Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CHM1A_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI004432 DOC_MIT_MIM_1 DOC 185 195 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CHM1A_HUMAN
GO:0046872 metal ion binding 26.9231 4 yes
GO:0019900 kinase binding 23.0769 4 no
GO:0042803 protein homodimerization activity 15.3846 4 yes
GO:0008270 zinc ion binding 11.5385 6 yes
GO:0046914 transition metal ion binding 11.5385 5 yes
GO:0008237 metallopeptidase activity 7.6923 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CHM1A_HUMAN
GO:0048523 negative regulation of cellular process 73.0769 4 yes
GO:0006996 organelle organization 69.2308 4 yes
GO:0071702 organic substance transport 69.2308 4 yes
GO:0071705 nitrogen compound transport 69.2308 4 yes
GO:0008104 protein localization 65.3846 4 yes
GO:0022607 cellular component assembly 65.3846 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 65.3846 4 yes
GO:0060255 regulation of macromolecule metabolic process 65.3846 4 yes
GO:0080090 regulation of primary metabolic process 65.3846 4 yes
GO:0048522 positive regulation of cellular process 65.3846 4 no
GO:0015031 protein transport 61.5385 4 yes
GO:0016192 vesicle-mediated transport 61.5385 4 yes
GO:0051128 regulation of cellular component organization 61.5385 4 yes
GO:0051049 regulation of transport 61.5385 4 no
GO:0031323 regulation of cellular metabolic process 57.6923 4 yes
GO:0051050 positive regulation of transport 53.8462 4 no
GO:0009892 negative regulation of metabolic process 50.0000 4 yes
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0051246 regulation of protein metabolic process 50.0000 5 no
GO:0010605 negative regulation of macromolecule metabolic process 46.1538 5 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 46.1538 5 yes
GO:0070925 organelle assembly 46.1538 5 yes
GO:0009893 positive regulation of metabolic process 46.1538 4 no
GO:0009966 regulation of signal transduction 46.1538 4 no
GO:0060627 regulation of vesicle-mediated transport 42.3077 4 no
GO:0006508 proteolysis 42.3077 4 yes
GO:0016050 vesicle organization 42.3077 5 yes
GO:0016197 endosomal transport 42.3077 4 yes
GO:0031324 negative regulation of cellular metabolic process 42.3077 5 yes
GO:0033043 regulation of organelle organization 42.3077 5 yes
GO:0043933 protein-containing complex organization 42.3077 4 yes
GO:0044087 regulation of cellular component biogenesis 42.3077 4 yes
GO:0051726 regulation of cell cycle 42.3077 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 42.3077 5 no
GO:0031399 regulation of protein modification process 42.3077 6 no
GO:0007032 endosome organization 38.4615 6 yes
GO:0007034 vacuolar transport 38.4615 4 yes
GO:0009057 macromolecule catabolic process 38.4615 4 yes
GO:0001932 regulation of protein phosphorylation 38.4615 7 no
GO:0019220 regulation of phosphate metabolic process 38.4615 6 no
GO:0042325 regulation of phosphorylation 38.4615 7 no
GO:0051173 positive regulation of nitrogen compound metabolic process 38.4615 5 no
GO:0051174 regulation of phosphorus metabolic process 38.4615 5 no
GO:0009894 regulation of catabolic process 38.4615 4 no
GO:0051046 regulation of secretion 34.6154 5 no
GO:1903530 regulation of secretion by cell 34.6154 4 no
GO:0006511 ubiquitin-dependent protein catabolic process 34.6154 7 yes
GO:0009889 regulation of biosynthetic process 34.6154 4 yes
GO:0010468 regulation of gene expression 34.6154 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 34.6154 5 yes
GO:0010564 regulation of cell cycle process 34.6154 5 yes
GO:0010941 regulation of cell death 34.6154 4 yes
GO:0019941 modification-dependent protein catabolic process 34.6154 6 yes
GO:0036257 multivesicular body organization 34.6154 7 yes
GO:0036258 multivesicular body assembly 34.6154 6 yes
GO:0043632 modification-dependent macromolecule catabolic process 34.6154 5 yes
GO:0044265 cellular macromolecule catabolic process 34.6154 4 yes
GO:0051603 proteolysis involved in protein catabolic process 34.6154 5 yes
GO:0061024 membrane organization 34.6154 4 yes
GO:0006886 intracellular protein transport 34.6154 4 no
GO:0031325 positive regulation of cellular metabolic process 34.6154 5 no
GO:0051247 positive regulation of protein metabolic process 34.6154 6 no
GO:0051338 regulation of transferase activity 34.6154 4 no
GO:0016236 macroautophagy 30.7692 4 no
GO:0017157 regulation of exocytosis 30.7692 5 no
GO:0051047 positive regulation of secretion 30.7692 5 no
GO:1903532 positive regulation of secretion by cell 30.7692 5 no
GO:0006355 regulation of DNA-templated transcription 30.7692 6 yes
GO:0007041 lysosomal transport 30.7692 5 yes
GO:0009890 negative regulation of biosynthetic process 30.7692 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 30.7692 6 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.7692 5 yes
GO:0031326 regulation of cellular biosynthetic process 30.7692 5 yes
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway 30.7692 8 yes
GO:0051252 regulation of RNA metabolic process 30.7692 5 yes
GO:0060548 negative regulation of cell death 30.7692 5 yes
GO:1903506 regulation of nucleic acid-templated transcription 30.7692 7 yes
GO:2001141 regulation of RNA biosynthetic process 30.7692 6 yes
GO:0032880 regulation of protein localization 30.7692 5 no
GO:0060341 regulation of cellular localization 30.7692 4 no
GO:0043549 regulation of kinase activity 30.7692 5 no
GO:0045859 regulation of protein kinase activity 30.7692 6 no
GO:0051248 negative regulation of protein metabolic process 30.7692 6 no
GO:0071900 regulation of protein serine/threonine kinase activity 30.7692 7 no
GO:0051130 positive regulation of cellular component organization 30.7692 5 no
GO:0048585 negative regulation of response to stimulus 30.7692 4 no
GO:0023057 negative regulation of signaling 26.9231 4 no
GO:0044089 positive regulation of cellular component biogenesis 26.9231 5 no
GO:0042176 regulation of protein catabolic process 26.9231 5 no
GO:0045921 positive regulation of exocytosis 26.9231 6 no
GO:0022411 cellular component disassembly 26.9231 4 yes
GO:0031327 negative regulation of cellular biosynthetic process 26.9231 6 yes
GO:0032984 protein-containing complex disassembly 26.9231 5 yes
GO:0035891 exit from host cell 26.9231 5 yes
GO:0044000 movement in host 26.9231 4 yes
GO:0045892 negative regulation of DNA-templated transcription 26.9231 7 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 26.9231 6 yes
GO:0051253 negative regulation of RNA metabolic process 26.9231 6 yes
GO:1902115 regulation of organelle assembly 26.9231 5 yes
GO:1902679 negative regulation of RNA biosynthetic process 26.9231 7 yes
GO:1903507 negative regulation of nucleic acid-templated transcription 26.9231 8 yes
GO:0001934 positive regulation of protein phosphorylation 26.9231 8 no
GO:0010562 positive regulation of phosphorus metabolic process 26.9231 6 no
GO:0031400 negative regulation of protein modification process 26.9231 7 no
GO:0031401 positive regulation of protein modification process 26.9231 7 no
GO:0034762 regulation of transmembrane transport 26.9231 4 no
GO:0042327 positive regulation of phosphorylation 26.9231 8 no
GO:0045937 positive regulation of phosphate metabolic process 26.9231 7 no
GO:1902531 regulation of intracellular signal transduction 26.9231 5 no
GO:0048584 positive regulation of response to stimulus 26.9231 4 no
GO:0009968 negative regulation of signal transduction 26.9231 5 no
GO:0010647 positive regulation of cell communication 26.9231 5 no
GO:0010648 negative regulation of cell communication 26.9231 5 no
GO:0023056 positive regulation of signaling 26.9231 4 no
GO:0031329 regulation of cellular catabolic process 23.0769 5 no
GO:0030100 regulation of endocytosis 23.0769 5 no
GO:0033365 protein localization to organelle 23.0769 5 no
GO:0072594 establishment of protein localization to organelle 23.0769 4 no
GO:0032509 endosome transport via multivesicular body sorting pathway 23.0769 5 yes
GO:0032886 regulation of microtubule-based process 23.0769 4 yes
GO:0045324 late endosome to vacuole transport 23.0769 5 yes
GO:0051493 regulation of cytoskeleton organization 23.0769 6 yes
GO:0070507 regulation of microtubule cytoskeleton organization 23.0769 5 yes
GO:0071985 multivesicular body sorting pathway 23.0769 5 yes
GO:0001933 negative regulation of protein phosphorylation 23.0769 8 no
GO:0010563 negative regulation of phosphorus metabolic process 23.0769 6 no
GO:0034764 positive regulation of transmembrane transport 23.0769 5 no
GO:0034765 regulation of ion transmembrane transport 23.0769 5 no
GO:0034767 positive regulation of ion transmembrane transport 23.0769 6 no
GO:0042326 negative regulation of phosphorylation 23.0769 8 no
GO:0043085 positive regulation of catalytic activity 23.0769 4 no
GO:0043269 regulation of ion transport 23.0769 5 no
GO:0043270 positive regulation of ion transport 23.0769 5 no
GO:0045936 negative regulation of phosphate metabolic process 23.0769 7 no
GO:0051051 negative regulation of transport 23.0769 4 no
GO:0051347 positive regulation of transferase activity 23.0769 5 no
GO:0006357 regulation of transcription by RNA polymerase II 23.0769 7 no
GO:0006997 nucleus organization 19.2308 5 yes
GO:0007080 mitotic metaphase plate congression 19.2308 4 yes
GO:0031468 nuclear membrane reassembly 19.2308 6 yes
GO:0051303 establishment of chromosome localization 19.2308 4 yes
GO:0051310 metaphase plate congression 19.2308 5 yes
GO:0060236 regulation of mitotic spindle organization 19.2308 7 yes
GO:0061952 midbody abscission 19.2308 5 yes
GO:0071709 membrane assembly 19.2308 5 yes
GO:0071763 nuclear membrane organization 19.2308 5 yes
GO:0090224 regulation of spindle organization 19.2308 6 yes
GO:0097352 autophagosome maturation 19.2308 6 yes
GO:1902410 mitotic cytokinetic process 19.2308 4 yes
GO:1904896 ESCRT complex disassembly 19.2308 6 yes
GO:1904903 ESCRT III complex disassembly 19.2308 7 yes
GO:0001778 plasma membrane repair 15.3846 6 yes
GO:0007009 plasma membrane organization 15.3846 5 yes
GO:0010824 regulation of centrosome duplication 15.3846 6 yes
GO:0046605 regulation of centrosome cycle 15.3846 5 yes
GO:0090169 regulation of spindle assembly 15.3846 6 yes
GO:1901673 regulation of mitotic spindle assembly 15.3846 7 yes
GO:1902774 late endosome to lysosome transport 15.3846 6 yes
GO:0045786 negative regulation of cell cycle 11.5385 5 yes
GO:0051276 chromosome organization 11.5385 5 yes
GO:0007076 mitotic chromosome condensation 7.6923 4 yes
GO:0030261 chromosome condensation 7.6923 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in CHM1A_HUMAN
DOID:0050700 cardiomyopathy 7.6923 4 no
DOID:0060036 intrinsic cardiomyopathy 7.6923 5 no
DOID:114 heart disease 7.6923 3 no
DOID:2843 long QT syndrome 7.6923 6 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
STABP_HUMAN [view interactions] Low throughput no yes
VPS4A_HUMAN [view entry] [view interactions] Low throughput yes yes
UBP8_HUMAN [view entry] [view interactions] Low throughput yes no
VPS4B_HUMAN [view interactions] Low throughput no yes
MITD1_HUMAN [view interactions] Low throughput no no
CHM1A_HUMAN [view entry] [view interactions] High throughput yes no
CHM1B_HUMAN [view interactions] High throughput no yes
UBC9_HUMAN [view interactions] High throughput no yes
EXOS9_HUMAN [view interactions] High throughput no yes
PIAS2_HUMAN [view interactions] High throughput no yes
RBP2_HUMAN [view interactions] High throughput no yes
TFG_HUMAN [view interactions] High throughput no yes
CD2AP_HUMAN [view interactions] High throughput no no
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
SPAST_HUMAN [view interactions] High throughput no yes
CHM2A_HUMAN [view interactions] High throughput no yes
PTN23_HUMAN [view entry] [view interactions] High throughput yes yes
UFL1_HUMAN [view interactions] High throughput no yes
GOT1B_HUMAN [view interactions] High throughput no yes
MECP2_HUMAN [view interactions] High throughput no yes
SIX2_HUMAN [view interactions] High throughput no no
GPX7_HUMAN [view interactions] High throughput no no
LHX4_HUMAN [view interactions] High throughput no no
VSX2_HUMAN [view interactions] High throughput no no
HMGN2_HUMAN [view interactions] High throughput no no
BROX_HUMAN [view interactions] High throughput no yes
MEOX1_HUMAN [view interactions] High throughput no no
HEY2_HUMAN [view interactions] High throughput no no
ZN524_HUMAN [view interactions] High throughput no no
CHMP5_HUMAN [view interactions] High throughput no yes
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
UBP54_HUMAN [view interactions] High throughput no yes
LNP_HUMAN [view interactions] High throughput no yes
VATA_HUMAN [view entry] [view interactions] High throughput yes yes
EGLN_HUMAN [view interactions] High throughput no no
BMI1_HUMAN [view interactions] High throughput no yes
ZDH17_HUMAN [view interactions] High throughput no yes
YES_HUMAN [view entry] [view interactions] High throughput yes yes
SDCB1_HUMAN [view entry] [view interactions] High throughput yes yes
CN119_HUMAN [view interactions] High throughput no yes
THIOM_HUMAN [view interactions] High throughput no yes
VTA1_HUMAN [view entry] [view interactions] High throughput yes yes
PSA1_HUMAN [view interactions] High throughput no yes
DDT4L_HUMAN [view interactions] High throughput no no
GORS2_HUMAN [view interactions] High throughput no yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
NR1I2_HUMAN [view interactions] High throughput no no
IST1_HUMAN [view interactions] High throughput no yes
VATB1_HUMAN [view interactions] High throughput no no
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
RUVB1_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
MERL_HUMAN [view interactions] High throughput no yes
KSR1_HUMAN [view interactions] High throughput no yes
IFIX_HUMAN [view interactions] High throughput no no
U5S1_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
CGAS_HUMAN [view interactions] High throughput no yes
WWP2_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
BCAR1_HUMAN [view interactions] High throughput no yes
MEOX2_HUMAN [view interactions] High throughput no no
FIBB_HUMAN [view entry] [view interactions] High throughput yes no
MAX_HUMAN [view interactions] High throughput no yes
DLX6_HUMAN [view interactions] High throughput no no
DPOE3_HUMAN [view interactions] High throughput no yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
TPX2_HUMAN [view interactions] High throughput no yes
EZH1_HUMAN [view interactions] High throughput no yes
FCGRN_HUMAN [view interactions] High throughput no yes
MND1_HUMAN [view interactions] High throughput no no
UN45A_HUMAN [view interactions] High throughput no yes
BBS1_HUMAN [view interactions] High throughput no no
AT5F1_HUMAN [view interactions] High throughput no yes
EST2_HUMAN [view interactions] High throughput no yes
PLPL1_HUMAN [view interactions] High throughput no no
ZNF8_HUMAN [view interactions] High throughput no yes
CB39L_HUMAN [view interactions] High throughput no yes
MILR1_HUMAN [view interactions] High throughput no no
ANR49_HUMAN [view interactions] High throughput no yes
RT18C_HUMAN [view interactions] High throughput no yes
STRN3_HUMAN [view interactions] High throughput no yes
ZBTB2_HUMAN [view interactions] High throughput no yes
AHR_HUMAN [view interactions] High throughput no yes
KPB2_HUMAN [view interactions] High throughput no yes
RPC10_HUMAN [view interactions] High throughput no yes
PGES2_HUMAN [view interactions] High throughput no yes
RNF31_HUMAN [view interactions] High throughput no yes
SPRTN_HUMAN [view interactions] High throughput no yes
RM38_HUMAN [view interactions] High throughput no yes
BTF3_HUMAN [view interactions] High throughput no yes
CLCB_HUMAN [view entry] [view interactions] High throughput yes yes
ROA2_HUMAN [view entry] [view interactions] High throughput yes yes
FXL18_HUMAN [view interactions] High throughput no no
OAS3_HUMAN [view interactions] High throughput no no
CHMP3_HUMAN [view interactions] High throughput no yes
TAXB1_HUMAN [view interactions] High throughput no yes
VPS36_HUMAN [view interactions] Computational no yes
VPS25_HUMAN [view interactions] Computational no yes
VP37B_HUMAN [view interactions] Computational no yes
CHMP6_HUMAN [view interactions] Computational no yes
VPS28_HUMAN [view entry] [view interactions] Computational yes yes
CHM4A_HUMAN [view interactions] Computational no no
CHMP7_HUMAN [view interactions] Computational no yes
VP37A_HUMAN [view interactions] Computational no yes
SNF8_HUMAN [view interactions] Computational no yes
TS101_HUMAN [view entry] [view interactions] Computational yes yes
CHM2B_HUMAN [view entry] [view interactions] Computational yes yes
CHM4C_HUMAN [view interactions] Computational no yes
HGS_HUMAN [view entry] [view interactions] Computational yes yes