | yes |
MPCP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
QCR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUA3_HUMAN | [view interactions] | High throughput | no | yes |
ATP5L_HUMAN | [view interactions] | High throughput | no | yes |
NDUA8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PREB_HUMAN | [view interactions] | High throughput | no | yes |
OCAD2_HUMAN | [view interactions] | High throughput | no | yes |
TOM6_HUMAN | [view interactions] | High throughput | no | yes |
VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LETM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RT23_HUMAN | [view interactions] | High throughput | no | yes |
ATPMK_HUMAN | [view interactions] | High throughput | no | no |
VDAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DHB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SPAT7_HUMAN | [view interactions] | High throughput | no | no |
VDAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AT2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PAK3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RL10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DPPA3_HUMAN | [view interactions] | High throughput | no | no |
MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DERL1_HUMAN | [view interactions] | High throughput | no | yes |
PANX1_HUMAN | [view interactions] | High throughput | no | no |
SIR4_HUMAN | [view interactions] | High throughput | no | yes |
KCNA5_HUMAN | [view interactions] | High throughput | no | no |
SL7A1_HUMAN | [view interactions] | High throughput | no | no |
MCLN3_HUMAN | [view interactions] | High throughput | no | no |
ZNRF4_HUMAN | [view interactions] | High throughput | no | no |
I20RA_HUMAN | [view interactions] | High throughput | no | no |
MFSD8_HUMAN | [view interactions] | High throughput | no | yes |
COQ9_HUMAN | [view interactions] | High throughput | no | yes |
SH2D3_HUMAN | [view interactions] | High throughput | no | no |
GATA3_HUMAN | [view interactions] | High throughput | no | no |
HSC20_HUMAN | [view interactions] | High throughput | no | yes |
TX101_HUMAN | [view interactions] | High throughput | no | no |
CNDD3_HUMAN | [view interactions] | High throughput | no | no |
UBQL4_HUMAN | [view interactions] | High throughput | no | yes |
UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
HIG1C_HUMAN | [view interactions] | High throughput | no | no |
TTC1_HUMAN | [view interactions] | High throughput | no | yes |
SGTB_HUMAN | [view interactions] | High throughput | no | yes |
SGTA_HUMAN | [view interactions] | High throughput | no | yes |
OSTB_HUMAN | [view interactions] | High throughput | no | no |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZACN_HUMAN | [view interactions] | High throughput | no | no |
NAAA_HUMAN | [view interactions] | High throughput | no | yes |
HECA2_HUMAN | [view interactions] | High throughput | no | no |
PCDG5_HUMAN | [view interactions] | High throughput | no | yes |
CC50A_HUMAN | [view interactions] | High throughput | no | yes |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
EMC1_HUMAN | [view interactions] | High throughput | no | yes |
EMC4_HUMAN | [view interactions] | High throughput | no | yes |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
ACHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PCDAB_HUMAN | [view interactions] | High throughput | no | no |
TTYH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NKAI1_HUMAN | [view interactions] | High throughput | no | no |
TTMP_HUMAN | [view interactions] | High throughput | no | no |
SCN4A_HUMAN | [view interactions] | High throughput | no | no |
5HT3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AQP3_HUMAN | [view interactions] | High throughput | no | no |
I22R1_HUMAN | [view interactions] | High throughput | no | no |
AT2A3_HUMAN | [view interactions] | High throughput | no | yes |
TSN15_HUMAN | [view interactions] | High throughput | no | yes |
PCDGL_HUMAN | [view interactions] | High throughput | no | no |
BTNL3_HUMAN | [view interactions] | High throughput | no | no |
ACHE_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
T106A_HUMAN | [view interactions] | High throughput | no | no |
2ABB_HUMAN | [view interactions] | High throughput | no | yes |
CA054_HUMAN | [view interactions] | High throughput | no | yes |
AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
KCNA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PCDGE_HUMAN | [view interactions] | High throughput | no | no |
LRC55_HUMAN | [view interactions] | High throughput | no | yes |
ACHA4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
S7A14_HUMAN | [view interactions] | High throughput | no | no |
ACHB4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
S22A4_HUMAN | [view interactions] | High throughput | no | yes |
CYB5_HUMAN | [view interactions] | Computational | no | no |
HBB_HUMAN | [view interactions] | Computational | no | no |