KC1E_HUMAN
Evidence for PS localization
Functions
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation. [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 91%
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
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KC1E_HUMAN has binary interactions with 50 proteins
Isoforms
Interacting regions
Canonical [KC1E_HUMAN]
Isoform [B0QY34] alignment
Isoform [B0QY35] alignment
Isoform [B0QY36] alignment
Isoform [H0Y5S9] alignment
Isoform [H0Y682] alignment
Isoform [H0Y645] alignment
Isoform [H7C3J2] alignment
Isoform [H7C0Y5] alignment
Isoform [A0A669KBC0] alignment
LOADING 62%
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KC1E_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 27.2727 | 4 | yes |
| GO:0043168 | anion binding | 25.2525 | 4 | yes |
| GO:0000166 | nucleotide binding | 23.2323 | 4 | yes |
| GO:0043169 | cation binding | 23.2323 | 4 | no |
| GO:0046872 | metal ion binding | 23.2323 | 5 | no |
| GO:0017076 | purine nucleotide binding | 22.2222 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 22.2222 | 4 | yes |
| GO:0045296 | cadherin binding | 21.2121 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 20.2020 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 20.2020 | 5 | yes |
| GO:0019900 | kinase binding | 20.2020 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 19.1919 | 4 | yes |
| GO:0005524 | ATP binding | 17.1717 | 5 | yes |
| GO:0016301 | kinase activity | 13.1313 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 11.1111 | 4 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 9.0909 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 8.0808 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KC1E_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 62.6263 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 56.5657 | 4 | yes |
| GO:0010646 | regulation of cell communication | 55.5556 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 54.5455 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 51.5152 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 51.5152 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 46.4646 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 41.4141 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 41.4141 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 41.4141 | 5 | yes |
| GO:0010468 | regulation of gene expression | 38.3838 | 6 | yes |
| GO:0051246 | regulation of protein metabolic process | 36.3636 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 36.3636 | 4 | no |
| GO:0008104 | protein localization | 35.3535 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 35.3535 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 34.3434 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 32.3232 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 32.3232 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 32.3232 | 4 | yes |
| GO:0051049 | regulation of transport | 32.3232 | 4 | no |
| GO:0022607 | cellular component assembly | 32.3232 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.3030 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 30.3030 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.2828 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2A5D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2A5E_HUMAN | [view interactions] | High throughput | no | yes |
| 7B2_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACACA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACVL1_HUMAN | [view interactions] | High throughput | no | yes |
| ADA22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AHNK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMRP_HUMAN | [view interactions] | High throughput | no | yes |
| ANKR6_HUMAN | [view interactions] | Low throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| ANM1_HUMAN | [view interactions] | High throughput | no | yes |
| ANM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANR49_HUMAN | [view interactions] | High throughput | no | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ARHG1_HUMAN | [view interactions] | High throughput | no | no |