NB5R1_HUMAN
Evidence for PS localization
Functions
NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NB5R1_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 32.5581 | 4 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 32.5581 | 4 | no |
| GO:0043169 | cation binding | 32.5581 | 4 | no |
| GO:0043168 | anion binding | 30.2326 | 4 | yes |
| GO:0046872 | metal ion binding | 25.5814 | 5 | no |
| GO:0017076 | purine nucleotide binding | 25.5814 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 25.5814 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 23.2558 | 4 | no |
| GO:0005216 | monoatomic ion channel activity | 20.9302 | 4 | no |
| GO:0015267 | channel activity | 20.9302 | 4 | no |
| GO:0022836 | gated channel activity | 20.9302 | 5 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 20.9302 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NB5R1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 32.5581 | 4 | no |
| GO:0006996 | organelle organization | 27.9070 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 27.9070 | 4 | no |
| GO:0006811 | monoatomic ion transport | 25.5814 | 4 | no |
| GO:0051049 | regulation of transport | 25.5814 | 4 | no |
| GO:0022607 | cellular component assembly | 25.5814 | 4 | no |
| GO:0010646 | regulation of cell communication | 25.5814 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 25.5814 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 25.5814 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 25.5814 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 23.2558 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 23.2558 | 4 | no |
| GO:0010468 | regulation of gene expression | 23.2558 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 23.2558 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 23.2558 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 23.2558 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 23.2558 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 23.2558 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 23.2558 | 5 | no |
| GO:0071702 | organic substance transport | 20.9302 | 4 | yes |
| GO:0006812 | monoatomic cation transport | 20.9302 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 20.9302 | 4 | no |
| GO:0009966 | regulation of signal transduction | 20.9302 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 20.9302 | 5 | no |
| GO:1901362 | organic cyclic compound biosynthetic process | 9.3023 | 4 | yes |
| GO:0008202 | steroid metabolic process | 6.9767 | 4 | yes |
| GO:0015711 | organic anion transport | 6.9767 | 5 | yes |
| GO:0008610 | lipid biosynthetic process | 4.6512 | 4 | yes |
| GO:0016125 | sterol metabolic process | 4.6512 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SIR4_HUMAN | [view interactions] | High throughput | no | yes |
| KCNA5_HUMAN | [view interactions] | High throughput | no | no |
| CTR1_HUMAN | [view interactions] | High throughput | no | no |
| MCLN3_HUMAN | [view interactions] | High throughput | no | no |
| I20RA_HUMAN | [view interactions] | High throughput | no | no |
| ZNRF4_HUMAN | [view interactions] | High throughput | no | no |
| MFSD8_HUMAN | [view interactions] | High throughput | no | yes |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| SH2D3_HUMAN | [view interactions] | High throughput | no | no |
| GATA3_HUMAN | [view interactions] | High throughput | no | no |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| TX101_HUMAN | [view interactions] | High throughput | no | no |
| CNDD3_HUMAN | [view interactions] | High throughput | no | no |
| UBQL4_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
| HIG1C_HUMAN | [view interactions] | High throughput | no | no |
| TTC1_HUMAN | [view interactions] | High throughput | no | yes |
| SGTB_HUMAN | [view interactions] | High throughput | no | yes |
| SGTA_HUMAN | [view interactions] | High throughput | no | yes |
| OSTB_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZACN_HUMAN | [view interactions] | High throughput | no | no |
| NAAA_HUMAN | [view interactions] | High throughput | no | yes |
| HECA2_HUMAN | [view interactions] | High throughput | no | no |
| PCDG5_HUMAN | [view interactions] | High throughput | no | yes |
| CC50A_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| EMC4_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| ACHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PCDAB_HUMAN | [view interactions] | High throughput | no | no |
| TTYH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NKAI1_HUMAN | [view interactions] | High throughput | no | no |
| TTMP_HUMAN | [view interactions] | High throughput | no | no |
| SCN4A_HUMAN | [view interactions] | High throughput | no | no |
| 5HT3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AQP3_HUMAN | [view interactions] | High throughput | no | no |
| I22R1_HUMAN | [view interactions] | High throughput | no | no |
| AT2A3_HUMAN | [view interactions] | High throughput | no | yes |
| TSN15_HUMAN | [view interactions] | High throughput | no | yes |
| PCDGL_HUMAN | [view interactions] | High throughput | no | no |
| BTNL3_HUMAN | [view interactions] | High throughput | no | no |
| ACHE_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| T106A_HUMAN | [view interactions] | High throughput | no | no |
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| CA054_HUMAN | [view interactions] | High throughput | no | yes |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCNA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCDGE_HUMAN | [view interactions] | High throughput | no | no |
| LRC55_HUMAN | [view interactions] | High throughput | no | yes |
| ACHA4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S7A14_HUMAN | [view interactions] | High throughput | no | no |
| ACHB4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S22A4_HUMAN | [view interactions] | High throughput | no | yes |
| TCPQM_HUMAN | [view interactions] | High throughput | no | no |
| RXFP1_HUMAN | [view interactions] | High throughput | no | yes |
| LY66F_HUMAN | [view interactions] | High throughput | no | no |
| MARH4_HUMAN | [view interactions] | High throughput | no | yes |
| SG2A2_HUMAN | [view interactions] | High throughput | no | no |
| PGFRA_HUMAN | [view interactions] | High throughput | no | no |
| COPT1_HUMAN | [view interactions] | High throughput | no | no |
| CCG1_HUMAN | [view interactions] | High throughput | no | no |
| MAGA8_HUMAN | [view interactions] | High throughput | no | no |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| SSUH2_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPV17_HUMAN | [view interactions] | High throughput | no | no |
| CYB5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NB5R3_HUMAN | [view interactions] | High throughput | no | yes |
| ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADAS_HUMAN | [view interactions] | High throughput | no | yes |
| QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCPDL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MGST1_HUMAN | [view interactions] | High throughput | no | no |
| PRDX3_HUMAN | [view interactions] | High throughput | no | yes |
| ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPB_HUMAN | [view interactions] | High throughput | no | yes |
| GBG5_HUMAN | [view interactions] | High throughput | no | no |
| RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APOE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCAT_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACOT9_HUMAN | [view interactions] | High throughput | no | yes |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SFXN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| S25A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| QCR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA3_HUMAN | [view interactions] | High throughput | no | yes |
| ATP5L_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PREB_HUMAN | [view interactions] | High throughput | no | yes |
| OCAD2_HUMAN | [view interactions] | High throughput | no | yes |
| TOM6_HUMAN | [view interactions] | High throughput | no | yes |
| VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LETM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT23_HUMAN | [view interactions] | High throughput | no | yes |
| ATPMK_HUMAN | [view interactions] | High throughput | no | no |
| VDAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPAT7_HUMAN | [view interactions] | High throughput | no | no |
| VDAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAK3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPPA3_HUMAN | [view interactions] | High throughput | no | no |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| PANX1_HUMAN | [view interactions] | High throughput | no | no |
| MARH5_HUMAN | [view interactions] | High throughput | no | no |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |