CNDP2_HUMAN
Evidence for PS localization
Functions
Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly (PubMed). Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation (PubMed). Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells (PubMed). Catalyzes the production of N-lactoyl-amino acids from lactate and amino acids by reverse proteolysis (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CNDP2_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 18.1818 | 4 | yes |
| GO:0008235 | metalloexopeptidase activity | 9.0909 | 5 | yes |
| GO:0008237 | metallopeptidase activity | 9.0909 | 4 | yes |
| GO:0008238 | exopeptidase activity | 9.0909 | 4 | yes |
| GO:0004180 | carboxypeptidase activity | 6.0606 | 5 | yes |
| GO:0016805 | dipeptidase activity | 6.0606 | 5 | yes |
| GO:0070573 | metallodipeptidase activity | 6.0606 | 6 | yes |
| GO:0103046 | alanylglutamate dipeptidase activity | 6.0606 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CNDP2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 42.4242 | 4 | no |
| GO:1901565 | organonitrogen compound catabolic process | 33.3333 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 30.3030 | 4 | no |
| GO:0010646 | regulation of cell communication | 30.3030 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 30.3030 | 5 | no |
| GO:0043436 | oxoacid metabolic process | 30.3030 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 27.2727 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 27.2727 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 27.2727 | 4 | no |
| GO:1901566 | organonitrogen compound biosynthetic process | 27.2727 | 4 | no |
| GO:0006508 | proteolysis | 24.2424 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 24.2424 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 21.2121 | 4 | no |
| GO:0051049 | regulation of transport | 21.2121 | 4 | no |
| GO:0009966 | regulation of signal transduction | 21.2121 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 21.2121 | 5 | no |
| GO:0023056 | positive regulation of signaling | 21.2121 | 4 | no |
| GO:0009063 | cellular amino acid catabolic process | 21.2121 | 4 | no |
| GO:0016054 | organic acid catabolic process | 21.2121 | 4 | no |
| GO:0046395 | carboxylic acid catabolic process | 21.2121 | 5 | no |
| GO:0036211 | protein modification process | 21.2121 | 4 | no |
| GO:0043412 | macromolecule modification | 21.2121 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CNDP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MP2K4_HUMAN | [view interactions] | High throughput | no | yes |
| PHAG1_HUMAN | [view interactions] | High throughput | no | yes |
| NDRG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| ZDH17_HUMAN | [view interactions] | High throughput | no | yes |
| STAT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAPP1_HUMAN | [view interactions] | High throughput | no | yes |
| CRK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| CNDP1_HUMAN | [view interactions] | High throughput | no | yes |
| LRC36_HUMAN | [view interactions] | High throughput | no | no |
| CH034_HUMAN | [view interactions] | High throughput | no | no |
| NSUN2_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| TRIP4_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
| GA2L2_HUMAN | [view interactions] | High throughput | no | no |
| LAGE3_HUMAN | [view interactions] | High throughput | no | yes |
| RAB8B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGO2_HUMAN | [view interactions] | High throughput | no | yes |
| NUMA1_HUMAN | [view interactions] | High throughput | no | yes |
| ITA2B_HUMAN | [view interactions] | High throughput | no | no |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARC1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASSY_HUMAN | [view interactions] | High throughput | no | yes |
| CAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CASP7_HUMAN | [view interactions] | High throughput | no | no |
| KCRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| XPO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| FTO_HUMAN | [view interactions] | High throughput | no | yes |
| GNS_HUMAN | [view interactions] | High throughput | no | yes |
| GSHR_HUMAN | [view interactions] | High throughput | no | yes |
| KYNU_HUMAN | [view interactions] | High throughput | no | no |
| LDHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDIA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RLA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P4R3B_HUMAN | [view interactions] | High throughput | no | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G6PD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBP2_HUMAN | [view interactions] | High throughput | no | yes |
| PSF2_HUMAN | [view interactions] | High throughput | no | no |
| AGAL_HUMAN | [view interactions] | High throughput | no | yes |
| MVD1_HUMAN | [view interactions] | High throughput | no | yes |
| SIAS_HUMAN | [view interactions] | High throughput | no | yes |
| PEPD_HUMAN | [view interactions] | High throughput | no | yes |
| RL23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KS6A1_HUMAN | [view interactions] | High throughput | no | yes |
| SCLY_HUMAN | [view interactions] | High throughput | no | yes |
| NHRF1_HUMAN | [view interactions] | High throughput | no | no |
| TGM2_HUMAN | [view interactions] | High throughput | no | no |
| UBFD1_HUMAN | [view interactions] | High throughput | no | no |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSTO2_HUMAN | [view interactions] | High throughput | no | no |
| HDHD1_HUMAN | [view interactions] | High throughput | no | yes |
| PLSL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GDPP1_HUMAN | [view interactions] | High throughput | no | yes |
| NMRL1_HUMAN | [view interactions] | High throughput | no | yes |
| CYTB_HUMAN | [view interactions] | High throughput | no | no |
| RINI_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
| ANC2_HUMAN | [view interactions] | High throughput | no | no |
| BUP1_HUMAN | [view interactions] | Computational | no | no |
| AL3B1_HUMAN | [view interactions] | Computational | no | yes |
| HUTH_HUMAN | [view interactions] | Computational | no | yes |
| AL3B2_HUMAN | [view interactions] | Computational | no | yes |
| PRDX6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GABT_HUMAN | [view interactions] | Computational | no | yes |
| CRNS1_HUMAN | [view interactions] | Computational | no | no |
| GLSK_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GSH0_HUMAN | [view interactions] | Computational | no | yes |
| AL3A2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AACS_HUMAN | [view interactions] | Computational | no | yes |
| DHE4_HUMAN | [view interactions] | Computational | no | yes |
| DHE3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GGT5_HUMAN | [view interactions] | Computational | no | yes |
| CARME_HUMAN | [view interactions] | Computational | no | yes |
| AL3A1_HUMAN | [view interactions] | Computational | no | no |
| DCE1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GLNA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GATM_HUMAN | [view interactions] | Computational | no | no |
| AL9A1_HUMAN | [view interactions] | Computational | no | yes |
| DCHS_HUMAN | [view interactions] | Computational | no | yes |
| GLSL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AL7A1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GRP75_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GADL1_HUMAN | [view interactions] | Computational | no | no |
| ALDH2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| AL1B1_HUMAN | [view interactions] | Computational | no | yes |
| DCE2_HUMAN | [view interactions] | Computational | no | yes |
| AL4A1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |