ADT3_HUMAN
Evidence for PS localization
Functions
ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell . Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane . In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (PubMed). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis . Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A6/ANT3 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) . Proton transporter activity requires free fatty acids as cofactor, but does not transport it . Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed). It is however unclear if SLC25A6/ANT3 constitutes a pore-forming component of mPTP or regulates it . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ADT3_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 26.3736 | 4 | no |
| GO:0000166 | nucleotide binding | 26.3736 | 4 | no |
| GO:0017076 | purine nucleotide binding | 26.3736 | 5 | no |
| GO:0046872 | metal ion binding | 24.1758 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 23.0769 | 6 | no |
| GO:0032555 | purine ribonucleotide binding | 23.0769 | 4 | no |
| GO:0043168 | anion binding | 23.0769 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.9780 | 4 | no |
| GO:0000295 | adenine nucleotide transmembrane transporter activity | 3.2967 | 6 | yes |
| GO:0005346 | purine ribonucleotide transmembrane transporter activity | 3.2967 | 4 | yes |
| GO:0005347 | ATP transmembrane transporter activity | 3.2967 | 4 | yes |
| GO:0005471 | ATP:ADP antiporter activity | 3.2967 | 5 | yes |
| GO:0015215 | nucleotide transmembrane transporter activity | 3.2967 | 4 | yes |
| GO:0015216 | purine nucleotide transmembrane transporter activity | 3.2967 | 5 | yes |
| GO:0015217 | ADP transmembrane transporter activity | 3.2967 | 4 | yes |
| GO:0015291 | secondary active transmembrane transporter activity | 3.2967 | 4 | yes |
| GO:0015297 | antiporter activity | 3.2967 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ADT3_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 54.9451 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 53.8462 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 49.4505 | 4 | no |
| GO:0010646 | regulation of cell communication | 48.3516 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 45.0549 | 4 | no |
| GO:0009966 | regulation of signal transduction | 43.9560 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 43.9560 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 41.7582 | 4 | no |
| GO:0008104 | protein localization | 38.4615 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 38.4615 | 4 | no |
| GO:0006996 | organelle organization | 37.3626 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 36.2637 | 4 | no |
| GO:0051049 | regulation of transport | 35.1648 | 4 | yes |
| GO:0010468 | regulation of gene expression | 35.1648 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 35.1648 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 35.1648 | 5 | no |
| GO:0022607 | cellular component assembly | 34.0659 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 31.8681 | 5 | yes |
| GO:0043067 | regulation of programmed cell death | 31.8681 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 30.7692 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 30.7692 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.7692 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.7692 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 30.7692 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 29.6703 | 5 | yes |
| GO:0048585 | negative regulation of response to stimulus | 29.6703 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 29.6703 | 4 | no |
| GO:0071702 | organic substance transport | 28.5714 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.5714 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 28.5714 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 28.5714 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.5714 | 4 | no |
| GO:0071705 | nitrogen compound transport | 27.4725 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 27.4725 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 27.4725 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 26.3736 | 5 | no |
| GO:0023056 | positive regulation of signaling | 26.3736 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 25.2747 | 6 | yes |
| GO:0043069 | negative regulation of programmed cell death | 25.2747 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 25.2747 | 4 | no |
| GO:0009894 | regulation of catabolic process | 25.2747 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 24.1758 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 24.1758 | 5 | no |
| GO:0032880 | regulation of protein localization | 23.0769 | 5 | no |
| GO:0036211 | protein modification process | 23.0769 | 4 | no |
| GO:0043412 | macromolecule modification | 23.0769 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 23.0769 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.0769 | 6 | no |
| GO:0031399 | regulation of protein modification process | 23.0769 | 6 | no |
| GO:0033043 | regulation of organelle organization | 21.9780 | 5 | yes |
| GO:0015031 | protein transport | 21.9780 | 4 | no |
| GO:0071310 | cellular response to organic substance | 21.9780 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 21.9780 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 21.9780 | 6 | no |
| GO:0009890 | negative regulation of biosynthetic process | 21.9780 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 21.9780 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 21.9780 | 6 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.9780 | 4 | no |
| GO:0051050 | positive regulation of transport | 20.8791 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 20.8791 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 17.5824 | 5 | yes |
| GO:0061024 | membrane organization | 16.4835 | 4 | yes |
| GO:2001233 | regulation of apoptotic signaling pathway | 15.3846 | 5 | yes |
| GO:0006915 | apoptotic process | 13.1868 | 4 | yes |
| GO:0007005 | mitochondrion organization | 13.1868 | 5 | yes |
| GO:2001234 | negative regulation of apoptotic signaling pathway | 12.0879 | 6 | yes |
| GO:0006839 | mitochondrial transport | 7.6923 | 4 | yes |
| GO:0010639 | negative regulation of organelle organization | 7.6923 | 6 | yes |
| GO:0007006 | mitochondrial membrane organization | 6.5934 | 5 | yes |
| GO:0010821 | regulation of mitochondrion organization | 6.5934 | 6 | yes |
| GO:0015711 | organic anion transport | 4.3956 | 5 | yes |
| GO:0015931 | nucleobase-containing compound transport | 4.3956 | 5 | yes |
| GO:0006862 | nucleotide transport | 3.2967 | 6 | yes |
| GO:0015748 | organophosphate ester transport | 3.2967 | 5 | yes |
| GO:0015865 | purine nucleotide transport | 3.2967 | 7 | yes |
| GO:0015866 | ADP transport | 3.2967 | 6 | yes |
| GO:0015867 | ATP transport | 3.2967 | 6 | yes |
| GO:0015868 | purine ribonucleotide transport | 3.2967 | 6 | yes |
| GO:0035795 | negative regulation of mitochondrial membrane permeability | 3.2967 | 5 | yes |
| GO:0046902 | regulation of mitochondrial membrane permeability | 3.2967 | 4 | yes |
| GO:0051503 | adenine nucleotide transport | 3.2967 | 8 | yes |
| GO:0140021 | mitochondrial ADP transmembrane transport | 3.2967 | 4 | yes |
| GO:1901028 | regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | 3.2967 | 5 | yes |
| GO:1901029 | negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | 3.2967 | 6 | yes |
| GO:1901264 | carbohydrate derivative transport | 3.2967 | 5 | yes |
| GO:1905709 | negative regulation of membrane permeability | 3.2967 | 4 | yes |
| GO:1990544 | mitochondrial ATP transmembrane transport | 3.2967 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| VDAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TIM9_HUMAN | [view interactions] | Low throughput | no | yes |
| TIM10_HUMAN | [view interactions] | Low throughput | no | yes |
| TOM70_HUMAN | [view interactions] | Low throughput | no | yes |
| SIR4_HUMAN | [view interactions] | Low throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
| SLAF1_HUMAN | [view interactions] | High throughput | no | no |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| OSTM1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLC4C_HUMAN | [view interactions] | High throughput | no | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| MAGA8_HUMAN | [view interactions] | High throughput | no | no |
| SCAFB_HUMAN | [view interactions] | High throughput | no | yes |
| ITAD_HUMAN | [view interactions] | High throughput | no | no |
| RPC5_HUMAN | [view interactions] | High throughput | no | yes |
| SG2A2_HUMAN | [view interactions] | High throughput | no | no |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S22A4_HUMAN | [view interactions] | High throughput | no | yes |
| PDCD1_HUMAN | [view interactions] | High throughput | no | yes |
| LRC25_HUMAN | [view interactions] | High throughput | no | yes |
| CNDP1_HUMAN | [view interactions] | High throughput | no | yes |
| POF1B_HUMAN | [view interactions] | High throughput | no | no |
| VSIG4_HUMAN | [view interactions] | High throughput | no | no |
| NAGK_HUMAN | [view interactions] | High throughput | no | no |
| ISLR_HUMAN | [view interactions] | High throughput | no | no |
| HUMMR_HUMAN | [view interactions] | High throughput | no | yes |
| TSP3_HUMAN | [view interactions] | High throughput | no | yes |
| S1A7A_HUMAN | [view interactions] | High throughput | no | no |
| SACA1_HUMAN | [view interactions] | High throughput | no | no |
| RDHE2_HUMAN | [view interactions] | High throughput | no | yes |
| LRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLK6_HUMAN | [view interactions] | High throughput | no | no |
| DKK3_HUMAN | [view interactions] | High throughput | no | yes |
| ST2B1_HUMAN | [view interactions] | High throughput | no | yes |
| ACM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPAP_HUMAN | [view interactions] | High throughput | no | no |
| F131B_HUMAN | [view interactions] | High throughput | no | no |
| FILA_HUMAN | [view interactions] | High throughput | no | no |
| TOM22_HUMAN | [view interactions] | High throughput | no | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYAG_HUMAN | [view interactions] | High throughput | no | yes |
| CASPE_HUMAN | [view interactions] | High throughput | no | no |
| F187B_HUMAN | [view interactions] | High throughput | no | no |
| S10A2_HUMAN | [view interactions] | High throughput | no | no |
| RRP1B_HUMAN | [view interactions] | High throughput | no | yes |
| RNAS7_HUMAN | [view interactions] | High throughput | no | no |
| ZCH18_HUMAN | [view interactions] | High throughput | no | yes |
| GLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
| KLK10_HUMAN | [view interactions] | High throughput | no | no |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| PRSS8_HUMAN | [view interactions] | High throughput | no | no |
| ABHDB_HUMAN | [view interactions] | High throughput | no | yes |
| KLK7_HUMAN | [view interactions] | High throughput | no | no |
| NMES1_HUMAN | [view interactions] | High throughput | no | no |
| CO3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CHC10_HUMAN | [view interactions] | High throughput | no | yes |
| ADT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHCH2_HUMAN | [view interactions] | High throughput | no | yes |
| LEG7_HUMAN | [view interactions] | High throughput | no | no |
| COQ7_HUMAN | [view interactions] | High throughput | no | yes |
| ITLN1_HUMAN | [view interactions] | High throughput | no | no |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| CRYAB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GPAT1_HUMAN | [view interactions] | High throughput | no | no |
| CTDS1_HUMAN | [view interactions] | High throughput | no | no |
| AFG1L_HUMAN | [view interactions] | High throughput | no | yes |
| CATL2_HUMAN | [view interactions] | High throughput | no | yes |
| LACTB_HUMAN | [view interactions] | High throughput | no | yes |
| CCG7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OPALI_HUMAN | [view interactions] | High throughput | no | yes |
| PTPM1_HUMAN | [view interactions] | High throughput | no | yes |
| TYPH_HUMAN | [view interactions] | High throughput | no | no |
| PPA6_HUMAN | [view interactions] | High throughput | no | no |
| ANXA8_HUMAN | [view interactions] | High throughput | no | no |
| GLUCM_HUMAN | [view interactions] | High throughput | no | yes |
| I12R1_HUMAN | [view interactions] | High throughput | no | no |
| SUCHY_HUMAN | [view interactions] | High throughput | no | yes |
| PA24D_HUMAN | [view interactions] | High throughput | no | no |
| CISD3_HUMAN | [view interactions] | High throughput | no | yes |
| TREX2_HUMAN | [view interactions] | High throughput | no | no |
| LYRM2_HUMAN | [view interactions] | High throughput | no | no |
| FIBB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LYRM4_HUMAN | [view interactions] | High throughput | no | yes |
| KLK9_HUMAN | [view interactions] | High throughput | no | no |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| PEPL_HUMAN | [view interactions] | High throughput | no | yes |
| CQ10B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LX12B_HUMAN | [view interactions] | High throughput | no | no |
| PRLD1_HUMAN | [view interactions] | High throughput | no | yes |
| CPNS2_HUMAN | [view interactions] | High throughput | no | no |
| NDUF5_HUMAN | [view interactions] | High throughput | no | yes |
| CBPA4_HUMAN | [view interactions] | High throughput | no | no |
| PPM1K_HUMAN | [view interactions] | High throughput | no | yes |
| TGM1_HUMAN | [view interactions] | High throughput | no | no |
| MET14_HUMAN | [view interactions] | High throughput | no | yes |
| SPB4_HUMAN | [view interactions] | High throughput | no | no |
| DICER_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRN4L_HUMAN | [view interactions] | High throughput | no | yes |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| SPB13_HUMAN | [view interactions] | High throughput | no | no |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| FBX50_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| APRV1_HUMAN | [view interactions] | High throughput | no | no |
| VAV_HUMAN | [view interactions] | High throughput | no | no |
| ACP7_HUMAN | [view interactions] | High throughput | no | no |
| SH3L1_HUMAN | [view interactions] | High throughput | no | yes |
| PGDH_HUMAN | [view interactions] | High throughput | no | no |
| MK07_HUMAN | [view interactions] | High throughput | no | yes |
| DPB1_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AQP3_HUMAN | [view interactions] | High throughput | no | no |
| PAXI_HUMAN | [view interactions] | High throughput | no | yes |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| M3K14_HUMAN | [view interactions] | High throughput | no | yes |
| RAMP3_HUMAN | [view interactions] | High throughput | no | no |
| KPCE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EVPL_HUMAN | [view interactions] | High throughput | no | yes |
| ELK1_HUMAN | [view interactions] | High throughput | no | yes |
| FCN3_HUMAN | [view interactions] | High throughput | no | no |
| PAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALL5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FCGBP_HUMAN | [view interactions] | High throughput | no | no |
| KPCI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NGAL_HUMAN | [view interactions] | High throughput | no | no |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| SBSN_HUMAN | [view interactions] | High throughput | no | no |
| SRC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AT12A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLBL1_HUMAN | [view interactions] | High throughput | no | no |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCBP2_HUMAN | [view interactions] | High throughput | no | yes |
| FIBG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MFD4A_HUMAN | [view interactions] | High throughput | no | yes |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| AK1BA_HUMAN | [view interactions] | High throughput | no | no |
| HUTH_HUMAN | [view interactions] | High throughput | no | yes |
| PAI2_HUMAN | [view interactions] | High throughput | no | no |
| COQ2_HUMAN | [view interactions] | High throughput | no | yes |
| DR9C7_HUMAN | [view interactions] | High throughput | no | no |
| COX15_HUMAN | [view interactions] | High throughput | no | yes |
| NDRG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNFL8_HUMAN | [view interactions] | High throughput | no | no |
| SOAT1_HUMAN | [view interactions] | High throughput | no | no |
| SPB3_HUMAN | [view interactions] | High throughput | no | no |
| RRBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INVO_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| E2F3_HUMAN | [view interactions] | High throughput | no | no |
| NAAA_HUMAN | [view interactions] | High throughput | no | yes |
| TE2IP_HUMAN | [view interactions] | High throughput | no | yes |
| SAP3_HUMAN | [view interactions] | High throughput | no | yes |
| DUX4_HUMAN | [view interactions] | High throughput | no | no |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| P2RY6_HUMAN | [view interactions] | High throughput | no | no |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| FSCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TYRO3_HUMAN | [view interactions] | High throughput | no | yes |
| NALP7_HUMAN | [view interactions] | High throughput | no | no |
| NDRG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| TM11B_HUMAN | [view interactions] | High throughput | no | no |
| TCTP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| CD177_HUMAN | [view interactions] | High throughput | no | no |
| PAXI1_HUMAN | [view interactions] | High throughput | no | no |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| PAGR1_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| WDR82_HUMAN | [view interactions] | High throughput | no | no |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| ZEB1_HUMAN | [view interactions] | High throughput | no | yes |
| LN28A_HUMAN | [view interactions] | High throughput | no | no |
| BRD3_HUMAN | [view interactions] | High throughput | no | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BRDT_HUMAN | [view interactions] | High throughput | no | no |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| ASSY_HUMAN | [view interactions] | High throughput | no | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| SERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHK2_HUMAN | [view interactions] | High throughput | no | yes |
| PSB10_HUMAN | [view interactions] | High throughput | no | no |
| TRI23_HUMAN | [view interactions] | High throughput | no | yes |
| SYSC_HUMAN | [view interactions] | High throughput | no | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI11_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF1_HUMAN | [view interactions] | High throughput | no | no |
| SHCAF_HUMAN | [view interactions] | High throughput | no | yes |
| K1H1_HUMAN | [view interactions] | High throughput | no | no |
| MYCN_HUMAN | [view interactions] | High throughput | no | no |
| TRIP6_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| NT2NA_HUMAN | [view interactions] | High throughput | no | no |
| TLS1_HUMAN | [view interactions] | High throughput | no | yes |
| TEKT4_HUMAN | [view interactions] | High throughput | no | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| KBTB4_HUMAN | [view interactions] | High throughput | no | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| CHD3_HUMAN | [view interactions] | High throughput | no | yes |
| MAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| RACK1_HUMAN | [view interactions] | High throughput | no | yes |
| DOT1L_HUMAN | [view interactions] | High throughput | no | yes |
| SCG1_HUMAN | [view interactions] | High throughput | no | no |
| TIF1A_HUMAN | [view interactions] | High throughput | no | yes |
| PRS23_HUMAN | [view interactions] | High throughput | no | no |
| R113A_HUMAN | [view interactions] | High throughput | no | yes |
| SYK_HUMAN | [view interactions] | High throughput | no | yes |
| CDK7_HUMAN | [view interactions] | High throughput | no | yes |
| CUTC_HUMAN | [view interactions] | High throughput | no | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TR10C_HUMAN | [view interactions] | High throughput | no | no |
| GBRA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STRN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| TMM62_HUMAN | [view interactions] | High throughput | no | yes |
| RUFY1_HUMAN | [view interactions] | High throughput | no | yes |
| PLS1_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| KR412_HUMAN | [view interactions] | High throughput | no | no |
| FBX42_HUMAN | [view interactions] | High throughput | no | yes |
| NEMO_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2O_HUMAN | [view interactions] | High throughput | no | yes |
| M3K1_HUMAN | [view interactions] | High throughput | no | yes |
| DDX24_HUMAN | [view interactions] | High throughput | no | yes |
| M3K3_HUMAN | [view interactions] | High throughput | no | no |
| HSF1_HUMAN | [view interactions] | High throughput | no | yes |
| TNR1A_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| TNR1B_HUMAN | [view interactions] | High throughput | no | no |
| MIDN_HUMAN | [view interactions] | High throughput | no | no |
| TRADD_HUMAN | [view interactions] | High throughput | no | yes |
| GRM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OTUD1_HUMAN | [view interactions] | High throughput | no | yes |
| SMAD2_HUMAN | [view interactions] | High throughput | no | yes |
| B3GN2_HUMAN | [view interactions] | High throughput | no | yes |
| CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| FLT3_HUMAN | [view interactions] | High throughput | no | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIM13_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| TIM50_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| RL10L_HUMAN | [view interactions] | High throughput | no | no |
| ATD3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KATIP_HUMAN | [view interactions] | High throughput | no | yes |
| VAMP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| A2MG_HUMAN | [view interactions] | High throughput | no | yes |
| RL7A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ADT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAX_HUMAN | [view interactions] | High throughput | no | yes |
| RL10A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NECD_HUMAN | [view interactions] | High throughput | no | no |
| NNTM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYRK2_HUMAN | [view interactions] | High throughput | no | yes |
| NDUB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FHI1A_HUMAN | [view interactions] | High throughput | no | yes |
| QCR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIM1_HUMAN | [view interactions] | High throughput | no | no |
| NDUV3_HUMAN | [view interactions] | High throughput | no | yes |
| MGMT_HUMAN | [view interactions] | High throughput | no | no |
| VA0D1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ICT1_HUMAN | [view interactions] | High throughput | no | yes |
| PMM2_HUMAN | [view interactions] | High throughput | no | no |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| MCAT_HUMAN | [view interactions] | High throughput | no | yes |
| SHIP2_HUMAN | [view interactions] | High throughput | no | yes |
| SCMC1_HUMAN | [view interactions] | High throughput | no | no |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| TOM20_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| UBL4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM47_HUMAN | [view interactions] | High throughput | no | yes |
| CLN3_HUMAN | [view interactions] | High throughput | no | no |
| TMM70_HUMAN | [view interactions] | High throughput | no | yes |
| CLN5_HUMAN | [view interactions] | High throughput | no | yes |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DNJA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HECW2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COIL_HUMAN | [view interactions] | High throughput | no | yes |
| ASB8_HUMAN | [view interactions] | High throughput | no | yes |
| COX8A_HUMAN | [view interactions] | High throughput | no | yes |
| ASB14_HUMAN | [view interactions] | High throughput | no | no |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| ASB18_HUMAN | [view interactions] | High throughput | no | no |
| T106B_HUMAN | [view interactions] | High throughput | no | yes |
| SMUF2_HUMAN | [view interactions] | High throughput | no | yes |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| ZBTB1_HUMAN | [view interactions] | High throughput | no | no |
| PCDH7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERBB3_HUMAN | [view interactions] | High throughput | no | yes |
| COP1_HUMAN | [view interactions] | High throughput | no | no |
| ERR2_HUMAN | [view interactions] | High throughput | no | no |
| SMU1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| CIA2B_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| LCOR_HUMAN | [view interactions] | High throughput | no | yes |
| AHSA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAN_HUMAN | [view interactions] | High throughput | no | yes |
| SKI_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| MERL_HUMAN | [view interactions] | High throughput | no | yes |
| GLMP_HUMAN | [view interactions] | High throughput | no | no |
| CD79B_HUMAN | [view interactions] | High throughput | no | no |
| ERGI3_HUMAN | [view interactions] | High throughput | no | yes |
| TMCO3_HUMAN | [view interactions] | High throughput | no | yes |
| CLC2D_HUMAN | [view interactions] | High throughput | no | yes |
| PMEL_HUMAN | [view interactions] | High throughput | no | no |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| ZN598_HUMAN | [view interactions] | High throughput | no | no |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRP8_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| SOCS2_HUMAN | [view interactions] | High throughput | no | yes |
| CHD4_HUMAN | [view interactions] | High throughput | no | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| RNF31_HUMAN | [view interactions] | High throughput | no | yes |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| MEPCE_HUMAN | [view interactions] | High throughput | no | yes |
| PPT1_HUMAN | [view interactions] | High throughput | no | yes |
| SNAI1_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| TXNIP_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| AMRA1_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H2_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBX1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TET2_HUMAN | [view interactions] | High throughput | no | yes |
| TGM2_HUMAN | [view interactions] | High throughput | no | no |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| UCHL3_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| VRK3_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| S15A3_HUMAN | [view interactions] | High throughput | no | yes |
| RU17_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARAF_HUMAN | [view interactions] | High throughput | no | yes |
| CLUA1_HUMAN | [view interactions] | High throughput | no | yes |
| NFX1_HUMAN | [view interactions] | High throughput | no | yes |
| BRD7_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| EMC4_HUMAN | [view interactions] | High throughput | no | yes |
| ANR55_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| NMRL1_HUMAN | [view interactions] | High throughput | no | yes |
| MAFB_HUMAN | [view interactions] | High throughput | no | yes |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| CIC_HUMAN | [view interactions] | High throughput | no | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| F16P1_HUMAN | [view interactions] | High throughput | no | no |
| KDF1_HUMAN | [view interactions] | High throughput | no | yes |
| MTUS2_HUMAN | [view interactions] | High throughput | no | yes |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| AGO1_HUMAN | [view interactions] | High throughput | no | no |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| AGO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| H2AX_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| GBRAP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ST1C2_HUMAN | [view interactions] | High throughput | no | no |