Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

COASY_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
499 Arg Cys Neurodegenerationwithbrainironaccumulation6(NBIA6) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in COASY_HUMAN
GO:0000166 nucleotide binding 34.7826 4 yes
GO:0017076 purine nucleotide binding 34.7826 5 yes
GO:0032555 purine ribonucleotide binding 34.7826 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 34.7826 4 yes
GO:0043168 anion binding 34.7826 4 yes
GO:0043169 cation binding 34.7826 4 no
GO:0046872 metal ion binding 34.7826 5 no
GO:0005524 ATP binding 26.0870 5 yes
GO:0030554 adenyl nucleotide binding 26.0870 6 yes
GO:0032559 adenyl ribonucleotide binding 26.0870 5 yes
GO:0045296 cadherin binding 26.0870 4 no
GO:0019900 kinase binding 21.7391 4 no
GO:0019901 protein kinase binding 21.7391 5 no
GO:0016301 kinase activity 17.3913 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 17.3913 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in COASY_HUMAN
GO:0048522 positive regulation of cellular process 69.5652 4 no
GO:0048523 negative regulation of cellular process 56.5217 4 no
GO:0051128 regulation of cellular component organization 56.5217 4 no
GO:0031323 regulation of cellular metabolic process 47.8261 4 no
GO:0009893 positive regulation of metabolic process 43.4783 4 no
GO:0010646 regulation of cell communication 43.4783 4 no
GO:0031325 positive regulation of cellular metabolic process 43.4783 5 no
GO:0060255 regulation of macromolecule metabolic process 43.4783 4 no
GO:0080090 regulation of primary metabolic process 43.4783 4 no
GO:0009889 regulation of biosynthetic process 39.1304 4 no
GO:0009966 regulation of signal transduction 39.1304 4 no
GO:0010468 regulation of gene expression 39.1304 6 no
GO:0010556 regulation of macromolecule biosynthetic process 39.1304 5 no
GO:0010604 positive regulation of macromolecule metabolic process 39.1304 5 no
GO:0010647 positive regulation of cell communication 39.1304 5 no
GO:0023056 positive regulation of signaling 39.1304 4 no
GO:0031326 regulation of cellular biosynthetic process 39.1304 5 no
GO:0036211 protein modification process 39.1304 4 no
GO:0043412 macromolecule modification 39.1304 4 no
GO:0051049 regulation of transport 39.1304 4 no
GO:1902531 regulation of intracellular signal transduction 39.1304 5 no
GO:0022607 cellular component assembly 34.7826 4 no
GO:0006796 phosphate-containing compound metabolic process 34.7826 4 yes
GO:0009967 positive regulation of signal transduction 34.7826 5 no
GO:0042981 regulation of apoptotic process 34.7826 5 no
GO:0043067 regulation of programmed cell death 34.7826 4 no
GO:0048584 positive regulation of response to stimulus 34.7826 4 no
GO:0051130 positive regulation of cellular component organization 34.7826 5 no
GO:0051246 regulation of protein metabolic process 34.7826 5 no
GO:0051247 positive regulation of protein metabolic process 34.7826 6 no
GO:0006996 organelle organization 34.7826 4 no
GO:0031328 positive regulation of cellular biosynthetic process 30.4348 6 no
GO:0044087 regulation of cellular component biogenesis 30.4348 4 no
GO:0051726 regulation of cell cycle 30.4348 4 no
GO:0001932 regulation of protein phosphorylation 30.4348 7 no
GO:0009892 negative regulation of metabolic process 30.4348 4 no
GO:0010605 negative regulation of macromolecule metabolic process 30.4348 5 no
GO:0010648 negative regulation of cell communication 30.4348 5 no
GO:0019220 regulation of phosphate metabolic process 30.4348 6 no
GO:0023057 negative regulation of signaling 30.4348 4 no
GO:0031324 negative regulation of cellular metabolic process 30.4348 5 no
GO:0031399 regulation of protein modification process 30.4348 6 no
GO:0031401 positive regulation of protein modification process 30.4348 7 no
GO:0042325 regulation of phosphorylation 30.4348 7 no
GO:0043408 regulation of MAPK cascade 30.4348 6 no
GO:0051094 positive regulation of developmental process 30.4348 4 no
GO:0051174 regulation of phosphorus metabolic process 30.4348 5 no
GO:0051240 positive regulation of multicellular organismal process 30.4348 4 no
GO:1902533 positive regulation of intracellular signal transduction 30.4348 6 no
GO:0009891 positive regulation of biosynthetic process 30.4348 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 30.4348 6 no
GO:0031327 negative regulation of cellular biosynthetic process 26.0870 6 no
GO:0008104 protein localization 26.0870 4 no
GO:0001934 positive regulation of protein phosphorylation 26.0870 8 no
GO:0009968 negative regulation of signal transduction 26.0870 5 no
GO:0010243 response to organonitrogen compound 26.0870 4 no
GO:0010562 positive regulation of phosphorus metabolic process 26.0870 6 no
GO:0030030 cell projection organization 26.0870 4 no
GO:0030334 regulation of cell migration 26.0870 5 no
GO:0032101 regulation of response to external stimulus 26.0870 4 no
GO:0042327 positive regulation of phosphorylation 26.0870 8 no
GO:0045595 regulation of cell differentiation 26.0870 4 no
GO:0045937 positive regulation of phosphate metabolic process 26.0870 7 no
GO:0048585 negative regulation of response to stimulus 26.0870 4 no
GO:0051093 negative regulation of developmental process 26.0870 4 no
GO:0071310 cellular response to organic substance 26.0870 4 no
GO:0080134 regulation of response to stress 26.0870 4 no
GO:0120036 plasma membrane bounded cell projection organization 26.0870 5 no
GO:1901701 cellular response to oxygen-containing compound 26.0870 4 no
GO:2000145 regulation of cell motility 26.0870 4 no
GO:0009890 negative regulation of biosynthetic process 26.0870 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 26.0870 6 no
GO:0010628 positive regulation of gene expression 26.0870 7 no
GO:0010629 negative regulation of gene expression 26.0870 7 no
GO:0032880 regulation of protein localization 21.7391 5 no
GO:0033043 regulation of organelle organization 21.7391 5 no
GO:0043066 negative regulation of apoptotic process 21.7391 6 no
GO:0043069 negative regulation of programmed cell death 21.7391 5 no
GO:0043933 protein-containing complex organization 21.7391 4 no
GO:0050890 cognition 21.7391 4 no
GO:0051050 positive regulation of transport 21.7391 4 no
GO:0060341 regulation of cellular localization 21.7391 4 no
GO:0065003 protein-containing complex assembly 21.7391 5 no
GO:0071363 cellular response to growth factor stimulus 21.7391 4 no
GO:0097435 supramolecular fiber organization 21.7391 4 no
GO:1901699 cellular response to nitrogen compound 21.7391 4 no
GO:0007346 regulation of mitotic cell cycle 21.7391 5 no
GO:0045787 positive regulation of cell cycle 21.7391 5 no
GO:0050804 modulation of chemical synaptic transmission 21.7391 5 no
GO:0099177 regulation of trans-synaptic signaling 21.7391 4 no
GO:0006915 apoptotic process 21.7391 4 no
GO:0098657 import into cell 21.7391 4 no
GO:0016310 phosphorylation 21.7391 5 yes
GO:0001817 regulation of cytokine production 21.7391 4 no
GO:0002684 positive regulation of immune system process 21.7391 4 no
GO:0002694 regulation of leukocyte activation 21.7391 4 no
GO:0022407 regulation of cell-cell adhesion 21.7391 5 no
GO:0030155 regulation of cell adhesion 21.7391 4 no
GO:0030335 positive regulation of cell migration 21.7391 6 no
GO:0031347 regulation of defense response 21.7391 5 no
GO:0040017 positive regulation of locomotion 21.7391 4 no
GO:0042127 regulation of cell population proliferation 21.7391 4 no
GO:0045596 negative regulation of cell differentiation 21.7391 5 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 21.7391 8 no
GO:0050776 regulation of immune response 21.7391 4 no
GO:0050863 regulation of T cell activation 21.7391 6 no
GO:0050865 regulation of cell activation 21.7391 4 no
GO:0051249 regulation of lymphocyte activation 21.7391 5 no
GO:0060627 regulation of vesicle-mediated transport 21.7391 4 no
GO:0070372 regulation of ERK1 and ERK2 cascade 21.7391 7 no
GO:0071702 organic substance transport 21.7391 4 no
GO:1902532 negative regulation of intracellular signal transduction 21.7391 6 no
GO:1903037 regulation of leukocyte cell-cell adhesion 21.7391 6 no
GO:2000026 regulation of multicellular organismal development 21.7391 4 no
GO:2000147 positive regulation of cell motility 21.7391 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.7391 5 no
GO:0034654 nucleobase-containing compound biosynthetic process 13.0435 4 yes
GO:1901362 organic cyclic compound biosynthetic process 13.0435 4 yes
GO:0006163 purine nucleotide metabolic process 8.6957 5 yes
GO:0006753 nucleoside phosphate metabolic process 8.6957 4 yes
GO:0009117 nucleotide metabolic process 8.6957 5 yes
GO:0009150 purine ribonucleotide metabolic process 8.6957 6 yes
GO:0009259 ribonucleotide metabolic process 8.6957 5 yes
GO:0019693 ribose phosphate metabolic process 8.6957 4 yes
GO:0072521 purine-containing compound metabolic process 8.6957 4 yes
GO:1901566 organonitrogen compound biosynthetic process 8.6957 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KS6B1_HUMAN [view entry] [view interactions] Low throughput yes yes
KS6B2_HUMAN [view interactions] Low throughput no yes
EDC4_HUMAN [view interactions] Low throughput no yes
PTN11_HUMAN [view entry] [view interactions] Low throughput yes yes
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
LYN_HUMAN [view entry] [view interactions] Low throughput yes no
KSYK_HUMAN [view interactions] Low throughput no no
BTK_HUMAN [view interactions] Low throughput no no
CISD3_HUMAN [view interactions] High throughput no yes
MIC27_HUMAN [view entry] [view interactions] High throughput yes yes
LRRK2_HUMAN [view interactions] High throughput no yes
VCAM1_HUMAN [view interactions] High throughput no no
EHD4_HUMAN [view entry] [view interactions] High throughput yes no
PRP4B_HUMAN [view interactions] High throughput no yes
DUS3_HUMAN [view entry] [view interactions] High throughput yes no
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
STA5B_HUMAN [view interactions] High throughput no yes
G3BP1_HUMAN [view interactions] High throughput no yes
K1C20_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
FHI1B_HUMAN [view interactions] High throughput no yes
TRADD_HUMAN [view interactions] High throughput no yes
CNTRB_HUMAN [view interactions] High throughput no yes
K1958_HUMAN [view interactions] High throughput no yes
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
HPHL1_HUMAN [view interactions] High throughput no no
CALL3_HUMAN [view interactions] High throughput no yes
S10A3_HUMAN [view interactions] High throughput no no
PKP1_HUMAN [view interactions] High throughput no no
LRC15_HUMAN [view interactions] High throughput no no
LEG3_HUMAN [view interactions] High throughput no yes
VSIG8_HUMAN [view interactions] High throughput no no
SNH28_HUMAN [view interactions] High throughput no no
DUS14_HUMAN [view interactions] High throughput no yes
DSG4_HUMAN [view interactions] High throughput no no
H2A1_HUMAN [view interactions] High throughput no yes
MIB1_HUMAN [view entry] [view interactions] High throughput yes yes
U5S1_HUMAN [view interactions] High throughput no yes
AAR2_HUMAN [view interactions] High throughput no no
PIHD1_HUMAN [view interactions] High throughput no yes
MD2L2_HUMAN [view interactions] High throughput no yes
HDAC2_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
EMC1_HUMAN [view interactions] High throughput no yes
EMC5_HUMAN [view interactions] High throughput no yes
KIF23_HUMAN [view interactions] High throughput no yes
RIGI_HUMAN [view interactions] High throughput no yes
WDR5_HUMAN [view interactions] High throughput no no
MTG8R_HUMAN [view interactions] High throughput no yes
RL28_HUMAN [view entry] [view interactions] High throughput yes yes
HNRC2_HUMAN [view interactions] High throughput no no
CENPM_HUMAN [view interactions] High throughput no yes
TCPQM_HUMAN [view interactions] High throughput no no
LGI1_HUMAN [view entry] [view interactions] High throughput yes no
SSX2_HUMAN [view interactions] High throughput no no
SEGN_HUMAN [view interactions] High throughput no no
UBP32_HUMAN [view interactions] High throughput no yes
DNAI2_HUMAN [view interactions] High throughput no no
YPEL3_HUMAN [view interactions] High throughput no yes
AMACR_HUMAN [view interactions] High throughput no yes
UBXN6_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN3_HUMAN [view entry] [view interactions] High throughput yes yes
CIB2_HUMAN [view interactions] High throughput no yes
NPAS1_HUMAN [view interactions] High throughput no no
EFMT3_HUMAN [view interactions] High throughput no no
KCD14_HUMAN [view interactions] High throughput no no
RFXK_HUMAN [view interactions] High throughput no yes
ACTS_HUMAN [view interactions] High throughput no no
SAP18_HUMAN [view interactions] High throughput no yes
PLBL1_HUMAN [view interactions] High throughput no no
CLASR_HUMAN [view interactions] High throughput no yes
GALT9_HUMAN [view interactions] High throughput no no
FAHD1_HUMAN [view interactions] High throughput no yes
PSG11_HUMAN [view interactions] High throughput no no
FSCN1_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
ATRX_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RIT1_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
PJA1_HUMAN [view interactions] High throughput no yes
EFHD2_HUMAN [view entry] [view interactions] High throughput yes no
ENOG_HUMAN [view entry] [view interactions] High throughput yes yes
GLRX3_HUMAN [view interactions] High throughput no yes
GUAA_HUMAN [view interactions] High throughput no no
PPME1_HUMAN [view interactions] High throughput no yes
FCL_HUMAN [view interactions] High throughput no yes
ASNS_HUMAN [view interactions] High throughput no yes
CLIC4_HUMAN [view interactions] High throughput no no
PCY2_HUMAN [view interactions] High throughput no yes
PEPL_HUMAN [view interactions] High throughput no yes
ACAP2_HUMAN [view interactions] High throughput no yes
DJB11_HUMAN [view interactions] High throughput no yes
DJC21_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes