ADA22_HUMAN

G2C

SynGO

SynaptomeDB

Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (PubMed). Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. [View more on UniProt]

Transmembrane

Phase separation

ELM

Phosphorylation

PFAM

Coiled coil

Anchor

Disordered

Interacting regions

Sequence

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ADA22_HUMAN

SCRIB_HUMAN

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ADA22_HUMAN

1433Z_HUMAN

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ADA22_HUMAN

1433B_HUMAN

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ADA22_HUMAN

1433T_HUMAN

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ADA22_HUMAN

HCK_HUMAN

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ADA22_HUMAN

LGI1_HUMAN

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ADA22_HUMAN

DLG1_HUMAN

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ADA22_HUMAN has binary interactions with 28 proteins

Download full PS network for entry.

Interacting regions

Canonical [ADA22_HUMAN]

Isoform [F8WAD8] alignment

Isoform [F8WAD8] sequence

Isoform [A0A804HHS1] alignment

Isoform [A0A804HHS1] sequence

Isoform [A0A804HIW1] alignment

Isoform [A0A804HIW1] sequence

Isoform [H7C3I4] alignment

Isoform [H7C3I4] sequence

Isoform [H7C0Q9] alignment

Isoform [H7C0Q9] sequence

Isoform [Q9P0K1-2] alignment

Isoform [Q9P0K1-2] sequence

Isoform [Q9P0K1-3] alignment

Isoform [Q9P0K1-3] sequence

Isoform [Q9P0K1-4] alignment

Isoform [Q9P0K1-4] sequence

Isoform [Q9P0K1-5] alignment

Isoform [Q9P0K1-5] sequence

Isoform [E9PF78] alignment

Isoform [E9PF78] sequence

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No data found.

ELM instance	Name	Type	Start	End	Partner
ELMI003017	LIG_14-3-3_CanoR_1	LIG	831	836	-
ELMI003016	LIG_14-3-3_CanoR_1	LIG	854	863	-
ELMI002436	LIG_PDZ_Class_1	LIG	901	906	-
ELMI002070	TRG_ER_diArg_1	TRG	851	854	-
ELMI003017	LIG_14-3-3_CanoR_1	LIG	831	836	-
ELMI003016	LIG_14-3-3_CanoR_1	LIG	854	863	-
ELMI002436	LIG_PDZ_Class_1	LIG	901	906	-
ELMI002070	TRG_ER_diArg_1	TRG	851	854	-

Molecular function

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Search:

Term	Name	%	Distance from the top of the tree	Annotated in ADA22_HUMAN
GO:0000166	nucleotide binding	27.5862	4	no
GO:0017076	purine nucleotide binding	27.5862	5	no
GO:0032555	purine ribonucleotide binding	27.5862	4	no
GO:0035639	purine ribonucleoside triphosphate binding	27.5862	4	no
GO:0043168	anion binding	27.5862	4	no
GO:0016301	kinase activity	20.6897	4	no
GO:0004175	endopeptidase activity	10.3448	4	yes
GO:0004222	metalloendopeptidase activity	10.3448	5	yes
GO:0008237	metallopeptidase activity	10.3448	4	yes

Showing 1 to 9 of 9 entries

Biological process

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Search:

Term	Name	%	Distance from top the of the tree	Annotated in ADA22_HUMAN
GO:0048523	negative regulation of cellular process	65.5172	4	yes
GO:0010646	regulation of cell communication	58.6207	4	no
GO:0048522	positive regulation of cellular process	55.1724	4	no
GO:0051128	regulation of cellular component organization	55.1724	4	no
GO:0031323	regulation of cellular metabolic process	51.7241	4	no
GO:0060255	regulation of macromolecule metabolic process	51.7241	4	no
GO:0009966	regulation of signal transduction	48.2759	4	no
GO:0008104	protein localization	48.2759	4	no
GO:0080090	regulation of primary metabolic process	44.8276	4	no
GO:0009889	regulation of biosynthetic process	37.9310	4	no
GO:0010468	regulation of gene expression	37.9310	6	no
GO:0010556	regulation of macromolecule biosynthetic process	37.9310	5	no
GO:0030030	cell projection organization	37.9310	4	no
GO:0031326	regulation of cellular biosynthetic process	37.9310	5	no
GO:0051049	regulation of transport	37.9310	4	no
GO:0031175	neuron projection development	34.4828	6	no
GO:0120036	plasma membrane bounded cell projection organization	34.4828	5	no
GO:0022607	cellular component assembly	31.0345	4	no
GO:0044087	regulation of cellular component biogenesis	31.0345	4	no
GO:0051130	positive regulation of cellular component organization	31.0345	5	no
GO:1902531	regulation of intracellular signal transduction	31.0345	5	no
GO:0009893	positive regulation of metabolic process	31.0345	4	no
GO:0010604	positive regulation of macromolecule metabolic process	31.0345	5	no
GO:0042127	regulation of cell population proliferation	31.0345	4	no
GO:0048585	negative regulation of response to stimulus	31.0345	4	no

Showing 1 to 25 of 77 entries

Disease

No data found.

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Search:

Uniprot ID	Details	Highest evidence	Localizing into PSD	HPA (protein expression in neurons)
1433B_HUMAN	[view entry] [view interactions]	Low throughput	yes	yes
1433T_HUMAN	[view entry] [view interactions]	Low throughput	yes	yes
1433Z_HUMAN	[view entry] [view interactions]	Low throughput	yes	yes
A4_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
ADA11_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
ADA12_HUMAN	[view interactions]	High throughput	no	no
ADA19_HUMAN	[view interactions]	High throughput	no	no
ADA23_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
ADA28_HUMAN	[view interactions]	High throughput	no	no
ADA32_HUMAN	[view interactions]	High throughput	no	no
ADAM2_HUMAN	[view interactions]	High throughput	no	no
ADAM5_HUMAN	[view interactions]	High throughput	no	no
ADAM7_HUMAN	[view interactions]	High throughput	no	no
ADAM8_HUMAN	[view interactions]	High throughput	no	yes
CALX_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
CNTP2_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
DLG1_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
DLG4_HUMAN	[view entry] [view interactions]	Low throughput	yes	yes
DLGP1_HUMAN	[view entry] [view interactions]	High throughput	yes	no
DYR1A_HUMAN	[view interactions]	High throughput	no	yes
EPS8_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
HCK_HUMAN	[view entry] [view interactions]	Low throughput	yes	no
HDBP1_HUMAN	[view interactions]	High throughput	no	no
HFE_HUMAN	[view interactions]	High throughput	no	yes
KALRN_HUMAN	[view entry] [view interactions]	High throughput	yes	yes

Showing 1 to 25 of 50 entries

ADA22_HUMAN

Evidence for PS localization

Functions

Protein features

Binary interactions with known binding regions

Network

Isoforms

Disease-causing germline mutations

Linear motifs

Fingerprint

Molecular function

Biological process

Disease

All partners