Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

FSCN1_HUMAN

Actin-binding protein that contains 2 major actin binding sites (PubMed, PubMed). Organizes filamentous actin into parallel bundles (PubMed, PubMed, PubMed). Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (PubMed). Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed, PubMed, PubMed). Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (PubMed). [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in FSCN1_HUMAN
GO:0003723 RNA binding 29.2929 4 yes
GO:0017076 purine nucleotide binding 27.2727 4 no
GO:0032555 purine ribonucleotide binding 26.2626 4 no
GO:0035639 purine ribonucleoside triphosphate binding 26.2626 4 no
GO:0019900 kinase binding 20.2020 4 no
GO:0045296 cadherin binding 19.1919 4 yes
GO:0003779 actin binding 11.1111 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in FSCN1_HUMAN
GO:0048522 positive regulation of cellular process 56.5657 4 yes
GO:0031323 regulation of cellular metabolic process 52.5253 4 no
GO:0060255 regulation of macromolecule metabolic process 50.5051 4 no
GO:0080090 regulation of primary metabolic process 48.4848 4 no
GO:0051171 regulation of nitrogen compound metabolic process 47.4747 4 no
GO:0010646 regulation of cell communication 44.4444 4 no
GO:0048523 negative regulation of cellular process 44.4444 4 no
GO:0009893 positive regulation of metabolic process 40.4040 4 no
GO:0010468 regulation of gene expression 40.4040 5 no
GO:0009966 regulation of signal transduction 39.3939 4 no
GO:0051128 regulation of cellular component organization 39.3939 4 yes
GO:0008104 protein localization 35.3535 4 no
GO:0010604 positive regulation of macromolecule metabolic process 34.3434 5 no
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0022607 cellular component assembly 33.3333 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 31.3131 5 no
GO:0009889 regulation of biosynthetic process 30.3030 4 no
GO:0009892 negative regulation of metabolic process 30.3030 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.3030 5 no
GO:0031326 regulation of cellular biosynthetic process 30.3030 5 no
GO:0006996 organelle organization 30.3030 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 29.2929 5 no
GO:0071702 organic substance transport 29.2929 4 no
GO:1902531 regulation of intracellular signal transduction 29.2929 5 no
GO:0010941 regulation of cell death 29.2929 4 no
GO:0010605 negative regulation of macromolecule metabolic process 28.2828 5 no
GO:0051252 regulation of RNA metabolic process 28.2828 5 no
GO:0071705 nitrogen compound transport 27.2727 4 no
GO:0033043 regulation of organelle organization 27.2727 5 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 26.2626 5 no
GO:0042981 regulation of apoptotic process 26.2626 6 no
GO:0043067 regulation of programmed cell death 26.2626 5 no
GO:0006355 regulation of DNA-templated transcription 25.2525 6 no
GO:0009894 regulation of catabolic process 25.2525 4 no
GO:0015031 protein transport 25.2525 4 no
GO:0048584 positive regulation of response to stimulus 25.2525 4 no
GO:1903506 regulation of nucleic acid-templated transcription 25.2525 7 no
GO:2001141 regulation of RNA biosynthetic process 25.2525 6 no
GO:0030030 cell projection organization 25.2525 4 yes
GO:0009967 positive regulation of signal transduction 24.2424 5 no
GO:0010647 positive regulation of cell communication 24.2424 5 no
GO:0023056 positive regulation of signaling 24.2424 4 no
GO:0031399 regulation of protein modification process 24.2424 6 no
GO:0043412 macromolecule modification 24.2424 4 no
GO:0080134 regulation of response to stress 24.2424 4 no
GO:0031324 negative regulation of cellular metabolic process 23.2323 5 no
GO:0036211 protein modification process 23.2323 4 no
GO:0051049 regulation of transport 23.2323 4 no
GO:0051247 positive regulation of protein metabolic process 22.2222 6 no
GO:0006796 phosphate-containing compound metabolic process 22.2222 4 no
GO:0006886 intracellular protein transport 21.2121 4 no
GO:0044087 regulation of cellular component biogenesis 21.2121 4 yes
GO:0051248 negative regulation of protein metabolic process 20.2020 6 no
GO:0045595 regulation of cell differentiation 20.2020 4 no
GO:0060548 negative regulation of cell death 20.2020 5 no
GO:0060341 regulation of cellular localization 20.2020 4 no
GO:0051240 positive regulation of multicellular organismal process 20.2020 4 no
GO:0031344 regulation of cell projection organization 19.1919 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 18.1818 6 yes
GO:0120036 plasma membrane bounded cell projection organization 18.1818 5 yes
GO:0051493 regulation of cytoskeleton organization 17.1717 6 yes
GO:0051130 positive regulation of cellular component organization 15.1515 5 yes
GO:0097435 supramolecular fiber organization 13.1313 4 yes
GO:0007010 cytoskeleton organization 12.1212 5 yes
GO:0032956 regulation of actin cytoskeleton organization 11.1111 5 yes
GO:0032970 regulation of actin filament-based process 11.1111 4 yes
GO:0043254 regulation of protein-containing complex assembly 10.1010 5 yes
GO:0007015 actin filament organization 9.0909 5 yes
GO:0010638 positive regulation of organelle organization 9.0909 6 yes
GO:0044089 positive regulation of cellular component biogenesis 9.0909 5 yes
GO:0034330 cell junction organization 8.0808 4 yes
GO:1902115 regulation of organelle assembly 8.0808 5 yes
GO:0030031 cell projection assembly 7.0707 5 yes
GO:0031334 positive regulation of protein-containing complex assembly 7.0707 6 yes
GO:0031346 positive regulation of cell projection organization 7.0707 6 yes
GO:0034329 cell junction assembly 7.0707 5 yes
GO:0045216 cell-cell junction organization 6.0606 5 yes
GO:0060491 regulation of cell projection assembly 6.0606 5 yes
GO:0120031 plasma membrane bounded cell projection assembly 6.0606 6 yes
GO:0120032 regulation of plasma membrane bounded cell projection assembly 6.0606 6 yes
GO:0007043 cell-cell junction assembly 4.0404 6 yes
GO:1902743 regulation of lamellipodium organization 3.0303 7 yes
GO:0010591 regulation of lamellipodium assembly 3.0303 7 yes
GO:0051017 actin filament bundle assembly 3.0303 5 yes
GO:0051489 regulation of filopodium assembly 3.0303 7 yes
GO:0061572 actin filament bundle organization 3.0303 6 yes
GO:1902745 positive regulation of lamellipodium organization 2.0202 7 yes
GO:0010592 positive regulation of lamellipodium assembly 2.0202 7 yes
GO:0035088 establishment or maintenance of apical/basal cell polarity 2.0202 4 yes
GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 2.0202 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in FSCN1_HUMAN
DOID:0050686 organ system cancer 3.0303 3 no
DOID:331 central nervous system disease 3.0303 3 no
DOID:612 primary immunodeficiency disease 2.0202 3 no
DOID:1289 neurodegenerative disease 2.0202 4 no
DOID:6457 Cowden syndrome 2.0202 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ACTS_HUMAN [view interactions] Low throughput no no
PLXB3_HUMAN [view interactions] Low throughput no yes
PMS2_HUMAN [view interactions] Low throughput no yes
MLH1_HUMAN [view interactions] Low throughput no yes
FACD2_HUMAN [view interactions] Low throughput no no
FANCI_HUMAN [view interactions] Low throughput no yes
MYO10_HUMAN [view interactions] Low throughput no no
TNR16_HUMAN [view entry] [view interactions] Low throughput yes no
KPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
SMUF1_HUMAN [view interactions] Low throughput no yes
PSB4_HUMAN [view interactions] High throughput no yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
P4HA1_HUMAN [view interactions] High throughput no yes
M2OM_HUMAN [view entry] [view interactions] High throughput yes yes
RT34_HUMAN [view interactions] High throughput no yes
RL38_HUMAN [view entry] [view interactions] High throughput yes yes
FAF2_HUMAN [view interactions] High throughput no yes
GNAI3_HUMAN [view entry] [view interactions] High throughput yes yes
TTL12_HUMAN [view interactions] High throughput no yes
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
PABP4_HUMAN [view entry] [view interactions] High throughput yes yes
EMD_HUMAN [view interactions] High throughput no yes
ARPC3_HUMAN [view entry] [view interactions] High throughput yes yes
BASI_HUMAN [view entry] [view interactions] High throughput yes no
ENOG_HUMAN [view entry] [view interactions] High throughput yes yes
RHEB_HUMAN [view entry] [view interactions] High throughput yes yes
HCDH_HUMAN [view entry] [view interactions] High throughput yes yes
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
GNL3_HUMAN [view interactions] High throughput no yes
PP2AB_HUMAN [view interactions] High throughput no yes
PTGR1_HUMAN [view interactions] High throughput no yes
RL1D1_HUMAN [view interactions] High throughput no yes
PAK2_HUMAN [view entry] [view interactions] High throughput yes no
DYN2_HUMAN [view entry] [view interactions] High throughput yes yes
LKHA4_HUMAN [view interactions] High throughput no yes
MTCH2_HUMAN [view entry] [view interactions] High throughput yes yes
IMPA2_HUMAN [view interactions] High throughput no no
RL5_HUMAN [view entry] [view interactions] High throughput yes yes
VP26A_HUMAN [view entry] [view interactions] High throughput yes no
TMM33_HUMAN [view entry] [view interactions] High throughput yes yes
VAPB_HUMAN [view entry] [view interactions] High throughput yes yes
AL1B1_HUMAN [view interactions] High throughput no yes
GALE_HUMAN [view interactions] High throughput no no
TECR_HUMAN [view interactions] High throughput no yes
MISP_HUMAN [view interactions] High throughput no no
K2C73_HUMAN [view interactions] High throughput no no
NDUAA_HUMAN [view entry] [view interactions] High throughput yes yes
SRP72_HUMAN [view interactions] High throughput no yes
RO60_HUMAN [view interactions] High throughput no yes
PRP31_HUMAN [view interactions] High throughput no yes
HDAC1_HUMAN [view interactions] High throughput no no
LRC40_HUMAN [view entry] [view interactions] High throughput yes yes
UGPA_HUMAN [view entry] [view interactions] High throughput yes no
PSA3_HUMAN [view interactions] High throughput no no
MMS19_HUMAN [view interactions] High throughput no yes
AL9A1_HUMAN [view interactions] High throughput no yes
SPTC1_HUMAN [view interactions] High throughput no yes
GTPB1_HUMAN [view interactions] High throughput no yes
LMAN2_HUMAN [view interactions] High throughput no yes
GT251_HUMAN [view interactions] High throughput no no
GTPB4_HUMAN [view interactions] High throughput no yes
FKBP8_HUMAN [view entry] [view interactions] High throughput yes yes
KBP_HUMAN [view interactions] High throughput no yes
KYNU_HUMAN [view interactions] High throughput no no
DAAF5_HUMAN [view interactions] High throughput no no
PICAL_HUMAN [view entry] [view interactions] High throughput yes yes
FBX22_HUMAN [view interactions] High throughput no no
SCFD1_HUMAN [view entry] [view interactions] High throughput yes yes
DEOC_HUMAN [view interactions] High throughput no no
ARAF_HUMAN [view interactions] High throughput no yes
ERO1A_HUMAN [view interactions] High throughput no yes
PRP4_HUMAN [view interactions] High throughput no yes
GLYR1_HUMAN [view interactions] High throughput no yes
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
COASY_HUMAN [view entry] [view interactions] High throughput yes yes
ES8L2_HUMAN [view interactions] High throughput no yes
IPO4_HUMAN [view interactions] High throughput no no
TEX10_HUMAN [view interactions] High throughput no no
UBP10_HUMAN [view interactions] High throughput no yes
NOC3L_HUMAN [view interactions] High throughput no no
PKP3_HUMAN [view interactions] High throughput no yes
ABCF3_HUMAN [view entry] [view interactions] High throughput yes yes
AP1G1_HUMAN [view entry] [view interactions] High throughput yes yes
PLPL6_HUMAN [view entry] [view interactions] High throughput yes yes
SYDM_HUMAN [view interactions] High throughput no yes
NOC2L_HUMAN [view interactions] High throughput no yes
SF3A1_HUMAN [view interactions] High throughput no yes
DHX36_HUMAN [view interactions] High throughput no yes
PDS5A_HUMAN [view interactions] High throughput no yes
SAFB1_HUMAN [view interactions] High throughput no yes
SNX2_HUMAN [view entry] [view interactions] High throughput yes no
AAAT_HUMAN [view interactions] High throughput no no
IPO8_HUMAN [view interactions] High throughput no no
NOG2_HUMAN [view interactions] High throughput no yes
ELP1_HUMAN [view interactions] High throughput no yes
ABCD1_HUMAN [view entry] [view interactions] High throughput yes no
RFC1_HUMAN [view interactions] High throughput no yes
PDE3A_HUMAN [view interactions] High throughput no no
DSRAD_HUMAN [view entry] [view interactions] High throughput yes yes
ELP3_HUMAN [view interactions] High throughput no no
PESC_HUMAN [view entry] [view interactions] High throughput yes yes
PELP1_HUMAN [view interactions] High throughput no yes
NFKB2_HUMAN [view interactions] High throughput no yes
LMO7_HUMAN [view entry] [view interactions] High throughput yes yes
PI3R4_HUMAN [view interactions] High throughput no yes
SKIV2_HUMAN [view entry] [view interactions] High throughput yes yes
GCN1_HUMAN [view interactions] High throughput no yes
RHOF_HUMAN [view interactions] High throughput no no
RHOV_HUMAN [view interactions] High throughput no no
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
ACTA_HUMAN [view interactions] High throughput no no
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
SEP11_HUMAN [view entry] [view interactions] High throughput yes yes
ZYX_HUMAN [view interactions] High throughput no no
CNN2_HUMAN [view interactions] High throughput no no
ASSY_HUMAN [view interactions] High throughput no yes
COTL1_HUMAN [view interactions] High throughput no yes
QOR_HUMAN [view entry] [view interactions] High throughput yes yes
KAD2_HUMAN [view interactions] High throughput no no
FUBP1_HUMAN [view interactions] High throughput no yes
MIF_HUMAN [view entry] [view interactions] High throughput yes yes
PCBP1_HUMAN [view entry] [view interactions] High throughput yes yes
PRDX1_HUMAN [view entry] [view interactions] High throughput yes yes
PRDX2_HUMAN [view entry] [view interactions] High throughput yes yes
TKT_HUMAN [view entry] [view interactions] High throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
SEC63_HUMAN [view interactions] High throughput no yes
JIP2_HUMAN [view entry] [view interactions] High throughput yes no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
IQCB1_HUMAN [view interactions] High throughput no no
ATF2_HUMAN [view interactions] High throughput no yes
AIM2_HUMAN [view interactions] High throughput no no
BMR1A_HUMAN [view interactions] High throughput no no
ANLN_HUMAN [view interactions] High throughput no yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
CALL3_HUMAN [view interactions] High throughput no yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
MET14_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
SH3G3_HUMAN [view entry] [view interactions] High throughput yes no
KPCE_HUMAN [view entry] [view interactions] High throughput yes yes
NTM2F_HUMAN [view interactions] High throughput no no
GATA3_HUMAN [view interactions] High throughput no no
RB_HUMAN [view interactions] High throughput no yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
VCAM1_HUMAN [view interactions] High throughput no no
FINC_HUMAN [view interactions] High throughput no yes
ODO2_HUMAN [view entry] [view interactions] High throughput yes yes
H2B2E_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
RFC4_HUMAN [view interactions] High throughput no yes
PMS1_HUMAN [view interactions] High throughput no no
UBB_HUMAN [view entry] [view interactions] High throughput yes yes
IMB1_HUMAN [view entry] [view interactions] High throughput yes yes
RFC3_HUMAN [view interactions] High throughput no yes
PCNA_HUMAN [view interactions] High throughput no no
FAN1_HUMAN [view interactions] High throughput no no
FANCG_HUMAN [view interactions] High throughput no yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
TRI63_HUMAN [view interactions] High throughput no no
TRI55_HUMAN [view interactions] High throughput no no
MP2K2_HUMAN [view entry] [view interactions] High throughput yes yes
RIPK4_HUMAN [view interactions] High throughput no no
TRAF6_HUMAN [view interactions] High throughput no yes
VHL_HUMAN [view entry] [view interactions] High throughput yes yes
TRM7_HUMAN [view interactions] High throughput no yes
EIF1B_HUMAN [view interactions] High throughput no no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
IF6_HUMAN [view interactions] High throughput no yes
TFE3_HUMAN [view interactions] High throughput no yes
ELF3_HUMAN [view interactions] High throughput no no
SGK1_HUMAN [view interactions] High throughput no yes
SOMA_HUMAN [view interactions] High throughput no no
HLAB_HUMAN [view interactions] High throughput no yes
CFLAR_HUMAN [view interactions] High throughput no yes
AAKB1_HUMAN [view interactions] High throughput no yes
VDAC1_HUMAN [view entry] [view interactions] High throughput yes yes
ARP6_HUMAN [view interactions] High throughput no yes
BCAR1_HUMAN [view interactions] High throughput no yes
LITD1_HUMAN [view interactions] High throughput no no
BMI1_HUMAN [view interactions] High throughput no yes
MET_HUMAN [view interactions] High throughput no yes
DNJB9_HUMAN [view interactions] High throughput no yes
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
MYCB2_HUMAN [view entry] [view interactions] High throughput yes no
OXYR_HUMAN [view interactions] High throughput no no
LIS1_HUMAN [view entry] [view interactions] High throughput yes yes
SAS6_HUMAN [view interactions] High throughput no no
NECD_HUMAN [view interactions] High throughput no no
SUMO2_HUMAN [view interactions] High throughput no yes
SUMO3_HUMAN [view interactions] High throughput no yes
SIR7_HUMAN [view interactions] High throughput no yes
CDK2_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
MK07_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
G3BP1_HUMAN [view interactions] High throughput no yes
TES_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
AAR2_HUMAN [view interactions] High throughput no no
EZH2_HUMAN [view interactions] High throughput no no
SUZ12_HUMAN [view interactions] High throughput no no
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
CGAS_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
ARM12_HUMAN [view interactions] High throughput no no
NR2C2_HUMAN [view interactions] High throughput no yes
TIA1_HUMAN [view interactions] High throughput no no
CLUA1_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
NGB_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4C_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
BAG5_HUMAN [view entry] [view interactions] High throughput yes no
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
NUDC2_HUMAN [view entry] [view interactions] High throughput yes yes
ABD18_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
CAC1A_HUMAN [view interactions] High throughput no no
ARF3_HUMAN [view entry] [view interactions] High throughput yes no
ADT3_HUMAN [view entry] [view interactions] High throughput yes yes
ARF4_HUMAN [view entry] [view interactions] High throughput yes no
RAB14_HUMAN [view entry] [view interactions] High throughput yes yes
PSB5_HUMAN [view interactions] High throughput no yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RL23_HUMAN [view entry] [view interactions] High throughput yes yes
RS27A_HUMAN [view entry] [view interactions] High throughput yes yes
ATPO_HUMAN [view interactions] High throughput no yes
FBRL_HUMAN [view interactions] High throughput no yes
RL36_HUMAN [view entry] [view interactions] High throughput yes yes
VDAC3_HUMAN [view entry] [view interactions] High throughput yes yes
UBE2N_HUMAN [view entry] [view interactions] High throughput yes yes
APT_HUMAN [view interactions] High throughput no yes
ARL1_HUMAN [view interactions] High throughput no yes
AIMP1_HUMAN [view interactions] High throughput no yes
PSME2_HUMAN [view interactions] High throughput no no
RL24_HUMAN [view entry] [view interactions] High throughput yes yes
TMEDA_HUMAN [view interactions] High throughput no yes
RL27A_HUMAN [view entry] [view interactions] High throughput yes yes
DEST_HUMAN [view entry] [view interactions] High throughput yes yes
SOCS3_HUMAN [view interactions] Computational no yes
ANGL4_HUMAN [view interactions] Computational no no
IRF4_HUMAN [view interactions] Computational no no
MCL1_HUMAN [view interactions] Computational no yes
AKT1_HUMAN [view entry] [view interactions] Computational yes yes
RAB35_HUMAN [view entry] [view interactions] Computational yes yes
CDN1A_HUMAN [view interactions] Computational no no
HS90A_HUMAN [view entry] [view interactions] Computational yes yes
VIME_HUMAN [view entry] [view interactions] Computational yes no
P85A_HUMAN [view interactions] Computational no yes
STAT3_HUMAN [view entry] [view interactions] Computational yes yes
DEMA_HUMAN [view entry] [view interactions] Computational yes yes
RHOU_HUMAN [view interactions] Computational no no
STAT1_HUMAN [view entry] [view interactions] Computational yes no
NOS2_HUMAN [view interactions] Computational no yes