CCG4_HUMAN
Evidence for PS localization
Functions
Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (PubMed). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CCG4_HUMAN |
|---|---|---|---|---|
| GO:0008324 | cation transmembrane transporter activity | 46.3415 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 46.3415 | 4 | yes |
| GO:0005216 | ion channel activity | 39.0244 | 4 | yes |
| GO:0005261 | cation channel activity | 39.0244 | 5 | yes |
| GO:0015267 | channel activity | 39.0244 | 4 | yes |
| GO:0022836 | gated channel activity | 39.0244 | 5 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 34.1463 | 5 | yes |
| GO:0015085 | calcium ion transmembrane transporter activity | 31.7073 | 6 | yes |
| GO:0005244 | voltage-gated ion channel activity | 29.2683 | 4 | yes |
| GO:0005262 | calcium channel activity | 29.2683 | 6 | yes |
| GO:0022832 | voltage-gated channel activity | 29.2683 | 6 | yes |
| GO:0022843 | voltage-gated cation channel activity | 29.2683 | 5 | yes |
| GO:0005245 | voltage-gated calcium channel activity | 26.8293 | 6 | yes |
| GO:0017076 | purine nucleotide binding | 24.3902 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 24.3902 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 24.3902 | 4 | no |
| GO:0046872 | metal ion binding | 21.9512 | 4 | no |
| GO:0005246 | calcium channel regulator activity | 9.7561 | 4 | yes |
| GO:0035254 | glutamate receptor binding | 9.7561 | 4 | yes |
| GO:0035255 | ionotropic glutamate receptor binding | 7.3171 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CCG4_HUMAN |
|---|---|---|---|---|
| GO:0051049 | regulation of transport | 56.0976 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 53.6585 | 4 | yes |
| GO:0010646 | regulation of cell communication | 48.7805 | 4 | yes |
| GO:0043269 | regulation of ion transport | 48.7805 | 5 | yes |
| GO:0034762 | regulation of transmembrane transport | 46.3415 | 4 | yes |
| GO:0034765 | regulation of ion transmembrane transport | 46.3415 | 5 | yes |
| GO:0008104 | protein localization | 39.0244 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 39.0244 | 4 | yes |
| GO:1904062 | regulation of cation transmembrane transport | 39.0244 | 6 | yes |
| GO:0022898 | regulation of transmembrane transporter activity | 34.1463 | 4 | yes |
| GO:0032412 | regulation of ion transmembrane transporter activity | 34.1463 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 34.1463 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 34.1463 | 4 | no |
| GO:2001257 | regulation of cation channel activity | 31.7073 | 6 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 31.7073 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 31.7073 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 31.7073 | 4 | no |
| GO:0006811 | ion transport | 29.2683 | 4 | no |
| GO:0044057 | regulation of system process | 26.8293 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 26.8293 | 5 | yes |
| GO:0071702 | organic substance transport | 26.8293 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 26.8293 | 4 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 26.8293 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 26.8293 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.8293 | 5 | no |
| GO:0006812 | cation transport | 26.8293 | 5 | no |
| GO:0007268 | chemical synaptic transmission | 26.8293 | 6 | no |
| GO:0030001 | metal ion transport | 26.8293 | 6 | no |
| GO:0051246 | regulation of protein metabolic process | 26.8293 | 5 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 26.8293 | 5 | no |
| GO:0099537 | trans-synaptic signaling | 26.8293 | 4 | no |
| GO:0015031 | protein transport | 24.3902 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 24.3902 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 24.3902 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 24.3902 | 5 | no |
| GO:0006816 | calcium ion transport | 24.3902 | 7 | no |
| GO:0010959 | regulation of metal ion transport | 24.3902 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 24.3902 | 4 | no |
| GO:0060341 | regulation of cellular localization | 24.3902 | 4 | no |
| GO:0006996 | organelle organization | 24.3902 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 21.9512 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 21.9512 | 4 | yes |
| GO:0051050 | positive regulation of transport | 21.9512 | 4 | yes |
| GO:0010468 | regulation of gene expression | 21.9512 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 21.9512 | 6 | no |
| GO:0051128 | regulation of cellular component organization | 21.9512 | 4 | no |
| GO:0006886 | intracellular protein transport | 19.5122 | 4 | yes |
| GO:0033365 | protein localization to organelle | 19.5122 | 5 | yes |
| GO:0006897 | endocytosis | 17.0732 | 5 | yes |
| GO:0010243 | response to organonitrogen compound | 17.0732 | 4 | yes |
| GO:0099601 | regulation of neurotransmitter receptor activity | 17.0732 | 4 | yes |
| GO:0043270 | positive regulation of ion transport | 14.6341 | 5 | yes |
| GO:0050806 | positive regulation of synaptic transmission | 14.6341 | 5 | yes |
| GO:2000311 | regulation of AMPA receptor activity | 14.6341 | 5 | yes |
| GO:0006898 | receptor-mediated endocytosis | 12.1951 | 6 | yes |
| GO:0031623 | receptor internalization | 12.1951 | 7 | yes |
| GO:0034764 | positive regulation of transmembrane transport | 12.1951 | 5 | yes |
| GO:0034767 | positive regulation of ion transmembrane transport | 12.1951 | 6 | yes |
| GO:0072594 | establishment of protein localization to organelle | 12.1951 | 4 | yes |
| GO:0098970 | postsynaptic neurotransmitter receptor diffusion trapping | 12.1951 | 4 | yes |
| GO:0099628 | neurotransmitter receptor diffusion trapping | 12.1951 | 4 | yes |
| GO:1904064 | positive regulation of cation transmembrane transport | 12.1951 | 7 | yes |
| GO:0007034 | vacuolar transport | 9.7561 | 4 | yes |
| GO:0007041 | lysosomal transport | 9.7561 | 5 | yes |
| GO:0008333 | endosome to lysosome transport | 9.7561 | 5 | yes |
| GO:0031644 | regulation of nervous system process | 9.7561 | 5 | yes |
| GO:0032411 | positive regulation of transporter activity | 9.7561 | 4 | yes |
| GO:0032414 | positive regulation of ion transmembrane transporter activity | 9.7561 | 5 | yes |
| GO:0051966 | regulation of synaptic transmission, glutamatergic | 9.7561 | 6 | yes |
| GO:0051968 | positive regulation of synaptic transmission, glutamatergic | 9.7561 | 6 | yes |
| GO:0061462 | protein localization to lysosome | 9.7561 | 7 | yes |
| GO:0072665 | protein localization to vacuole | 9.7561 | 6 | yes |
| GO:0072666 | establishment of protein localization to vacuole | 9.7561 | 5 | yes |
| GO:0098943 | neurotransmitter receptor transport, postsynaptic endosome to lysosome | 9.7561 | 4 | yes |
| GO:2001259 | positive regulation of cation channel activity | 9.7561 | 6 | yes |
| GO:0014070 | response to organic cyclic compound | 7.3171 | 4 | yes |
| GO:0098962 | regulation of postsynaptic neurotransmitter receptor activity | 4.8780 | 5 | yes |
| GO:2000273 | positive regulation of signaling receptor activity | 4.8780 | 4 | yes |
| GO:2000969 | positive regulation of AMPA receptor activity | 4.8780 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DLG3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GOPC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MAP1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MAGI2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MAGI3_HUMAN | [view interactions] | Low throughput | no | no |
| RMND1_HUMAN | [view interactions] | High throughput | no | yes |
| RSPRY_HUMAN | [view interactions] | High throughput | no | yes |
| ARL10_HUMAN | [view interactions] | High throughput | no | yes |
| D19L3_HUMAN | [view interactions] | High throughput | no | yes |
| OSTP_HUMAN | [view interactions] | High throughput | no | yes |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| ALG5_HUMAN | [view interactions] | High throughput | no | yes |
| COQ5_HUMAN | [view interactions] | High throughput | no | yes |
| APC7_HUMAN | [view interactions] | High throughput | no | yes |
| CNDH2_HUMAN | [view interactions] | High throughput | no | no |
| KC1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KC1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| T126B_HUMAN | [view interactions] | High throughput | no | yes |
| YIF1A_HUMAN | [view interactions] | High throughput | no | yes |
| MRS2_HUMAN | [view interactions] | High throughput | no | no |
| MTX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTX3_HUMAN | [view interactions] | High throughput | no | yes |
| LRRC1_HUMAN | [view interactions] | High throughput | no | yes |
| TTI1_HUMAN | [view interactions] | High throughput | no | yes |
| CY24A_HUMAN | [view interactions] | High throughput | no | no |
| UCK2_HUMAN | [view interactions] | High throughput | no | no |
| AVR2A_HUMAN | [view interactions] | High throughput | no | yes |
| IMB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TX264_HUMAN | [view interactions] | High throughput | no | no |
| MTOR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AL3B1_HUMAN | [view interactions] | High throughput | no | yes |
| EFNMT_HUMAN | [view interactions] | High throughput | no | yes |
| EI2BE_HUMAN | [view interactions] | High throughput | no | yes |
| PISD_HUMAN | [view interactions] | High throughput | no | yes |
| IPIL1_HUMAN | [view interactions] | High throughput | no | no |
| STYK1_HUMAN | [view interactions] | High throughput | no | yes |
| GNA13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFB2M_HUMAN | [view interactions] | High throughput | no | no |
| AT2A3_HUMAN | [view interactions] | High throughput | no | yes |
| C2CD2_HUMAN | [view interactions] | High throughput | no | yes |
| SEC63_HUMAN | [view interactions] | High throughput | no | yes |
| PYRG2_HUMAN | [view interactions] | High throughput | no | yes |
| RHDF2_HUMAN | [view interactions] | High throughput | no | yes |
| AT1A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STAR3_HUMAN | [view interactions] | High throughput | no | yes |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EI2BG_HUMAN | [view interactions] | High throughput | no | yes |
| CDC45_HUMAN | [view interactions] | High throughput | no | no |
| PKP2_HUMAN | [view interactions] | High throughput | no | yes |
| AT2B4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODR4_HUMAN | [view interactions] | High throughput | no | yes |
| UBE3C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNDD3_HUMAN | [view interactions] | High throughput | no | no |
| MYADM_HUMAN | [view interactions] | High throughput | no | no |
| ECM29_HUMAN | [view interactions] | High throughput | no | no |
| IQGA3_HUMAN | [view interactions] | High throughput | no | no |
| SORT_HUMAN | [view interactions] | High throughput | no | yes |
| PKHH3_HUMAN | [view interactions] | High throughput | no | no |
| ACSL1_HUMAN | [view interactions] | High throughput | no | no |
| CAC1D_HUMAN | [view interactions] | Computational | no | yes |
| CAC1F_HUMAN | [view interactions] | Computational | no | no |
| CAC1S_HUMAN | [view interactions] | Computational | no | no |
| CCG6_HUMAN | [view interactions] | Computational | no | no |
| CACB4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CA2D4_HUMAN | [view interactions] | Computational | no | no |
| GRIA4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GRIA2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CCG1_HUMAN | [view interactions] | Computational | no | no |
| CCG3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CAC1C_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CACB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CACB3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CCG7_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GRIA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MYO6_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CAC1B_HUMAN | [view interactions] | Computational | no | yes |
| AKAP5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CNIH2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| E41L1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GRIA3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CA2D1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DLG1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CCG8_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| KCC2D_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CAC1H_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KCC2B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CNIH3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CAC1E_HUMAN | [view entry] [view interactions] | Computational | yes | no |