VPS52_HUMAN
Evidence for PS localization
Functions
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed, PubMed). Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VPS52_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 35.7143 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 35.7143 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 35.7143 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 30.9524 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 30.9524 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 30.9524 | 6 | no |
| GO:0003924 | GTPase activity | 23.8095 | 7 | no |
| GO:0005525 | GTP binding | 23.8095 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 23.8095 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 23.8095 | 5 | no |
| GO:0019905 | syntaxin binding | 4.7619 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VPS52_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 50.0000 | 4 | yes |
| GO:0071702 | organic substance transport | 45.2381 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 45.2381 | 4 | yes |
| GO:0015031 | protein transport | 42.8571 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 38.0952 | 4 | yes |
| GO:0006996 | organelle organization | 35.7143 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 35.7143 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 33.3333 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 33.3333 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | no |
| GO:0051049 | regulation of transport | 28.5714 | 4 | no |
| GO:0022607 | cellular component assembly | 28.5714 | 4 | no |
| GO:0006886 | intracellular protein transport | 26.1905 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 26.1905 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 23.8095 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 23.8095 | 5 | no |
| GO:0010468 | regulation of gene expression | 21.4286 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 21.4286 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 21.4286 | 5 | no |
| GO:0048193 | Golgi vesicle transport | 19.0476 | 5 | yes |
| GO:0016197 | endosomal transport | 19.0476 | 4 | yes |
| GO:0016482 | cytosolic transport | 14.2857 | 4 | yes |
| GO:0007034 | vacuolar transport | 14.2857 | 4 | yes |
| GO:0042147 | retrograde transport, endosome to Golgi | 11.9048 | 5 | yes |
| GO:0098876 | vesicle-mediated transport to the plasma membrane | 11.9048 | 4 | yes |
| GO:0007041 | lysosomal transport | 11.9048 | 5 | yes |
| GO:0032456 | endocytic recycling | 9.5238 | 5 | yes |
| GO:0006892 | post-Golgi vesicle-mediated transport | 7.1429 | 6 | yes |
| GO:0048565 | digestive tract development | 4.7619 | 4 | yes |
| GO:0048566 | embryonic digestive tract development | 4.7619 | 5 | yes |
| GO:0048568 | embryonic organ development | 4.7619 | 4 | yes |
| GO:0048611 | embryonic ectodermal digestive tract development | 4.7619 | 6 | yes |
| GO:0006896 | Golgi to vacuole transport | 4.7619 | 5 | yes |
| GO:0010668 | ectodermal cell differentiation | 4.7619 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| STX6_HUMAN | [view interactions] | Low throughput | no | yes |
| VAMP4_HUMAN | [view interactions] | Low throughput | no | yes |
| ARF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VPS50_HUMAN | [view interactions] | Low throughput | no | yes |
| VPS51_HUMAN | [view interactions] | Low throughput | no | yes |
| RNF41_HUMAN | [view interactions] | Low throughput | no | yes |
| VPS53_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VPS54_HUMAN | [view interactions] | Low throughput | no | no |
| VPS52_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RABE2_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| DCX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTG8_HUMAN | [view interactions] | High throughput | no | yes |
| ZC21C_HUMAN | [view interactions] | High throughput | no | yes |
| DTNB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KIFC3_HUMAN | [view interactions] | High throughput | no | no |
| CD20B_HUMAN | [view interactions] | High throughput | no | no |
| CCD57_HUMAN | [view interactions] | High throughput | no | yes |
| CCHCR_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C4BPB_HUMAN | [view interactions] | High throughput | no | no |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SLAF1_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| IKIP_HUMAN | [view interactions] | High throughput | no | no |
| CD79B_HUMAN | [view interactions] | High throughput | no | no |
| ZUP1_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| CTDP1_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| SMC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRD1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI66_HUMAN | [view interactions] | High throughput | no | yes |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| NKG2D_HUMAN | [view interactions] | High throughput | no | no |
| RABE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FCERA_HUMAN | [view interactions] | High throughput | no | yes |
| ODAD1_HUMAN | [view interactions] | High throughput | no | no |
| CXCR4_HUMAN | [view interactions] | High throughput | no | no |
| VMAT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| THAP8_HUMAN | [view interactions] | High throughput | no | yes |
| AQP3_HUMAN | [view interactions] | High throughput | no | no |
| KXDL1_HUMAN | [view interactions] | High throughput | no | yes |
| EFNA4_HUMAN | [view interactions] | High throughput | no | no |
| INSY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CML1_HUMAN | [view interactions] | High throughput | no | yes |
| PSF2_HUMAN | [view interactions] | High throughput | no | no |
| GTR9_HUMAN | [view interactions] | High throughput | no | no |
| GPR17_HUMAN | [view interactions] | High throughput | no | no |
| CCD96_HUMAN | [view interactions] | High throughput | no | no |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| TMEM9_HUMAN | [view interactions] | High throughput | no | no |
| CLC2B_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| PTAR1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FITM2_HUMAN | [view interactions] | High throughput | no | no |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| VRK1_HUMAN | [view interactions] | High throughput | no | yes |
| PCID2_HUMAN | [view interactions] | High throughput | no | yes |
| SRP68_HUMAN | [view interactions] | High throughput | no | yes |
| TSG10_HUMAN | [view interactions] | High throughput | no | no |
| KS6A1_HUMAN | [view interactions] | High throughput | no | yes |
| KS6A2_HUMAN | [view interactions] | High throughput | no | yes |
| DBLOH_HUMAN | [view interactions] | High throughput | no | no |
| EXD2_HUMAN | [view interactions] | High throughput | no | yes |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAC1A_HUMAN | [view interactions] | High throughput | no | no |
| VPS28_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| PRS8_HUMAN | [view interactions] | High throughput | no | yes |
| SACA1_HUMAN | [view interactions] | High throughput | no | no |
| CNGA3_HUMAN | [view interactions] | High throughput | no | no |
| EIPR1_HUMAN | [view interactions] | High throughput | no | yes |
| ENOPH_HUMAN | [view interactions] | High throughput | no | yes |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPM1G_HUMAN | [view interactions] | High throughput | no | no |
| STX11_HUMAN | [view interactions] | High throughput | no | yes |
| UBP2_HUMAN | [view interactions] | High throughput | no | yes |
| TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TXLNA_HUMAN | [view interactions] | High throughput | no | yes |
| NOP2_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK2_HUMAN | [view interactions] | High throughput | no | yes |
| MFAP1_HUMAN | [view interactions] | High throughput | no | yes |
| LMO4_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| FL2D_HUMAN | [view interactions] | High throughput | no | yes |
| IKBB_HUMAN | [view interactions] | High throughput | no | no |
| TSTD2_HUMAN | [view interactions] | High throughput | no | yes |
| KANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPR18_HUMAN | [view interactions] | High throughput | no | no |
| KLC3_HUMAN | [view interactions] | High throughput | no | no |
| EPMIP_HUMAN | [view interactions] | High throughput | no | no |
| EFNMT_HUMAN | [view interactions] | High throughput | no | yes |
| TEANC_HUMAN | [view interactions] | High throughput | no | no |
| GOGA1_HUMAN | [view interactions] | High throughput | no | yes |
| RRF2M_HUMAN | [view interactions] | High throughput | no | yes |
| HAUS1_HUMAN | [view interactions] | High throughput | no | yes |
| THA11_HUMAN | [view interactions] | High throughput | no | yes |
| ZMAT2_HUMAN | [view interactions] | High throughput | no | yes |
| TSSK3_HUMAN | [view interactions] | High throughput | no | no |
| THIOM_HUMAN | [view interactions] | High throughput | no | yes |
| SH24A_HUMAN | [view interactions] | High throughput | no | no |
| TB22B_HUMAN | [view interactions] | High throughput | no | no |
| CA109_HUMAN | [view interactions] | High throughput | no | yes |
| RM11_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF6_HUMAN | [view interactions] | High throughput | no | yes |
| VATD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARNT2_HUMAN | [view interactions] | High throughput | no | yes |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TEAD4_HUMAN | [view interactions] | High throughput | no | no |
| HGS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIMRE_HUMAN | [view interactions] | High throughput | no | no |
| JKIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HXB5_HUMAN | [view interactions] | High throughput | no | no |
| SMCE1_HUMAN | [view interactions] | High throughput | no | yes |
| GPKOW_HUMAN | [view interactions] | High throughput | no | yes |
| BORC6_HUMAN | [view interactions] | High throughput | no | yes |
| T11L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LNX1_HUMAN | [view interactions] | High throughput | no | yes |
| CDK18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2CA_HUMAN | [view interactions] | High throughput | no | yes |
| WASC3_HUMAN | [view interactions] | High throughput | no | yes |
| RAB4B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRAF4_HUMAN | [view interactions] | High throughput | no | yes |
| TBCD1_HUMAN | [view interactions] | High throughput | no | no |
| OTU6A_HUMAN | [view interactions] | High throughput | no | no |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| C2CD6_HUMAN | [view interactions] | High throughput | no | no |
| ZN417_HUMAN | [view interactions] | High throughput | no | yes |
| PKN3_HUMAN | [view interactions] | High throughput | no | yes |
| CEP19_HUMAN | [view interactions] | High throughput | no | no |
| F110A_HUMAN | [view interactions] | High throughput | no | yes |
| RM01_HUMAN | [view interactions] | High throughput | no | yes |
| CC146_HUMAN | [view interactions] | High throughput | no | yes |
| CA216_HUMAN | [view interactions] | High throughput | no | yes |
| F161B_HUMAN | [view interactions] | High throughput | no | yes |
| CC185_HUMAN | [view interactions] | High throughput | no | no |
| VEZF1_HUMAN | [view interactions] | High throughput | no | yes |
| FA50B_HUMAN | [view interactions] | High throughput | no | yes |
| CF206_HUMAN | [view interactions] | High throughput | no | yes |
| F161A_HUMAN | [view interactions] | High throughput | no | no |
| GORS2_HUMAN | [view interactions] | High throughput | no | yes |
| NDC80_HUMAN | [view interactions] | High throughput | no | no |
| C102B_HUMAN | [view interactions] | High throughput | no | yes |
| KIF9_HUMAN | [view interactions] | High throughput | no | yes |
| SCNM1_HUMAN | [view interactions] | High throughput | no | no |
| TAB2_HUMAN | [view interactions] | High throughput | no | yes |
| TXLNB_HUMAN | [view interactions] | High throughput | no | no |
| GEM_HUMAN | [view interactions] | High throughput | no | yes |
| CCD13_HUMAN | [view interactions] | High throughput | no | no |
| KLH42_HUMAN | [view interactions] | High throughput | no | yes |
| C19L2_HUMAN | [view interactions] | High throughput | no | yes |
| DJC11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CABP5_HUMAN | [view interactions] | High throughput | no | no |
| BYST_HUMAN | [view interactions] | High throughput | no | yes |
| ZN587_HUMAN | [view interactions] | High throughput | no | yes |
| AAMP_HUMAN | [view interactions] | High throughput | no | yes |
| KINH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HEAT1_HUMAN | [view interactions] | High throughput | no | yes |
| SKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F184A_HUMAN | [view interactions] | High throughput | no | no |
| CCD33_HUMAN | [view interactions] | High throughput | no | no |
| COG3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RS18_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| STX16_HUMAN | [view interactions] | Computational | no | yes |
| COG7_HUMAN | [view interactions] | Computational | no | yes |
| STX10_HUMAN | [view interactions] | Computational | no | yes |
| VTI1A_HUMAN | [view interactions] | Computational | no | yes |
| COG5_HUMAN | [view interactions] | Computational | no | yes |
| RAB6A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAB43_HUMAN | [view interactions] | Computational | no | yes |
| RGP1_HUMAN | [view interactions] | Computational | no | yes |
| COG8_HUMAN | [view interactions] | Computational | no | no |
| COG6_HUMAN | [view interactions] | Computational | no | yes |
| RAB6B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| COG1_HUMAN | [view interactions] | Computational | no | yes |
| SOAT2_HUMAN | [view interactions] | Computational | no | no |