CHM1A_HUMAN
Evidence for PS localization
Functions
Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI004432 | DOC_MIT_MIM_1 | DOC | 185 | 195 | - |
| ELMI004432 | DOC_MIT_MIM_1 | DOC | 185 | 195 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CHM1A_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 29.0323 | 4 | no |
| GO:0043169 | cation binding | 25.8065 | 4 | yes |
| GO:0046872 | metal ion binding | 25.8065 | 5 | yes |
| GO:0000166 | nucleotide binding | 25.8065 | 4 | no |
| GO:0017076 | purine nucleotide binding | 25.8065 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 25.8065 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.5806 | 4 | no |
| GO:0008270 | zinc ion binding | 9.6774 | 7 | yes |
| GO:0042803 | protein homodimerization activity | 9.6774 | 4 | yes |
| GO:0046914 | transition metal ion binding | 9.6774 | 6 | yes |
| GO:0008237 | metallopeptidase activity | 6.4516 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CHM1A_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 61.2903 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 58.0645 | 4 | no |
| GO:0008104 | protein localization | 54.8387 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 54.8387 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 54.8387 | 4 | yes |
| GO:0006996 | organelle organization | 51.6129 | 4 | yes |
| GO:0022607 | cellular component assembly | 51.6129 | 4 | yes |
| GO:0071702 | organic substance transport | 51.6129 | 4 | yes |
| GO:0010646 | regulation of cell communication | 51.6129 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 48.3871 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 48.3871 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 48.3871 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 45.1613 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 45.1613 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 45.1613 | 4 | no |
| GO:0015031 | protein transport | 41.9355 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 41.9355 | 4 | no |
| GO:0051049 | regulation of transport | 41.9355 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 38.7097 | 5 | yes |
| GO:0006508 | proteolysis | 35.4839 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 35.4839 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 35.4839 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 35.4839 | 5 | yes |
| GO:0043933 | protein-containing complex organization | 35.4839 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.4839 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 35.4839 | 5 | no |
| GO:0051050 | positive regulation of transport | 35.4839 | 4 | no |
| GO:0010468 | regulation of gene expression | 32.2581 | 6 | yes |
| GO:0033043 | regulation of organelle organization | 32.2581 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 32.2581 | 4 | yes |
| GO:0051726 | regulation of cell cycle | 32.2581 | 4 | yes |
| GO:0023056 | positive regulation of signaling | 32.2581 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 32.2581 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 32.2581 | 4 | no |
| GO:0009057 | macromolecule catabolic process | 29.0323 | 4 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 29.0323 | 5 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 29.0323 | 6 | yes |
| GO:0010564 | regulation of cell cycle process | 29.0323 | 5 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 29.0323 | 6 | yes |
| GO:0070925 | organelle assembly | 29.0323 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 29.0323 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 29.0323 | 6 | no |
| GO:0031399 | regulation of protein modification process | 29.0323 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 29.0323 | 7 | no |
| GO:0043085 | positive regulation of catalytic activity | 29.0323 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 29.0323 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 29.0323 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 29.0323 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 29.0323 | 5 | no |
| GO:0007034 | vacuolar transport | 25.8065 | 4 | yes |
| GO:0016050 | vesicle organization | 25.8065 | 5 | yes |
| GO:0061024 | membrane organization | 25.8065 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 25.8065 | 7 | no |
| GO:0006355 | regulation of DNA-templated transcription | 25.8065 | 7 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 25.8065 | 8 | no |
| GO:0009968 | negative regulation of signal transduction | 25.8065 | 5 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 25.8065 | 6 | no |
| GO:0010648 | negative regulation of cell communication | 25.8065 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.8065 | 5 | no |
| GO:0023057 | negative regulation of signaling | 25.8065 | 4 | no |
| GO:0042327 | positive regulation of phosphorylation | 25.8065 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 25.8065 | 7 | no |
| GO:0051252 | regulation of RNA metabolic process | 25.8065 | 5 | no |
| GO:0141124 | intracellular signaling cassette | 25.8065 | 4 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 25.8065 | 6 | no |
| GO:0034762 | regulation of transmembrane transport | 25.8065 | 4 | no |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 22.5806 | 7 | yes |
| GO:0007032 | endosome organization | 22.5806 | 6 | yes |
| GO:0007033 | vacuole organization | 22.5806 | 5 | yes |
| GO:0019941 | modification-dependent protein catabolic process | 22.5806 | 6 | yes |
| GO:0032509 | endosome transport via multivesicular body sorting pathway | 22.5806 | 4 | yes |
| GO:0043632 | modification-dependent macromolecule catabolic process | 22.5806 | 5 | yes |
| GO:0051603 | proteolysis involved in protein catabolic process | 22.5806 | 5 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 22.5806 | 8 | no |
| GO:0009967 | positive regulation of signal transduction | 22.5806 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 22.5806 | 7 | no |
| GO:0043067 | regulation of programmed cell death | 22.5806 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 22.5806 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.5806 | 5 | no |
| GO:0051338 | regulation of transferase activity | 22.5806 | 4 | no |
| GO:0032880 | regulation of protein localization | 22.5806 | 5 | no |
| GO:0060341 | regulation of cellular localization | 22.5806 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 22.5806 | 4 | no |
| GO:0098657 | import into cell | 22.5806 | 4 | no |
| GO:0009894 | regulation of catabolic process | 22.5806 | 4 | no |
| GO:0006906 | vesicle fusion | 19.3548 | 6 | yes |
| GO:0007041 | lysosomal transport | 19.3548 | 5 | yes |
| GO:0022411 | cellular component disassembly | 19.3548 | 4 | yes |
| GO:0031468 | nuclear membrane reassembly | 19.3548 | 6 | yes |
| GO:0032886 | regulation of microtubule-based process | 19.3548 | 4 | yes |
| GO:0032984 | protein-containing complex disassembly | 19.3548 | 5 | yes |
| GO:0035891 | exit from host cell | 19.3548 | 4 | yes |
| GO:0036257 | multivesicular body organization | 19.3548 | 7 | yes |
| GO:0036258 | multivesicular body assembly | 19.3548 | 6 | yes |
| GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | 19.3548 | 8 | yes |
| GO:0048284 | organelle fusion | 19.3548 | 5 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 19.3548 | 6 | yes |
| GO:0061025 | membrane fusion | 19.3548 | 5 | yes |
| GO:0070507 | regulation of microtubule cytoskeleton organization | 19.3548 | 5 | yes |
| GO:0071709 | membrane assembly | 19.3548 | 5 | yes |
| GO:0071763 | nuclear membrane organization | 19.3548 | 5 | yes |
| GO:0090174 | organelle membrane fusion | 19.3548 | 6 | yes |
| GO:1902115 | regulation of organelle assembly | 19.3548 | 5 | yes |
| GO:0001778 | plasma membrane repair | 16.1290 | 6 | yes |
| GO:0006997 | nucleus organization | 16.1290 | 5 | yes |
| GO:0007009 | plasma membrane organization | 16.1290 | 5 | yes |
| GO:0007080 | mitotic metaphase chromosome alignment | 16.1290 | 4 | yes |
| GO:0051303 | establishment of chromosome localization | 16.1290 | 4 | yes |
| GO:0051310 | metaphase chromosome alignment | 16.1290 | 5 | yes |
| GO:0060236 | regulation of mitotic spindle organization | 16.1290 | 7 | yes |
| GO:0061952 | midbody abscission | 16.1290 | 5 | yes |
| GO:0090148 | membrane fission | 16.1290 | 5 | yes |
| GO:0090224 | regulation of spindle organization | 16.1290 | 6 | yes |
| GO:0097352 | autophagosome maturation | 16.1290 | 6 | yes |
| GO:1902410 | mitotic cytokinetic process | 16.1290 | 4 | yes |
| GO:1902774 | late endosome to lysosome transport | 16.1290 | 6 | yes |
| GO:1904896 | ESCRT complex disassembly | 16.1290 | 6 | yes |
| GO:1904903 | ESCRT III complex disassembly | 16.1290 | 7 | yes |
| GO:0010629 | negative regulation of gene expression | 12.9032 | 7 | yes |
| GO:0010824 | regulation of centrosome duplication | 12.9032 | 6 | yes |
| GO:0046605 | regulation of centrosome cycle | 12.9032 | 5 | yes |
| GO:0051469 | vesicle fusion with vacuole | 12.9032 | 7 | yes |
| GO:0061763 | multivesicular body-lysosome fusion | 12.9032 | 6 | yes |
| GO:0090169 | regulation of spindle assembly | 12.9032 | 6 | yes |
| GO:0097212 | lysosomal membrane organization | 12.9032 | 5 | yes |
| GO:0097576 | vacuole fusion | 12.9032 | 6 | yes |
| GO:1901673 | regulation of mitotic spindle assembly | 12.9032 | 7 | yes |
| GO:0051276 | chromosome organization | 9.6774 | 5 | yes |
| GO:0007076 | mitotic chromosome condensation | 6.4516 | 4 | yes |
| GO:0030261 | chromosome condensation | 6.4516 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MITD1_HUMAN | [view interactions] | Low throughput | no | no |
| STABP_HUMAN | [view interactions] | Low throughput | no | yes |
| VPS4A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBP8_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| VPS4B_HUMAN | [view interactions] | Low throughput | no | yes |
| VSX2_HUMAN | [view interactions] | High throughput | no | no |
| HMGN2_HUMAN | [view interactions] | High throughput | no | no |
| BROX_HUMAN | [view interactions] | High throughput | no | yes |
| MEOX1_HUMAN | [view interactions] | High throughput | no | no |
| HEY2_HUMAN | [view interactions] | High throughput | no | no |
| ZN524_HUMAN | [view interactions] | High throughput | no | no |
| CHMP5_HUMAN | [view interactions] | High throughput | no | yes |
| PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP54_HUMAN | [view interactions] | High throughput | no | yes |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGLN_HUMAN | [view interactions] | High throughput | no | no |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| ZDH17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YES_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CN119_HUMAN | [view interactions] | High throughput | no | yes |
| THIOM_HUMAN | [view interactions] | High throughput | no | yes |
| VTA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSA1_HUMAN | [view interactions] | High throughput | no | yes |
| DDT4L_HUMAN | [view interactions] | High throughput | no | no |
| GORS2_HUMAN | [view interactions] | High throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR1I2_HUMAN | [view interactions] | High throughput | no | no |
| IST1_HUMAN | [view interactions] | High throughput | no | yes |
| VATB1_HUMAN | [view interactions] | High throughput | no | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| RUVB1_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| MERL_HUMAN | [view interactions] | High throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| IFIX_HUMAN | [view interactions] | High throughput | no | no |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| CGAS_HUMAN | [view interactions] | High throughput | no | yes |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| MEOX2_HUMAN | [view interactions] | High throughput | no | no |
| FIBB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MAX_HUMAN | [view interactions] | High throughput | no | yes |
| DLX6_HUMAN | [view interactions] | High throughput | no | no |
| DPOE3_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPX2_HUMAN | [view interactions] | High throughput | no | yes |
| EZH1_HUMAN | [view interactions] | High throughput | no | yes |
| FCGRN_HUMAN | [view interactions] | High throughput | no | yes |
| MND1_HUMAN | [view interactions] | High throughput | no | no |
| UN45A_HUMAN | [view interactions] | High throughput | no | yes |
| BBS1_HUMAN | [view interactions] | High throughput | no | no |
| AT5F1_HUMAN | [view interactions] | High throughput | no | yes |
| EST2_HUMAN | [view interactions] | High throughput | no | yes |
| PLPL1_HUMAN | [view interactions] | High throughput | no | no |
| ZNF8_HUMAN | [view interactions] | High throughput | no | yes |
| CB39L_HUMAN | [view interactions] | High throughput | no | yes |
| MILR1_HUMAN | [view interactions] | High throughput | no | no |
| ANR49_HUMAN | [view interactions] | High throughput | no | yes |
| RT18C_HUMAN | [view interactions] | High throughput | no | yes |
| STRN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBTB2_HUMAN | [view interactions] | High throughput | no | yes |
| AHR_HUMAN | [view interactions] | High throughput | no | yes |
| KPB2_HUMAN | [view interactions] | High throughput | no | yes |
| RPC10_HUMAN | [view interactions] | High throughput | no | yes |
| PGES2_HUMAN | [view interactions] | High throughput | no | yes |
| RNF31_HUMAN | [view interactions] | High throughput | no | yes |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| RM38_HUMAN | [view interactions] | High throughput | no | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOXA1_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| GATA4_HUMAN | [view interactions] | High throughput | no | no |
| VIGLN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FXL18_HUMAN | [view interactions] | High throughput | no | no |
| OAS3_HUMAN | [view interactions] | High throughput | no | no |
| CHMP3_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4A_HUMAN | [view interactions] | High throughput | no | no |
| CHM2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| CHM1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CHM1B_HUMAN | [view interactions] | High throughput | no | yes |
| UBC9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOS9_HUMAN | [view interactions] | High throughput | no | yes |
| PIAS2_HUMAN | [view interactions] | High throughput | no | yes |
| RBP2_HUMAN | [view interactions] | High throughput | no | yes |
| TFG_HUMAN | [view interactions] | High throughput | no | yes |
| CD2AP_HUMAN | [view interactions] | High throughput | no | no |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPAST_HUMAN | [view interactions] | High throughput | no | yes |
| CHM2A_HUMAN | [view interactions] | High throughput | no | yes |
| PTN23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| GOT1B_HUMAN | [view interactions] | High throughput | no | yes |
| MECP2_HUMAN | [view interactions] | High throughput | no | yes |
| SIX2_HUMAN | [view interactions] | High throughput | no | no |
| GPX7_HUMAN | [view interactions] | High throughput | no | no |
| LHX4_HUMAN | [view interactions] | High throughput | no | no |