CHM2B_HUMAN
Evidence for PS localization
Functions
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CHM2B_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 34.1463 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 34.1463 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 34.1463 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 26.8293 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 26.8293 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 26.8293 | 6 | no |
| GO:0045296 | cadherin binding | 19.5122 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CHM2B_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 65.8537 | 4 | yes |
| GO:0008104 | protein localization | 60.9756 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 56.0976 | 4 | no |
| GO:0015031 | protein transport | 53.6585 | 4 | yes |
| GO:0022607 | cellular component assembly | 53.6585 | 4 | yes |
| GO:0071702 | organic substance transport | 53.6585 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 53.6585 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 48.7805 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 46.3415 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 43.9024 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 43.9024 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 43.9024 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 43.9024 | 4 | no |
| GO:0070925 | organelle assembly | 39.0244 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 39.0244 | 4 | no |
| GO:0051049 | regulation of transport | 36.5854 | 4 | no |
| GO:0010646 | regulation of cell communication | 36.5854 | 4 | no |
| GO:0016050 | vesicle organization | 31.7073 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 31.7073 | 4 | no |
| GO:0010468 | regulation of gene expression | 31.7073 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 31.7073 | 5 | no |
| GO:0032880 | regulation of protein localization | 31.7073 | 5 | no |
| GO:0060341 | regulation of cellular localization | 31.7073 | 4 | no |
| GO:0006508 | proteolysis | 29.2683 | 4 | yes |
| GO:0007034 | vacuolar transport | 29.2683 | 4 | yes |
| GO:0009057 | macromolecule catabolic process | 29.2683 | 4 | yes |
| GO:0016236 | macroautophagy | 29.2683 | 4 | yes |
| GO:0022411 | cellular component disassembly | 29.2683 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 29.2683 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 29.2683 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 29.2683 | 5 | no |
| GO:0009894 | regulation of catabolic process | 29.2683 | 4 | no |
| GO:0006886 | intracellular protein transport | 29.2683 | 4 | no |
| GO:0016197 | endosomal transport | 26.8293 | 4 | yes |
| GO:0051050 | positive regulation of transport | 26.8293 | 4 | no |
| GO:0009966 | regulation of signal transduction | 26.8293 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.8293 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 26.8293 | 5 | no |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 24.3902 | 7 | yes |
| GO:0007032 | endosome organization | 24.3902 | 6 | yes |
| GO:0007041 | lysosomal transport | 24.3902 | 5 | yes |
| GO:0019941 | modification-dependent protein catabolic process | 24.3902 | 6 | yes |
| GO:0032984 | protein-containing complex disassembly | 24.3902 | 5 | yes |
| GO:0043632 | modification-dependent macromolecule catabolic process | 24.3902 | 5 | yes |
| GO:0044265 | cellular macromolecule catabolic process | 24.3902 | 4 | yes |
| GO:0051603 | proteolysis involved in protein catabolic process | 24.3902 | 5 | yes |
| GO:0051726 | regulation of cell cycle | 24.3902 | 4 | yes |
| GO:0061024 | membrane organization | 24.3902 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 24.3902 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 24.3902 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 24.3902 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 24.3902 | 4 | no |
| GO:0007010 | cytoskeleton organization | 24.3902 | 5 | no |
| GO:0033043 | regulation of organelle organization | 21.9512 | 5 | yes |
| GO:0036257 | multivesicular body organization | 21.9512 | 7 | yes |
| GO:0036258 | multivesicular body assembly | 21.9512 | 6 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 21.9512 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 21.9512 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.9512 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 21.9512 | 5 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 21.9512 | 6 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 21.9512 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 21.9512 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 21.9512 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 21.9512 | 6 | no |
| GO:0042176 | regulation of protein catabolic process | 21.9512 | 5 | no |
| GO:0010941 | regulation of cell death | 19.5122 | 4 | yes |
| GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | 19.5122 | 8 | yes |
| GO:0032509 | endosome transport via multivesicular body sorting pathway | 17.0732 | 5 | yes |
| GO:0035891 | exit from host cell | 17.0732 | 5 | yes |
| GO:0044000 | movement in host | 17.0732 | 4 | yes |
| GO:0060548 | negative regulation of cell death | 17.0732 | 5 | yes |
| GO:0071985 | multivesicular body sorting pathway | 17.0732 | 5 | yes |
| GO:0097352 | autophagosome maturation | 17.0732 | 6 | yes |
| GO:0010564 | regulation of cell cycle process | 14.6341 | 5 | yes |
| GO:0032886 | regulation of microtubule-based process | 14.6341 | 4 | yes |
| GO:0045324 | late endosome to vacuole transport | 14.6341 | 5 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 14.6341 | 6 | yes |
| GO:0071763 | nuclear membrane organization | 14.6341 | 5 | yes |
| GO:0006906 | vesicle fusion | 12.1951 | 6 | yes |
| GO:0006997 | nucleus organization | 12.1951 | 5 | yes |
| GO:0007080 | mitotic metaphase plate congression | 12.1951 | 4 | yes |
| GO:0010824 | regulation of centrosome duplication | 12.1951 | 6 | yes |
| GO:0031468 | nuclear membrane reassembly | 12.1951 | 6 | yes |
| GO:0046605 | regulation of centrosome cycle | 12.1951 | 5 | yes |
| GO:0048284 | organelle fusion | 12.1951 | 5 | yes |
| GO:0051303 | establishment of chromosome localization | 12.1951 | 4 | yes |
| GO:0051310 | metaphase plate congression | 12.1951 | 5 | yes |
| GO:0060249 | anatomical structure homeostasis | 12.1951 | 4 | yes |
| GO:0061025 | membrane fusion | 12.1951 | 5 | yes |
| GO:0061952 | midbody abscission | 12.1951 | 5 | yes |
| GO:0070507 | regulation of microtubule cytoskeleton organization | 12.1951 | 5 | yes |
| GO:0071709 | membrane assembly | 12.1951 | 5 | yes |
| GO:0090174 | organelle membrane fusion | 12.1951 | 6 | yes |
| GO:1902115 | regulation of organelle assembly | 12.1951 | 5 | yes |
| GO:1902410 | mitotic cytokinetic process | 12.1951 | 4 | yes |
| GO:1904896 | ESCRT complex disassembly | 12.1951 | 6 | yes |
| GO:1904903 | ESCRT III complex disassembly | 12.1951 | 7 | yes |
| GO:0001778 | plasma membrane repair | 9.7561 | 6 | yes |
| GO:0007009 | plasma membrane organization | 9.7561 | 5 | yes |
| GO:0060236 | regulation of mitotic spindle organization | 9.7561 | 7 | yes |
| GO:0090169 | regulation of spindle assembly | 9.7561 | 6 | yes |
| GO:0090224 | regulation of spindle organization | 9.7561 | 6 | yes |
| GO:1901673 | regulation of mitotic spindle assembly | 9.7561 | 7 | yes |
| GO:1902774 | late endosome to lysosome transport | 9.7561 | 6 | yes |
| GO:0050890 | cognition | 7.3171 | 4 | yes |
| GO:0061763 | multivesicular body-lysosome fusion | 4.8780 | 6 | yes |
| GO:0097212 | lysosomal membrane organization | 4.8780 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in CHM2B_HUMAN |
|---|---|---|---|---|
| DOID:1289 | neurodegenerative disease | 4.8780 | 4 | no |
| DOID:331 | central nervous system disease | 4.8780 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SQSTM_HUMAN | [view interactions] | Low throughput | no | yes |
| T106B_HUMAN | [view interactions] | Low throughput | no | yes |
| CHMP3_HUMAN | [view interactions] | Low throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VPS4B_HUMAN | [view interactions] | Low throughput | no | yes |
| UBP8_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| UBP54_HUMAN | [view interactions] | Low throughput | no | yes |
| VPS4A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VATB1_HUMAN | [view interactions] | High throughput | no | no |
| BUB1_HUMAN | [view interactions] | High throughput | no | no |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| CGAS_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT7B_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| SUV92_HUMAN | [view interactions] | High throughput | no | no |
| VTA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBTB2_HUMAN | [view interactions] | High throughput | no | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| CAPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| CHM2A_HUMAN | [view interactions] | High throughput | no | yes |
| LIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM1B_HUMAN | [view interactions] | High throughput | no | yes |
| CHMP5_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FKBP8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI36_HUMAN | [view interactions] | High throughput | no | no |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CHM2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PNMA1_HUMAN | [view interactions] | High throughput | no | yes |
| DPY30_HUMAN | [view interactions] | High throughput | no | yes |
| MASU1_HUMAN | [view interactions] | High throughput | no | yes |
| CENPF_HUMAN | [view interactions] | High throughput | no | no |
| SERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIPIN_HUMAN | [view interactions] | High throughput | no | no |
| NUP98_HUMAN | [view interactions] | High throughput | no | no |
| PAPS1_HUMAN | [view interactions] | High throughput | no | yes |
| BMR1A_HUMAN | [view interactions] | High throughput | no | no |
| TIM_HUMAN | [view interactions] | High throughput | no | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEP55_HUMAN | [view interactions] | High throughput | no | yes |
| SGO1_HUMAN | [view interactions] | High throughput | no | no |
| MYH14_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CD2AP_HUMAN | [view interactions] | High throughput | no | no |
| RENR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCC1_HUMAN | [view interactions] | High throughput | no | yes |
| TEN1L_HUMAN | [view interactions] | High throughput | no | no |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELOC_HUMAN | [view interactions] | High throughput | no | no |
| SPAST_HUMAN | [view interactions] | High throughput | no | yes |
| TS101_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTN23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS28_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LTN1_HUMAN | [view interactions] | High throughput | no | no |
| MD2L1_HUMAN | [view interactions] | High throughput | no | no |
| GOT1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHG3_HUMAN | [view interactions] | High throughput | no | yes |
| IFTAP_HUMAN | [view interactions] | High throughput | no | no |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATP5I_HUMAN | [view interactions] | High throughput | no | yes |
| TE2IP_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| ATPG_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
| PRAF1_HUMAN | [view interactions] | High throughput | no | yes |
| NR4A1_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| TBB6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TBB2B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PLIN3_HUMAN | [view interactions] | Computational | no | yes |
| TBA8_HUMAN | [view interactions] | Computational | no | yes |
| STAM1_HUMAN | [view interactions] | Computational | no | yes |
| HBB_HUMAN | [view interactions] | Computational | no | no |
| GBRAP_HUMAN | [view interactions] | Computational | no | no |
| PLIN2_HUMAN | [view interactions] | Computational | no | no |
| FUS_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ATF1_HUMAN | [view interactions] | Computational | no | yes |
| AR13B_HUMAN | [view interactions] | Computational | no | yes |
| MLP3B_HUMAN | [view interactions] | Computational | no | yes |
| CHMP6_HUMAN | [view interactions] | Computational | no | yes |
| SNF8_HUMAN | [view interactions] | Computational | no | yes |
| TBB4B_HUMAN | [view interactions] | Computational | no | yes |
| VPS25_HUMAN | [view interactions] | Computational | no | yes |
| VPS36_HUMAN | [view interactions] | Computational | no | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CHM1A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| VP37B_HUMAN | [view interactions] | Computational | no | yes |
| TBA1C_HUMAN | [view interactions] | Computational | no | yes |
| CHMP7_HUMAN | [view interactions] | Computational | no | yes |
| TBB8_HUMAN | [view interactions] | Computational | no | no |
| CHM4A_HUMAN | [view interactions] | Computational | no | no |
| TBB2A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VP37D_HUMAN | [view interactions] | Computational | no | no |
| IFT88_HUMAN | [view interactions] | Computational | no | no |
| VP37A_HUMAN | [view interactions] | Computational | no | yes |
| CETN1_HUMAN | [view interactions] | Computational | no | no |
| TBAL3_HUMAN | [view interactions] | Computational | no | no |
| GRN_HUMAN | [view interactions] | Computational | no | no |
| TERA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VP37C_HUMAN | [view interactions] | Computational | no | yes |
| GBRL1_HUMAN | [view interactions] | Computational | no | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| UBAP1_HUMAN | [view interactions] | Computational | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MLP3C_HUMAN | [view interactions] | Computational | no | no |
| PARK7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CI072_HUMAN | [view interactions] | Computational | no | no |
| PCNT_HUMAN | [view interactions] | Computational | no | yes |
| CHM4C_HUMAN | [view interactions] | Computational | no | yes |
| TBA3E_HUMAN | [view interactions] | Computational | no | no |
| HGS_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| HDAC6_HUMAN | [view interactions] | Computational | no | yes |
| MB12A_HUMAN | [view interactions] | Computational | no | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CFTR_HUMAN | [view interactions] | Computational | no | no |
| RNAS1_HUMAN | [view interactions] | Computational | no | yes |
| MB12B_HUMAN | [view interactions] | Computational | no | no |
| MLP3A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TBB4A_HUMAN | [view interactions] | Computational | no | yes |
| GBRL2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TBB1_HUMAN | [view interactions] | Computational | no | yes |
| IST1_HUMAN | [view interactions] | Computational | no | yes |