VPS52_HUMAN
Evidence for PS localization
Functions
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed, PubMed). Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VPS52_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 31.1111 | 4 | no |
| GO:0017076 | purine nucleotide binding | 31.1111 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 31.1111 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 31.1111 | 4 | no |
| GO:0043168 | anion binding | 31.1111 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 24.4444 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 24.4444 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 24.4444 | 6 | no |
| GO:0043169 | cation binding | 22.2222 | 4 | no |
| GO:0046872 | metal ion binding | 22.2222 | 5 | no |
| GO:0019905 | syntaxin binding | 6.6667 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VPS52_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 42.2222 | 4 | no |
| GO:0008104 | protein localization | 42.2222 | 4 | yes |
| GO:0071702 | organic substance transport | 40.0000 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 40.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 37.7778 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 35.5556 | 4 | no |
| GO:0022607 | cellular component assembly | 35.5556 | 4 | no |
| GO:0071705 | nitrogen compound transport | 35.5556 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 31.1111 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 31.1111 | 4 | no |
| GO:0051049 | regulation of transport | 31.1111 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 28.8889 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 28.8889 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 28.8889 | 5 | no |
| GO:0010646 | regulation of cell communication | 28.8889 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 28.8889 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 28.8889 | 5 | no |
| GO:0015031 | protein transport | 28.8889 | 4 | no |
| GO:0010468 | regulation of gene expression | 26.6667 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 26.6667 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 26.6667 | 5 | no |
| GO:0009966 | regulation of signal transduction | 24.4444 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 24.4444 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 22.2222 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 22.2222 | 5 | no |
| GO:0098657 | import into cell | 22.2222 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.2222 | 4 | no |
| GO:0061024 | membrane organization | 22.2222 | 4 | no |
| GO:0007034 | vacuolar transport | 15.5556 | 4 | yes |
| GO:0032456 | endocytic recycling | 13.3333 | 4 | yes |
| GO:0007041 | lysosomal transport | 13.3333 | 5 | yes |
| GO:0015850 | organic hydroxy compound transport | 13.3333 | 5 | yes |
| GO:0006605 | protein targeting | 8.8889 | 4 | yes |
| GO:0016482 | cytosolic transport | 8.8889 | 4 | yes |
| GO:0032367 | intracellular cholesterol transport | 6.6667 | 6 | yes |
| GO:0042147 | retrograde transport, endosome to Golgi | 6.6667 | 4 | yes |
| GO:0006869 | lipid transport | 6.6667 | 5 | yes |
| GO:0006892 | post-Golgi vesicle-mediated transport | 6.6667 | 4 | yes |
| GO:0015918 | sterol transport | 6.6667 | 6 | yes |
| GO:0030301 | cholesterol transport | 6.6667 | 7 | yes |
| GO:0032365 | intracellular lipid transport | 6.6667 | 4 | yes |
| GO:0032366 | intracellular sterol transport | 6.6667 | 5 | yes |
| GO:0048565 | digestive tract development | 4.4444 | 4 | yes |
| GO:0048566 | embryonic digestive tract development | 4.4444 | 5 | yes |
| GO:0048568 | embryonic organ development | 4.4444 | 4 | yes |
| GO:0048611 | embryonic ectodermal digestive tract development | 4.4444 | 6 | yes |
| GO:0006896 | Golgi to vacuole transport | 4.4444 | 5 | yes |
| GO:0010668 | ectodermal cell differentiation | 4.4444 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| VPS53_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VPS54_HUMAN | [view interactions] | Low throughput | no | no |
| VPS52_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| STX6_HUMAN | [view interactions] | Low throughput | no | yes |
| VAMP4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VPS50_HUMAN | [view interactions] | Low throughput | no | yes |
| VPS51_HUMAN | [view interactions] | Low throughput | no | yes |
| RNF41_HUMAN | [view interactions] | Low throughput | no | yes |
| SCNM1_HUMAN | [view interactions] | High throughput | no | no |
| TAB2_HUMAN | [view interactions] | High throughput | no | yes |
| TXLNB_HUMAN | [view interactions] | High throughput | no | no |
| GEM_HUMAN | [view interactions] | High throughput | no | yes |
| CCD13_HUMAN | [view interactions] | High throughput | no | no |
| KLH42_HUMAN | [view interactions] | High throughput | no | yes |
| C19L2_HUMAN | [view interactions] | High throughput | no | yes |
| DJC11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CABP5_HUMAN | [view interactions] | High throughput | no | no |
| BYST_HUMAN | [view interactions] | High throughput | no | yes |
| ZN587_HUMAN | [view interactions] | High throughput | no | yes |
| AAMP_HUMAN | [view interactions] | High throughput | no | yes |
| CTDP1_HUMAN | [view interactions] | High throughput | no | yes |
| KINH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HEAT1_HUMAN | [view interactions] | High throughput | no | yes |
| SKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F184A_HUMAN | [view interactions] | High throughput | no | no |
| CCD33_HUMAN | [view interactions] | High throughput | no | no |
| RABE2_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| DCX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTG8_HUMAN | [view interactions] | High throughput | no | yes |
| ZC21C_HUMAN | [view interactions] | High throughput | no | yes |
| DTNB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KIFC3_HUMAN | [view interactions] | High throughput | no | no |
| CD20B_HUMAN | [view interactions] | High throughput | no | no |
| CCD57_HUMAN | [view interactions] | High throughput | no | yes |
| CCHCR_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C4BPB_HUMAN | [view interactions] | High throughput | no | no |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SLAF1_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| IKIP_HUMAN | [view interactions] | High throughput | no | no |
| CD79B_HUMAN | [view interactions] | High throughput | no | no |
| ZUP1_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| SMC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRD1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI66_HUMAN | [view interactions] | High throughput | no | no |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| NKG2D_HUMAN | [view interactions] | High throughput | no | no |
| RABE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FCERA_HUMAN | [view interactions] | High throughput | no | yes |
| ODAD1_HUMAN | [view interactions] | High throughput | no | no |
| CXCR4_HUMAN | [view interactions] | High throughput | no | no |
| VMAT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| THAP8_HUMAN | [view interactions] | High throughput | no | yes |
| AQP3_HUMAN | [view interactions] | High throughput | no | no |
| KXDL1_HUMAN | [view interactions] | High throughput | no | yes |
| EFNA4_HUMAN | [view interactions] | High throughput | no | no |
| INSY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CML1_HUMAN | [view interactions] | High throughput | no | yes |
| PSF2_HUMAN | [view interactions] | High throughput | no | no |
| GTR9_HUMAN | [view interactions] | High throughput | no | no |
| GPR17_HUMAN | [view interactions] | High throughput | no | no |
| CCD96_HUMAN | [view interactions] | High throughput | no | no |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| TMEM9_HUMAN | [view interactions] | High throughput | no | no |
| CLC2B_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| MYCN_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| TLS1_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| CL16A_HUMAN | [view interactions] | High throughput | no | yes |
| PTAR1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FITM2_HUMAN | [view interactions] | High throughput | no | no |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| SPPL3_HUMAN | [view interactions] | High throughput | no | no |
| VRK1_HUMAN | [view interactions] | High throughput | no | yes |
| PCID2_HUMAN | [view interactions] | High throughput | no | yes |
| SRP68_HUMAN | [view interactions] | High throughput | no | yes |
| TSG10_HUMAN | [view interactions] | High throughput | no | no |
| KS6A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KS6A2_HUMAN | [view interactions] | High throughput | no | yes |
| DBLOH_HUMAN | [view interactions] | High throughput | no | no |
| EXD2_HUMAN | [view interactions] | High throughput | no | yes |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| ARL10_HUMAN | [view interactions] | High throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| CAC1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VPS28_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| PRS8_HUMAN | [view interactions] | High throughput | no | yes |
| SACA1_HUMAN | [view interactions] | High throughput | no | no |
| CNGA3_HUMAN | [view interactions] | High throughput | no | no |
| EIPR1_HUMAN | [view interactions] | High throughput | no | yes |
| ENOPH_HUMAN | [view interactions] | High throughput | no | yes |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPM1G_HUMAN | [view interactions] | High throughput | no | no |
| STX11_HUMAN | [view interactions] | High throughput | no | yes |
| UBP2_HUMAN | [view interactions] | High throughput | no | yes |
| TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TXLNA_HUMAN | [view interactions] | High throughput | no | yes |
| NOP2_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK2_HUMAN | [view interactions] | High throughput | no | yes |
| MFAP1_HUMAN | [view interactions] | High throughput | no | yes |
| LMO4_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| FL2D_HUMAN | [view interactions] | High throughput | no | yes |
| IKBB_HUMAN | [view interactions] | High throughput | no | no |
| TSTD2_HUMAN | [view interactions] | High throughput | no | yes |
| KANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPR18_HUMAN | [view interactions] | High throughput | no | no |
| KLC3_HUMAN | [view interactions] | High throughput | no | no |
| EPMIP_HUMAN | [view interactions] | High throughput | no | no |
| EFNMT_HUMAN | [view interactions] | High throughput | no | yes |
| TEANC_HUMAN | [view interactions] | High throughput | no | no |
| GOGA1_HUMAN | [view interactions] | High throughput | no | yes |
| RRF2M_HUMAN | [view interactions] | High throughput | no | yes |
| HAUS1_HUMAN | [view interactions] | High throughput | no | yes |
| THA11_HUMAN | [view interactions] | High throughput | no | yes |
| ZMAT2_HUMAN | [view interactions] | High throughput | no | yes |
| TSSK3_HUMAN | [view interactions] | High throughput | no | no |
| THIOM_HUMAN | [view interactions] | High throughput | no | yes |
| SH24A_HUMAN | [view interactions] | High throughput | no | no |
| TB22B_HUMAN | [view interactions] | High throughput | no | no |
| AIRIM_HUMAN | [view interactions] | High throughput | no | yes |
| RM11_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARNT2_HUMAN | [view interactions] | High throughput | no | yes |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TEAD4_HUMAN | [view interactions] | High throughput | no | no |
| HGS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIMRE_HUMAN | [view interactions] | High throughput | no | no |
| JKIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SMCE1_HUMAN | [view interactions] | High throughput | no | yes |
| HXB5_HUMAN | [view interactions] | High throughput | no | no |
| GPKOW_HUMAN | [view interactions] | High throughput | no | yes |
| BORC6_HUMAN | [view interactions] | High throughput | no | yes |
| T11L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2CA_HUMAN | [view interactions] | High throughput | no | yes |
| WASC3_HUMAN | [view interactions] | High throughput | no | yes |
| RAB4B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRAF4_HUMAN | [view interactions] | High throughput | no | yes |
| TBCD1_HUMAN | [view interactions] | High throughput | no | no |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| OTU6A_HUMAN | [view interactions] | High throughput | no | no |
| ZN417_HUMAN | [view interactions] | High throughput | no | yes |
| CTSRT_HUMAN | [view interactions] | High throughput | no | no |
| PKN3_HUMAN | [view interactions] | High throughput | no | yes |
| CEP19_HUMAN | [view interactions] | High throughput | no | no |
| F110A_HUMAN | [view interactions] | High throughput | no | yes |
| RM01_HUMAN | [view interactions] | High throughput | no | yes |
| CC146_HUMAN | [view interactions] | High throughput | no | yes |
| CA216_HUMAN | [view interactions] | High throughput | no | yes |
| F161B_HUMAN | [view interactions] | High throughput | no | yes |
| CC185_HUMAN | [view interactions] | High throughput | no | no |
| VEZF1_HUMAN | [view interactions] | High throughput | no | yes |
| FA50B_HUMAN | [view interactions] | High throughput | no | yes |
| CF206_HUMAN | [view interactions] | High throughput | no | yes |
| F161A_HUMAN | [view interactions] | High throughput | no | no |
| GORS2_HUMAN | [view interactions] | High throughput | no | yes |
| NDC80_HUMAN | [view interactions] | High throughput | no | no |
| C102B_HUMAN | [view interactions] | High throughput | no | yes |
| KIF9_HUMAN | [view interactions] | High throughput | no | yes |