CNDP2_HUMAN
Evidence for PS localization
Functions
Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly (PubMed). Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation (PubMed). Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells (PubMed). Catalyzes the production of N-lactoyl-amino acids from lactate and amino acids by reverse proteolysis (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CNDP2_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 37.2549 | 4 | no |
| GO:0000166 | nucleotide binding | 31.3725 | 4 | no |
| GO:0017076 | purine nucleotide binding | 29.4118 | 5 | no |
| GO:0043168 | anion binding | 27.4510 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 23.5294 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 23.5294 | 4 | no |
| GO:0043169 | cation binding | 17.6471 | 4 | yes |
| GO:0046872 | metal ion binding | 17.6471 | 5 | yes |
| GO:0008235 | metalloexopeptidase activity | 5.8824 | 5 | yes |
| GO:0008237 | metallopeptidase activity | 5.8824 | 4 | yes |
| GO:0008238 | exopeptidase activity | 5.8824 | 4 | yes |
| GO:0004180 | carboxypeptidase activity | 3.9216 | 5 | yes |
| GO:0016805 | dipeptidase activity | 3.9216 | 5 | yes |
| GO:0070573 | metallodipeptidase activity | 3.9216 | 6 | yes |
| GO:0103046 | alanylglutamate dipeptidase activity | 3.9216 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CNDP2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 58.8235 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 50.9804 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 50.9804 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 47.0588 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 45.0980 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 41.1765 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 41.1765 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 39.2157 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 39.2157 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 37.2549 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 37.2549 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 37.2549 | 4 | no |
| GO:0008104 | protein localization | 37.2549 | 4 | no |
| GO:0010468 | regulation of gene expression | 35.2941 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 35.2941 | 5 | no |
| GO:0071702 | organic substance transport | 35.2941 | 4 | no |
| GO:0071705 | nitrogen compound transport | 35.2941 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 33.3333 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 33.3333 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0006996 | organelle organization | 33.3333 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 31.3725 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 31.3725 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 31.3725 | 5 | no |
| GO:0015031 | protein transport | 31.3725 | 4 | no |
| GO:0010646 | regulation of cell communication | 29.4118 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 29.4118 | 5 | no |
| GO:0009894 | regulation of catabolic process | 29.4118 | 4 | no |
| GO:0022607 | cellular component assembly | 29.4118 | 4 | no |
| GO:0009966 | regulation of signal transduction | 27.4510 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 27.4510 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 27.4510 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 27.4510 | 6 | no |
| GO:0043933 | protein-containing complex organization | 27.4510 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 25.4902 | 7 | no |
| GO:0032880 | regulation of protein localization | 25.4902 | 5 | no |
| GO:0060341 | regulation of cellular localization | 25.4902 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 23.5294 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 23.5294 | 4 | no |
| GO:0006886 | intracellular protein transport | 23.5294 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.5294 | 6 | no |
| GO:0030162 | regulation of proteolysis | 21.5686 | 6 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 21.5686 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 21.5686 | 6 | no |
| GO:0010629 | negative regulation of gene expression | 21.5686 | 7 | no |
| GO:0010647 | positive regulation of cell communication | 21.5686 | 5 | no |
| GO:0023056 | positive regulation of signaling | 21.5686 | 4 | no |
| GO:0071310 | cellular response to organic substance | 21.5686 | 4 | no |
| GO:0006508 | proteolysis | 19.6078 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CNDP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| FTO_HUMAN | [view interactions] | High throughput | no | yes |
| GNS_HUMAN | [view interactions] | High throughput | no | yes |
| GSHR_HUMAN | [view interactions] | High throughput | no | yes |
| KYNU_HUMAN | [view interactions] | High throughput | no | no |
| LDHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDIA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RLA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P4R3B_HUMAN | [view interactions] | High throughput | no | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G6PD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBP2_HUMAN | [view interactions] | High throughput | no | yes |
| PSF2_HUMAN | [view interactions] | High throughput | no | no |
| AGAL_HUMAN | [view interactions] | High throughput | no | yes |
| MVD1_HUMAN | [view interactions] | High throughput | no | yes |
| SIAS_HUMAN | [view interactions] | High throughput | no | yes |
| PEPD_HUMAN | [view interactions] | High throughput | no | yes |
| RL23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KS6A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCLY_HUMAN | [view interactions] | High throughput | no | yes |
| NHRF1_HUMAN | [view interactions] | High throughput | no | no |
| TGM2_HUMAN | [view interactions] | High throughput | no | no |
| UBFD1_HUMAN | [view interactions] | High throughput | no | no |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSTO2_HUMAN | [view interactions] | High throughput | no | no |
| HDHD1_HUMAN | [view interactions] | High throughput | no | yes |
| PLSL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GDPP1_HUMAN | [view interactions] | High throughput | no | yes |
| NMRL1_HUMAN | [view interactions] | High throughput | no | yes |
| CYTB_HUMAN | [view interactions] | High throughput | no | no |
| RINI_HUMAN | [view interactions] | High throughput | no | yes |
| SHOT1_HUMAN | [view interactions] | High throughput | no | no |
| IPO5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAPS1_HUMAN | [view interactions] | High throughput | no | yes |
| E41L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSDE1_HUMAN | [view interactions] | High throughput | no | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1C18_HUMAN | [view interactions] | High throughput | no | no |
| PDIA1_HUMAN | [view interactions] | High throughput | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PABP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPR_HUMAN | [view interactions] | High throughput | no | yes |
| EF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| PSA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYVC_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| COPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SERPH_HUMAN | [view interactions] | High throughput | no | no |
| HDGF_HUMAN | [view interactions] | High throughput | no | yes |
| ROA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAZA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COPZ1_HUMAN | [view interactions] | High throughput | no | no |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| IF5A1_HUMAN | [view interactions] | High throughput | no | yes |
| TCPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLOD1_HUMAN | [view interactions] | High throughput | no | yes |
| ILF3_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| SF3B2_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
| PCBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STXB2_HUMAN | [view interactions] | High throughput | no | no |
| CCDC6_HUMAN | [view interactions] | High throughput | no | yes |
| DDB1_HUMAN | [view interactions] | High throughput | no | yes |
| UBR7_HUMAN | [view interactions] | High throughput | no | yes |
| GEMI5_HUMAN | [view interactions] | High throughput | no | yes |
| RENT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCAL4_HUMAN | [view interactions] | High throughput | no | no |
| PAWR_HUMAN | [view interactions] | High throughput | no | yes |
| RAB1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUCKS_HUMAN | [view interactions] | High throughput | no | yes |
| VTA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
| ANC2_HUMAN | [view interactions] | High throughput | no | no |
| CNTP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| RAB25_HUMAN | [view interactions] | High throughput | no | no |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| SIM43_HUMAN | [view interactions] | High throughput | no | no |
| MP2K4_HUMAN | [view interactions] | High throughput | no | yes |
| PHAG1_HUMAN | [view interactions] | High throughput | no | yes |
| NDRG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| ZDH17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAPP1_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| CRK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| CNDP1_HUMAN | [view interactions] | High throughput | no | yes |
| LRC36_HUMAN | [view interactions] | High throughput | no | no |
| CH034_HUMAN | [view interactions] | High throughput | no | no |
| NSUN2_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| TRIP4_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
| GA2L2_HUMAN | [view interactions] | High throughput | no | no |
| LAGE3_HUMAN | [view interactions] | High throughput | no | yes |
| RAB8B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUMA1_HUMAN | [view interactions] | High throughput | no | yes |
| PLD6_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITA2B_HUMAN | [view interactions] | High throughput | no | no |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARC1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASSY_HUMAN | [view interactions] | High throughput | no | yes |
| CAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CASP7_HUMAN | [view interactions] | High throughput | no | no |
| KCRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| XPO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |