MAP1A_HUMAN
Evidence for PS localization
Functions
Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MAP1A_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 30.6452 | 4 | no |
| GO:0019900 | kinase binding | 27.4194 | 4 | no |
| GO:0000166 | nucleotide binding | 25.8065 | 4 | no |
| GO:0017076 | purine nucleotide binding | 25.8065 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 25.8065 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.8065 | 4 | no |
| GO:0043169 | cation binding | 22.5806 | 4 | no |
| GO:0019901 | protein kinase binding | 20.9677 | 5 | no |
| GO:0046872 | metal ion binding | 20.9677 | 5 | no |
| GO:0003779 | actin binding | 19.3548 | 4 | yes |
| GO:0015631 | tubulin binding | 16.1290 | 4 | yes |
| GO:0008017 | microtubule binding | 12.9032 | 5 | yes |
| GO:0048156 | tau protein binding | 9.6774 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MAP1A_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 69.3548 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 58.0645 | 4 | yes |
| GO:0006996 | organelle organization | 53.2258 | 4 | yes |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | yes |
| GO:0008104 | protein localization | 48.3871 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 45.1613 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 43.5484 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 43.5484 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 41.9355 | 4 | yes |
| GO:0022607 | cellular component assembly | 41.9355 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 40.3226 | 4 | yes |
| GO:0051049 | regulation of transport | 35.4839 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 33.8710 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 33.8710 | 5 | no |
| GO:0023056 | positive regulation of signaling | 33.8710 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 32.2581 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 32.2581 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 32.2581 | 4 | no |
| GO:0033043 | regulation of organelle organization | 30.6452 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 30.6452 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 30.6452 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 30.6452 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 30.6452 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.6452 | 5 | no |
| GO:0007010 | cytoskeleton organization | 30.6452 | 5 | yes |
| GO:0009894 | regulation of catabolic process | 30.6452 | 4 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 29.0323 | 6 | yes |
| GO:0010468 | regulation of gene expression | 29.0323 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 29.0323 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 29.0323 | 4 | no |
| GO:0030030 | cell projection organization | 27.4194 | 4 | yes |
| GO:0071702 | organic substance transport | 27.4194 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 27.4194 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 27.4194 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 27.4194 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 27.4194 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 25.8065 | 6 | no |
| GO:0051094 | positive regulation of developmental process | 25.8065 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 24.1935 | 5 | yes |
| GO:0015031 | protein transport | 24.1935 | 4 | yes |
| GO:0033365 | protein localization to organelle | 24.1935 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.1935 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 24.1935 | 4 | no |
| GO:0060341 | regulation of cellular localization | 22.5806 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 22.5806 | 5 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 22.5806 | 5 | yes |
| GO:0098657 | import into cell | 22.5806 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.5806 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 22.5806 | 5 | no |
| GO:0034330 | cell junction organization | 22.5806 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 22.5806 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 22.5806 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 22.5806 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 22.5806 | 5 | no |
| GO:0030162 | regulation of proteolysis | 20.9677 | 6 | yes |
| GO:0010638 | positive regulation of organelle organization | 20.9677 | 6 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 20.9677 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 20.9677 | 7 | no |
| GO:0019220 | regulation of phosphate metabolic process | 20.9677 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 20.9677 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 20.9677 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 20.9677 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 20.9677 | 4 | no |
| GO:0006886 | intracellular protein transport | 20.9677 | 4 | yes |
| GO:0032880 | regulation of protein localization | 19.3548 | 5 | yes |
| GO:0031175 | neuron projection development | 17.7419 | 6 | yes |
| GO:0032886 | regulation of microtubule-based process | 17.7419 | 4 | yes |
| GO:0050890 | cognition | 17.7419 | 4 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 17.7419 | 6 | yes |
| GO:0042176 | regulation of protein catabolic process | 16.1290 | 5 | yes |
| GO:0048812 | neuron projection morphogenesis | 16.1290 | 5 | yes |
| GO:0070507 | regulation of microtubule cytoskeleton organization | 16.1290 | 5 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 16.1290 | 4 | yes |
| GO:1903829 | positive regulation of protein localization | 16.1290 | 5 | yes |
| GO:0031110 | regulation of microtubule polymerization or depolymerization | 14.5161 | 6 | yes |
| GO:1902414 | protein localization to cell junction | 14.5161 | 5 | yes |
| GO:1903050 | regulation of proteolysis involved in protein catabolic process | 14.5161 | 7 | yes |
| GO:2000058 | regulation of ubiquitin-dependent protein catabolic process | 14.5161 | 5 | yes |
| GO:0032434 | regulation of proteasomal ubiquitin-dependent protein catabolic process | 12.9032 | 6 | yes |
| GO:0035418 | protein localization to synapse | 12.9032 | 6 | yes |
| GO:0061136 | regulation of proteasomal protein catabolic process | 12.9032 | 6 | yes |
| GO:0007612 | learning | 12.9032 | 4 | yes |
| GO:0009895 | negative regulation of catabolic process | 9.6774 | 5 | yes |
| GO:0010970 | transport along microtubule | 9.6774 | 4 | yes |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 9.6774 | 4 | yes |
| GO:0099111 | microtubule-based transport | 9.6774 | 4 | yes |
| GO:0042177 | negative regulation of protein catabolic process | 8.0645 | 6 | yes |
| GO:0045861 | negative regulation of proteolysis | 8.0645 | 7 | yes |
| GO:0050905 | neuromuscular process | 8.0645 | 4 | yes |
| GO:0106027 | neuron projection organization | 8.0645 | 6 | yes |
| GO:0007409 | axonogenesis | 8.0645 | 6 | yes |
| GO:0007613 | memory | 8.0645 | 4 | yes |
| GO:1903828 | negative regulation of protein localization | 6.4516 | 5 | yes |
| GO:0008088 | axo-dendritic transport | 6.4516 | 5 | yes |
| GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process | 4.8387 | 7 | yes |
| GO:0098930 | axonal transport | 4.8387 | 6 | yes |
| GO:1901799 | negative regulation of proteasomal protein catabolic process | 4.8387 | 7 | yes |
| GO:1903051 | negative regulation of proteolysis involved in protein catabolic process | 4.8387 | 8 | yes |
| GO:2000059 | negative regulation of ubiquitin-dependent protein catabolic process | 4.8387 | 6 | yes |
| GO:0008306 | associative learning | 4.8387 | 5 | yes |
| GO:0031114 | regulation of microtubule depolymerization | 3.2258 | 6 | yes |
| GO:0043244 | regulation of protein-containing complex disassembly | 3.2258 | 5 | yes |
| GO:0098840 | protein transport along microtubule | 3.2258 | 4 | yes |
| GO:0099640 | axo-dendritic protein transport | 3.2258 | 5 | yes |
| GO:0099641 | anterograde axonal protein transport | 3.2258 | 6 | yes |
| GO:0099642 | retrograde axonal protein transport | 3.2258 | 6 | yes |
| GO:1901879 | regulation of protein depolymerization | 3.2258 | 6 | yes |
| GO:1905383 | protein localization to presynapse | 3.2258 | 7 | yes |
| GO:1990535 | neuron projection maintenance | 3.2258 | 7 | yes |
| GO:0008089 | anterograde axonal transport | 3.2258 | 7 | yes |
| GO:0008090 | retrograde axonal transport | 3.2258 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DLG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KC1D_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| OSTP_HUMAN | [view interactions] | Low throughput | no | yes |
| NXF1_HUMAN | [view interactions] | Low throughput | no | yes |
| MIB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACTB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TBA1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLGP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CCG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CCG3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CCG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CCG5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CCG7_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCMA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DISC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MLP3B_HUMAN | [view interactions] | Low throughput | no | yes |
| MLP3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| APBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIPT3_HUMAN | [view interactions] | High throughput | no | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOX4_HUMAN | [view interactions] | High throughput | no | yes |
| ST38L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RENT2_HUMAN | [view interactions] | High throughput | no | no |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAKG2_HUMAN | [view interactions] | High throughput | no | yes |
| AP1G1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GGA1_HUMAN | [view interactions] | High throughput | no | yes |
| GGA2_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| ATOH1_HUMAN | [view interactions] | High throughput | no | no |
| SR1IP_HUMAN | [view interactions] | High throughput | no | no |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| IFT1B_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| JADE1_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CGAS_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| TIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRD1_HUMAN | [view interactions] | High throughput | no | yes |
| BAG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZBT44_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABCF3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SLU7_HUMAN | [view interactions] | High throughput | no | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTSRT_HUMAN | [view interactions] | High throughput | no | no |
| TPC6B_HUMAN | [view interactions] | High throughput | no | yes |
| GARS_HUMAN | [view interactions] | High throughput | no | yes |
| CAN10_HUMAN | [view interactions] | High throughput | no | yes |
| KLK12_HUMAN | [view interactions] | High throughput | no | no |
| ARAF_HUMAN | [view interactions] | High throughput | no | yes |
| CCD71_HUMAN | [view interactions] | High throughput | no | no |
| SPCS1_HUMAN | [view interactions] | High throughput | no | yes |
| O13C3_HUMAN | [view interactions] | High throughput | no | no |
| K0408_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DIDO1_HUMAN | [view interactions] | High throughput | no | yes |
| INSI1_HUMAN | [view interactions] | High throughput | no | no |
| DDX55_HUMAN | [view interactions] | High throughput | no | yes |
| T2R31_HUMAN | [view interactions] | High throughput | no | no |
| SPB1_HUMAN | [view interactions] | High throughput | no | yes |
| NOG2_HUMAN | [view interactions] | High throughput | no | yes |
| CNTP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| CFAH_HUMAN | [view interactions] | High throughput | no | no |
| RN207_HUMAN | [view interactions] | High throughput | no | no |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CENPE_HUMAN | [view interactions] | High throughput | no | no |
| MAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARE2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYVC_HUMAN | [view interactions] | High throughput | no | yes |
| DCA15_HUMAN | [view interactions] | High throughput | no | no |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI36_HUMAN | [view interactions] | High throughput | no | no |
| VASP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| AP2S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CNOT3_HUMAN | [view interactions] | High throughput | no | yes |
| PPP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHEB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPAST_HUMAN | [view interactions] | High throughput | no | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSK3A_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 5HT2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| P63_HUMAN | [view interactions] | High throughput | no | no |