Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ADA22_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (PubMed). Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI003017 LIG_14-3-3_CanoR_1 LIG 831 836 -
ELMI003016 LIG_14-3-3_CanoR_1 LIG 854 863 -
ELMI002436 LIG_PDZ_Class_1 LIG 901 906 -
ELMI002070 TRG_ER_diArg_1 TRG 851 854 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ADA22_HUMAN
GO:0017076 purine nucleotide binding 27.5862 4 no
GO:0032555 purine ribonucleotide binding 27.5862 4 no
GO:0035639 purine ribonucleoside triphosphate binding 27.5862 4 no
GO:0019900 kinase binding 24.1379 4 no
GO:0016301 kinase activity 24.1379 4 no
GO:0004175 endopeptidase activity 10.3448 4 yes
GO:0004222 metalloendopeptidase activity 10.3448 5 yes
GO:0008237 metallopeptidase activity 10.3448 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ADA22_HUMAN
GO:0010646 regulation of cell communication 62.0690 4 no
GO:0048523 negative regulation of cellular process 58.6207 4 yes
GO:0048522 positive regulation of cellular process 58.6207 4 no
GO:0009966 regulation of signal transduction 55.1724 4 no
GO:0060255 regulation of macromolecule metabolic process 51.7241 4 no
GO:0008104 protein localization 51.7241 4 no
GO:0031323 regulation of cellular metabolic process 48.2759 4 no
GO:0051128 regulation of cellular component organization 48.2759 4 no
GO:0051171 regulation of nitrogen compound metabolic process 44.8276 4 no
GO:0080090 regulation of primary metabolic process 44.8276 4 no
GO:0010468 regulation of gene expression 37.9310 5 no
GO:0071702 organic substance transport 37.9310 4 no
GO:0071705 nitrogen compound transport 37.9310 4 no
GO:0051049 regulation of transport 37.9310 4 no
GO:0006996 organelle organization 34.4828 4 no
GO:0009893 positive regulation of metabolic process 34.4828 4 no
GO:0010604 positive regulation of macromolecule metabolic process 34.4828 5 no
GO:0022607 cellular component assembly 34.4828 4 no
GO:0030030 cell projection organization 34.4828 4 no
GO:0031175 neuron projection development 34.4828 6 no
GO:0050804 modulation of chemical synaptic transmission 34.4828 5 no
GO:0051246 regulation of protein metabolic process 34.4828 5 no
GO:0099177 regulation of trans-synaptic signaling 34.4828 4 no
GO:0120036 plasma membrane bounded cell projection organization 34.4828 5 no
GO:0016192 vesicle-mediated transport 34.4828 4 no
GO:1902531 regulation of intracellular signal transduction 31.0345 5 no
GO:0015031 protein transport 31.0345 4 no
GO:0042127 regulation of cell population proliferation 31.0345 4 no
GO:0009892 negative regulation of metabolic process 27.5862 4 no
GO:0010605 negative regulation of macromolecule metabolic process 27.5862 5 no
GO:0010941 regulation of cell death 27.5862 4 no
GO:0019220 regulation of phosphate metabolic process 27.5862 6 no
GO:0031324 negative regulation of cellular metabolic process 27.5862 5 no
GO:0031325 positive regulation of cellular metabolic process 27.5862 5 no
GO:0031399 regulation of protein modification process 27.5862 6 no
GO:0032880 regulation of protein localization 27.5862 5 no
GO:0051130 positive regulation of cellular component organization 27.5862 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 27.5862 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 27.5862 5 no
GO:0051174 regulation of phosphorus metabolic process 27.5862 5 no
GO:0051247 positive regulation of protein metabolic process 27.5862 6 no
GO:0060341 regulation of cellular localization 27.5862 4 no
GO:0023056 positive regulation of signaling 27.5862 4 no
GO:0072657 protein localization to membrane 27.5862 4 no
GO:0022603 regulation of anatomical structure morphogenesis 24.1379 4 no
GO:0031344 regulation of cell projection organization 24.1379 5 no
GO:0033043 regulation of organelle organization 24.1379 5 no
GO:0036211 protein modification process 24.1379 4 no
GO:0042325 regulation of phosphorylation 24.1379 7 no
GO:0043085 positive regulation of catalytic activity 24.1379 4 no
GO:0043412 macromolecule modification 24.1379 4 no
GO:0044087 regulation of cellular component biogenesis 24.1379 4 no
GO:0045595 regulation of cell differentiation 24.1379 4 no
GO:0050890 cognition 24.1379 4 no
GO:0071310 cellular response to organic substance 24.1379 4 no
GO:1903829 positive regulation of protein localization 24.1379 5 no
GO:0006886 intracellular protein transport 24.1379 4 no
GO:0048584 positive regulation of response to stimulus 24.1379 4 no
GO:0051050 positive regulation of transport 24.1379 4 no
GO:0060627 regulation of vesicle-mediated transport 24.1379 4 no
GO:0010647 positive regulation of cell communication 24.1379 5 no
GO:0033365 protein localization to organelle 24.1379 5 no
GO:1990778 protein localization to cell periphery 24.1379 5 no
GO:0042981 regulation of apoptotic process 24.1379 6 no
GO:0043067 regulation of programmed cell death 24.1379 5 no
GO:0048585 negative regulation of response to stimulus 24.1379 4 no
GO:0010648 negative regulation of cell communication 24.1379 5 no
GO:0023057 negative regulation of signaling 24.1379 4 no
GO:0043269 regulation of ion transport 24.1379 5 no
GO:0010038 response to metal ion 20.6897 4 no
GO:0010562 positive regulation of phosphorus metabolic process 20.6897 6 no
GO:0042327 positive regulation of phosphorylation 20.6897 8 no
GO:0044089 positive regulation of cellular component biogenesis 20.6897 5 no
GO:0045937 positive regulation of phosphate metabolic process 20.6897 7 no
GO:0051093 negative regulation of developmental process 20.6897 4 no
GO:0051129 negative regulation of cellular component organization 20.6897 5 no
GO:0051336 regulation of hydrolase activity 20.6897 4 no
GO:0097435 supramolecular fiber organization 20.6897 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 20.6897 6 no
GO:0035418 protein localization to synapse 20.6897 6 no
GO:1902414 protein localization to cell junction 20.6897 5 no
GO:0006468 protein phosphorylation 20.6897 5 no
GO:0006796 phosphate-containing compound metabolic process 20.6897 4 no
GO:0016310 phosphorylation 20.6897 5 no
GO:0006897 endocytosis 20.6897 5 no
GO:0001932 regulation of protein phosphorylation 20.6897 7 no
GO:0009968 negative regulation of signal transduction 20.6897 5 no
GO:0034762 regulation of transmembrane transport 20.6897 4 no
GO:0034765 regulation of ion transmembrane transport 20.6897 5 no
GO:1904062 regulation of cation transmembrane transport 20.6897 6 no
GO:0030155 regulation of cell adhesion 17.2414 4 yes
GO:0007162 negative regulation of cell adhesion 10.3448 5 yes
GO:0007417 central nervous system development 10.3448 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in ADA22_HUMAN
DOID:331 central nervous system disease 6.8966 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
1433Z_HUMAN [view entry] [view interactions] Low throughput yes yes
1433B_HUMAN [view entry] [view interactions] Low throughput yes yes
1433T_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
HCK_HUMAN [view entry] [view interactions] Low throughput yes no
LGI1_HUMAN [view entry] [view interactions] Low throughput yes no
SCRIB_HUMAN [view entry] [view interactions] High throughput yes no
EPS8_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
KC1E_HUMAN [view entry] [view interactions] High throughput yes yes
MYB_HUMAN [view interactions] High throughput no yes
DLG1_HUMAN [view entry] [view interactions] High throughput yes yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
NXF1_HUMAN [view interactions] High throughput no yes
PPARG_HUMAN [view interactions] High throughput no yes
KALRN_HUMAN [view entry] [view interactions] High throughput yes yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
VIR_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
HFE_HUMAN [view interactions] High throughput no yes
LSME2_HUMAN [view interactions] High throughput no no
PCDAB_HUMAN [view interactions] High throughput no no
TMM74_HUMAN [view interactions] High throughput no no
HDBP1_HUMAN [view interactions] High throughput no no
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
TBB4B_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
OTUD4_HUMAN [view interactions] High throughput no yes
ADA11_HUMAN [view entry] [view interactions] High throughput yes yes
ADA12_HUMAN [view interactions] High throughput no no
ADA19_HUMAN [view interactions] High throughput no no
ADAM2_HUMAN [view interactions] High throughput no no
ADA28_HUMAN [view interactions] High throughput no no
ADA32_HUMAN [view interactions] High throughput no no
ADAM5_HUMAN [view interactions] High throughput no no
ADAM7_HUMAN [view interactions] High throughput no no
ADAM8_HUMAN [view interactions] High throughput no yes
ADA23_HUMAN [view entry] [view interactions] High throughput yes yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
LGI2_HUMAN [view interactions] Computational no yes
DLG2_HUMAN [view entry] [view interactions] Computational yes yes
LGI4_HUMAN [view interactions] Computational no yes
LGI3_HUMAN [view interactions] Computational no no
KCNA1_HUMAN [view entry] [view interactions] Computational yes yes
CCG2_HUMAN [view entry] [view interactions] Computational yes no