Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

COASY_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
499 Arg Cys Neurodegenerationwithbrainironaccumulation6(NBIA6) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in COASY_HUMAN
GO:0017076 purine nucleotide binding 39.1304 4 yes
GO:0032555 purine ribonucleotide binding 34.7826 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 34.7826 4 yes
GO:0046872 metal ion binding 34.7826 4 no
GO:0030554 adenyl nucleotide binding 30.4348 5 yes
GO:0005524 ATP binding 26.0870 5 yes
GO:0032559 adenyl ribonucleotide binding 26.0870 5 yes
GO:0045296 cadherin binding 26.0870 4 no
GO:0019900 kinase binding 21.7391 4 no
GO:0019901 protein kinase binding 21.7391 5 no
GO:0016301 kinase activity 17.3913 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 17.3913 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in COASY_HUMAN
GO:0048522 positive regulation of cellular process 65.2174 4 no
GO:0048523 negative regulation of cellular process 56.5217 4 no
GO:0051128 regulation of cellular component organization 52.1739 4 no
GO:0031323 regulation of cellular metabolic process 43.4783 4 no
GO:0043412 macromolecule modification 43.4783 4 no
GO:0051171 regulation of nitrogen compound metabolic process 43.4783 4 no
GO:0060255 regulation of macromolecule metabolic process 43.4783 4 no
GO:0080090 regulation of primary metabolic process 43.4783 4 no
GO:0010646 regulation of cell communication 39.1304 4 no
GO:0031325 positive regulation of cellular metabolic process 39.1304 5 no
GO:0036211 protein modification process 39.1304 4 no
GO:0010941 regulation of cell death 39.1304 4 no
GO:0009893 positive regulation of metabolic process 39.1304 4 no
GO:0010468 regulation of gene expression 39.1304 5 no
GO:0051049 regulation of transport 34.7826 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 34.7826 5 no
GO:0051246 regulation of protein metabolic process 34.7826 5 no
GO:0051726 regulation of cell cycle 34.7826 4 no
GO:0071310 cellular response to organic substance 34.7826 4 no
GO:0006996 organelle organization 34.7826 4 no
GO:0042981 regulation of apoptotic process 34.7826 6 no
GO:0043067 regulation of programmed cell death 34.7826 5 no
GO:0006796 phosphate-containing compound metabolic process 34.7826 4 yes
GO:0009966 regulation of signal transduction 34.7826 4 no
GO:0010604 positive regulation of macromolecule metabolic process 34.7826 5 no
GO:0010647 positive regulation of cell communication 30.4348 5 no
GO:0010648 negative regulation of cell communication 30.4348 5 no
GO:0023056 positive regulation of signaling 30.4348 4 no
GO:0023057 negative regulation of signaling 30.4348 4 no
GO:0031399 regulation of protein modification process 30.4348 6 no
GO:0051247 positive regulation of protein metabolic process 30.4348 6 no
GO:1902531 regulation of intracellular signal transduction 30.4348 5 no
GO:0051130 positive regulation of cellular component organization 30.4348 5 no
GO:0016192 vesicle-mediated transport 30.4348 4 no
GO:0019220 regulation of phosphate metabolic process 26.0870 6 no
GO:0030030 cell projection organization 26.0870 4 no
GO:0031401 positive regulation of protein modification process 26.0870 7 no
GO:0032101 regulation of response to external stimulus 26.0870 4 no
GO:0042325 regulation of phosphorylation 26.0870 7 no
GO:0042327 positive regulation of phosphorylation 26.0870 8 no
GO:0043408 regulation of MAPK cascade 26.0870 6 no
GO:0044087 regulation of cellular component biogenesis 26.0870 4 no
GO:0045787 positive regulation of cell cycle 26.0870 5 no
GO:0045937 positive regulation of phosphate metabolic process 26.0870 7 no
GO:0048584 positive regulation of response to stimulus 26.0870 4 no
GO:0050776 regulation of immune response 26.0870 4 no
GO:0051174 regulation of phosphorus metabolic process 26.0870 5 no
GO:0070848 response to growth factor 26.0870 4 no
GO:0071363 cellular response to growth factor stimulus 26.0870 5 no
GO:0080134 regulation of response to stress 26.0870 4 no
GO:0120036 plasma membrane bounded cell projection organization 26.0870 5 no
GO:0030334 regulation of cell migration 26.0870 5 no
GO:0033043 regulation of organelle organization 26.0870 5 no
GO:2000145 regulation of cell motility 26.0870 4 no
GO:0022607 cellular component assembly 26.0870 4 no
GO:0009889 regulation of biosynthetic process 26.0870 4 no
GO:0009968 negative regulation of signal transduction 26.0870 5 no
GO:0010556 regulation of macromolecule biosynthetic process 26.0870 5 no
GO:0031326 regulation of cellular biosynthetic process 26.0870 5 no
GO:0048585 negative regulation of response to stimulus 26.0870 4 no
GO:0060548 negative regulation of cell death 26.0870 5 no
GO:0009892 negative regulation of metabolic process 26.0870 4 no
GO:0010605 negative regulation of macromolecule metabolic process 26.0870 5 no
GO:0001932 regulation of protein phosphorylation 26.0870 7 no
GO:0001934 positive regulation of protein phosphorylation 26.0870 8 no
GO:0009967 positive regulation of signal transduction 26.0870 5 no
GO:0010562 positive regulation of phosphorus metabolic process 26.0870 6 no
GO:0031347 regulation of defense response 21.7391 5 no
GO:0045595 regulation of cell differentiation 21.7391 4 no
GO:0045596 negative regulation of cell differentiation 21.7391 5 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 21.7391 8 no
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 21.7391 9 no
GO:0050865 regulation of cell activation 21.7391 4 no
GO:0051050 positive regulation of transport 21.7391 4 no
GO:0051093 negative regulation of developmental process 21.7391 4 no
GO:0051240 positive regulation of multicellular organismal process 21.7391 4 no
GO:0070372 regulation of ERK1 and ERK2 cascade 21.7391 7 no
GO:1902533 positive regulation of intracellular signal transduction 21.7391 6 no
GO:0007010 cytoskeleton organization 21.7391 5 no
GO:0008104 protein localization 21.7391 4 no
GO:0010942 positive regulation of cell death 21.7391 5 no
GO:0030335 positive regulation of cell migration 21.7391 6 no
GO:0040017 positive regulation of locomotion 21.7391 4 no
GO:0043065 positive regulation of apoptotic process 21.7391 7 no
GO:0043068 positive regulation of programmed cell death 21.7391 6 no
GO:0051094 positive regulation of developmental process 21.7391 4 no
GO:1901701 cellular response to oxygen-containing compound 21.7391 4 no
GO:2000147 positive regulation of cell motility 21.7391 5 no
GO:0060627 regulation of vesicle-mediated transport 21.7391 4 no
GO:0014070 response to organic cyclic compound 21.7391 4 no
GO:0016310 phosphorylation 21.7391 5 no
GO:0031324 negative regulation of cellular metabolic process 21.7391 5 no
GO:0031344 regulation of cell projection organization 21.7391 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 21.7391 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 21.7391 6 no
GO:0006355 regulation of DNA-templated transcription 21.7391 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.7391 5 no
GO:0051252 regulation of RNA metabolic process 21.7391 5 no
GO:1903506 regulation of nucleic acid-templated transcription 21.7391 7 no
GO:2001141 regulation of RNA biosynthetic process 21.7391 6 no
GO:0010243 response to organonitrogen compound 21.7391 4 no
GO:0001817 regulation of cytokine production 21.7391 4 no
GO:0007346 regulation of mitotic cell cycle 21.7391 5 no
GO:0010628 positive regulation of gene expression 21.7391 6 no
GO:1901566 organonitrogen compound biosynthetic process 13.0435 4 yes
GO:0006163 purine nucleotide metabolic process 8.6957 5 yes
GO:0006753 nucleoside phosphate metabolic process 8.6957 4 yes
GO:0009117 nucleotide metabolic process 8.6957 5 yes
GO:0009150 purine ribonucleotide metabolic process 8.6957 6 yes
GO:0009259 ribonucleotide metabolic process 8.6957 5 yes
GO:0019693 ribose phosphate metabolic process 8.6957 4 yes
GO:0044271 cellular nitrogen compound biosynthetic process 8.6957 4 yes
GO:0072521 purine-containing compound metabolic process 8.6957 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in COASY_HUMAN
DOID:331 central nervous system disease 8.6957 3 yes

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KS6B1_HUMAN [view entry] [view interactions] Low throughput yes yes
KS6B2_HUMAN [view interactions] Low throughput no yes
EDC4_HUMAN [view interactions] Low throughput no yes
PTN11_HUMAN [view entry] [view interactions] Low throughput yes yes
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
LYN_HUMAN [view entry] [view interactions] Low throughput yes no
KSYK_HUMAN [view interactions] Low throughput no no
BTK_HUMAN [view interactions] Low throughput no no
CISD3_HUMAN [view interactions] High throughput no yes
MIC27_HUMAN [view entry] [view interactions] High throughput yes yes
LRRK2_HUMAN [view interactions] High throughput no yes
VCAM1_HUMAN [view interactions] High throughput no no
EHD4_HUMAN [view entry] [view interactions] High throughput yes no
PRP4B_HUMAN [view interactions] High throughput no yes
DUS3_HUMAN [view entry] [view interactions] High throughput yes no
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
STA5B_HUMAN [view interactions] High throughput no yes
G3BP1_HUMAN [view interactions] High throughput no yes
K1C20_HUMAN [view interactions] High throughput no no
FHI1B_HUMAN [view interactions] High throughput no yes
TRADD_HUMAN [view interactions] High throughput no yes
CNTRB_HUMAN [view interactions] High throughput no yes
K1958_HUMAN [view interactions] High throughput no yes
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
HPHL1_HUMAN [view interactions] High throughput no no
CALL3_HUMAN [view interactions] High throughput no yes
S10A3_HUMAN [view interactions] High throughput no no
PKP1_HUMAN [view interactions] High throughput no no
LRC15_HUMAN [view interactions] High throughput no no
LEG3_HUMAN [view interactions] High throughput no yes
VSIG8_HUMAN [view interactions] High throughput no no
SNH28_HUMAN [view interactions] High throughput no no
DUS14_HUMAN [view interactions] High throughput no yes
DSG4_HUMAN [view interactions] High throughput no no
H2A1_HUMAN [view interactions] High throughput no yes
MIB1_HUMAN [view entry] [view interactions] High throughput yes yes
U5S1_HUMAN [view interactions] High throughput no yes
AAR2_HUMAN [view interactions] High throughput no no
PIHD1_HUMAN [view interactions] High throughput no yes
MD2L2_HUMAN [view interactions] High throughput no yes
HDAC2_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
EMC1_HUMAN [view interactions] High throughput no yes
EMC5_HUMAN [view interactions] High throughput no yes
KIF23_HUMAN [view interactions] High throughput no yes
DDX58_HUMAN [view interactions] High throughput no yes
WDR5_HUMAN [view interactions] High throughput no no
MTG8R_HUMAN [view interactions] High throughput no yes
RL28_HUMAN [view entry] [view interactions] High throughput yes yes
HNRC2_HUMAN [view interactions] High throughput no no
CENPM_HUMAN [view interactions] High throughput no yes
TCPQM_HUMAN [view interactions] High throughput no no
LGI1_HUMAN [view entry] [view interactions] High throughput yes no
SSX2_HUMAN [view interactions] High throughput no no
SEGN_HUMAN [view interactions] High throughput no no
UBP32_HUMAN [view interactions] High throughput no yes
DNAI2_HUMAN [view interactions] High throughput no no
YPEL3_HUMAN [view interactions] High throughput no yes
AMACR_HUMAN [view interactions] High throughput no yes
UBXN6_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN3_HUMAN [view entry] [view interactions] High throughput yes yes
CIB2_HUMAN [view interactions] High throughput no yes
NPAS1_HUMAN [view interactions] High throughput no no
EFMT3_HUMAN [view interactions] High throughput no no
KCD14_HUMAN [view interactions] High throughput no no
RFXK_HUMAN [view interactions] High throughput no yes
ACTS_HUMAN [view interactions] High throughput no no
SAP18_HUMAN [view interactions] High throughput no yes
PLBL1_HUMAN [view interactions] High throughput no no
CLASR_HUMAN [view interactions] High throughput no yes
GALT9_HUMAN [view interactions] High throughput no no
FAHD1_HUMAN [view interactions] High throughput no yes
PSG11_HUMAN [view interactions] High throughput no no
FSCN1_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
ATRX_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RIT1_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
PJA1_HUMAN [view interactions] High throughput no yes
EFHD2_HUMAN [view entry] [view interactions] High throughput yes no
ENOG_HUMAN [view entry] [view interactions] High throughput yes yes
GLRX3_HUMAN [view interactions] High throughput no yes
GUAA_HUMAN [view interactions] High throughput no no
PPME1_HUMAN [view interactions] High throughput no yes
FCL_HUMAN [view interactions] High throughput no yes
ASNS_HUMAN [view interactions] High throughput no yes
CLIC4_HUMAN [view interactions] High throughput no no
PCY2_HUMAN [view interactions] High throughput no yes
DJB11_HUMAN [view interactions] High throughput no yes
DJC21_HUMAN [view interactions] High throughput no yes
PPCS_HUMAN [view interactions] Computational no yes
ENPP3_HUMAN [view interactions] Computational no no
HMCS2_HUMAN [view interactions] Computational no no
COAC_HUMAN [view interactions] Computational no yes
ADPPT_HUMAN [view entry] [view interactions] Computational yes yes
PANK2_HUMAN [view interactions] Computational no yes
PANK4_HUMAN [view interactions] Computational no no
PANK3_HUMAN [view interactions] Computational no yes