VATD_HUMAN
Evidence for PS localization
Functions
Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system . May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VATD_HUMAN |
|---|---|---|---|---|
| GO:0015399 | primary active transmembrane transporter activity | 31.4286 | 4 | yes |
| GO:0008324 | cation transmembrane transporter activity | 28.5714 | 4 | yes |
| GO:0015078 | proton transmembrane transporter activity | 28.5714 | 5 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 28.5714 | 4 | yes |
| GO:0009678 | pyrophosphate hydrolysis-driven proton transmembrane transporter activity | 25.7143 | 5 | yes |
| GO:0022853 | active ion transmembrane transporter activity | 25.7143 | 4 | yes |
| GO:0044769 | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism | 25.7143 | 4 | yes |
| GO:0046961 | proton-transporting ATPase activity, rotational mechanism | 25.7143 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VATD_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 60.0000 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 42.8571 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 42.8571 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 40.0000 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 40.0000 | 4 | no |
| GO:0008104 | protein localization | 37.1429 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 37.1429 | 4 | no |
| GO:0010646 | regulation of cell communication | 37.1429 | 4 | no |
| GO:0006996 | organelle organization | 34.2857 | 4 | yes |
| GO:0010506 | regulation of autophagy | 34.2857 | 6 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 34.2857 | 4 | no |
| GO:0016241 | regulation of macroautophagy | 31.4286 | 7 | yes |
| GO:0022607 | cellular component assembly | 31.4286 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 31.4286 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 31.4286 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 31.4286 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 28.5714 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 28.5714 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 28.5714 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.7143 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.7143 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.7143 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 22.8571 | 5 | no |
| GO:0031399 | regulation of protein modification process | 22.8571 | 6 | no |
| GO:0006811 | ion transport | 22.8571 | 4 | no |
| GO:0006812 | cation transport | 22.8571 | 5 | no |
| GO:0015031 | protein transport | 22.8571 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 22.8571 | 4 | no |
| GO:0071702 | organic substance transport | 22.8571 | 4 | no |
| GO:0071705 | nitrogen compound transport | 22.8571 | 4 | no |
| GO:0006873 | cellular ion homeostasis | 22.8571 | 4 | no |
| GO:0030003 | cellular cation homeostasis | 22.8571 | 5 | no |
| GO:0048878 | chemical homeostasis | 22.8571 | 4 | no |
| GO:0050801 | ion homeostasis | 22.8571 | 5 | no |
| GO:0055080 | cation homeostasis | 22.8571 | 6 | no |
| GO:0098771 | inorganic ion homeostasis | 22.8571 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 22.8571 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.8571 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.8571 | 4 | no |
| GO:0030030 | cell projection organization | 20.0000 | 4 | yes |
| GO:0033365 | protein localization to organelle | 20.0000 | 5 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 20.0000 | 5 | yes |
| GO:0070925 | organelle assembly | 14.2857 | 5 | yes |
| GO:0030031 | cell projection assembly | 11.4286 | 5 | yes |
| GO:0120031 | plasma membrane bounded cell projection assembly | 11.4286 | 6 | yes |
| GO:0044782 | cilium organization | 8.5714 | 5 | yes |
| GO:0060271 | cilium assembly | 8.5714 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| VA0E2_HUMAN | [view interactions] | Low throughput | no | no |
| VATL_HUMAN | [view interactions] | Low throughput | no | no |
| VAS1_HUMAN | [view interactions] | Low throughput | no | yes |
| RNK_HUMAN | [view interactions] | Low throughput | no | yes |
| RRAGB_HUMAN | [view interactions] | Low throughput | no | yes |
| VA0D1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RENR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VATA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VATF_HUMAN | [view interactions] | Low throughput | no | yes |
| VATO_HUMAN | [view interactions] | Low throughput | no | no |
| TOM34_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VATG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VATB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VATE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VPP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| PP2AA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH7_HUMAN | [view interactions] | High throughput | no | no |
| TMEDA_HUMAN | [view interactions] | High throughput | no | yes |
| PRS4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOT1B_HUMAN | [view interactions] | High throughput | no | yes |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| VATC2_HUMAN | [view interactions] | High throughput | no | yes |
| DEF5_HUMAN | [view interactions] | High throughput | no | no |
| NDUAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COG6_HUMAN | [view interactions] | High throughput | no | yes |
| UBA5_HUMAN | [view interactions] | High throughput | no | yes |
| TNR8_HUMAN | [view interactions] | High throughput | no | no |
| ISK2_HUMAN | [view interactions] | High throughput | no | no |
| VPP2_HUMAN | [view interactions] | High throughput | no | yes |
| MRP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VATB1_HUMAN | [view interactions] | High throughput | no | no |
| TLDC2_HUMAN | [view interactions] | High throughput | no | no |
| PLM_HUMAN | [view interactions] | High throughput | no | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VPS52_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| K1C27_HUMAN | [view interactions] | High throughput | no | no |
| BBLN_HUMAN | [view interactions] | High throughput | no | yes |
| HAUS1_HUMAN | [view interactions] | High throughput | no | yes |
| NDC80_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SMAD2_HUMAN | [view interactions] | High throughput | no | yes |
| NR2F6_HUMAN | [view interactions] | High throughput | no | no |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFE3_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| PKD2_HUMAN | [view interactions] | High throughput | no | yes |
| ADDA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| T10B_HUMAN | [view interactions] | High throughput | no | yes |
| VATE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBP13_HUMAN | [view interactions] | High throughput | no | yes |
| AN13D_HUMAN | [view interactions] | High throughput | no | yes |
| NOTC1_HUMAN | [view interactions] | High throughput | no | yes |
| TIM29_HUMAN | [view interactions] | High throughput | no | no |
| TBC24_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AQR_HUMAN | [view interactions] | High throughput | no | no |
| VPP3_HUMAN | [view interactions] | High throughput | no | no |
| NCOA7_HUMAN | [view interactions] | High throughput | no | yes |
| VPP4_HUMAN | [view interactions] | High throughput | no | no |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| DAG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| ATG10_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| XPP1_HUMAN | [view interactions] | High throughput | no | yes |
| PTH2_HUMAN | [view interactions] | High throughput | no | yes |
| RS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM40_HUMAN | [view interactions] | High throughput | no | yes |
| SNX8_HUMAN | [view interactions] | High throughput | no | yes |
| DDX28_HUMAN | [view interactions] | High throughput | no | yes |
| MPV17_HUMAN | [view interactions] | High throughput | no | no |
| RS18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABCB7_HUMAN | [view interactions] | High throughput | no | yes |
| AIMP2_HUMAN | [view interactions] | High throughput | no | yes |
| CPIN1_HUMAN | [view interactions] | High throughput | no | no |
| COMD4_HUMAN | [view interactions] | High throughput | no | no |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RANG_HUMAN | [view interactions] | High throughput | no | no |
| COMD8_HUMAN | [view interactions] | High throughput | no | yes |
| CUL2_HUMAN | [view interactions] | High throughput | no | yes |
| MCMBP_HUMAN | [view interactions] | High throughput | no | yes |
| SC31A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| ATPO_HUMAN | [view interactions] | Computational | no | yes |
| CAST1_HUMAN | [view interactions] | Computational | no | yes |
| ATPB_HUMAN | [view interactions] | Computational | no | yes |
| ATP8_HUMAN | [view interactions] | Computational | no | no |
| TM199_HUMAN | [view interactions] | Computational | no | yes |
| ATP5E_HUMAN | [view interactions] | Computational | no | no |
| CAST2_HUMAN | [view interactions] | Computational | no | no |
| ATPD_HUMAN | [view interactions] | Computational | no | yes |
| SH3B4_HUMAN | [view interactions] | Computational | no | yes |
| SAMTR_HUMAN | [view interactions] | Computational | no | yes |
| NPRL2_HUMAN | [view interactions] | Computational | no | yes |
| ITFG2_HUMAN | [view interactions] | Computational | no | yes |
| AT5G3_HUMAN | [view interactions] | Computational | no | no |
| VATG3_HUMAN | [view interactions] | Computational | no | no |
| FNIP1_HUMAN | [view interactions] | Computational | no | yes |
| AT5G1_HUMAN | [view interactions] | Computational | no | no |
| KPTN_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ATP5L_HUMAN | [view interactions] | Computational | no | yes |
| CC115_HUMAN | [view interactions] | Computational | no | no |
| ATP5I_HUMAN | [view interactions] | Computational | no | yes |
| WDR59_HUMAN | [view interactions] | Computational | no | yes |
| VA0E1_HUMAN | [view interactions] | Computational | no | no |
| SEH1_HUMAN | [view interactions] | Computational | no | no |
| ATPK_HUMAN | [view interactions] | Computational | no | yes |
| WDR24_HUMAN | [view interactions] | Computational | no | yes |
| AT5G2_HUMAN | [view interactions] | Computational | no | yes |
| ATPG_HUMAN | [view interactions] | Computational | no | yes |
| ATP5H_HUMAN | [view interactions] | Computational | no | yes |
| SEC13_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ATP5J_HUMAN | [view interactions] | Computational | no | yes |
| SZT2_HUMAN | [view interactions] | Computational | no | yes |
| AT5F1_HUMAN | [view interactions] | Computational | no | yes |
| SESN1_HUMAN | [view interactions] | Computational | no | no |
| FNIP2_HUMAN | [view interactions] | Computational | no | yes |
| ATP6_HUMAN | [view interactions] | Computational | no | no |
| FLCN_HUMAN | [view interactions] | Computational | no | yes |
| ATPA_HUMAN | [view interactions] | Computational | no | yes |
| VA0D2_HUMAN | [view interactions] | Computational | no | no |
| SESN2_HUMAN | [view interactions] | Computational | no | no |
| MIO_HUMAN | [view interactions] | Computational | no | yes |