VTA1_HUMAN
Evidence for PS localization
Functions
Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR . Involved in HIV-1 budding. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VTA1_HUMAN |
|---|---|---|---|---|
| GO:0031625 | ubiquitin protein ligase binding | 30.4348 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 30.4348 | 4 | no |
| GO:0042803 | protein homodimerization activity | 26.0870 | 4 | no |
| GO:0046872 | metal ion binding | 21.7391 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VTA1_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 52.1739 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 52.1739 | 4 | yes |
| GO:0006508 | proteolysis | 52.1739 | 4 | no |
| GO:0008104 | protein localization | 47.8261 | 4 | yes |
| GO:0022607 | cellular component assembly | 47.8261 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 47.8261 | 4 | yes |
| GO:0009057 | macromolecule catabolic process | 47.8261 | 4 | no |
| GO:0019941 | modification-dependent protein catabolic process | 47.8261 | 6 | no |
| GO:0043632 | modification-dependent macromolecule catabolic process | 47.8261 | 5 | no |
| GO:0044265 | cellular macromolecule catabolic process | 47.8261 | 4 | no |
| GO:0051603 | proteolysis involved in protein catabolic process | 47.8261 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 47.8261 | 4 | no |
| GO:0015031 | protein transport | 43.4783 | 4 | yes |
| GO:0071702 | organic substance transport | 43.4783 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 43.4783 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 43.4783 | 5 | no |
| GO:0036211 | protein modification process | 39.1304 | 4 | no |
| GO:0043412 | macromolecule modification | 39.1304 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 39.1304 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 39.1304 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 39.1304 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 39.1304 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 39.1304 | 4 | no |
| GO:0009894 | regulation of catabolic process | 39.1304 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 39.1304 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 34.7826 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 34.7826 | 5 | no |
| GO:0007032 | endosome organization | 30.4348 | 6 | yes |
| GO:0007034 | vacuolar transport | 30.4348 | 4 | yes |
| GO:0016050 | vesicle organization | 30.4348 | 5 | yes |
| GO:0022411 | cellular component disassembly | 30.4348 | 4 | yes |
| GO:0032984 | protein-containing complex disassembly | 30.4348 | 5 | yes |
| GO:0036257 | multivesicular body organization | 30.4348 | 7 | yes |
| GO:0036258 | multivesicular body assembly | 30.4348 | 6 | yes |
| GO:0070925 | organelle assembly | 30.4348 | 5 | yes |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 30.4348 | 7 | no |
| GO:0009892 | negative regulation of metabolic process | 30.4348 | 4 | no |
| GO:0010941 | regulation of cell death | 30.4348 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 30.4348 | 6 | no |
| GO:0051726 | regulation of cell cycle | 30.4348 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 30.4348 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 30.4348 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.4348 | 5 | no |
| GO:0031399 | regulation of protein modification process | 30.4348 | 6 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 30.4348 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.4348 | 6 | no |
| GO:0051049 | regulation of transport | 30.4348 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 30.4348 | 4 | no |
| GO:0016197 | endosomal transport | 26.0870 | 4 | yes |
| GO:0016236 | macroautophagy | 26.0870 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 26.0870 | 4 | no |
| GO:0010468 | regulation of gene expression | 26.0870 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 26.0870 | 5 | no |
| GO:0010564 | regulation of cell cycle process | 26.0870 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.0870 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.0870 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 26.0870 | 5 | no |
| GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | 26.0870 | 8 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 26.0870 | 5 | no |
| GO:0060548 | negative regulation of cell death | 26.0870 | 5 | no |
| GO:0061024 | membrane organization | 26.0870 | 4 | no |
| GO:0006886 | intracellular protein transport | 26.0870 | 4 | no |
| GO:0009966 | regulation of signal transduction | 26.0870 | 4 | no |
| GO:0010646 | regulation of cell communication | 26.0870 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 26.0870 | 5 | no |
| GO:0060341 | regulation of cellular localization | 26.0870 | 4 | no |
| GO:0032509 | endosome transport via multivesicular body sorting pathway | 21.7391 | 5 | yes |
| GO:0045324 | late endosome to vacuole transport | 21.7391 | 5 | yes |
| GO:0071985 | multivesicular body sorting pathway | 21.7391 | 5 | yes |
| GO:0016567 | protein ubiquitination | 21.7391 | 7 | no |
| GO:0032446 | protein modification by small protein conjugation | 21.7391 | 6 | no |
| GO:0070647 | protein modification by small protein conjugation or removal | 21.7391 | 5 | no |
| GO:0007041 | lysosomal transport | 21.7391 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.7391 | 5 | no |
| GO:0032886 | regulation of microtubule-based process | 21.7391 | 4 | no |
| GO:0035891 | exit from host cell | 21.7391 | 5 | no |
| GO:0044000 | movement in host | 21.7391 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 21.7391 | 5 | no |
| GO:0070507 | regulation of microtubule cytoskeleton organization | 21.7391 | 5 | no |
| GO:1902115 | regulation of organelle assembly | 21.7391 | 5 | no |
| GO:0010506 | regulation of autophagy | 21.7391 | 6 | no |
| GO:0065003 | protein-containing complex assembly | 21.7391 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 21.7391 | 4 | no |
| GO:0032880 | regulation of protein localization | 21.7391 | 5 | no |
| GO:0051050 | positive regulation of transport | 21.7391 | 4 | no |
| GO:0033365 | protein localization to organelle | 21.7391 | 5 | no |
| GO:1904896 | ESCRT complex disassembly | 17.3913 | 6 | yes |
| GO:1904903 | ESCRT III complex disassembly | 17.3913 | 7 | yes |
| GO:0032511 | late endosome to vacuole transport via multivesicular body sorting pathway | 13.0435 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CHMP5_HUMAN | [view interactions] | Low throughput | no | yes |
| VPS4B_HUMAN | [view interactions] | Low throughput | no | yes |
| VPS4A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CHM2A_HUMAN | [view interactions] | Low throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | Low throughput | no | yes |
| CHM1B_HUMAN | [view interactions] | Low throughput | no | yes |
| CHMP3_HUMAN | [view interactions] | Low throughput | no | yes |
| IST1_HUMAN | [view interactions] | Low throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPP1_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN1_HUMAN | [view interactions] | High throughput | no | no |
| VATC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAOX_HUMAN | [view interactions] | High throughput | no | yes |
| SYDC_HUMAN | [view interactions] | High throughput | no | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIRO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSK3A_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BEX3_HUMAN | [view interactions] | High throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| FSD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TEAD4_HUMAN | [view interactions] | High throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| TBCK_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF6_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| CHM1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCNC_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT16_HUMAN | [view interactions] | High throughput | no | yes |
| CBS_HUMAN | [view interactions] | High throughput | no | yes |
| NBR1_HUMAN | [view interactions] | High throughput | no | yes |
| PRAF1_HUMAN | [view interactions] | High throughput | no | yes |
| MAGAB_HUMAN | [view interactions] | High throughput | no | no |
| BACD1_HUMAN | [view interactions] | High throughput | no | no |
| RPIA_HUMAN | [view interactions] | High throughput | no | yes |
| MBIP1_HUMAN | [view interactions] | High throughput | no | yes |
| KLH12_HUMAN | [view interactions] | High throughput | no | no |
| ZNRD2_HUMAN | [view interactions] | High throughput | no | yes |
| DPPA2_HUMAN | [view interactions] | High throughput | no | no |
| CDK4_HUMAN | [view interactions] | High throughput | no | no |
| ERBB3_HUMAN | [view interactions] | High throughput | no | yes |
| NECA2_HUMAN | [view interactions] | High throughput | no | yes |
| LYST_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| MERL_HUMAN | [view interactions] | High throughput | no | yes |
| STMN4_HUMAN | [view interactions] | High throughput | no | no |
| SPAST_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| LZTR1_HUMAN | [view interactions] | High throughput | no | no |
| CGAS_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| ANCHR_HUMAN | [view interactions] | High throughput | no | yes |
| DIAP3_HUMAN | [view interactions] | High throughput | no | no |
| FNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| FLCN_HUMAN | [view interactions] | High throughput | no | yes |
| CPXCR_HUMAN | [view interactions] | High throughput | no | no |
| FNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| SYT6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PAIRB_HUMAN | [view interactions] | High throughput | no | yes |
| CHM2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD003_HUMAN | [view interactions] | High throughput | no | yes |
| ZN215_HUMAN | [view interactions] | High throughput | no | no |
| CHM4A_HUMAN | [view interactions] | High throughput | no | no |
| DERL2_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CHMP7_HUMAN | [view interactions] | Computational | no | yes |
| VP37B_HUMAN | [view interactions] | Computational | no | yes |
| UBB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RS27A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL40_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CHMP6_HUMAN | [view interactions] | Computational | no | yes |
| TS101_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CHM4C_HUMAN | [view interactions] | Computational | no | yes |
| AQP2_HUMAN | [view interactions] | Computational | no | no |
| VPS28_HUMAN | [view entry] [view interactions] | Computational | yes | yes |