EHD4_HUMAN
Evidence for PS localization
Functions
ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in early endosomal transport. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in EHD4_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 42.2222 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 40.0000 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 40.0000 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 33.3333 | 5 | yes |
| GO:0046872 | metal ion binding | 33.3333 | 4 | yes |
| GO:0005524 | ATP binding | 31.1111 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 31.1111 | 5 | yes |
| GO:0019900 | kinase binding | 31.1111 | 4 | no |
| GO:0019901 | protein kinase binding | 28.8889 | 5 | no |
| GO:0005525 | GTP binding | 15.5556 | 5 | yes |
| GO:0019001 | guanyl nucleotide binding | 15.5556 | 5 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 15.5556 | 5 | yes |
| GO:0045296 | cadherin binding | 15.5556 | 4 | yes |
| GO:0005509 | calcium ion binding | 13.3333 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in EHD4_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 71.1111 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 57.7778 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 53.3333 | 4 | yes |
| GO:0010646 | regulation of cell communication | 53.3333 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 51.1111 | 4 | yes |
| GO:0051049 | regulation of transport | 48.8889 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 46.6667 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 46.6667 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 46.6667 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 44.4444 | 4 | yes |
| GO:0010468 | regulation of gene expression | 42.2222 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 42.2222 | 4 | no |
| GO:0009966 | regulation of signal transduction | 42.2222 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.0000 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 37.7778 | 5 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 37.7778 | 5 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 35.5556 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 35.5556 | 5 | no |
| GO:0023056 | positive regulation of signaling | 35.5556 | 4 | no |
| GO:0008104 | protein localization | 35.5556 | 4 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 35.5556 | 6 | yes |
| GO:0022607 | cellular component assembly | 35.5556 | 4 | yes |
| GO:0042325 | regulation of phosphorylation | 33.3333 | 7 | yes |
| GO:0071310 | cellular response to organic substance | 33.3333 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 33.3333 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 33.3333 | 5 | no |
| GO:0006996 | organelle organization | 33.3333 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 33.3333 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 31.1111 | 6 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 31.1111 | 6 | yes |
| GO:0009889 | regulation of biosynthetic process | 31.1111 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 31.1111 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 31.1111 | 5 | no |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 31.1111 | 4 | no |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 31.1111 | 5 | no |
| GO:0036211 | protein modification process | 31.1111 | 4 | no |
| GO:0043412 | macromolecule modification | 31.1111 | 4 | no |
| GO:0042327 | positive regulation of phosphorylation | 28.8889 | 8 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 28.8889 | 7 | yes |
| GO:0051050 | positive regulation of transport | 28.8889 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 28.8889 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 28.8889 | 6 | no |
| GO:0001932 | regulation of protein phosphorylation | 28.8889 | 7 | yes |
| GO:0010562 | positive regulation of phosphorus metabolic process | 28.8889 | 6 | yes |
| GO:0030030 | cell projection organization | 28.8889 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 26.6667 | 4 | yes |
| GO:0070848 | response to growth factor | 26.6667 | 4 | yes |
| GO:0071363 | cellular response to growth factor stimulus | 26.6667 | 5 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 26.6667 | 5 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 26.6667 | 5 | no |
| GO:0033043 | regulation of organelle organization | 26.6667 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 26.6667 | 4 | no |
| GO:0010941 | regulation of cell death | 26.6667 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 24.4444 | 7 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 24.4444 | 5 | no |
| GO:0071702 | organic substance transport | 24.4444 | 4 | no |
| GO:0071705 | nitrogen compound transport | 24.4444 | 4 | no |
| GO:0008284 | positive regulation of cell population proliferation | 24.4444 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 24.4444 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 24.4444 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 24.4444 | 5 | no |
| GO:0030155 | regulation of cell adhesion | 24.4444 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 24.4444 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 24.4444 | 6 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 24.4444 | 8 | yes |
| GO:0043933 | protein-containing complex organization | 22.2222 | 4 | yes |
| GO:0015031 | protein transport | 22.2222 | 4 | no |
| GO:0060341 | regulation of cellular localization | 22.2222 | 4 | no |
| GO:0002684 | positive regulation of immune system process | 22.2222 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 22.2222 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 22.2222 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 22.2222 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 22.2222 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 22.2222 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 22.2222 | 4 | no |
| GO:0045785 | positive regulation of cell adhesion | 22.2222 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.2222 | 5 | no |
| GO:0006897 | endocytosis | 22.2222 | 5 | yes |
| GO:0030100 | regulation of endocytosis | 22.2222 | 5 | yes |
| GO:0065003 | protein-containing complex assembly | 20.0000 | 5 | yes |
| GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 17.7778 | 8 | yes |
| GO:0120031 | plasma membrane bounded cell projection assembly | 15.5556 | 6 | yes |
| GO:0030031 | cell projection assembly | 15.5556 | 5 | yes |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 13.3333 | 9 | yes |
| GO:0072657 | protein localization to membrane | 13.3333 | 4 | yes |
| GO:0072659 | protein localization to plasma membrane | 13.3333 | 5 | yes |
| GO:1990778 | protein localization to cell periphery | 13.3333 | 5 | yes |
| GO:0016197 | endosomal transport | 11.1111 | 4 | yes |
| GO:0070925 | organelle assembly | 8.8889 | 5 | yes |
| GO:0098876 | vesicle-mediated transport to the plasma membrane | 8.8889 | 4 | yes |
| GO:0032456 | endocytic recycling | 6.6667 | 5 | yes |
| GO:0044782 | cilium organization | 6.6667 | 5 | yes |
| GO:0051259 | protein complex oligomerization | 6.6667 | 6 | yes |
| GO:0051260 | protein homooligomerization | 6.6667 | 7 | yes |
| GO:0060271 | cilium assembly | 6.6667 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in EHD4_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 4.4444 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SNP29_HUMAN | [view interactions] | Low throughput | no | yes |
| PACN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ANK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MILK1_HUMAN | [view interactions] | Low throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOLM1_HUMAN | [view interactions] | High throughput | no | yes |
| TPC2_HUMAN | [view interactions] | High throughput | no | no |
| PCDBG_HUMAN | [view interactions] | High throughput | no | no |
| EXOC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBNS5_HUMAN | [view interactions] | High throughput | no | yes |
| POC5_HUMAN | [view interactions] | High throughput | no | yes |
| EHD2_HUMAN | [view interactions] | High throughput | no | no |
| VPS45_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EHD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMX3_HUMAN | [view interactions] | High throughput | no | yes |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLPX_HUMAN | [view interactions] | High throughput | no | yes |
| DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH2B1_HUMAN | [view interactions] | High throughput | no | yes |
| COASY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHIP1_HUMAN | [view interactions] | High throughput | no | no |
| SHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HAKAI_HUMAN | [view interactions] | High throughput | no | yes |
| SH22A_HUMAN | [view interactions] | High throughput | no | no |
| GRB10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FER_HUMAN | [view interactions] | High throughput | no | yes |
| ABL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MEMO1_HUMAN | [view interactions] | High throughput | no | yes |
| ACADS_HUMAN | [view interactions] | High throughput | no | yes |
| YES_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASA1_HUMAN | [view interactions] | High throughput | no | yes |
| ZAP70_HUMAN | [view interactions] | High throughput | no | no |
| STAP1_HUMAN | [view interactions] | High throughput | no | no |
| TNS2_HUMAN | [view interactions] | High throughput | no | no |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KSYK_HUMAN | [view interactions] | High throughput | no | no |
| TENS3_HUMAN | [view interactions] | High throughput | no | no |
| TENS1_HUMAN | [view interactions] | High throughput | no | no |
| NCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRKL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHLA3_HUMAN | [view interactions] | High throughput | no | yes |
| STYL1_HUMAN | [view interactions] | High throughput | no | yes |
| GSTK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCAF1_HUMAN | [view interactions] | High throughput | no | yes |
| T22D1_HUMAN | [view interactions] | High throughput | no | no |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB2_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FETA_HUMAN | [view interactions] | High throughput | no | no |
| RGRF1_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRM_HUMAN | [view interactions] | High throughput | no | yes |
| P5F1B_HUMAN | [view interactions] | High throughput | no | no |
| PO5F1_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| TGFR2_HUMAN | [view interactions] | High throughput | no | no |
| FSD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DD19B_HUMAN | [view interactions] | High throughput | no | yes |
| HECA2_HUMAN | [view interactions] | High throughput | no | no |
| CS054_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| VMA5A_HUMAN | [view interactions] | High throughput | no | no |
| IQCF1_HUMAN | [view interactions] | High throughput | no | no |
| TR13B_HUMAN | [view interactions] | High throughput | no | yes |
| NOE3_HUMAN | [view interactions] | High throughput | no | no |
| TRI11_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM52B_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| HECD1_HUMAN | [view interactions] | High throughput | no | yes |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| CGAS_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| ETFA_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| UBR5_HUMAN | [view interactions] | High throughput | no | no |
| FA20C_HUMAN | [view interactions] | High throughput | no | no |
| SPXN5_HUMAN | [view interactions] | High throughput | no | no |
| CDCP2_HUMAN | [view interactions] | High throughput | no | no |
| EHD3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| F174A_HUMAN | [view interactions] | High throughput | no | yes |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| WIF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MAP7_HUMAN | [view interactions] | High throughput | no | yes |
| NTNG1_HUMAN | [view interactions] | High throughput | no | no |
| SYT6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUMO2_HUMAN | [view interactions] | High throughput | no | yes |
| DGKQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PUR8_HUMAN | [view interactions] | High throughput | no | yes |
| SZRD1_HUMAN | [view interactions] | High throughput | no | yes |
| PYRG2_HUMAN | [view interactions] | High throughput | no | yes |
| ADPPT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TF3C4_HUMAN | [view interactions] | High throughput | no | no |
| H2A1B_HUMAN | [view interactions] | High throughput | no | yes |
| NOL3_HUMAN | [view interactions] | High throughput | no | yes |
| PLCG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMG1_HUMAN | [view interactions] | High throughput | no | yes |
| RL38_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NIPA_HUMAN | [view interactions] | High throughput | no | yes |
| LRSM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTMR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 5NTC_HUMAN | [view interactions] | High throughput | no | yes |
| SAE2_HUMAN | [view interactions] | High throughput | no | yes |
| OST48_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYWC_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RFFL_HUMAN | [view interactions] | High throughput | no | yes |
| EXD2_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTF4_HUMAN | [view interactions] | Computational | no | no |
| NTF3_HUMAN | [view interactions] | Computational | no | no |
| CAD23_HUMAN | [view interactions] | Computational | no | yes |
| NGF_HUMAN | [view interactions] | Computational | no | no |
| NTRK2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| BDNF_HUMAN | [view interactions] | Computational | no | yes |