Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

VATB2_HUMAN

Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons . V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed). In renal intercalated cells, can partially compensate the lack of ATP6V1B1 and mediate secretion of protons (H+) into the urine under base-line conditions but not in conditions of acid load . [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in VATB2_HUMAN
GO:0015399 primary active transmembrane transporter activity 23.2323 4 yes
GO:0017076 purine nucleotide binding 19.1919 4 yes
GO:0032555 purine ribonucleotide binding 19.1919 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 19.1919 4 yes
GO:0008324 cation transmembrane transporter activity 17.1717 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 16.1616 4 yes
GO:0015078 proton transmembrane transporter activity 14.1414 5 yes
GO:0022853 active ion transmembrane transporter activity 14.1414 4 yes
GO:0009678 pyrophosphate hydrolysis-driven proton transmembrane transporter activity 10.1010 5 yes
GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 10.1010 4 yes
GO:0046961 proton-transporting ATPase activity, rotational mechanism 10.1010 4 yes
GO:0005524 ATP binding 9.0909 5 yes
GO:0030554 adenyl nucleotide binding 9.0909 5 yes
GO:0032559 adenyl ribonucleotide binding 9.0909 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in VATB2_HUMAN
GO:0031323 regulation of cellular metabolic process 43.4343 4 yes
GO:0048522 positive regulation of cellular process 43.4343 4 no
GO:0022607 cellular component assembly 37.3737 4 no
GO:0008104 protein localization 34.3434 4 no
GO:0060255 regulation of macromolecule metabolic process 34.3434 4 no
GO:0006996 organelle organization 34.3434 4 no
GO:0051128 regulation of cellular component organization 33.3333 4 no
GO:0080090 regulation of primary metabolic process 32.3232 4 no
GO:0010646 regulation of cell communication 31.3131 4 no
GO:0048523 negative regulation of cellular process 30.3030 4 no
GO:0051171 regulation of nitrogen compound metabolic process 30.3030 4 no
GO:0071702 organic substance transport 28.2828 4 no
GO:0009893 positive regulation of metabolic process 27.2727 4 no
GO:0009894 regulation of catabolic process 25.2525 4 yes
GO:0071705 nitrogen compound transport 25.2525 4 no
GO:0051246 regulation of protein metabolic process 25.2525 5 no
GO:0009966 regulation of signal transduction 25.2525 4 no
GO:0051049 regulation of transport 24.2424 4 no
GO:0010604 positive regulation of macromolecule metabolic process 24.2424 5 no
GO:0031325 positive regulation of cellular metabolic process 22.2222 5 no
GO:0031329 regulation of cellular catabolic process 21.2121 5 yes
GO:0015031 protein transport 21.2121 4 no
GO:0016192 vesicle-mediated transport 21.2121 4 no
GO:0043933 protein-containing complex organization 21.2121 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 21.2121 5 no
GO:0065003 protein-containing complex assembly 20.2020 5 no
GO:0023056 positive regulation of signaling 20.2020 4 no
GO:0048584 positive regulation of response to stimulus 20.2020 4 no
GO:0010506 regulation of autophagy 17.1717 6 yes
GO:0006811 ion transport 17.1717 4 yes
GO:0006812 cation transport 15.1515 5 yes
GO:0016241 regulation of macroautophagy 14.1414 7 yes
GO:0098655 cation transmembrane transport 13.1313 4 yes
GO:0098660 inorganic ion transmembrane transport 12.1212 4 yes
GO:0098662 inorganic cation transmembrane transport 12.1212 5 yes
GO:1902600 proton transmembrane transport 10.1010 6 yes
GO:0006796 phosphate-containing compound metabolic process 8.0808 4 yes
GO:0006753 nucleoside phosphate metabolic process 5.0505 4 yes
GO:0009117 nucleotide metabolic process 5.0505 5 yes
GO:0019693 ribose phosphate metabolic process 4.0404 4 yes
GO:0009205 purine ribonucleoside triphosphate metabolic process 3.0303 7 yes
GO:0009259 ribonucleotide metabolic process 3.0303 5 yes
GO:0046034 ATP metabolic process 3.0303 7 yes
GO:0072521 purine-containing compound metabolic process 3.0303 4 yes
GO:0006163 purine nucleotide metabolic process 3.0303 5 yes
GO:0009141 nucleoside triphosphate metabolic process 3.0303 5 yes
GO:0009144 purine nucleoside triphosphate metabolic process 3.0303 6 yes
GO:0009150 purine ribonucleotide metabolic process 3.0303 6 yes
GO:0009199 ribonucleoside triphosphate metabolic process 3.0303 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in VATB2_HUMAN
DOID:331 central nervous system disease 3.0303 3 no
DOID:0050155 sensory system disease 2.0202 3 no
DOID:0050563 nonsyndromic deafness 2.0202 5 no
DOID:0050564 autosomal dominant nonsyndromic deafness 2.0202 6 no
DOID:2742 auditory system disease 2.0202 4 no
DOID:936 brain disease 2.0202 4 no
DOID:2355 anemia 2.0202 3 no
DOID:583 hemolytic anemia 2.0202 5 no
DOID:720 normocytic anemia 2.0202 4 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
VATB2_HUMAN [view entry] [view interactions] Low throughput yes yes
VATA_HUMAN [view entry] [view interactions] Low throughput yes yes
VATD_HUMAN [view entry] [view interactions] Low throughput yes yes
VATG2_HUMAN [view entry] [view interactions] Low throughput yes yes
VATE1_HUMAN [view entry] [view interactions] Low throughput yes yes
UBE2C_HUMAN [view interactions] High throughput no yes
SRXN1_HUMAN [view interactions] High throughput no no
UBQL1_HUMAN [view interactions] High throughput no yes
UBXN7_HUMAN [view interactions] High throughput no yes
ST1A1_HUMAN [view interactions] High throughput no no
UBP34_HUMAN [view interactions] High throughput no yes
PIMT_HUMAN [view entry] [view interactions] High throughput yes yes
SAHH2_HUMAN [view entry] [view interactions] High throughput yes yes
INT2_HUMAN [view interactions] High throughput no yes
RUVB1_HUMAN [view interactions] High throughput no yes
WDR5_HUMAN [view interactions] High throughput no no
TBB4B_HUMAN [view interactions] High throughput no yes
YIF1B_HUMAN [view interactions] High throughput no yes
PABP1_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
PIN1_HUMAN [view entry] [view interactions] High throughput yes yes
TBA1C_HUMAN [view interactions] High throughput no yes
UB2V1_HUMAN [view entry] [view interactions] High throughput yes no
ANCHR_HUMAN [view interactions] High throughput no yes
VIGLN_HUMAN [view entry] [view interactions] High throughput yes yes
TRM6_HUMAN [view interactions] High throughput no yes
ZYX_HUMAN [view interactions] High throughput no no
RPB2_HUMAN [view interactions] High throughput no yes
TCPQ_HUMAN [view entry] [view interactions] High throughput yes yes
ABCF3_HUMAN [view entry] [view interactions] High throughput yes yes
UFC1_HUMAN [view interactions] High throughput no yes
ZPR1_HUMAN [view interactions] High throughput no yes
SYEP_HUMAN [view interactions] High throughput no yes
SKP1_HUMAN [view interactions] High throughput no yes
RS5_HUMAN [view entry] [view interactions] High throughput yes yes
RPB1_HUMAN [view interactions] High throughput no no
ZBED1_HUMAN [view interactions] High throughput no yes
SAE2_HUMAN [view interactions] High throughput no yes
DPYL1_HUMAN [view entry] [view interactions] High throughput yes yes
PBDC1_HUMAN [view interactions] High throughput no no
MSH2_HUMAN [view interactions] High throughput no yes
PDE3A_HUMAN [view interactions] High throughput no no
SC24C_HUMAN [view entry] [view interactions] High throughput yes yes
SSRP1_HUMAN [view interactions] High throughput no yes
CUL2_HUMAN [view interactions] High throughput no yes
CSDE1_HUMAN [view interactions] High throughput no yes
GANAB_HUMAN [view interactions] High throughput no yes
GMPPB_HUMAN [view interactions] High throughput no yes
HYOU1_HUMAN [view interactions] High throughput no yes
PLAK_HUMAN [view entry] [view interactions] High throughput yes yes
MSH6_HUMAN [view interactions] High throughput no yes
SPT5H_HUMAN [view interactions] High throughput no yes
SWP70_HUMAN [view interactions] High throughput no no
XRCC6_HUMAN [view interactions] High throughput no yes
ATPG_HUMAN [view interactions] High throughput no yes
CPIN1_HUMAN [view interactions] High throughput no no
SNAA_HUMAN [view entry] [view interactions] High throughput yes yes
RPR1B_HUMAN [view interactions] High throughput no yes
STX16_HUMAN [view interactions] High throughput no yes
TMOD3_HUMAN [view interactions] High throughput no yes
XPO2_HUMAN [view entry] [view interactions] High throughput yes no
MCA3_HUMAN [view interactions] High throughput no yes
GCC1_HUMAN [view interactions] High throughput no yes
SYIC_HUMAN [view interactions] High throughput no yes
CNOT9_HUMAN [view interactions] High throughput no yes
TMOD2_HUMAN [view entry] [view interactions] High throughput yes yes
WDR61_HUMAN [view interactions] High throughput no yes
NCPR_HUMAN [view entry] [view interactions] High throughput yes yes
HMOX2_HUMAN [view entry] [view interactions] High throughput yes yes
NNTM_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS7_HUMAN [view entry] [view interactions] High throughput yes no
NDUS8_HUMAN [view interactions] High throughput no yes
NDUS3_HUMAN [view entry] [view interactions] High throughput yes yes
QCR2_HUMAN [view entry] [view interactions] High throughput yes yes
EMC8_HUMAN [view interactions] High throughput no no
ODBA_HUMAN [view interactions] High throughput no yes
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
QCR6_HUMAN [view interactions] High throughput no yes
NDUS1_HUMAN [view entry] [view interactions] High throughput yes no
EMC2_HUMAN [view interactions] High throughput no yes
ADAS_HUMAN [view interactions] High throughput no yes
NDUV1_HUMAN [view entry] [view interactions] High throughput yes yes
EF2_HUMAN [view entry] [view interactions] High throughput yes yes
CY1_HUMAN [view entry] [view interactions] High throughput yes yes
RCN2_HUMAN [view interactions] High throughput no yes
TPP1_HUMAN [view entry] [view interactions] High throughput yes yes
NDUB8_HUMAN [view entry] [view interactions] High throughput yes yes
NDUV2_HUMAN [view entry] [view interactions] High throughput yes yes
LACTB_HUMAN [view interactions] High throughput no yes
NDUA8_HUMAN [view entry] [view interactions] High throughput yes yes
PGES2_HUMAN [view interactions] High throughput no yes
AT2A2_HUMAN [view entry] [view interactions] High throughput yes yes
P4HA1_HUMAN [view interactions] High throughput no yes
SQOR_HUMAN [view interactions] High throughput no yes
QCR1_HUMAN [view entry] [view interactions] High throughput yes yes
CPT1A_HUMAN [view entry] [view interactions] High throughput yes yes
NB5R1_HUMAN [view entry] [view interactions] High throughput yes yes
NB5R3_HUMAN [view interactions] High throughput no yes
SFXN1_HUMAN [view entry] [view interactions] High throughput yes yes
NDUBA_HUMAN [view entry] [view interactions] High throughput yes yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
MTCH2_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA5_HUMAN [view entry] [view interactions] High throughput yes yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
CX6A1_HUMAN [view interactions] High throughput no yes
LTOR3_HUMAN [view interactions] High throughput no yes
RRAGA_HUMAN [view interactions] High throughput no yes
LEG9_HUMAN [view interactions] High throughput no yes
DNJC5_HUMAN [view interactions] High throughput no yes
RCAS1_HUMAN [view interactions] High throughput no yes
GOGA1_HUMAN [view interactions] High throughput no yes
GORS1_HUMAN [view interactions] High throughput no yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB3B_HUMAN [view interactions] High throughput no no
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
STX6_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
IFM1_HUMAN [view interactions] High throughput no no
IFM3_HUMAN [view interactions] High throughput no yes
ACE2_HUMAN [view interactions] High throughput no no
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
GLUT4_HUMAN [view interactions] High throughput no no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
RRAGC_HUMAN [view interactions] High throughput no yes
IFIX_HUMAN [view interactions] High throughput no no
BMR1A_HUMAN [view interactions] High throughput no no
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
CEP55_HUMAN [view interactions] High throughput no yes
RMD3_HUMAN [view interactions] High throughput no yes
FLOT2_HUMAN [view entry] [view interactions] High throughput yes yes
TFG_HUMAN [view interactions] High throughput no yes
CD2AP_HUMAN [view interactions] High throughput no no
RENR_HUMAN [view entry] [view interactions] High throughput yes yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
SPAST_HUMAN [view interactions] High throughput no yes
PTN23_HUMAN [view entry] [view interactions] High throughput yes yes
PP4P2_HUMAN [view interactions] High throughput no yes
TMED2_HUMAN [view interactions] High throughput no yes
VPS4B_HUMAN [view interactions] High throughput no yes
VAPA_HUMAN [view entry] [view interactions] High throughput yes yes
VPS28_HUMAN [view entry] [view interactions] High throughput yes yes
PTN1_HUMAN [view interactions] High throughput no yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
VATC2_HUMAN [view interactions] High throughput no yes
WBP11_HUMAN [view interactions] High throughput no yes
CSCL2_HUMAN [view interactions] High throughput no yes
GOT1B_HUMAN [view interactions] High throughput no yes
VPP2_HUMAN [view interactions] High throughput no yes
VATB1_HUMAN [view interactions] High throughput no no
TLDC2_HUMAN [view interactions] High throughput no no
S38A9_HUMAN [view interactions] High throughput no yes
LTOR2_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
EYA1_HUMAN [view interactions] High throughput no no
FINC_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
MED4_HUMAN [view interactions] High throughput no yes
PPT1_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
JUN_HUMAN [view interactions] High throughput no yes
INSR_HUMAN [view interactions] High throughput no yes
ITM2B_HUMAN [view interactions] High throughput no yes
ITF2_HUMAN [view interactions] High throughput no yes
GFAP_HUMAN [view entry] [view interactions] High throughput yes no
NFL_HUMAN [view entry] [view interactions] High throughput yes yes
WFS1_HUMAN [view entry] [view interactions] High throughput yes yes
RNF11_HUMAN [view interactions] High throughput no yes
JPH3_HUMAN [view interactions] High throughput no no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
ESR1_HUMAN [view interactions] High throughput no no
CSAG1_HUMAN [view interactions] High throughput no no
CSAG2_HUMAN [view interactions] High throughput no no
A2MG_HUMAN [view interactions] High throughput no yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
RAB9A_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view interactions] High throughput no yes
VATO_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
PAN2_HUMAN [view interactions] High throughput no no
MOV10_HUMAN [view interactions] High throughput no no
CCDC8_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
CCDC9_HUMAN [view interactions] High throughput no yes
OXDA_HUMAN [view interactions] High throughput no no
HDAC4_HUMAN [view interactions] High throughput no yes
TNIP2_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
VIR_HUMAN [view interactions] High throughput no yes
GLUC_HUMAN [view interactions] High throughput no no
TFE3_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
NUPR1_HUMAN [view interactions] High throughput no no
NPC1_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
DX39A_HUMAN [view interactions] High throughput no yes
DMXL1_HUMAN [view interactions] High throughput no yes
WDR7_HUMAN [view entry] [view interactions] High throughput yes no
TBC24_HUMAN [view entry] [view interactions] High throughput yes yes
VATC1_HUMAN [view entry] [view interactions] High throughput yes yes
NCOA7_HUMAN [view interactions] High throughput no yes
DMXL2_HUMAN [view entry] [view interactions] High throughput yes yes
VATF_HUMAN [view interactions] High throughput no yes
VATG1_HUMAN [view entry] [view interactions] High throughput yes yes
VATE2_HUMAN [view entry] [view interactions] High throughput yes no
G6PD_HUMAN [view entry] [view interactions] High throughput yes no
LRC57_HUMAN [view entry] [view interactions] High throughput yes yes
VATH_HUMAN [view entry] [view interactions] High throughput yes yes
VPP3_HUMAN [view interactions] High throughput no no
VPP1_HUMAN [view entry] [view interactions] High throughput yes yes
VPP4_HUMAN [view interactions] High throughput no no
VA0D2_HUMAN [view interactions] High throughput no no
TM192_HUMAN [view interactions] High throughput no yes
VAS1_HUMAN [view interactions] High throughput no yes
VA0D1_HUMAN [view entry] [view interactions] High throughput yes yes
NSA2_HUMAN [view interactions] High throughput no yes
VATL_HUMAN [view interactions] High throughput no no
ROGDI_HUMAN [view entry] [view interactions] High throughput yes yes
RAB14_HUMAN [view entry] [view interactions] High throughput yes yes
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
VAMP3_HUMAN [view entry] [view interactions] High throughput yes no
ATRX_HUMAN [view entry] [view interactions] High throughput yes yes
ATG7_HUMAN [view interactions] High throughput no yes
ATG10_HUMAN [view interactions] High throughput no yes
ATG3_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RIT1_HUMAN [view interactions] High throughput no yes
ATPB_HUMAN [view interactions] High throughput no yes
ATPA_HUMAN [view interactions] High throughput no yes
ZNRD2_HUMAN [view interactions] High throughput no yes
UNK_HUMAN [view interactions] High throughput no yes
SYDC_HUMAN [view interactions] High throughput no yes
UB2V2_HUMAN [view entry] [view interactions] High throughput yes no
TRM1_HUMAN [view interactions] High throughput no yes
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
CAST1_HUMAN [view interactions] Computational no yes
MIO_HUMAN [view interactions] Computational no yes
FLCN_HUMAN [view interactions] Computational no yes
SESN2_HUMAN [view interactions] Computational no no
ITFG2_HUMAN [view interactions] Computational no yes
VATG3_HUMAN [view interactions] Computational no no
NPRL2_HUMAN [view interactions] Computational no yes
SAMTR_HUMAN [view interactions] Computational no yes
VA0E2_HUMAN [view interactions] Computational no no
CAST2_HUMAN [view interactions] Computational no no
SH3B4_HUMAN [view interactions] Computational no yes
WDR59_HUMAN [view interactions] Computational no yes
VA0E1_HUMAN [view interactions] Computational no no
KPTN_HUMAN [view entry] [view interactions] Computational yes yes
FNIP1_HUMAN [view interactions] Computational no yes
FNIP2_HUMAN [view interactions] Computational no yes
SZT2_HUMAN [view interactions] Computational no yes
SESN1_HUMAN [view interactions] Computational no no
WDR24_HUMAN [view interactions] Computational no yes
SEC13_HUMAN [view entry] [view interactions] Computational yes yes
SEH1_HUMAN [view interactions] Computational no no