MAP1A_HUMAN
Evidence for PS localization
Functions
Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MAP1A_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 31.4815 | 4 | no |
| GO:0019900 | kinase binding | 27.7778 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 27.7778 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.7778 | 4 | no |
| GO:0019901 | protein kinase binding | 24.0741 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 24.0741 | 5 | no |
| GO:0005524 | ATP binding | 20.3704 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 20.3704 | 5 | no |
| GO:0015631 | tubulin binding | 18.5185 | 4 | yes |
| GO:0003779 | actin binding | 16.6667 | 4 | yes |
| GO:0008017 | microtubule binding | 16.6667 | 5 | yes |
| GO:0048156 | tau protein binding | 7.4074 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MAP1A_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 66.6667 | 4 | yes |
| GO:0006996 | organelle organization | 51.8519 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 51.8519 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 48.1481 | 4 | yes |
| GO:0010646 | regulation of cell communication | 44.4444 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 44.4444 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 44.4444 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 44.4444 | 4 | yes |
| GO:0008104 | protein localization | 42.5926 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 38.8889 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 38.8889 | 4 | no |
| GO:0007010 | cytoskeleton organization | 37.0370 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 37.0370 | 4 | yes |
| GO:0022607 | cellular component assembly | 37.0370 | 4 | no |
| GO:0051049 | regulation of transport | 33.3333 | 4 | no |
| GO:0031399 | regulation of protein modification process | 33.3333 | 6 | no |
| GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 31.4815 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 31.4815 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.6296 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 29.6296 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 29.6296 | 5 | no |
| GO:0009894 | regulation of catabolic process | 27.7778 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 27.7778 | 5 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 27.7778 | 5 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 27.7778 | 6 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 27.7778 | 4 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 27.7778 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 27.7778 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 27.7778 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 27.7778 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 27.7778 | 5 | no |
| GO:0023056 | positive regulation of signaling | 27.7778 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 25.9259 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 25.9259 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 24.0741 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 24.0741 | 5 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 24.0741 | 5 | yes |
| GO:0010468 | regulation of gene expression | 24.0741 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.0741 | 5 | no |
| GO:0033365 | protein localization to organelle | 24.0741 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 24.0741 | 7 | no |
| GO:0030030 | cell projection organization | 22.2222 | 4 | yes |
| GO:0071702 | organic substance transport | 22.2222 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 22.2222 | 4 | yes |
| GO:0006897 | endocytosis | 22.2222 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.2222 | 4 | no |
| GO:0051338 | regulation of transferase activity | 22.2222 | 4 | no |
| GO:0015031 | protein transport | 20.3704 | 4 | yes |
| GO:0030162 | regulation of proteolysis | 20.3704 | 6 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 20.3704 | 5 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 20.3704 | 6 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 20.3704 | 5 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 20.3704 | 5 | yes |
| GO:0010941 | regulation of cell death | 20.3704 | 4 | no |
| GO:0036211 | protein modification process | 20.3704 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 20.3704 | 4 | no |
| GO:0043412 | macromolecule modification | 20.3704 | 4 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 20.3704 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 20.3704 | 4 | no |
| GO:0071310 | cellular response to organic substance | 20.3704 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 20.3704 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 20.3704 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 20.3704 | 5 | no |
| GO:0034762 | regulation of transmembrane transport | 20.3704 | 4 | no |
| GO:0043269 | regulation of ion transport | 20.3704 | 5 | no |
| GO:0032886 | regulation of microtubule-based process | 18.5185 | 4 | yes |
| GO:0060341 | regulation of cellular localization | 18.5185 | 4 | yes |
| GO:0006886 | intracellular protein transport | 16.6667 | 4 | yes |
| GO:0031110 | regulation of microtubule polymerization or depolymerization | 16.6667 | 6 | yes |
| GO:0070507 | regulation of microtubule cytoskeleton organization | 16.6667 | 5 | yes |
| GO:0031175 | neuron projection development | 14.8148 | 6 | yes |
| GO:0032880 | regulation of protein localization | 14.8148 | 5 | yes |
| GO:0042176 | regulation of protein catabolic process | 14.8148 | 5 | yes |
| GO:1902414 | protein localization to cell junction | 14.8148 | 5 | yes |
| GO:0032990 | cell part morphogenesis | 12.9630 | 4 | yes |
| GO:0035418 | protein localization to synapse | 12.9630 | 6 | yes |
| GO:0050890 | cognition | 12.9630 | 4 | yes |
| GO:1903050 | regulation of proteolysis involved in protein catabolic process | 12.9630 | 7 | yes |
| GO:1903829 | positive regulation of protein localization | 12.9630 | 5 | yes |
| GO:2000058 | regulation of ubiquitin-dependent protein catabolic process | 12.9630 | 6 | yes |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 11.1111 | 4 | yes |
| GO:0032434 | regulation of proteasomal ubiquitin-dependent protein catabolic process | 11.1111 | 7 | yes |
| GO:0048812 | neuron projection morphogenesis | 11.1111 | 7 | yes |
| GO:0048858 | cell projection morphogenesis | 11.1111 | 5 | yes |
| GO:0061136 | regulation of proteasomal protein catabolic process | 11.1111 | 6 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 11.1111 | 6 | yes |
| GO:0009895 | negative regulation of catabolic process | 9.2593 | 5 | yes |
| GO:0042177 | negative regulation of protein catabolic process | 9.2593 | 6 | yes |
| GO:0045861 | negative regulation of proteolysis | 9.2593 | 7 | yes |
| GO:0007612 | learning | 7.4074 | 4 | yes |
| GO:0010970 | transport along microtubule | 7.4074 | 4 | yes |
| GO:0031330 | negative regulation of cellular catabolic process | 7.4074 | 6 | yes |
| GO:0099111 | microtubule-based transport | 7.4074 | 4 | yes |
| GO:0007409 | axonogenesis | 5.5556 | 8 | yes |
| GO:0007613 | memory | 5.5556 | 4 | yes |
| GO:0008088 | axo-dendritic transport | 5.5556 | 5 | yes |
| GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process | 5.5556 | 8 | yes |
| GO:0050905 | neuromuscular process | 5.5556 | 4 | yes |
| GO:0060249 | anatomical structure homeostasis | 5.5556 | 4 | yes |
| GO:0098930 | axonal transport | 5.5556 | 6 | yes |
| GO:0106027 | neuron projection organization | 5.5556 | 6 | yes |
| GO:1901799 | negative regulation of proteasomal protein catabolic process | 5.5556 | 7 | yes |
| GO:1903051 | negative regulation of proteolysis involved in protein catabolic process | 5.5556 | 8 | yes |
| GO:2000059 | negative regulation of ubiquitin-dependent protein catabolic process | 5.5556 | 7 | yes |
| GO:0008089 | anterograde axonal transport | 3.7037 | 7 | yes |
| GO:0008090 | retrograde axonal transport | 3.7037 | 7 | yes |
| GO:0031114 | regulation of microtubule depolymerization | 3.7037 | 6 | yes |
| GO:0043244 | regulation of protein-containing complex disassembly | 3.7037 | 5 | yes |
| GO:0098840 | protein transport along microtubule | 3.7037 | 4 | yes |
| GO:0099640 | axo-dendritic protein transport | 3.7037 | 5 | yes |
| GO:0099641 | anterograde axonal protein transport | 3.7037 | 6 | yes |
| GO:0099642 | retrograde axonal protein transport | 3.7037 | 6 | yes |
| GO:1901879 | regulation of protein depolymerization | 3.7037 | 6 | yes |
| GO:1903828 | negative regulation of protein localization | 3.7037 | 5 | yes |
| GO:1905383 | protein localization to presynapse | 3.7037 | 7 | yes |
| GO:1990535 | neuron projection maintenance | 3.7037 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in MAP1A_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 3.7037 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MLP3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCMA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DISC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MLP3B_HUMAN | [view interactions] | Low throughput | no | yes |
| DLG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KC1D_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| OSTP_HUMAN | [view interactions] | Low throughput | no | yes |
| NXF1_HUMAN | [view interactions] | Low throughput | no | yes |
| MIB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACTB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TBA1B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLGP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CCG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CCG3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CCG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CCG5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CCG7_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YES_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 5HT2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| P63_HUMAN | [view interactions] | High throughput | no | no |
| PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| APBB1_HUMAN | [view interactions] | High throughput | no | yes |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIPT3_HUMAN | [view interactions] | High throughput | no | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| ST38L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RENT2_HUMAN | [view interactions] | High throughput | no | no |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAKG2_HUMAN | [view interactions] | High throughput | no | yes |
| AP1G1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GGA1_HUMAN | [view interactions] | High throughput | no | yes |
| GGA2_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| ATOH1_HUMAN | [view interactions] | High throughput | no | no |
| SR1IP_HUMAN | [view interactions] | High throughput | no | no |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| IFT1B_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| JADE1_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CGAS_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| TIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRD1_HUMAN | [view interactions] | High throughput | no | yes |
| BAG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZBT44_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABCF3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SLU7_HUMAN | [view interactions] | High throughput | no | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| C2CD6_HUMAN | [view interactions] | High throughput | no | no |
| TPC6B_HUMAN | [view interactions] | High throughput | no | yes |
| GARS_HUMAN | [view interactions] | High throughput | no | yes |
| CAN10_HUMAN | [view interactions] | High throughput | no | yes |
| KLK12_HUMAN | [view interactions] | High throughput | no | no |
| ARAF_HUMAN | [view interactions] | High throughput | no | yes |
| CCD71_HUMAN | [view interactions] | High throughput | no | no |
| SPCS1_HUMAN | [view interactions] | High throughput | no | yes |
| O13C3_HUMAN | [view interactions] | High throughput | no | no |
| K0408_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DIDO1_HUMAN | [view interactions] | High throughput | no | yes |
| INSI1_HUMAN | [view interactions] | High throughput | no | no |
| DDX55_HUMAN | [view interactions] | High throughput | no | yes |
| T2R31_HUMAN | [view interactions] | High throughput | no | no |
| SPB1_HUMAN | [view interactions] | High throughput | no | yes |
| NOG2_HUMAN | [view interactions] | High throughput | no | yes |
| CNTP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CENPE_HUMAN | [view interactions] | High throughput | no | no |
| MAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARE2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYVC_HUMAN | [view interactions] | High throughput | no | yes |
| DCA15_HUMAN | [view interactions] | High throughput | no | no |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI36_HUMAN | [view interactions] | High throughput | no | no |
| VASP_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | Computational | no | yes |
| DNAL1_HUMAN | [view interactions] | Computational | no | no |