VATD_HUMAN
Evidence for PS localization
Functions
Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system . May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VATD_HUMAN |
|---|---|---|---|---|
| GO:0008324 | monoatomic cation transmembrane transporter activity | 29.2683 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 29.2683 | 4 | yes |
| GO:0015078 | proton transmembrane transporter activity | 26.8293 | 5 | yes |
| GO:0015399 | primary active transmembrane transporter activity | 26.8293 | 4 | yes |
| GO:0022853 | active monoatomic ion transmembrane transporter activity | 26.8293 | 4 | yes |
| GO:0044769 | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism | 26.8293 | 4 | yes |
| GO:0046961 | proton-transporting ATPase activity, rotational mechanism | 26.8293 | 4 | yes |
| GO:0043169 | cation binding | 21.9512 | 4 | no |
| GO:0046872 | metal ion binding | 21.9512 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VATD_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 63.4146 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 48.7805 | 4 | no |
| GO:0009894 | regulation of catabolic process | 43.9024 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 43.9024 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 43.9024 | 4 | no |
| GO:0009966 | regulation of signal transduction | 43.9024 | 4 | no |
| GO:0010646 | regulation of cell communication | 43.9024 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 41.4634 | 4 | no |
| GO:0008104 | protein localization | 39.0244 | 4 | yes |
| GO:0022607 | cellular component assembly | 39.0244 | 4 | yes |
| GO:0006996 | organelle organization | 36.5854 | 4 | yes |
| GO:0031329 | regulation of cellular catabolic process | 34.1463 | 5 | yes |
| GO:0080090 | regulation of primary metabolic process | 34.1463 | 4 | no |
| GO:0006811 | monoatomic ion transport | 31.7073 | 4 | yes |
| GO:0006812 | monoatomic cation transport | 31.7073 | 5 | yes |
| GO:0010506 | regulation of autophagy | 31.7073 | 6 | yes |
| GO:0009889 | regulation of biosynthetic process | 31.7073 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 31.7073 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 31.7073 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 31.7073 | 4 | no |
| GO:0098655 | monoatomic cation transmembrane transport | 29.2683 | 4 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 29.2683 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 29.2683 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 29.2683 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 29.2683 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 29.2683 | 5 | no |
| GO:0023056 | positive regulation of signaling | 29.2683 | 4 | no |
| GO:0006873 | intracellular monoatomic ion homeostasis | 26.8293 | 4 | yes |
| GO:0016241 | regulation of macroautophagy | 26.8293 | 7 | yes |
| GO:0030003 | intracellular monoatomic cation homeostasis | 26.8293 | 5 | yes |
| GO:0055080 | monoatomic cation homeostasis | 26.8293 | 4 | yes |
| GO:0097401 | synaptic vesicle lumen acidification | 26.8293 | 4 | yes |
| GO:1902600 | proton transmembrane transport | 26.8293 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 26.8293 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 26.8293 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.8293 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 26.8293 | 5 | no |
| GO:0030030 | cell projection organization | 24.3902 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 24.3902 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 24.3902 | 4 | no |
| GO:0031399 | regulation of protein modification process | 24.3902 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 24.3902 | 6 | no |
| GO:0071702 | organic substance transport | 24.3902 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 24.3902 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 24.3902 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 24.3902 | 4 | no |
| GO:0010468 | regulation of gene expression | 21.9512 | 6 | no |
| GO:0009891 | positive regulation of biosynthetic process | 21.9512 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 21.9512 | 5 | no |
| GO:0043933 | protein-containing complex organization | 21.9512 | 4 | no |
| GO:0071705 | nitrogen compound transport | 21.9512 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 21.9512 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 21.9512 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 21.9512 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.9512 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.9512 | 5 | no |
| GO:0007035 | vacuolar acidification | 17.0732 | 5 | yes |
| GO:0033365 | protein localization to organelle | 17.0732 | 5 | yes |
| GO:0051452 | intracellular pH reduction | 17.0732 | 4 | yes |
| GO:0070925 | organelle assembly | 14.6341 | 5 | yes |
| GO:0007042 | lysosomal lumen acidification | 12.1951 | 5 | yes |
| GO:0030031 | cell projection assembly | 12.1951 | 5 | yes |
| GO:0035751 | regulation of lysosomal lumen pH | 12.1951 | 4 | yes |
| GO:0048388 | endosomal lumen acidification | 12.1951 | 5 | yes |
| GO:0120031 | plasma membrane bounded cell projection assembly | 12.1951 | 6 | yes |
| GO:0044782 | cilium organization | 9.7561 | 5 | yes |
| GO:0060271 | cilium assembly | 9.7561 | 6 | yes |
| GO:0061795 | Golgi lumen acidification | 9.7561 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RRAGB_HUMAN | [view interactions] | Low throughput | no | yes |
| RENR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VATF_HUMAN | [view interactions] | Low throughput | no | yes |
| TOM34_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VATG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VATB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VATE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VPP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VATL_HUMAN | [view interactions] | Low throughput | no | no |
| VA0E2_HUMAN | [view interactions] | Low throughput | no | no |
| VAS1_HUMAN | [view interactions] | Low throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| PP2AA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH7_HUMAN | [view interactions] | High throughput | no | no |
| TMEDA_HUMAN | [view interactions] | High throughput | no | yes |
| PRS4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOT1B_HUMAN | [view interactions] | High throughput | no | yes |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| VA0D1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATC2_HUMAN | [view interactions] | High throughput | no | yes |
| DEF5_HUMAN | [view interactions] | High throughput | no | no |
| NDUAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COG6_HUMAN | [view interactions] | High throughput | no | yes |
| UBA5_HUMAN | [view interactions] | High throughput | no | yes |
| TNR8_HUMAN | [view interactions] | High throughput | no | no |
| ISK2_HUMAN | [view interactions] | High throughput | no | no |
| MRP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VPP2_HUMAN | [view interactions] | High throughput | no | yes |
| VATB1_HUMAN | [view interactions] | High throughput | no | no |
| TLDC2_HUMAN | [view interactions] | High throughput | no | no |
| PLM_HUMAN | [view interactions] | High throughput | no | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIMS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| VPS52_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| K1C27_HUMAN | [view interactions] | High throughput | no | no |
| BBLN_HUMAN | [view interactions] | High throughput | no | yes |
| HAUS1_HUMAN | [view interactions] | High throughput | no | yes |
| NDC80_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SMAD2_HUMAN | [view interactions] | High throughput | no | yes |
| NR2F6_HUMAN | [view interactions] | High throughput | no | no |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFE3_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| PKD2_HUMAN | [view interactions] | High throughput | no | yes |
| ADDA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| T10B_HUMAN | [view interactions] | High throughput | no | yes |
| VATE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBP13_HUMAN | [view interactions] | High throughput | no | yes |
| AN13D_HUMAN | [view interactions] | High throughput | no | yes |
| NOTC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIM29_HUMAN | [view interactions] | High throughput | no | no |
| TBC24_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AQR_HUMAN | [view interactions] | High throughput | no | no |
| VPP3_HUMAN | [view interactions] | High throughput | no | no |
| NCOA7_HUMAN | [view interactions] | High throughput | no | yes |
| VPP4_HUMAN | [view interactions] | High throughput | no | no |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| DAG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBL_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| ATG10_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPP1_HUMAN | [view interactions] | High throughput | no | yes |
| PTH2_HUMAN | [view interactions] | High throughput | no | yes |
| RS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM40_HUMAN | [view interactions] | High throughput | no | yes |
| SNX8_HUMAN | [view interactions] | High throughput | no | yes |
| DDX28_HUMAN | [view interactions] | High throughput | no | yes |
| MPV17_HUMAN | [view interactions] | High throughput | no | no |
| RS18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABCB7_HUMAN | [view interactions] | High throughput | no | yes |
| AIMP2_HUMAN | [view interactions] | High throughput | no | yes |
| CPIN1_HUMAN | [view interactions] | High throughput | no | no |
| COMD4_HUMAN | [view interactions] | High throughput | no | no |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RANG_HUMAN | [view interactions] | High throughput | no | no |
| COMD8_HUMAN | [view interactions] | High throughput | no | yes |
| CUL2_HUMAN | [view interactions] | High throughput | no | yes |
| MCMBP_HUMAN | [view interactions] | High throughput | no | yes |
| SC31A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARMD3_HUMAN | [view interactions] | High throughput | no | yes |
| ZN622_HUMAN | [view interactions] | High throughput | no | yes |
| PP14B_HUMAN | [view interactions] | High throughput | no | yes |
| PIN4_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| TP4A2_HUMAN | [view interactions] | High throughput | no | yes |