CHM2B_HUMAN
Evidence for PS localization
Functions
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CHM2B_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 27.7778 | 4 | no |
| GO:0017076 | purine nucleotide binding | 27.7778 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 25.0000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.0000 | 4 | no |
| GO:0043168 | anion binding | 25.0000 | 4 | no |
| GO:0045296 | cadherin binding | 22.2222 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CHM2B_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 72.2222 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 61.1111 | 4 | no |
| GO:0006996 | organelle organization | 55.5556 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 55.5556 | 4 | yes |
| GO:0022607 | cellular component assembly | 52.7778 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 52.7778 | 4 | no |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | yes |
| GO:0071702 | organic substance transport | 50.0000 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 50.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
| GO:0015031 | protein transport | 47.2222 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 47.2222 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 41.6667 | 4 | no |
| GO:0010468 | regulation of gene expression | 41.6667 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 41.6667 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 41.6667 | 5 | no |
| GO:0009057 | macromolecule catabolic process | 38.8889 | 4 | yes |
| GO:0051049 | regulation of transport | 38.8889 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 38.8889 | 4 | no |
| GO:0007034 | vacuolar transport | 36.1111 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 36.1111 | 5 | yes |
| GO:0070925 | organelle assembly | 36.1111 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0006508 | proteolysis | 33.3333 | 4 | yes |
| GO:0016050 | vesicle organization | 33.3333 | 5 | yes |
| GO:0051726 | regulation of cell cycle | 33.3333 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 33.3333 | 4 | no |
| GO:0009966 | regulation of signal transduction | 33.3333 | 4 | no |
| GO:0060341 | regulation of cellular localization | 33.3333 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 30.5556 | 4 | no |
| GO:0043933 | protein-containing complex organization | 30.5556 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 30.5556 | 4 | yes |
| GO:0061024 | membrane organization | 30.5556 | 4 | yes |
| GO:0006886 | intracellular protein transport | 30.5556 | 4 | no |
| GO:0032880 | regulation of protein localization | 30.5556 | 5 | no |
| GO:0051050 | positive regulation of transport | 30.5556 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 30.5556 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 30.5556 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 30.5556 | 5 | no |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 27.7778 | 7 | yes |
| GO:0007041 | lysosomal transport | 27.7778 | 5 | yes |
| GO:0010564 | regulation of cell cycle process | 27.7778 | 5 | yes |
| GO:0019941 | modification-dependent protein catabolic process | 27.7778 | 6 | yes |
| GO:0043632 | modification-dependent macromolecule catabolic process | 27.7778 | 5 | yes |
| GO:0051603 | proteolysis involved in protein catabolic process | 27.7778 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 27.7778 | 5 | no |
| GO:0023056 | positive regulation of signaling | 27.7778 | 4 | no |
| GO:0033365 | protein localization to organelle | 27.7778 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.0000 | 6 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.0000 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 25.0000 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 25.0000 | 6 | no |
| GO:0007032 | endosome organization | 25.0000 | 6 | yes |
| GO:0016236 | macroautophagy | 25.0000 | 4 | yes |
| GO:0022411 | cellular component disassembly | 25.0000 | 4 | yes |
| GO:0032509 | endosome transport via multivesicular body sorting pathway | 25.0000 | 4 | yes |
| GO:0032886 | regulation of microtubule-based process | 25.0000 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 25.0000 | 5 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 25.0000 | 6 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 25.0000 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 25.0000 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 25.0000 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 25.0000 | 7 | no |
| GO:0009967 | positive regulation of signal transduction | 22.2222 | 5 | no |
| GO:0036257 | multivesicular body organization | 22.2222 | 7 | yes |
| GO:0036258 | multivesicular body assembly | 22.2222 | 6 | yes |
| GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | 22.2222 | 8 | yes |
| GO:0009968 | negative regulation of signal transduction | 22.2222 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 22.2222 | 5 | no |
| GO:0023057 | negative regulation of signaling | 22.2222 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 22.2222 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 22.2222 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 22.2222 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 22.2222 | 4 | no |
| GO:0042176 | regulation of protein catabolic process | 22.2222 | 5 | no |
| GO:0009890 | negative regulation of biosynthetic process | 22.2222 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 22.2222 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 22.2222 | 6 | no |
| GO:0006906 | vesicle fusion | 19.4444 | 6 | yes |
| GO:0032984 | protein-containing complex disassembly | 19.4444 | 5 | yes |
| GO:0035891 | exit from host cell | 19.4444 | 4 | yes |
| GO:0048284 | organelle fusion | 19.4444 | 5 | yes |
| GO:0061025 | membrane fusion | 19.4444 | 5 | yes |
| GO:0070507 | regulation of microtubule cytoskeleton organization | 19.4444 | 5 | yes |
| GO:0090148 | membrane fission | 19.4444 | 5 | yes |
| GO:0090174 | organelle membrane fusion | 19.4444 | 6 | yes |
| GO:1902115 | regulation of organelle assembly | 19.4444 | 5 | yes |
| GO:0007033 | vacuole organization | 16.6667 | 5 | yes |
| GO:0060236 | regulation of mitotic spindle organization | 16.6667 | 7 | yes |
| GO:0071763 | nuclear membrane organization | 16.6667 | 5 | yes |
| GO:0090169 | regulation of spindle assembly | 16.6667 | 6 | yes |
| GO:0090224 | regulation of spindle organization | 16.6667 | 6 | yes |
| GO:0097352 | autophagosome maturation | 16.6667 | 6 | yes |
| GO:1901673 | regulation of mitotic spindle assembly | 16.6667 | 7 | yes |
| GO:0001778 | plasma membrane repair | 13.8889 | 6 | yes |
| GO:0006997 | nucleus organization | 13.8889 | 5 | yes |
| GO:0007009 | plasma membrane organization | 13.8889 | 5 | yes |
| GO:0007080 | mitotic metaphase chromosome alignment | 13.8889 | 4 | yes |
| GO:0010824 | regulation of centrosome duplication | 13.8889 | 6 | yes |
| GO:0031468 | nuclear membrane reassembly | 13.8889 | 6 | yes |
| GO:0046605 | regulation of centrosome cycle | 13.8889 | 5 | yes |
| GO:0050890 | cognition | 13.8889 | 4 | yes |
| GO:0051303 | establishment of chromosome localization | 13.8889 | 4 | yes |
| GO:0051310 | metaphase chromosome alignment | 13.8889 | 5 | yes |
| GO:0061952 | midbody abscission | 13.8889 | 5 | yes |
| GO:0071709 | membrane assembly | 13.8889 | 5 | yes |
| GO:1902410 | mitotic cytokinetic process | 13.8889 | 4 | yes |
| GO:1902774 | late endosome to lysosome transport | 13.8889 | 6 | yes |
| GO:1904896 | ESCRT complex disassembly | 13.8889 | 6 | yes |
| GO:1904903 | ESCRT III complex disassembly | 13.8889 | 7 | yes |
| GO:0051469 | vesicle fusion with vacuole | 11.1111 | 7 | yes |
| GO:0061763 | multivesicular body-lysosome fusion | 11.1111 | 6 | yes |
| GO:0097212 | lysosomal membrane organization | 11.1111 | 5 | yes |
| GO:0097576 | vacuole fusion | 11.1111 | 6 | yes |
| GO:0050807 | regulation of synapse organization | 8.3333 | 5 | yes |
| GO:0099175 | regulation of postsynapse organization | 8.3333 | 6 | yes |
| GO:0099159 | regulation of modification of postsynaptic structure | 5.5556 | 7 | yes |
| GO:1905244 | regulation of modification of synaptic structure | 5.5556 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CHMP3_HUMAN | [view interactions] | Low throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VPS4B_HUMAN | [view interactions] | Low throughput | no | yes |
| UBP8_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| UBP54_HUMAN | [view interactions] | Low throughput | no | yes |
| VPS4A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SQSTM_HUMAN | [view interactions] | Low throughput | no | yes |
| T106B_HUMAN | [view interactions] | Low throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KBTB4_HUMAN | [view interactions] | High throughput | no | yes |
| SND1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA4_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CHM2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PNMA1_HUMAN | [view interactions] | High throughput | no | yes |
| DPY30_HUMAN | [view interactions] | High throughput | no | yes |
| MASU1_HUMAN | [view interactions] | High throughput | no | yes |
| CENPF_HUMAN | [view interactions] | High throughput | no | no |
| SERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIPIN_HUMAN | [view interactions] | High throughput | no | no |
| NUP98_HUMAN | [view interactions] | High throughput | no | no |
| PAPS1_HUMAN | [view interactions] | High throughput | no | yes |
| BMR1A_HUMAN | [view interactions] | High throughput | no | no |
| TIM_HUMAN | [view interactions] | High throughput | no | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEP55_HUMAN | [view interactions] | High throughput | no | yes |
| SGO1_HUMAN | [view interactions] | High throughput | no | no |
| MYH14_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CD2AP_HUMAN | [view interactions] | High throughput | no | no |
| RENR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCC1_HUMAN | [view interactions] | High throughput | no | yes |
| TEN1L_HUMAN | [view interactions] | High throughput | no | no |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELOC_HUMAN | [view interactions] | High throughput | no | no |
| SPAST_HUMAN | [view interactions] | High throughput | no | yes |
| TS101_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTN23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS28_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LTN1_HUMAN | [view interactions] | High throughput | no | no |
| MD2L1_HUMAN | [view interactions] | High throughput | no | no |
| GOT1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHG3_HUMAN | [view interactions] | High throughput | no | yes |
| IFTAP_HUMAN | [view interactions] | High throughput | no | no |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATP5I_HUMAN | [view interactions] | High throughput | no | yes |
| TE2IP_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPG_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
| PRAF1_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| NR4A1_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| SWAP1_HUMAN | [view interactions] | High throughput | no | no |
| VATB1_HUMAN | [view interactions] | High throughput | no | no |
| BUB1_HUMAN | [view interactions] | High throughput | no | no |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| CGAS_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT7B_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| SUV92_HUMAN | [view interactions] | High throughput | no | no |
| VTA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBTB2_HUMAN | [view interactions] | High throughput | no | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| CAPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FOXA1_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| CHM2A_HUMAN | [view interactions] | High throughput | no | yes |
| LIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHMP5_HUMAN | [view interactions] | High throughput | no | yes |
| HMGN2_HUMAN | [view interactions] | High throughput | no | no |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4A_HUMAN | [view interactions] | High throughput | no | no |
| CHM1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FKBP8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI36_HUMAN | [view interactions] | High throughput | no | no |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |