UBP8_HUMAN
Evidence for PS localization
Functions
Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both Lys-48 an Lys-63-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-mediated APP cleavage and amyloid-beta formation (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI004785 | LIG_SH3_PxxxRxxKP_6 | LIG | 405 | 413 | - |
| ELMI004786 | LIG_SH3_PxxxRxxKP_6 | LIG | 738 | 746 | - |
| ELMI004785 | LIG_SH3_PxxxRxxKP_6 | LIG | 405 | 413 | - |
| ELMI004786 | LIG_SH3_PxxxRxxKP_6 | LIG | 738 | 746 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in UBP8_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 31.9149 | 4 | no |
| GO:0019901 | protein kinase binding | 29.7872 | 5 | no |
| GO:0045296 | cadherin binding | 27.6596 | 4 | yes |
| GO:0043169 | cation binding | 27.6596 | 4 | no |
| GO:0046872 | metal ion binding | 27.6596 | 5 | no |
| GO:0043168 | anion binding | 21.2766 | 4 | no |
| GO:0017124 | SH3 domain binding | 14.8936 | 4 | yes |
| GO:0004175 | endopeptidase activity | 8.5106 | 4 | yes |
| GO:0004197 | cysteine-type endopeptidase activity | 8.5106 | 5 | yes |
| GO:0004843 | cysteine-type deubiquitinase activity | 8.5106 | 5 | yes |
| GO:0008234 | cysteine-type peptidase activity | 8.5106 | 4 | yes |
| GO:0019783 | ubiquitin-like protein peptidase activity | 8.5106 | 4 | yes |
| GO:0101005 | deubiquitinase activity | 8.5106 | 5 | yes |
| GO:1990380 | K48-linked deubiquitinase activity | 6.3830 | 6 | yes |
| GO:0061578 | K63-linked deubiquitinase activity | 4.2553 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in UBP8_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 70.2128 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 70.2128 | 4 | no |
| GO:0010646 | regulation of cell communication | 68.0851 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 63.8298 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 61.7021 | 4 | no |
| GO:0009966 | regulation of signal transduction | 59.5745 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 57.4468 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 55.3191 | 4 | yes |
| GO:0006996 | organelle organization | 53.1915 | 4 | yes |
| GO:0023056 | positive regulation of signaling | 51.0638 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 51.0638 | 4 | yes |
| GO:0022607 | cellular component assembly | 51.0638 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 48.9362 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 48.9362 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 48.9362 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 46.8085 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 46.8085 | 4 | no |
| GO:0010468 | regulation of gene expression | 46.8085 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 46.8085 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 46.8085 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 44.6809 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 44.6809 | 5 | yes |
| GO:0008104 | protein localization | 44.6809 | 4 | no |
| GO:0051049 | regulation of transport | 42.5532 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 42.5532 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 42.5532 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.4255 | 5 | yes |
| GO:0042981 | regulation of apoptotic process | 38.2979 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 38.2979 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 36.1702 | 5 | no |
| GO:0031399 | regulation of protein modification process | 36.1702 | 6 | no |
| GO:0036211 | protein modification process | 34.0426 | 4 | yes |
| GO:0043412 | macromolecule modification | 34.0426 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 34.0426 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 34.0426 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 34.0426 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 31.9149 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 31.9149 | 4 | yes |
| GO:0051252 | regulation of RNA metabolic process | 31.9149 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 31.9149 | 5 | no |
| GO:0023057 | negative regulation of signaling | 31.9149 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 31.9149 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 31.9149 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 31.9149 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 31.9149 | 4 | no |
| GO:0032880 | regulation of protein localization | 29.7872 | 5 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 29.7872 | 6 | yes |
| GO:0060341 | regulation of cellular localization | 29.7872 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 29.7872 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 29.7872 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 29.7872 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 29.7872 | 7 | no |
| GO:0009890 | negative regulation of biosynthetic process | 29.7872 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 29.7872 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 29.7872 | 6 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 29.7872 | 6 | no |
| GO:0001932 | regulation of protein phosphorylation | 29.7872 | 7 | no |
| GO:0009891 | positive regulation of biosynthetic process | 29.7872 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 29.7872 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 29.7872 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 29.7872 | 7 | no |
| GO:0043066 | negative regulation of apoptotic process | 29.7872 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 29.7872 | 5 | no |
| GO:0071702 | organic substance transport | 29.7872 | 4 | no |
| GO:0071705 | nitrogen compound transport | 29.7872 | 4 | no |
| GO:0009894 | regulation of catabolic process | 27.6596 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 27.6596 | 6 | yes |
| GO:0008284 | positive regulation of cell population proliferation | 27.6596 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 27.6596 | 6 | no |
| GO:0051050 | positive regulation of transport | 27.6596 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 27.6596 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 27.6596 | 4 | no |
| GO:0006508 | proteolysis | 25.5319 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 25.5319 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 25.5319 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 25.5319 | 4 | no |
| GO:0030334 | regulation of cell migration | 25.5319 | 5 | no |
| GO:0051338 | regulation of transferase activity | 25.5319 | 4 | no |
| GO:2000145 | regulation of cell motility | 25.5319 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 23.4043 | 5 | yes |
| GO:0071310 | cellular response to organic substance | 23.4043 | 4 | yes |
| GO:0141124 | intracellular signaling cassette | 23.4043 | 4 | yes |
| GO:0034762 | regulation of transmembrane transport | 23.4043 | 4 | no |
| GO:0050890 | cognition | 23.4043 | 4 | no |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 23.4043 | 5 | no |
| GO:0043549 | regulation of kinase activity | 23.4043 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 23.4043 | 4 | no |
| GO:0043408 | regulation of MAPK cascade | 23.4043 | 6 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 21.2766 | 4 | yes |
| GO:0030030 | cell projection organization | 21.2766 | 4 | no |
| GO:0034330 | cell junction organization | 21.2766 | 4 | no |
| GO:0044057 | regulation of system process | 21.2766 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 21.2766 | 5 | no |
| GO:0043269 | regulation of monoatomic ion transport | 21.2766 | 5 | no |
| GO:0051253 | negative regulation of RNA metabolic process | 21.2766 | 6 | no |
| GO:0009057 | macromolecule catabolic process | 21.2766 | 4 | no |
| GO:0015031 | protein transport | 21.2766 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 21.2766 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 21.2766 | 7 | no |
| GO:0032101 | regulation of response to external stimulus | 21.2766 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 21.2766 | 4 | no |
| GO:0045859 | regulation of protein kinase activity | 21.2766 | 6 | no |
| GO:0051726 | regulation of cell cycle | 21.2766 | 4 | no |
| GO:0051960 | regulation of nervous system development | 21.2766 | 5 | no |
| GO:0060284 | regulation of cell development | 21.2766 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 21.2766 | 6 | no |
| GO:1903829 | positive regulation of protein localization | 21.2766 | 5 | no |
| GO:0043687 | post-translational protein modification | 19.1489 | 5 | yes |
| GO:0070647 | protein modification by small protein conjugation or removal | 19.1489 | 6 | yes |
| GO:0071363 | cellular response to growth factor stimulus | 19.1489 | 4 | yes |
| GO:0032870 | cellular response to hormone stimulus | 17.0213 | 4 | yes |
| GO:0016050 | vesicle organization | 14.8936 | 5 | yes |
| GO:0033993 | response to lipid | 14.8936 | 4 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 14.8936 | 5 | yes |
| GO:0007032 | endosome organization | 12.7660 | 6 | yes |
| GO:0007264 | small GTPase-mediated signal transduction | 12.7660 | 5 | yes |
| GO:0014070 | response to organic cyclic compound | 12.7660 | 4 | yes |
| GO:0030111 | regulation of Wnt signaling pathway | 12.7660 | 5 | yes |
| GO:0042176 | regulation of protein catabolic process | 12.7660 | 5 | yes |
| GO:0060828 | regulation of canonical Wnt signaling pathway | 12.7660 | 6 | yes |
| GO:0071407 | cellular response to organic cyclic compound | 12.7660 | 5 | yes |
| GO:0007265 | Ras protein signal transduction | 10.6383 | 6 | yes |
| GO:0009895 | negative regulation of catabolic process | 10.6383 | 5 | yes |
| GO:0071396 | cellular response to lipid | 10.6383 | 5 | yes |
| GO:1901654 | response to ketone | 10.6383 | 4 | yes |
| GO:1901655 | cellular response to ketone | 10.6383 | 5 | yes |
| GO:0016579 | protein deubiquitination | 8.5106 | 8 | yes |
| GO:0031960 | response to corticosteroid | 8.5106 | 5 | yes |
| GO:0048545 | response to steroid hormone | 8.5106 | 4 | yes |
| GO:0070646 | protein modification by small protein removal | 8.5106 | 7 | yes |
| GO:0071383 | cellular response to steroid hormone stimulus | 8.5106 | 5 | yes |
| GO:1990089 | response to nerve growth factor | 8.5106 | 4 | yes |
| GO:1990090 | cellular response to nerve growth factor stimulus | 8.5106 | 5 | yes |
| GO:0000281 | mitotic cytokinesis | 6.3830 | 4 | yes |
| GO:0030177 | positive regulation of Wnt signaling pathway | 6.3830 | 6 | yes |
| GO:0042177 | negative regulation of protein catabolic process | 6.3830 | 6 | yes |
| GO:0051384 | response to glucocorticoid | 6.3830 | 6 | yes |
| GO:0061640 | cytoskeleton-dependent cytokinesis | 6.3830 | 4 | yes |
| GO:0071384 | cellular response to corticosteroid stimulus | 6.3830 | 6 | yes |
| GO:0071385 | cellular response to glucocorticoid stimulus | 6.3830 | 7 | yes |
| GO:0071548 | response to dexamethasone | 6.3830 | 5 | yes |
| GO:0071549 | cellular response to dexamethasone stimulus | 6.3830 | 6 | yes |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway | 6.3830 | 7 | yes |
| GO:0099170 | postsynaptic modulation of chemical synaptic transmission | 6.3830 | 6 | yes |
| GO:0099576 | regulation of protein catabolic process at postsynapse, modulating synaptic transmission | 6.3830 | 6 | yes |
| GO:1902905 | positive regulation of supramolecular fiber organization | 6.3830 | 6 | yes |
| GO:0070536 | protein K63-linked deubiquitination | 4.2553 | 9 | yes |
| GO:0071108 | protein K48-linked deubiquitination | 4.2553 | 9 | yes |
| GO:1904350 | regulation of protein catabolic process in the vacuole | 4.2553 | 6 | yes |
| GO:1904351 | negative regulation of protein catabolic process in the vacuole | 4.2553 | 7 | yes |
| GO:1905165 | regulation of lysosomal protein catabolic process | 4.2553 | 7 | yes |
| GO:1905166 | negative regulation of lysosomal protein catabolic process | 4.2553 | 8 | yes |
| GO:1905906 | regulation of amyloid fibril formation | 4.2553 | 6 | yes |
| GO:1905908 | positive regulation of amyloid fibril formation | 4.2553 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SCNNB_HUMAN | [view interactions] | Low throughput | no | yes |
| SCNNG_HUMAN | [view interactions] | Low throughput | no | no |
| MCPH1_HUMAN | [view interactions] | Low throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CFLAR_HUMAN | [view interactions] | Low throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTPA_HUMAN | [view interactions] | Low throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EPG5_HUMAN | [view interactions] | Low throughput | no | yes |
| LEPR_HUMAN | [view interactions] | Low throughput | no | no |
| ERBB3_HUMAN | [view interactions] | Low throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SQSTM_HUMAN | [view interactions] | Low throughput | no | yes |
| NOTC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| P63_HUMAN | [view interactions] | Low throughput | no | no |
| TYY1_HUMAN | [view interactions] | Low throughput | no | yes |
| NTRK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| M3K7_HUMAN | [view interactions] | Low throughput | no | yes |
| ID1_HUMAN | [view interactions] | Low throughput | no | yes |
| PD1L1_HUMAN | [view interactions] | Low throughput | no | no |
| TGFR2_HUMAN | [view interactions] | Low throughput | no | no |
| ESR1_HUMAN | [view interactions] | Low throughput | no | no |
| DNJB3_HUMAN | [view interactions] | Low throughput | no | no |
| CHMP7_HUMAN | [view interactions] | Low throughput | no | yes |
| SC31A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| H2A2C_HUMAN | [view interactions] | Low throughput | no | yes |
| H2B2E_HUMAN | [view interactions] | Low throughput | no | yes |
| BACE1_HUMAN | [view interactions] | Low throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SHAN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBP8_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EEA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CHM1B_HUMAN | [view interactions] | Low throughput | no | yes |
| NBR1_HUMAN | [view interactions] | Low throughput | no | yes |
| BIRC6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KIF23_HUMAN | [view interactions] | Low throughput | no | yes |
| CHM1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FZD4_HUMAN | [view interactions] | Low throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRAP2_HUMAN | [view interactions] | Low throughput | no | no |
| 1433T_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STAM2_HUMAN | [view interactions] | Low throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433S_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CHM4C_HUMAN | [view interactions] | Low throughput | no | yes |
| CHM2A_HUMAN | [view interactions] | Low throughput | no | yes |
| CHM2B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HIF1A_HUMAN | [view interactions] | Low throughput | no | no |
| EPAS1_HUMAN | [view interactions] | Low throughput | no | no |
| RNF41_HUMAN | [view interactions] | Low throughput | no | yes |
| M3K1_HUMAN | [view interactions] | Low throughput | no | yes |
| TADBP_HUMAN | [view interactions] | Low throughput | no | yes |
| OTUB1_HUMAN | [view interactions] | Low throughput | no | yes |
| RN128_HUMAN | [view interactions] | Low throughput | no | yes |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| AKT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EPS15_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCNN4_HUMAN | [view interactions] | Low throughput | no | no |
| STAM1_HUMAN | [view interactions] | Low throughput | no | yes |
| RGRF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ERBB4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTN23_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTEN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LRIG1_HUMAN | [view interactions] | Low throughput | no | yes |
| VAMP8_HUMAN | [view interactions] | Low throughput | no | no |
| SCNNA_HUMAN | [view interactions] | Low throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| UCHL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMM79_HUMAN | [view interactions] | High throughput | no | no |
| FZD5_HUMAN | [view interactions] | High throughput | no | yes |
| TPC2_HUMAN | [view interactions] | High throughput | no | no |
| RN149_HUMAN | [view interactions] | High throughput | no | no |
| ACTT1_HUMAN | [view interactions] | High throughput | no | no |
| IST1_HUMAN | [view interactions] | High throughput | no | yes |
| KCNE3_HUMAN | [view interactions] | High throughput | no | yes |
| MARH1_HUMAN | [view interactions] | High throughput | no | yes |
| SIX1_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| ARMD3_HUMAN | [view interactions] | High throughput | no | yes |
| PTAR1_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| ARI1A_HUMAN | [view interactions] | High throughput | no | yes |
| SPPL3_HUMAN | [view interactions] | High throughput | no | no |
| ITB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PJA1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| TRI55_HUMAN | [view interactions] | High throughput | no | no |
| TRI54_HUMAN | [view interactions] | High throughput | no | no |
| UBP21_HUMAN | [view interactions] | High throughput | no | no |
| UBP15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP28_HUMAN | [view interactions] | High throughput | no | yes |
| PA2GA_HUMAN | [view interactions] | High throughput | no | no |
| UBC9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UB2G1_HUMAN | [view interactions] | High throughput | no | yes |
| SYFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS4B_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPOD3_HUMAN | [view interactions] | High throughput | no | yes |
| STAT6_HUMAN | [view interactions] | High throughput | no | yes |
| SEN2_HUMAN | [view interactions] | High throughput | no | yes |
| THIM_HUMAN | [view interactions] | High throughput | no | yes |
| TATD1_HUMAN | [view interactions] | High throughput | no | yes |
| UB2E1_HUMAN | [view interactions] | High throughput | no | yes |
| REEP1_HUMAN | [view interactions] | High throughput | no | yes |
| COMD2_HUMAN | [view interactions] | High throughput | no | yes |
| PTGR2_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| SPTCS_HUMAN | [view interactions] | High throughput | no | yes |
| KRT85_HUMAN | [view interactions] | High throughput | no | no |
| KRT36_HUMAN | [view interactions] | High throughput | no | no |
| K1H1_HUMAN | [view interactions] | High throughput | no | no |
| UBP22_HUMAN | [view interactions] | High throughput | no | yes |
| CD2AP_HUMAN | [view interactions] | High throughput | no | no |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD83_HUMAN | [view interactions] | High throughput | no | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQCF5_HUMAN | [view interactions] | High throughput | no | no |
| PSMD4_HUMAN | [view interactions] | High throughput | no | yes |
| CHMP3_HUMAN | [view interactions] | High throughput | no | yes |
| CHMP5_HUMAN | [view interactions] | High throughput | no | yes |
| CHMP6_HUMAN | [view interactions] | High throughput | no | yes |
| DSCR9_HUMAN | [view interactions] | High throughput | no | no |
| BTG3_HUMAN | [view interactions] | High throughput | no | yes |
| HUNK_HUMAN | [view interactions] | High throughput | no | yes |
| BET1_HUMAN | [view interactions] | High throughput | no | no |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR2_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| PGFRA_HUMAN | [view interactions] | High throughput | no | no |
| PGFRB_HUMAN | [view interactions] | High throughput | no | yes |
| RYK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB3I_HUMAN | [view interactions] | High throughput | no | no |
| CBY1_HUMAN | [view interactions] | High throughput | no | no |
| OSTP_HUMAN | [view interactions] | High throughput | no | yes |