VTA1_HUMAN
Evidence for PS localization
Functions
Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR . Involved in HIV-1 budding. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VTA1_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 37.5000 | 4 | no |
| GO:0043168 | anion binding | 35.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 32.5000 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 32.5000 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 30.0000 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 30.0000 | 5 | no |
| GO:0043169 | cation binding | 27.5000 | 4 | no |
| GO:0046872 | metal ion binding | 27.5000 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.5000 | 4 | no |
| GO:0005524 | ATP binding | 25.0000 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VTA1_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 45.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 45.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 40.0000 | 4 | yes |
| GO:0006508 | proteolysis | 40.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 40.0000 | 4 | no |
| GO:0006996 | organelle organization | 37.5000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 37.5000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 37.5000 | 4 | no |
| GO:0043933 | protein-containing complex organization | 35.0000 | 4 | yes |
| GO:0009057 | macromolecule catabolic process | 35.0000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 35.0000 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 35.0000 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 35.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 35.0000 | 5 | no |
| GO:0008104 | protein localization | 32.5000 | 4 | yes |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 32.5000 | 7 | no |
| GO:0019941 | modification-dependent protein catabolic process | 32.5000 | 6 | no |
| GO:0043632 | modification-dependent macromolecule catabolic process | 32.5000 | 5 | no |
| GO:0051603 | proteolysis involved in protein catabolic process | 32.5000 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 32.5000 | 4 | no |
| GO:0009894 | regulation of catabolic process | 30.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 30.0000 | 6 | no |
| GO:0071702 | organic substance transport | 27.5000 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 27.5000 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 27.5000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 27.5000 | 5 | no |
| GO:0051049 | regulation of transport | 27.5000 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.0000 | 6 | no |
| GO:0010646 | regulation of cell communication | 25.0000 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.0000 | 6 | no |
| GO:0015031 | protein transport | 22.5000 | 4 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 22.5000 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 22.5000 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 22.5000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 22.5000 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.5000 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.5000 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 22.5000 | 5 | no |
| GO:0033043 | regulation of organelle organization | 22.5000 | 5 | no |
| GO:0022411 | cellular component disassembly | 17.5000 | 4 | yes |
| GO:0007034 | vacuolar transport | 15.0000 | 4 | yes |
| GO:0016236 | macroautophagy | 15.0000 | 4 | yes |
| GO:0032984 | protein-containing complex disassembly | 15.0000 | 5 | yes |
| GO:0070925 | organelle assembly | 15.0000 | 5 | yes |
| GO:0007032 | endosome organization | 12.5000 | 6 | yes |
| GO:0016050 | vesicle organization | 12.5000 | 5 | yes |
| GO:0032509 | endosome transport via multivesicular body sorting pathway | 12.5000 | 4 | yes |
| GO:0036257 | multivesicular body organization | 12.5000 | 7 | yes |
| GO:0036258 | multivesicular body assembly | 12.5000 | 6 | yes |
| GO:1904896 | ESCRT complex disassembly | 10.0000 | 6 | yes |
| GO:1904903 | ESCRT III complex disassembly | 10.0000 | 7 | yes |
| GO:0032511 | late endosome to vacuole transport via multivesicular body sorting pathway | 5.0000 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CHMP5_HUMAN | [view interactions] | Low throughput | no | yes |
| VPS4B_HUMAN | [view interactions] | Low throughput | no | yes |
| VPS4A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CHM2A_HUMAN | [view interactions] | Low throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | Low throughput | no | yes |
| CHM1B_HUMAN | [view interactions] | Low throughput | no | yes |
| CHMP3_HUMAN | [view interactions] | Low throughput | no | yes |
| IST1_HUMAN | [view interactions] | Low throughput | no | yes |
| GSK3A_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BEX3_HUMAN | [view interactions] | High throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| FSD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TEAD4_HUMAN | [view interactions] | High throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| E2F1_HUMAN | [view interactions] | High throughput | no | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| TBCK_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| CHM1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCNC_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT16_HUMAN | [view interactions] | High throughput | no | yes |
| CBS_HUMAN | [view interactions] | High throughput | no | yes |
| NBR1_HUMAN | [view interactions] | High throughput | no | yes |
| PRAF1_HUMAN | [view interactions] | High throughput | no | yes |
| MAGAB_HUMAN | [view interactions] | High throughput | no | no |
| BACD1_HUMAN | [view interactions] | High throughput | no | no |
| RPIA_HUMAN | [view interactions] | High throughput | no | yes |
| MBIP1_HUMAN | [view interactions] | High throughput | no | yes |
| KLH12_HUMAN | [view interactions] | High throughput | no | no |
| ZNRD2_HUMAN | [view interactions] | High throughput | no | yes |
| DPPA2_HUMAN | [view interactions] | High throughput | no | no |
| CDK4_HUMAN | [view interactions] | High throughput | no | no |
| ERBB3_HUMAN | [view interactions] | High throughput | no | yes |
| SWAP1_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| NECA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYST_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| MERL_HUMAN | [view interactions] | High throughput | no | yes |
| STMN4_HUMAN | [view interactions] | High throughput | no | no |
| SPAST_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| LZTR1_HUMAN | [view interactions] | High throughput | no | no |
| CGAS_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| ANCHR_HUMAN | [view interactions] | High throughput | no | yes |
| DIAP3_HUMAN | [view interactions] | High throughput | no | no |
| FNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| FLCN_HUMAN | [view interactions] | High throughput | no | yes |
| CPXCR_HUMAN | [view interactions] | High throughput | no | no |
| FNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| SYT6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SERB1_HUMAN | [view interactions] | High throughput | no | yes |
| CHM2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD003_HUMAN | [view interactions] | High throughput | no | yes |
| ZN215_HUMAN | [view interactions] | High throughput | no | no |
| CHM4A_HUMAN | [view interactions] | High throughput | no | no |
| DERL2_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FOXA1_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPP1_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN1_HUMAN | [view interactions] | High throughput | no | no |
| VATC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAOX_HUMAN | [view interactions] | High throughput | no | yes |
| SYDC_HUMAN | [view interactions] | High throughput | no | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSD11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD3_HUMAN | [view interactions] | High throughput | no | yes |
| JIP4_HUMAN | [view interactions] | High throughput | no | yes |
| ANM3_HUMAN | [view interactions] | High throughput | no | yes |
| SMC2_HUMAN | [view interactions] | High throughput | no | yes |
| RPA1_HUMAN | [view interactions] | High throughput | no | yes |
| XRCC5_HUMAN | [view interactions] | High throughput | no | yes |
| KAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRS6A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ML12A_HUMAN | [view interactions] | High throughput | no | no |
| TGM2_HUMAN | [view interactions] | High throughput | no | no |
| PSA3_HUMAN | [view interactions] | High throughput | no | no |
| PYR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MCM7_HUMAN | [view interactions] | High throughput | no | no |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRS7_HUMAN | [view interactions] | High throughput | no | yes |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRS6B_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| PRS4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRS8_HUMAN | [view interactions] | High throughput | no | yes |
| SMD2_HUMAN | [view interactions] | High throughput | no | yes |
| PRS10_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABA_HUMAN | [view interactions] | High throughput | no | yes |
| XPC_HUMAN | [view interactions] | High throughput | no | yes |
| ACACA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SF3B2_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| MCM6_HUMAN | [view interactions] | High throughput | no | yes |
| SMC1A_HUMAN | [view interactions] | High throughput | no | yes |
| GAPD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CND1_HUMAN | [view interactions] | High throughput | no | yes |
| ADRM1_HUMAN | [view interactions] | High throughput | no | yes |
| PP6R3_HUMAN | [view interactions] | High throughput | no | yes |
| HS105_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNDP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRPK1_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CND3_HUMAN | [view interactions] | High throughput | no | yes |
| PHF23_HUMAN | [view interactions] | High throughput | no | yes |
| NADAP_HUMAN | [view interactions] | High throughput | no | yes |
| BRD8_HUMAN | [view interactions] | High throughput | no | yes |
| GOPC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMC4_HUMAN | [view interactions] | High throughput | no | yes |
| MBD2_HUMAN | [view interactions] | High throughput | no | yes |
| RCOR1_HUMAN | [view interactions] | High throughput | no | yes |
| PSD13_HUMAN | [view interactions] | High throughput | no | yes |
| NS1BP_HUMAN | [view interactions] | High throughput | no | yes |
| MIRO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |