Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RGRF1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Promotes the exchange of Ras-bound GDP by GTP. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RGRF1_HUMAN
GO:0043168 anion binding 47.3684 4 no
GO:0000166 nucleotide binding 42.1053 4 no
GO:0017076 purine nucleotide binding 42.1053 5 no
GO:0032555 purine ribonucleotide binding 42.1053 4 no
GO:0035639 purine ribonucleoside triphosphate binding 42.1053 4 no
GO:0005524 ATP binding 31.5789 5 no
GO:0016301 kinase activity 31.5789 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 31.5789 4 no
GO:0030554 adenyl nucleotide binding 31.5789 6 no
GO:0032559 adenyl ribonucleotide binding 31.5789 5 no
GO:0043169 cation binding 26.3158 4 no
GO:0046872 metal ion binding 26.3158 5 no
GO:0045296 cadherin binding 26.3158 4 no
GO:0019900 kinase binding 26.3158 4 no
GO:0019901 protein kinase binding 21.0526 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in RGRF1_HUMAN
GO:0048522 positive regulation of cellular process 84.2105 4 yes
GO:0009966 regulation of signal transduction 78.9474 4 yes
GO:0010646 regulation of cell communication 78.9474 4 yes
GO:0048523 negative regulation of cellular process 73.6842 4 no
GO:0060255 regulation of macromolecule metabolic process 73.6842 4 no
GO:0080090 regulation of primary metabolic process 73.6842 4 no
GO:0051128 regulation of cellular component organization 68.4211 4 no
GO:0051246 regulation of protein metabolic process 68.4211 5 no
GO:0009893 positive regulation of metabolic process 63.1579 4 no
GO:0010604 positive regulation of macromolecule metabolic process 63.1579 5 no
GO:0031323 regulation of cellular metabolic process 63.1579 4 no
GO:0051247 positive regulation of protein metabolic process 57.8947 6 no
GO:0031325 positive regulation of cellular metabolic process 52.6316 5 no
GO:0009892 negative regulation of metabolic process 52.6316 4 no
GO:0019220 regulation of phosphate metabolic process 52.6316 6 no
GO:0031399 regulation of protein modification process 52.6316 6 no
GO:0051174 regulation of phosphorus metabolic process 52.6316 5 no
GO:0009967 positive regulation of signal transduction 47.3684 5 yes
GO:0010647 positive regulation of cell communication 47.3684 5 yes
GO:0023056 positive regulation of signaling 47.3684 4 yes
GO:0048584 positive regulation of response to stimulus 47.3684 4 yes
GO:0022607 cellular component assembly 47.3684 4 no
GO:0031344 regulation of cell projection organization 47.3684 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 47.3684 6 no
GO:0042127 regulation of cell population proliferation 47.3684 4 no
GO:0010605 negative regulation of macromolecule metabolic process 47.3684 5 no
GO:0001932 regulation of protein phosphorylation 47.3684 7 no
GO:0042325 regulation of phosphorylation 47.3684 7 no
GO:0043085 positive regulation of catalytic activity 42.1053 4 yes
GO:1902531 regulation of intracellular signal transduction 42.1053 5 yes
GO:0036211 protein modification process 42.1053 4 no
GO:0043412 macromolecule modification 42.1053 4 no
GO:0009889 regulation of biosynthetic process 42.1053 4 no
GO:0010468 regulation of gene expression 42.1053 6 no
GO:0010556 regulation of macromolecule biosynthetic process 42.1053 5 no
GO:0031326 regulation of cellular biosynthetic process 42.1053 5 no
GO:0031324 negative regulation of cellular metabolic process 42.1053 5 no
GO:0051130 positive regulation of cellular component organization 42.1053 5 no
GO:0001934 positive regulation of protein phosphorylation 42.1053 8 no
GO:0010562 positive regulation of phosphorus metabolic process 42.1053 6 no
GO:0031401 positive regulation of protein modification process 42.1053 7 no
GO:0042327 positive regulation of phosphorylation 42.1053 8 no
GO:0045937 positive regulation of phosphate metabolic process 42.1053 7 no
GO:0051336 regulation of hydrolase activity 36.8421 4 yes
GO:1902533 positive regulation of intracellular signal transduction 36.8421 6 yes
GO:0009968 negative regulation of signal transduction 36.8421 5 no
GO:0010648 negative regulation of cell communication 36.8421 5 no
GO:0023057 negative regulation of signaling 36.8421 4 no
GO:0048585 negative regulation of response to stimulus 36.8421 4 no
GO:0006996 organelle organization 36.8421 4 no
GO:0009891 positive regulation of biosynthetic process 36.8421 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 36.8421 6 no
GO:0010628 positive regulation of gene expression 36.8421 7 no
GO:0031328 positive regulation of cellular biosynthetic process 36.8421 6 no
GO:0051248 negative regulation of protein metabolic process 36.8421 6 no
GO:0071363 cellular response to growth factor stimulus 36.8421 4 no
GO:0030334 regulation of cell migration 36.8421 5 no
GO:2000145 regulation of cell motility 36.8421 4 no
GO:0050804 modulation of chemical synaptic transmission 31.5789 5 yes
GO:0050890 cognition 31.5789 4 yes
GO:0099177 regulation of trans-synaptic signaling 31.5789 4 yes
GO:0006796 phosphate-containing compound metabolic process 31.5789 4 no
GO:0016310 phosphorylation 31.5789 5 no
GO:0044057 regulation of system process 31.5789 4 no
GO:0051049 regulation of transport 31.5789 4 no
GO:0043933 protein-containing complex organization 31.5789 4 no
GO:0008284 positive regulation of cell population proliferation 31.5789 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 31.5789 5 no
GO:0042981 regulation of apoptotic process 31.5789 5 no
GO:0043067 regulation of programmed cell death 31.5789 4 no
GO:0051726 regulation of cell cycle 31.5789 4 no
GO:0071310 cellular response to organic substance 31.5789 4 no
GO:1901701 cellular response to oxygen-containing compound 31.5789 4 no
GO:0030335 positive regulation of cell migration 31.5789 6 no
GO:0040017 positive regulation of locomotion 31.5789 4 no
GO:2000147 positive regulation of cell motility 31.5789 5 no
GO:0043549 regulation of kinase activity 31.5789 5 no
GO:0044087 regulation of cellular component biogenesis 31.5789 4 no
GO:0045859 regulation of protein kinase activity 31.5789 6 no
GO:0051338 regulation of transferase activity 31.5789 4 no
GO:0051345 positive regulation of hydrolase activity 26.3158 5 yes
GO:0141124 intracellular signaling cassette 26.3158 4 yes
GO:0006468 protein phosphorylation 26.3158 5 no
GO:0050807 regulation of synapse organization 26.3158 5 no
GO:0065003 protein-containing complex assembly 26.3158 5 no
GO:0051252 regulation of RNA metabolic process 26.3158 5 no
GO:0008104 protein localization 26.3158 4 no
GO:0032880 regulation of protein localization 26.3158 5 no
GO:0033993 response to lipid 26.3158 4 no
GO:0060341 regulation of cellular localization 26.3158 4 no
GO:0009890 negative regulation of biosynthetic process 26.3158 5 no
GO:0010975 regulation of neuron projection development 26.3158 7 no
GO:0043066 negative regulation of apoptotic process 26.3158 6 no
GO:0043069 negative regulation of programmed cell death 26.3158 5 no
GO:0097435 supramolecular fiber organization 26.3158 4 no
GO:0034330 cell junction organization 26.3158 4 no
GO:0033674 positive regulation of kinase activity 26.3158 6 no
GO:0044089 positive regulation of cellular component biogenesis 26.3158 5 no
GO:0045860 positive regulation of protein kinase activity 26.3158 7 no
GO:0051240 positive regulation of multicellular organismal process 26.3158 4 no
GO:0051347 positive regulation of transferase activity 26.3158 5 no
GO:0031346 positive regulation of cell projection organization 26.3158 6 no
GO:0043408 regulation of MAPK cascade 26.3158 6 no
GO:0043410 positive regulation of MAPK cascade 26.3158 7 no
GO:0007264 small GTPase-mediated signal transduction 21.0526 5 yes
GO:0030030 cell projection organization 21.0526 4 yes
GO:0043087 regulation of GTPase activity 21.0526 5 yes
GO:0048168 regulation of neuronal synaptic plasticity 21.0526 4 yes
GO:0120036 plasma membrane bounded cell projection organization 21.0526 5 yes
GO:0018193 peptidyl-amino acid modification 21.0526 5 no
GO:0098657 import into cell 21.0526 4 no
GO:1903522 regulation of blood circulation 21.0526 5 no
GO:0043523 regulation of neuron apoptotic process 21.0526 6 no
GO:0045787 positive regulation of cell cycle 21.0526 5 no
GO:0090304 nucleic acid metabolic process 21.0526 4 no
GO:0014070 response to organic cyclic compound 21.0526 4 no
GO:0030111 regulation of Wnt signaling pathway 21.0526 5 no
GO:0048545 response to steroid hormone 21.0526 4 no
GO:0071396 cellular response to lipid 21.0526 5 no
GO:0071407 cellular response to organic cyclic compound 21.0526 5 no
GO:0006355 regulation of DNA-templated transcription 21.0526 7 no
GO:0006357 regulation of transcription by RNA polymerase II 21.0526 8 no
GO:0006915 apoptotic process 21.0526 4 no
GO:0010243 response to organonitrogen compound 21.0526 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 21.0526 6 no
GO:0010564 regulation of cell cycle process 21.0526 5 no
GO:0010629 negative regulation of gene expression 21.0526 7 no
GO:0031327 negative regulation of cellular biosynthetic process 21.0526 6 no
GO:0045595 regulation of cell differentiation 21.0526 4 no
GO:0051094 positive regulation of developmental process 21.0526 4 no
GO:0071417 cellular response to organonitrogen compound 21.0526 4 no
GO:0080134 regulation of response to stress 21.0526 4 no
GO:1901699 cellular response to nitrogen compound 21.0526 4 no
GO:1903829 positive regulation of protein localization 21.0526 5 no
GO:2001141 regulation of RNA biosynthetic process 21.0526 6 no
GO:0034329 cell junction assembly 21.0526 5 no
GO:0002684 positive regulation of immune system process 21.0526 4 no
GO:0007010 cytoskeleton organization 21.0526 5 no
GO:0071900 regulation of protein serine/threonine kinase activity 21.0526 7 no
GO:0071902 positive regulation of protein serine/threonine kinase activity 21.0526 8 no
GO:1901888 regulation of cell junction assembly 21.0526 5 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 21.0526 8 no
GO:0007167 enzyme-linked receptor protein signaling pathway 21.0526 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 21.0526 5 no
GO:0022603 regulation of anatomical structure morphogenesis 21.0526 4 no
GO:0007265 Ras protein signal transduction 15.7895 6 yes
GO:0031175 neuron projection development 15.7895 6 yes
GO:0043547 positive regulation of GTPase activity 15.7895 6 yes
GO:0046578 regulation of Ras protein signal transduction 10.5263 7 yes
GO:0046579 positive regulation of Ras protein signal transduction 10.5263 8 yes
GO:0051056 regulation of small GTPase mediated signal transduction 10.5263 6 yes
GO:0051057 positive regulation of small GTPase mediated signal transduction 10.5263 7 yes
GO:0090630 activation of GTPase activity 10.5263 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NTRK1_HUMAN [view interactions] Low throughput no yes
NTRK3_HUMAN [view entry] [view interactions] Low throughput yes yes
NTRK2_HUMAN [view entry] [view interactions] Low throughput yes yes
PLK1_HUMAN [view interactions] Low throughput no yes
P53_HUMAN [view interactions] Low throughput no no
A4_HUMAN [view entry] [view interactions] Low throughput yes yes
RASH_HUMAN [view entry] [view interactions] Low throughput yes no
NMDE2_HUMAN [view entry] [view interactions] Low throughput yes no
MARK3_HUMAN [view interactions] Low throughput no yes
NEB2_HUMAN [view entry] [view interactions] Low throughput yes yes
UBP8_HUMAN [view entry] [view interactions] Low throughput yes no
CTND1_HUMAN [view entry] [view interactions] Low throughput yes no
RHOA_HUMAN [view entry] [view interactions] Low throughput yes yes
1433B_HUMAN [view entry] [view interactions] Low throughput yes yes
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
FKBP5_HUMAN [view interactions] High throughput no yes
PALM_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
ARBK1_HUMAN [view entry] [view interactions] High throughput yes yes
CEBPA_HUMAN [view interactions] High throughput no yes
RU17_HUMAN [view interactions] High throughput no yes
EHD4_HUMAN [view entry] [view interactions] High throughput yes no
MDM2_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
AKT3_HUMAN [view interactions] High throughput no yes
RBCC1_HUMAN [view interactions] High throughput no no
UBP48_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
SRPK2_HUMAN [view entry] [view interactions] High throughput yes yes
RPGF5_HUMAN [view interactions] High throughput no yes
RPGFL_HUMAN [view interactions] High throughput no no
SOS2_HUMAN [view interactions] High throughput no yes