Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RAB1B_HUMAN

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed, PubMed). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (PubMed). Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments . Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment . [View more on UniProt]

Interacting region for partners were not defined.

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in RAB1B_HUMAN
GO:0000166 nucleotide binding 39.8148 4 yes
GO:0017076 purine nucleotide binding 39.8148 5 yes
GO:0032555 purine ribonucleotide binding 37.9630 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 37.9630 4 yes
GO:0043168 anion binding 37.9630 4 yes
GO:0016462 pyrophosphatase activity 30.5556 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 30.5556 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 30.5556 6 yes
GO:0019001 guanyl nucleotide binding 25.9259 6 yes
GO:0032561 guanyl ribonucleotide binding 25.9259 5 yes
GO:0003924 GTPase activity 25.0000 7 yes
GO:0005525 GTP binding 25.0000 5 yes
GO:0043169 cation binding 24.0741 4 no
GO:0046872 metal ion binding 23.1481 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in RAB1B_HUMAN
GO:0008104 protein localization 58.3333 4 yes
GO:0071702 organic substance transport 49.0741 4 yes
GO:0071705 nitrogen compound transport 46.2963 4 yes
GO:0006996 organelle organization 44.4444 4 yes
GO:0015031 protein transport 43.5185 4 yes
GO:0048522 positive regulation of cellular process 43.5185 4 no
GO:0048523 negative regulation of cellular process 36.1111 4 no
GO:0051128 regulation of cellular component organization 34.2593 4 yes
GO:0051049 regulation of transport 33.3333 4 no
GO:0060255 regulation of macromolecule metabolic process 32.4074 4 yes
GO:0009893 positive regulation of metabolic process 31.4815 4 yes
GO:0031323 regulation of cellular metabolic process 31.4815 4 no
GO:0022607 cellular component assembly 29.6296 4 yes
GO:0080090 regulation of primary metabolic process 29.6296 4 yes
GO:0010646 regulation of cell communication 29.6296 4 no
GO:0010604 positive regulation of macromolecule metabolic process 28.7037 5 yes
GO:0006886 intracellular protein transport 27.7778 4 yes
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0009966 regulation of signal transduction 25.0000 4 no
GO:0051246 regulation of protein metabolic process 23.1481 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 23.1481 5 no
GO:0051247 positive regulation of protein metabolic process 22.2222 6 yes
GO:0009892 negative regulation of metabolic process 22.2222 4 no
GO:0031325 positive regulation of cellular metabolic process 22.2222 5 no
GO:0048584 positive regulation of response to stimulus 22.2222 4 no
GO:1902531 regulation of intracellular signal transduction 22.2222 5 no
GO:0010468 regulation of gene expression 22.2222 6 no
GO:0033365 protein localization to organelle 22.2222 5 no
GO:0033043 regulation of organelle organization 21.2963 5 yes
GO:0036211 protein modification process 21.2963 4 no
GO:0043412 macromolecule modification 21.2963 4 no
GO:0072657 protein localization to membrane 21.2963 4 no
GO:0060341 regulation of cellular localization 21.2963 4 no
GO:0044087 regulation of cellular component biogenesis 20.3704 4 yes
GO:0023056 positive regulation of signaling 20.3704 4 no
GO:0060627 regulation of vesicle-mediated transport 20.3704 4 no
GO:0061024 membrane organization 20.3704 4 no
GO:0032880 regulation of protein localization 20.3704 5 no
GO:0070925 organelle assembly 14.8148 5 yes
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 10.1852 4 yes
GO:0007033 vacuole organization 9.2593 5 yes
GO:0007030 Golgi organization 7.4074 5 yes
GO:0000045 autophagosome assembly 6.4815 6 yes
GO:1902115 regulation of organelle assembly 6.4815 5 yes
GO:1905037 autophagosome organization 6.4815 6 yes
GO:0044088 regulation of vacuole organization 2.7778 6 yes
GO:1903018 regulation of glycoprotein metabolic process 2.7778 6 yes
GO:1903020 positive regulation of glycoprotein metabolic process 2.7778 7 yes
GO:2000785 regulation of autophagosome assembly 2.7778 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MICA1_HUMAN [view interactions] Low throughput no yes
GOGA2_HUMAN [view entry] [view interactions] Low throughput yes yes
PITC1_HUMAN [view interactions] Low throughput no yes
RAE1_HUMAN [view interactions] Low throughput no yes
GDIA_HUMAN [view entry] [view interactions] Low throughput yes yes
OCRL_HUMAN [view interactions] Low throughput no yes
TBC20_HUMAN [view interactions] Low throughput no yes
MICA2_HUMAN [view interactions] Low throughput no yes
RUSC2_HUMAN [view interactions] Low throughput no yes
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
SMRC2_HUMAN [view interactions] High throughput no yes
TM40L_HUMAN [view entry] [view interactions] High throughput yes yes
FAKD3_HUMAN [view interactions] High throughput no yes
SHCBP_HUMAN [view interactions] High throughput no no
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
PTPA_HUMAN [view interactions] High throughput no yes
RAB13_HUMAN [view entry] [view interactions] High throughput yes yes
RAB10_HUMAN [view entry] [view interactions] High throughput yes yes
S12A5_HUMAN [view entry] [view interactions] High throughput yes yes
ST32C_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
ASAP2_HUMAN [view interactions] High throughput no yes
CNOT7_HUMAN [view interactions] High throughput no no
RAB3C_HUMAN [view entry] [view interactions] High throughput yes yes
RB39B_HUMAN [view interactions] High throughput no no
ESR1_HUMAN [view interactions] High throughput no no
RAB8A_HUMAN [view entry] [view interactions] High throughput yes no
TOM22_HUMAN [view interactions] High throughput no yes
PSA1_HUMAN [view interactions] High throughput no yes
RAB9A_HUMAN [view interactions] High throughput no yes
LTK_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
UBL4A_HUMAN [view entry] [view interactions] High throughput yes yes
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
EED_HUMAN [view interactions] High throughput no yes
5MP1_HUMAN [view interactions] High throughput no no
RB33B_HUMAN [view interactions] High throughput no no
GDS1_HUMAN [view entry] [view interactions] High throughput yes yes
ACL6A_HUMAN [view interactions] High throughput no yes
RNF26_HUMAN [view interactions] High throughput no yes
CDC73_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
AAR2_HUMAN [view interactions] High throughput no no
CHD3_HUMAN [view interactions] High throughput no yes
UB2R1_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
HEXI1_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
PKHA2_HUMAN [view interactions] High throughput no no
UCHL3_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
BAG6_HUMAN [view entry] [view interactions] High throughput yes yes
ANO7_HUMAN [view interactions] High throughput no no
TIF1B_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
PINK1_HUMAN [view interactions] High throughput no yes
EMC2_HUMAN [view interactions] High throughput no yes
I5P2_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
KIF14_HUMAN [view interactions] High throughput no no
PRC1_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
CUL4A_HUMAN [view interactions] High throughput no no
APR_HUMAN [view interactions] High throughput no yes
WDR5_HUMAN [view interactions] High throughput no no
LDAF1_HUMAN [view interactions] High throughput no yes
RBM14_HUMAN [view interactions] High throughput no yes
VP13C_HUMAN [view interactions] High throughput no yes
TBB1_HUMAN [view interactions] High throughput no yes
SYT6_HUMAN [view entry] [view interactions] High throughput yes no
BASI_HUMAN [view entry] [view interactions] High throughput yes no
CLC4D_HUMAN [view interactions] High throughput no no
ACE2_HUMAN [view interactions] High throughput no no
TMPS4_HUMAN [view interactions] High throughput no yes
BAG1_HUMAN [view interactions] High throughput no yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
GORS2_HUMAN [view interactions] High throughput no yes
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
MIF_HUMAN [view entry] [view interactions] High throughput yes yes
TOM40_HUMAN [view interactions] High throughput no yes
PRAF1_HUMAN [view interactions] High throughput no yes
NSF_HUMAN [view entry] [view interactions] High throughput yes yes
VDAC1_HUMAN [view entry] [view interactions] High throughput yes yes
COG2_HUMAN [view interactions] High throughput no no
ZNT6_HUMAN [view interactions] High throughput no yes
TMED7_HUMAN [view interactions] High throughput no yes
PANK4_HUMAN [view interactions] High throughput no no
SCFD1_HUMAN [view entry] [view interactions] High throughput yes yes
GOGA5_HUMAN [view interactions] High throughput no yes
COG3_HUMAN [view entry] [view interactions] High throughput yes yes
ERGI1_HUMAN [view interactions] High throughput no yes
VPP2_HUMAN [view interactions] High throughput no yes
TOM20_HUMAN [view entry] [view interactions] High throughput yes yes
RAB14_HUMAN [view entry] [view interactions] High throughput yes yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
YIF1B_HUMAN [view interactions] High throughput no yes
SFT2C_HUMAN [view interactions] High throughput no no
RB11B_HUMAN [view entry] [view interactions] High throughput yes no
VAMP3_HUMAN [view entry] [view interactions] High throughput yes no
TM9S3_HUMAN [view interactions] High throughput no yes
RTN4_HUMAN [view entry] [view interactions] High throughput yes yes
SCAM1_HUMAN [view interactions] High throughput no no
SC61B_HUMAN [view interactions] High throughput no yes
TMED2_HUMAN [view interactions] High throughput no yes
YIPF5_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC6_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
VIGLN_HUMAN [view entry] [view interactions] High throughput yes yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
PRRT2_HUMAN [view entry] [view interactions] High throughput yes no
TRAF6_HUMAN [view entry] [view interactions] High throughput yes yes
EZH2_HUMAN [view interactions] High throughput no no
CL16A_HUMAN [view interactions] High throughput no yes
GOLI_HUMAN [view interactions] High throughput no yes
RN149_HUMAN [view interactions] High throughput no no
B3GN2_HUMAN [view interactions] High throughput no yes
TNIP1_HUMAN [view interactions] High throughput no yes
RAB18_HUMAN [view entry] [view interactions] High throughput yes yes
VPS52_HUMAN [view entry] [view interactions] High throughput yes no
TPC12_HUMAN [view interactions] High throughput no yes
RIC1_HUMAN [view interactions] High throughput no no
COG7_HUMAN [view interactions] High throughput no yes
TPC13_HUMAN [view interactions] High throughput no yes
VPS54_HUMAN [view interactions] High throughput no no
ARFG2_HUMAN [view entry] [view interactions] High throughput yes yes
ARF1_HUMAN [view entry] [view interactions] High throughput yes yes
ZNT5_HUMAN [view interactions] High throughput no yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
ARL5A_HUMAN [view interactions] High throughput no yes
NCOR1_HUMAN [view interactions] High throughput no yes
MA1A1_HUMAN [view interactions] High throughput no yes
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
UBC12_HUMAN [view entry] [view interactions] High throughput yes yes
FUT8_HUMAN [view interactions] High throughput no yes
IF2B1_HUMAN [view interactions] High throughput no no
TBL1R_HUMAN [view interactions] High throughput no yes
HMDH_HUMAN [view interactions] High throughput no yes
S23IP_HUMAN [view interactions] High throughput no yes
S39A9_HUMAN [view interactions] High throughput no yes
CHRC1_HUMAN [view interactions] High throughput no no
HDAC8_HUMAN [view interactions] High throughput no yes
TPC11_HUMAN [view interactions] High throughput no no
CUL5_HUMAN [view entry] [view interactions] High throughput yes yes
EP300_HUMAN [view interactions] High throughput no yes
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
ARI2_HUMAN [view interactions] High throughput no no
MA1B1_HUMAN [view interactions] High throughput no yes
MOGS_HUMAN [view interactions] High throughput no yes
SC23B_HUMAN [view interactions] High throughput no yes
HNRPD_HUMAN [view entry] [view interactions] High throughput yes yes
BAZ1A_HUMAN [view interactions] High throughput no no
NPRL2_HUMAN [view interactions] High throughput no yes
VPS53_HUMAN [view entry] [view interactions] High throughput yes yes
VPS45_HUMAN [view entry] [view interactions] High throughput yes yes
SC31A_HUMAN [view entry] [view interactions] High throughput yes yes
TPC2A_HUMAN [view interactions] High throughput no yes
SAR1A_HUMAN [view entry] [view interactions] High throughput yes yes
S39A3_HUMAN [view interactions] High throughput no yes
TPC2L_HUMAN [view interactions] High throughput no yes
VPS51_HUMAN [view interactions] High throughput no yes
TPPC5_HUMAN [view interactions] High throughput no yes
SC24C_HUMAN [view entry] [view interactions] High throughput yes yes
ATG12_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
FND3B_HUMAN [view interactions] High throughput no no
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
LSM2_HUMAN [view interactions] High throughput no yes
RINI_HUMAN [view interactions] High throughput no yes
AT1A1_HUMAN [view entry] [view interactions] High throughput yes no
AT1A3_HUMAN [view entry] [view interactions] High throughput yes no
CCD47_HUMAN [view interactions] High throughput no yes
CY1_HUMAN [view entry] [view interactions] High throughput yes yes
DRS7B_HUMAN [view entry] [view interactions] High throughput yes yes
DNJA3_HUMAN [view entry] [view interactions] High throughput yes yes
ETFA_HUMAN [view interactions] High throughput no yes
KDSR_HUMAN [view interactions] High throughput no yes
LDHA_HUMAN [view entry] [view interactions] High throughput yes yes
LDHB_HUMAN [view entry] [view interactions] High throughput yes yes
LDHC_HUMAN [view interactions] High throughput no no
COX2_HUMAN [view entry] [view interactions] High throughput yes yes
PDCD6_HUMAN [view interactions] High throughput no no
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
AHSA1_HUMAN [view entry] [view interactions] High throughput yes yes
AT1B1_HUMAN [view entry] [view interactions] High throughput yes no
AT1B3_HUMAN [view interactions] High throughput no yes
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
DUT_HUMAN [view interactions] High throughput no yes
DHB12_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS8_HUMAN [view interactions] High throughput no yes
PLIN3_HUMAN [view interactions] High throughput no yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5B_HUMAN [view entry] [view interactions] High throughput yes yes
RAP2C_HUMAN [view entry] [view interactions] High throughput yes no
SSRP1_HUMAN [view interactions] High throughput no yes
TECR_HUMAN [view interactions] High throughput no yes
TMCO1_HUMAN [view interactions] High throughput no yes
QCR2_HUMAN [view entry] [view interactions] High throughput yes yes
QCR8_HUMAN [view interactions] High throughput no yes
RAB6A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB6B_HUMAN [view entry] [view interactions] High throughput yes yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
RDH13_HUMAN [view interactions] High throughput no no
RPN1_HUMAN [view entry] [view interactions] High throughput yes yes
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
STX12_HUMAN [view entry] [view interactions] High throughput yes yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
VAPA_HUMAN [view entry] [view interactions] High throughput yes yes
PEPD_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
DESP_HUMAN [view entry] [view interactions] High throughput yes no
CNDP2_HUMAN [view entry] [view interactions] High throughput yes yes
DC1L1_HUMAN [view entry] [view interactions] High throughput yes yes
OPTN_HUMAN [view interactions] High throughput no yes
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP2_HUMAN [view interactions] High throughput no yes
GLUT4_HUMAN [view interactions] High throughput no no
LAMP3_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB2B_HUMAN [view interactions] High throughput no no
TMPS2_HUMAN [view interactions] High throughput no no
FURIN_HUMAN [view interactions] High throughput no yes
RAE2_HUMAN [view interactions] High throughput no yes
IFM3_HUMAN [view interactions] High throughput no yes
CLC4E_HUMAN [view interactions] High throughput no no
MSS4_HUMAN [view interactions] High throughput no yes
NBR1_HUMAN [view interactions] High throughput no yes
GDIB_HUMAN [view entry] [view interactions] High throughput yes yes
LNP_HUMAN [view interactions] High throughput no yes
PGTA_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
RAB8B_HUMAN [view entry] [view interactions] High throughput yes no
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
CNPY3_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
PPM1H_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
CAV2_HUMAN [view interactions] High throughput no no
RFA2_HUMAN [view interactions] High throughput no yes
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
RFA3_HUMAN [view interactions] High throughput no yes
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
MOT11_HUMAN [view interactions] High throughput no no
NPC1_HUMAN [view interactions] High throughput no yes
ODO2_HUMAN [view entry] [view interactions] High throughput yes yes
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
SPTCS_HUMAN [view interactions] High throughput no yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
TYRO3_HUMAN [view interactions] High throughput no yes
VHL_HUMAN [view entry] [view interactions] High throughput yes yes
CRCM_HUMAN [view interactions] High throughput no no
HLAB_HUMAN [view interactions] High throughput no yes
CD177_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
RYBP_HUMAN [view interactions] High throughput no no
CNDD3_HUMAN [view interactions] High throughput no no