Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CCG7_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (PubMed). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity only for GRIA1 and GRIA2 (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CCG7_HUMAN
GO:0008324 cation transmembrane transporter activity 75.0000 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 75.0000 4 yes
GO:0005216 ion channel activity 71.4286 4 yes
GO:0005261 cation channel activity 71.4286 5 yes
GO:0015267 channel activity 71.4286 4 yes
GO:0022836 gated channel activity 71.4286 5 yes
GO:0005262 calcium channel activity 57.1429 6 yes
GO:0015085 calcium ion transmembrane transporter activity 57.1429 6 yes
GO:0046873 metal ion transmembrane transporter activity 57.1429 5 yes
GO:0005244 voltage-gated ion channel activity 53.5714 4 yes
GO:0022832 voltage-gated channel activity 53.5714 6 yes
GO:0022843 voltage-gated cation channel activity 53.5714 5 yes
GO:0005245 voltage-gated calcium channel activity 39.2857 6 yes
GO:0004970 ionotropic glutamate receptor activity 32.1429 5 no
GO:0005230 extracellular ligand-gated ion channel activity 32.1429 6 no
GO:0008066 glutamate receptor activity 32.1429 4 no
GO:0015276 ligand-gated ion channel activity 32.1429 5 no
GO:0022824 transmitter-gated ion channel activity 32.1429 5 no
GO:0022834 ligand-gated channel activity 32.1429 6 no
GO:0022835 transmitter-gated channel activity 32.1429 4 no
GO:0046872 metal ion binding 32.1429 4 no
GO:0099094 ligand-gated cation channel activity 28.5714 6 no
GO:0001540 amyloid-beta binding 25.0000 4 no
GO:0005246 calcium channel regulator activity 14.2857 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CCG7_HUMAN
GO:0048522 positive regulation of cellular process 57.1429 4 yes
GO:0051049 regulation of transport 57.1429 4 yes
GO:0043269 regulation of ion transport 53.5714 5 yes
GO:0034762 regulation of transmembrane transport 50.0000 4 yes
GO:0034765 regulation of ion transmembrane transport 50.0000 5 yes
GO:0006811 ion transport 50.0000 4 yes
GO:0010646 regulation of cell communication 50.0000 4 yes
GO:0030001 metal ion transport 42.8571 6 yes
GO:0050804 modulation of chemical synaptic transmission 42.8571 5 yes
GO:0099177 regulation of trans-synaptic signaling 42.8571 4 yes
GO:1904062 regulation of cation transmembrane transport 42.8571 6 yes
GO:0007268 chemical synaptic transmission 42.8571 6 no
GO:0098916 anterograde trans-synaptic signaling 42.8571 5 no
GO:0099537 trans-synaptic signaling 42.8571 4 no
GO:0006812 cation transport 42.8571 5 yes
GO:0006816 calcium ion transport 42.8571 7 yes
GO:0008104 protein localization 35.7143 4 yes
GO:0023056 positive regulation of signaling 32.1429 4 yes
GO:0032412 regulation of ion transmembrane transporter activity 32.1429 5 yes
GO:0071702 organic substance transport 32.1429 4 yes
GO:0071705 nitrogen compound transport 32.1429 4 yes
GO:2001257 regulation of cation channel activity 32.1429 6 yes
GO:0009966 regulation of signal transduction 32.1429 4 yes
GO:0010647 positive regulation of cell communication 32.1429 5 yes
GO:0022898 regulation of transmembrane transporter activity 32.1429 4 yes
GO:0050806 positive regulation of synaptic transmission 28.5714 5 yes
GO:0098655 cation transmembrane transport 28.5714 4 no
GO:0098660 inorganic ion transmembrane transport 28.5714 4 no
GO:0098662 inorganic cation transmembrane transport 28.5714 5 no
GO:0048523 negative regulation of cellular process 28.5714 4 no
GO:0051171 regulation of nitrogen compound metabolic process 25.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 25.0000 4 yes
GO:0080090 regulation of primary metabolic process 25.0000 4 yes
GO:0007215 glutamate receptor signaling pathway 25.0000 4 no
GO:0010243 response to organonitrogen compound 25.0000 4 no
GO:0010959 regulation of metal ion transport 25.0000 6 no
GO:0044057 regulation of system process 25.0000 4 no
GO:0051924 regulation of calcium ion transport 25.0000 7 no
GO:0070588 calcium ion transmembrane transport 25.0000 6 no
GO:0097553 calcium ion transmembrane import into cytosol 25.0000 7 no
GO:0006886 intracellular protein transport 25.0000 4 yes
GO:0015031 protein transport 25.0000 4 yes
GO:0031323 regulation of cellular metabolic process 21.4286 4 yes
GO:0051128 regulation of cellular component organization 21.4286 4 yes
GO:0072657 protein localization to membrane 21.4286 4 yes
GO:0009893 positive regulation of metabolic process 21.4286 4 no
GO:0050890 cognition 21.4286 4 no
GO:0051050 positive regulation of transport 21.4286 4 no
GO:0051246 regulation of protein metabolic process 21.4286 5 no
GO:1903169 regulation of calcium ion transmembrane transport 21.4286 7 no
GO:0010941 regulation of cell death 21.4286 4 no
GO:0016192 vesicle-mediated transport 21.4286 4 yes
GO:0031623 receptor internalization 17.8571 7 yes
GO:0033365 protein localization to organelle 17.8571 5 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 17.8571 6 yes
GO:0051968 positive regulation of synaptic transmission, glutamatergic 17.8571 6 yes
GO:0072594 establishment of protein localization to organelle 17.8571 4 yes
GO:0099601 regulation of neurotransmitter receptor activity 17.8571 4 yes
GO:2000311 regulation of AMPA receptor activity 17.8571 5 yes
GO:0006897 endocytosis 17.8571 5 yes
GO:0006898 receptor-mediated endocytosis 17.8571 6 yes
GO:0009894 regulation of catabolic process 17.8571 4 yes
GO:0035418 protein localization to synapse 14.2857 6 yes
GO:0061462 protein localization to lysosome 14.2857 7 yes
GO:0072665 protein localization to vacuole 14.2857 6 yes
GO:0072666 establishment of protein localization to vacuole 14.2857 5 yes
GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome 14.2857 4 yes
GO:0098970 postsynaptic neurotransmitter receptor diffusion trapping 14.2857 4 yes
GO:0099628 neurotransmitter receptor diffusion trapping 14.2857 4 yes
GO:1902414 protein localization to cell junction 14.2857 5 yes
GO:1990778 protein localization to cell periphery 14.2857 5 yes
GO:0007034 vacuolar transport 14.2857 4 yes
GO:0007041 lysosomal transport 14.2857 5 yes
GO:0008333 endosome to lysosome transport 14.2857 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 14.2857 5 yes
GO:0031329 regulation of cellular catabolic process 10.7143 5 yes
GO:0051252 regulation of RNA metabolic process 10.7143 5 yes
GO:0062237 protein localization to postsynapse 10.7143 7 yes
GO:1903539 protein localization to postsynaptic membrane 10.7143 5 yes
GO:0010468 regulation of gene expression 10.7143 5 yes
GO:0099633 protein localization to postsynaptic specialization membrane 7.1429 6 yes
GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane 7.1429 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MAP1A_HUMAN [view entry] [view interactions] Low throughput yes yes
TNKS1_HUMAN [view interactions] High throughput no yes
SACA1_HUMAN [view interactions] High throughput no no
ADT1_HUMAN [view entry] [view interactions] High throughput yes yes
TSYL1_HUMAN [view interactions] High throughput no yes
RAB7L_HUMAN [view interactions] High throughput no yes
CY24A_HUMAN [view interactions] High throughput no no
DRB1_HUMAN [view interactions] High throughput no no
FBXL6_HUMAN [view interactions] High throughput no no
ACSL1_HUMAN [view interactions] High throughput no no
ADT3_HUMAN [view entry] [view interactions] High throughput yes yes
IQEC1_HUMAN [view entry] [view interactions] High throughput yes yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
KIRR1_HUMAN [view interactions] High throughput no no
FUT8_HUMAN [view interactions] High throughput no yes
SAM50_HUMAN [view entry] [view interactions] High throughput yes yes
S38A5_HUMAN [view interactions] High throughput no yes
UCK2_HUMAN [view interactions] High throughput no no
VRK2_HUMAN [view interactions] High throughput no no
PLD2_HUMAN [view interactions] High throughput no yes
CEP78_HUMAN [view interactions] High throughput no yes
GRIA2_HUMAN [view entry] [view interactions] Computational yes yes
GRIA4_HUMAN [view entry] [view interactions] Computational yes no
CA2D4_HUMAN [view interactions] Computational no no
CCG1_HUMAN [view interactions] Computational no no
CCG3_HUMAN [view entry] [view interactions] Computational yes no
CAC1C_HUMAN [view entry] [view interactions] Computational yes no
CAC1D_HUMAN [view interactions] Computational no yes
CAC1F_HUMAN [view interactions] Computational no no
CCG6_HUMAN [view interactions] Computational no no
CACB4_HUMAN [view entry] [view interactions] Computational yes yes
CAC1S_HUMAN [view interactions] Computational no no
NMD3B_HUMAN [view entry] [view interactions] Computational yes no
CACB3_HUMAN [view entry] [view interactions] Computational yes no
CACB1_HUMAN [view entry] [view interactions] Computational yes yes
NMDE4_HUMAN [view entry] [view interactions] Computational yes yes
NMDE1_HUMAN [view entry] [view interactions] Computational yes yes
KPCG_HUMAN [view entry] [view interactions] Computational yes yes
CA2D1_HUMAN [view entry] [view interactions] Computational yes yes
CCG8_HUMAN [view entry] [view interactions] Computational yes no
CAC1B_HUMAN [view interactions] Computational no yes
GRIA1_HUMAN [view entry] [view interactions] Computational yes yes
CNIH2_HUMAN [view entry] [view interactions] Computational yes no
GRIA3_HUMAN [view entry] [view interactions] Computational yes yes
CAC1E_HUMAN [view entry] [view interactions] Computational yes no
NMDZ1_HUMAN [view entry] [view interactions] Computational yes yes
CCG4_HUMAN [view entry] [view interactions] Computational yes no
CAC1H_HUMAN [view entry] [view interactions] Computational yes yes
NMDE2_HUMAN [view entry] [view interactions] Computational yes no