ADT3_HUMAN
Evidence for PS localization
Functions
ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell . Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane . In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (PubMed). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis . Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A6/ANT3 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) . Proton transporter activity requires free fatty acids as cofactor, but does not transport it . Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed). It is however unclear if SLC25A6/ANT3 constitutes a pore-forming component of mPTP or regulates it . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ADT3_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 21.6867 | 4 | no |
| GO:0046872 | metal ion binding | 21.6867 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 20.4819 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 20.4819 | 4 | no |
| GO:0008509 | anion transmembrane transporter activity | 8.4337 | 4 | yes |
| GO:0022853 | active ion transmembrane transporter activity | 8.4337 | 4 | yes |
| GO:0000295 | adenine nucleotide transmembrane transporter activity | 4.8193 | 6 | yes |
| GO:0005346 | purine ribonucleotide transmembrane transporter activity | 4.8193 | 4 | yes |
| GO:0005347 | ATP transmembrane transporter activity | 4.8193 | 5 | yes |
| GO:0005471 | ATP:ADP antiporter activity | 4.8193 | 5 | yes |
| GO:0008514 | organic anion transmembrane transporter activity | 4.8193 | 5 | yes |
| GO:0015215 | nucleotide transmembrane transporter activity | 4.8193 | 4 | yes |
| GO:0015216 | purine nucleotide transmembrane transporter activity | 4.8193 | 5 | yes |
| GO:0015217 | ADP transmembrane transporter activity | 4.8193 | 5 | yes |
| GO:0015291 | secondary active transmembrane transporter activity | 4.8193 | 4 | yes |
| GO:0015297 | antiporter activity | 4.8193 | 5 | yes |
| GO:0140323 | solute:anion antiporter activity | 4.8193 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ADT3_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 55.4217 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 54.2169 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 48.1928 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 46.9880 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 45.7831 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 43.3735 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 43.3735 | 4 | no |
| GO:0010646 | regulation of cell communication | 43.3735 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 39.7590 | 4 | no |
| GO:0006996 | organelle organization | 38.5542 | 4 | no |
| GO:0009966 | regulation of signal transduction | 38.5542 | 4 | no |
| GO:0010468 | regulation of gene expression | 37.3494 | 5 | no |
| GO:0051049 | regulation of transport | 34.9398 | 4 | no |
| GO:0010941 | regulation of cell death | 34.9398 | 4 | no |
| GO:0071702 | organic substance transport | 32.5301 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 32.5301 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 32.5301 | 5 | no |
| GO:0008104 | protein localization | 32.5301 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 31.3253 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 31.3253 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.1205 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 30.1205 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 30.1205 | 6 | no |
| GO:0022607 | cellular component assembly | 28.9157 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 28.9157 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 28.9157 | 5 | no |
| GO:0036211 | protein modification process | 28.9157 | 4 | no |
| GO:0043412 | macromolecule modification | 28.9157 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 28.9157 | 4 | no |
| GO:0060548 | negative regulation of cell death | 27.7108 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 27.7108 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 27.7108 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 27.7108 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.7108 | 5 | no |
| GO:0060341 | regulation of cellular localization | 27.7108 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 27.7108 | 5 | no |
| GO:0032880 | regulation of protein localization | 26.5060 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 26.5060 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 26.5060 | 5 | no |
| GO:0023057 | negative regulation of signaling | 26.5060 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 26.5060 | 4 | no |
| GO:0043069 | negative regulation of programmed cell death | 25.3012 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 25.3012 | 6 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 25.3012 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 25.3012 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.3012 | 6 | no |
| GO:0051050 | positive regulation of transport | 25.3012 | 4 | no |
| GO:0015031 | protein transport | 25.3012 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 24.0964 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 24.0964 | 5 | no |
| GO:0023056 | positive regulation of signaling | 24.0964 | 4 | no |
| GO:0033043 | regulation of organelle organization | 24.0964 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 24.0964 | 5 | no |
| GO:0043066 | negative regulation of apoptotic process | 24.0964 | 7 | no |
| GO:0043933 | protein-containing complex organization | 22.8916 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.8916 | 5 | no |
| GO:0031399 | regulation of protein modification process | 22.8916 | 6 | no |
| GO:1903829 | positive regulation of protein localization | 22.8916 | 5 | no |
| GO:0009894 | regulation of catabolic process | 22.8916 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.6867 | 4 | no |
| GO:0071310 | cellular response to organic substance | 21.6867 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 20.4819 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 20.4819 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 20.4819 | 5 | no |
| GO:0006811 | ion transport | 15.6627 | 4 | yes |
| GO:0006915 | apoptotic process | 13.2530 | 4 | yes |
| GO:0006820 | anion transport | 7.2289 | 5 | yes |
| GO:0015931 | nucleobase-containing compound transport | 6.0241 | 5 | yes |
| GO:0006862 | nucleotide transport | 4.8193 | 6 | yes |
| GO:0015711 | organic anion transport | 4.8193 | 5 | yes |
| GO:0015748 | organophosphate ester transport | 4.8193 | 5 | yes |
| GO:0015865 | purine nucleotide transport | 4.8193 | 7 | yes |
| GO:0015866 | ADP transport | 4.8193 | 6 | yes |
| GO:0015867 | ATP transport | 4.8193 | 6 | yes |
| GO:0015868 | purine ribonucleotide transport | 4.8193 | 6 | yes |
| GO:0051503 | adenine nucleotide transport | 4.8193 | 8 | yes |
| GO:0098656 | anion transmembrane transport | 4.8193 | 4 | yes |
| GO:0140021 | mitochondrial ADP transmembrane transport | 4.8193 | 4 | yes |
| GO:1901264 | carbohydrate derivative transport | 4.8193 | 5 | yes |
| GO:1990544 | mitochondrial ATP transmembrane transport | 4.8193 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in ADT3_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 3.6145 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 3.6145 | 5 | no |
| DOID:0080000 | muscular disease | 3.6145 | 3 | no |
| DOID:114 | heart disease | 3.6145 | 3 | no |
| DOID:12930 | dilated cardiomyopathy | 3.6145 | 6 | no |
| DOID:423 | myopathy | 3.6145 | 5 | no |
| DOID:66 | muscle tissue disease | 3.6145 | 4 | no |
| DOID:0050539 | Charcot-Marie-Tooth disease type 2 | 2.4096 | 7 | no |
| DOID:10595 | Charcot-Marie-Tooth disease | 2.4096 | 6 | no |
| DOID:1289 | neurodegenerative disease | 2.4096 | 4 | no |
| DOID:331 | central nervous system disease | 2.4096 | 3 | no |
| DOID:440 | neuromuscular disease | 2.4096 | 5 | no |
| DOID:574 | peripheral nervous system disease | 2.4096 | 3 | no |
| DOID:870 | neuropathy | 2.4096 | 4 | no |
| DOID:37 | skin disease | 2.4096 | 3 | no |
| DOID:0080307 | myofibrillar myopathy | 2.4096 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SIR4_HUMAN | [view interactions] | Low throughput | no | yes |
| VDAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
| TIM9_HUMAN | [view interactions] | Low throughput | no | yes |
| TIM10_HUMAN | [view interactions] | Low throughput | no | yes |
| TOM70_HUMAN | [view interactions] | Low throughput | no | yes |
| SMAD2_HUMAN | [view interactions] | High throughput | no | yes |
| T106B_HUMAN | [view interactions] | High throughput | no | yes |
| CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| ATD3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KATIP_HUMAN | [view interactions] | High throughput | no | yes |
| A2MG_HUMAN | [view interactions] | High throughput | no | yes |
| ADT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAX_HUMAN | [view interactions] | High throughput | no | yes |
| NECD_HUMAN | [view interactions] | High throughput | no | no |
| DYRK2_HUMAN | [view interactions] | High throughput | no | yes |
| FHI1A_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM1_HUMAN | [view interactions] | High throughput | no | no |
| MGMT_HUMAN | [view interactions] | High throughput | no | no |
| ICT1_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| SHIP2_HUMAN | [view interactions] | High throughput | no | yes |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBL4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLN3_HUMAN | [view interactions] | High throughput | no | no |
| CLN5_HUMAN | [view interactions] | High throughput | no | yes |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HECW2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ASB8_HUMAN | [view interactions] | High throughput | no | yes |
| ASB14_HUMAN | [view interactions] | High throughput | no | no |
| ASB18_HUMAN | [view interactions] | High throughput | no | no |
| SMUF2_HUMAN | [view interactions] | High throughput | no | yes |
| ZBTB1_HUMAN | [view interactions] | High throughput | no | no |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERBB3_HUMAN | [view interactions] | High throughput | no | yes |
| ERR2_HUMAN | [view interactions] | High throughput | no | no |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| CIA2B_HUMAN | [view interactions] | High throughput | no | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| LCOR_HUMAN | [view interactions] | High throughput | no | yes |
| AHSA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAN_HUMAN | [view interactions] | High throughput | no | yes |
| SKI_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| MERL_HUMAN | [view interactions] | High throughput | no | yes |
| GLMP_HUMAN | [view interactions] | High throughput | no | no |
| CD79B_HUMAN | [view interactions] | High throughput | no | no |
| ERGI3_HUMAN | [view interactions] | High throughput | no | yes |
| TMCO3_HUMAN | [view interactions] | High throughput | no | yes |
| CLC2D_HUMAN | [view interactions] | High throughput | no | yes |
| PMEL_HUMAN | [view interactions] | High throughput | no | no |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| ZN598_HUMAN | [view interactions] | High throughput | no | no |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| PRP8_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| SOCS2_HUMAN | [view interactions] | High throughput | no | yes |
| CHD4_HUMAN | [view interactions] | High throughput | no | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| RNF31_HUMAN | [view interactions] | High throughput | no | yes |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| MEPCE_HUMAN | [view interactions] | High throughput | no | yes |
| PPT1_HUMAN | [view interactions] | High throughput | no | yes |
| SNAI1_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| TXNIP_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| AMRA1_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H2_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBX1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TET2_HUMAN | [view interactions] | High throughput | no | yes |
| TGM2_HUMAN | [view interactions] | High throughput | no | no |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| UCHL3_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| VRK3_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| S15A3_HUMAN | [view interactions] | High throughput | no | yes |
| RU17_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARAF_HUMAN | [view interactions] | High throughput | no | yes |
| CLUA1_HUMAN | [view interactions] | High throughput | no | yes |
| NFX1_HUMAN | [view interactions] | High throughput | no | yes |
| BRD7_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| EMC4_HUMAN | [view interactions] | High throughput | no | yes |
| ANR55_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| NMRL1_HUMAN | [view interactions] | High throughput | no | yes |
| MAFB_HUMAN | [view interactions] | High throughput | no | yes |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| CIC_HUMAN | [view interactions] | High throughput | no | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| F16P1_HUMAN | [view interactions] | High throughput | no | no |
| KDF1_HUMAN | [view interactions] | High throughput | no | yes |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTUS2_HUMAN | [view interactions] | High throughput | no | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| AGO1_HUMAN | [view interactions] | High throughput | no | no |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| AGO2_HUMAN | [view interactions] | High throughput | no | yes |
| NUDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2AX_HUMAN | [view interactions] | High throughput | no | yes |
| ST1C2_HUMAN | [view interactions] | High throughput | no | no |
| SLAF1_HUMAN | [view interactions] | High throughput | no | no |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OSTM1_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4C_HUMAN | [view interactions] | High throughput | no | yes |
| GBRAP_HUMAN | [view interactions] | High throughput | no | no |
| MAGA8_HUMAN | [view interactions] | High throughput | no | no |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITAD_HUMAN | [view interactions] | High throughput | no | no |
| SG2A2_HUMAN | [view interactions] | High throughput | no | no |
| S22A4_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| LRC25_HUMAN | [view interactions] | High throughput | no | yes |
| NDUAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| POF1B_HUMAN | [view interactions] | High throughput | no | no |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| NAGK_HUMAN | [view interactions] | High throughput | no | no |
| SCAFB_HUMAN | [view interactions] | High throughput | no | yes |
| HUMMR_HUMAN | [view interactions] | High throughput | no | yes |
| RPC5_HUMAN | [view interactions] | High throughput | no | yes |
| S1A7A_HUMAN | [view interactions] | High throughput | no | no |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RDHE2_HUMAN | [view interactions] | High throughput | no | yes |
| PDCD1_HUMAN | [view interactions] | High throughput | no | yes |
| KLK6_HUMAN | [view interactions] | High throughput | no | no |
| CNDP1_HUMAN | [view interactions] | High throughput | no | yes |
| ST2B1_HUMAN | [view interactions] | High throughput | no | yes |
| VSIG4_HUMAN | [view interactions] | High throughput | no | no |
| PPAP_HUMAN | [view interactions] | High throughput | no | no |
| ISLR_HUMAN | [view interactions] | High throughput | no | no |
| FILA_HUMAN | [view interactions] | High throughput | no | no |
| TSP3_HUMAN | [view interactions] | High throughput | no | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SACA1_HUMAN | [view interactions] | High throughput | no | no |
| CASPE_HUMAN | [view interactions] | High throughput | no | no |
| LRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S10A2_HUMAN | [view interactions] | High throughput | no | no |
| DKK3_HUMAN | [view interactions] | High throughput | no | yes |
| RNAS7_HUMAN | [view interactions] | High throughput | no | no |
| ACM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F131B_HUMAN | [view interactions] | High throughput | no | no |
| KLK10_HUMAN | [view interactions] | High throughput | no | no |
| TOM22_HUMAN | [view interactions] | High throughput | no | yes |
| PRSS8_HUMAN | [view interactions] | High throughput | no | no |
| LYAG_HUMAN | [view interactions] | High throughput | no | yes |
| KLK7_HUMAN | [view interactions] | High throughput | no | no |
| F187B_HUMAN | [view interactions] | High throughput | no | no |
| CO3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RRP1B_HUMAN | [view interactions] | High throughput | no | yes |
| ADT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZCH18_HUMAN | [view interactions] | High throughput | no | yes |
| LEG7_HUMAN | [view interactions] | High throughput | no | no |
| MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
| ITLN1_HUMAN | [view interactions] | High throughput | no | no |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| CRYAB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ABHDB_HUMAN | [view interactions] | High throughput | no | yes |
| CTDS1_HUMAN | [view interactions] | High throughput | no | no |
| NMES1_HUMAN | [view interactions] | High throughput | no | no |
| CATL2_HUMAN | [view interactions] | High throughput | no | yes |
| CHC10_HUMAN | [view interactions] | High throughput | no | yes |
| CCG7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CHCH2_HUMAN | [view interactions] | High throughput | no | yes |
| OPALI_HUMAN | [view interactions] | High throughput | no | yes |
| COQ7_HUMAN | [view interactions] | High throughput | no | yes |
| TYPH_HUMAN | [view interactions] | High throughput | no | no |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| ANXA8_HUMAN | [view interactions] | High throughput | no | no |
| GPAT1_HUMAN | [view interactions] | High throughput | no | no |
| I12R1_HUMAN | [view interactions] | High throughput | no | no |
| LACTB_HUMAN | [view interactions] | High throughput | no | yes |
| PA24D_HUMAN | [view interactions] | High throughput | no | no |
| AFG1L_HUMAN | [view interactions] | High throughput | no | yes |
| TREX2_HUMAN | [view interactions] | High throughput | no | no |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FIBB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTPM1_HUMAN | [view interactions] | High throughput | no | yes |
| KLK9_HUMAN | [view interactions] | High throughput | no | no |
| PPA6_HUMAN | [view interactions] | High throughput | no | no |
| PEPL_HUMAN | [view interactions] | High throughput | no | yes |
| GLUCM_HUMAN | [view interactions] | High throughput | no | yes |
| LX12B_HUMAN | [view interactions] | High throughput | no | no |
| SUCHY_HUMAN | [view interactions] | High throughput | no | yes |
| CPNS2_HUMAN | [view interactions] | High throughput | no | no |
| CISD3_HUMAN | [view interactions] | High throughput | no | yes |
| CBPA4_HUMAN | [view interactions] | High throughput | no | no |
| LYRM4_HUMAN | [view interactions] | High throughput | no | yes |
| TGM1_HUMAN | [view interactions] | High throughput | no | no |
| LYRM2_HUMAN | [view interactions] | High throughput | no | no |
| SPB4_HUMAN | [view interactions] | High throughput | no | no |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| LRN4L_HUMAN | [view interactions] | High throughput | no | yes |
| CQ10B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPB13_HUMAN | [view interactions] | High throughput | no | no |
| PRLD1_HUMAN | [view interactions] | High throughput | no | yes |
| FBX50_HUMAN | [view interactions] | High throughput | no | no |
| NDUF5_HUMAN | [view interactions] | High throughput | no | yes |
| APRV1_HUMAN | [view interactions] | High throughput | no | no |
| PPM1K_HUMAN | [view interactions] | High throughput | no | yes |
| ACP7_HUMAN | [view interactions] | High throughput | no | no |
| MET14_HUMAN | [view interactions] | High throughput | no | yes |
| PGDH_HUMAN | [view interactions] | High throughput | no | no |
| DICER_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPB1_HUMAN | [view interactions] | High throughput | no | no |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| AQP3_HUMAN | [view interactions] | High throughput | no | no |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| RAMP3_HUMAN | [view interactions] | High throughput | no | no |
| VAV_HUMAN | [view interactions] | High throughput | no | no |
| EVPL_HUMAN | [view interactions] | High throughput | no | yes |
| SH3L1_HUMAN | [view interactions] | High throughput | no | yes |
| FCN3_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALL5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MK07_HUMAN | [view interactions] | High throughput | no | yes |
| FCGBP_HUMAN | [view interactions] | High throughput | no | no |
| PAXI_HUMAN | [view interactions] | High throughput | no | yes |
| NGAL_HUMAN | [view interactions] | High throughput | no | no |
| KPCE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SBSN_HUMAN | [view interactions] | High throughput | no | no |
| M3K14_HUMAN | [view interactions] | High throughput | no | yes |
| AT12A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ELK1_HUMAN | [view interactions] | High throughput | no | yes |
| PLBL1_HUMAN | [view interactions] | High throughput | no | no |
| PAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FIBG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KPCI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MFD4A_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| AK1BA_HUMAN | [view interactions] | High throughput | no | no |
| SRC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HUTH_HUMAN | [view interactions] | High throughput | no | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PAI2_HUMAN | [view interactions] | High throughput | no | no |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DR9C7_HUMAN | [view interactions] | High throughput | no | no |
| NCBP2_HUMAN | [view interactions] | High throughput | no | yes |
| NDRG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNFL8_HUMAN | [view interactions] | High throughput | no | no |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| SPB3_HUMAN | [view interactions] | High throughput | no | no |
| INVO_HUMAN | [view interactions] | High throughput | no | no |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| COQ2_HUMAN | [view interactions] | High throughput | no | yes |
| NAAA_HUMAN | [view interactions] | High throughput | no | yes |
| COX15_HUMAN | [view interactions] | High throughput | no | yes |
| SAP3_HUMAN | [view interactions] | High throughput | no | yes |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SOAT1_HUMAN | [view interactions] | High throughput | no | no |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| RRBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| E2F3_HUMAN | [view interactions] | High throughput | no | no |
| FSCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TE2IP_HUMAN | [view interactions] | High throughput | no | yes |
| NALP7_HUMAN | [view interactions] | High throughput | no | no |
| DUX4_HUMAN | [view interactions] | High throughput | no | no |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM11B_HUMAN | [view interactions] | High throughput | no | no |
| P2RY6_HUMAN | [view interactions] | High throughput | no | no |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| PAXI1_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| PAGR1_HUMAN | [view interactions] | High throughput | no | yes |
| TYRO3_HUMAN | [view interactions] | High throughput | no | yes |
| WDR82_HUMAN | [view interactions] | High throughput | no | no |
| NDRG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZEB1_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| BRD3_HUMAN | [view interactions] | High throughput | no | yes |
| TCTP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRDT_HUMAN | [view interactions] | High throughput | no | no |
| CD177_HUMAN | [view interactions] | High throughput | no | no |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| ASSY_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| SERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| PSB10_HUMAN | [view interactions] | High throughput | no | no |
| CHK2_HUMAN | [view interactions] | High throughput | no | yes |
| SYSC_HUMAN | [view interactions] | High throughput | no | yes |
| TRI23_HUMAN | [view interactions] | High throughput | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLT3_HUMAN | [view interactions] | High throughput | no | no |
| TRAF1_HUMAN | [view interactions] | High throughput | no | no |
| TIM13_HUMAN | [view interactions] | High throughput | no | yes |
| K1H1_HUMAN | [view interactions] | High throughput | no | no |
| TIM50_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIP6_HUMAN | [view interactions] | High throughput | no | yes |
| RL10L_HUMAN | [view interactions] | High throughput | no | no |
| NT2NA_HUMAN | [view interactions] | High throughput | no | no |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TEKT4_HUMAN | [view interactions] | High throughput | no | no |
| VAMP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| RL7A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHD3_HUMAN | [view interactions] | High throughput | no | yes |
| RL10A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| NNTM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RACK1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCG1_HUMAN | [view interactions] | High throughput | no | no |
| QCR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRS23_HUMAN | [view interactions] | High throughput | no | no |
| NDUV3_HUMAN | [view interactions] | High throughput | no | yes |
| SYK_HUMAN | [view interactions] | High throughput | no | yes |
| VA0D1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUTC_HUMAN | [view interactions] | High throughput | no | yes |
| PMM2_HUMAN | [view interactions] | High throughput | no | no |
| TR10C_HUMAN | [view interactions] | High throughput | no | no |
| MCAT_HUMAN | [view interactions] | High throughput | no | yes |
| STRN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCMC1_HUMAN | [view interactions] | High throughput | no | no |
| TMM62_HUMAN | [view interactions] | High throughput | no | yes |
| TOM20_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLS1_HUMAN | [view interactions] | High throughput | no | no |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| KR412_HUMAN | [view interactions] | High throughput | no | no |
| RBM47_HUMAN | [view interactions] | High throughput | no | yes |
| NEMO_HUMAN | [view interactions] | High throughput | no | yes |
| TMM70_HUMAN | [view interactions] | High throughput | no | yes |
| M3K1_HUMAN | [view interactions] | High throughput | no | yes |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| M3K3_HUMAN | [view interactions] | High throughput | no | no |
| DNJA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNR1A_HUMAN | [view interactions] | High throughput | no | yes |
| COIL_HUMAN | [view interactions] | High throughput | no | yes |
| TNR1B_HUMAN | [view interactions] | High throughput | no | no |
| COX8A_HUMAN | [view interactions] | High throughput | no | yes |
| TRADD_HUMAN | [view interactions] | High throughput | no | yes |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| TAZ_HUMAN | [view interactions] | Computational | no | yes |
| ADT4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ATPB_HUMAN | [view interactions] | Computational | no | yes |
| TI17A_HUMAN | [view interactions] | Computational | no | yes |
| PPIF_HUMAN | [view interactions] | Computational | no | no |
| VDAC2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TI17B_HUMAN | [view interactions] | Computational | no | no |
| RAB28_HUMAN | [view interactions] | Computational | no | yes |
| CYC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TIM23_HUMAN | [view interactions] | Computational | no | yes |
| PPID_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ASML_HUMAN | [view interactions] | Computational | no | yes |
| TSPO_HUMAN | [view interactions] | Computational | no | yes |
| TIM21_HUMAN | [view interactions] | Computational | no | yes |
| ASMT_HUMAN | [view interactions] | Computational | no | no |
| VDAC3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |